Gregory I Liou

Summary

Affiliation: Medical College of Georgia
Country: USA

Publications

  1. pmc Neuroprotective and blood-retinal barrier-preserving effects of cannabidiol in experimental diabetes
    Azza B el-Remessy
    Department of Pharmacology and Toxicology, Medical College of Georgia, 1120 15th St, Augusta, GA 30912, USA
    Am J Pathol 168:235-44. 2006
  2. ncbi request reprint HGF regulation of RPE proliferation in an IL-1beta/retinal hole-induced rabbit model of PVR
    Gregory I Liou
    Department of Ophthalmology, Medical College of Georgia, Augusta, GA 30912, USA
    Mol Vis 8:494-501. 2002
  3. ncbi request reprint MAP kinase and beta-catenin signaling in HGF induced RPE migration
    Gregory I Liou
    Department of Ophthalmology, Medical College of Georgia, Augusta, GA 30912, USA
    Mol Vis 8:483-93. 2002
  4. ncbi request reprint Alternative splicing of the APC gene in the neural retina and retinal pigment epithelium
    Gregory I Liou
    Department of Ophthalmology, Medical College of Georgia, Augusta, GA 30912, USA
    Mol Vis 10:383-91. 2004
  5. doi request reprint ABT-702, an adenosine kinase inhibitor, attenuates inflammation in diabetic retinopathy
    Nehal M Elsherbiny
    Department of Ophthalmology, Georgia Regents University, 30909, USA
    Life Sci 93:78-88. 2013
  6. doi request reprint Potential role of A2A adenosine receptor in traumatic optic neuropathy
    Saif Ahmad
    Department of Ophthalmology, Georgia Regents University GRU, Augusta, GA, USA Departmet of Biological Sciences, College of Science and Arts, King Abdulaziz University, Rabigh, Saudi Arabia Electronic address
    J Neuroimmunol 264:54-64. 2013
  7. pmc Role of IL-6 in angiotensin II-induced retinal vascular inflammation
    Modesto Rojas
    VA Medical Center, Augusta, Georgia, USA
    Invest Ophthalmol Vis Sci 51:1709-18. 2010
  8. pmc Retinal microglial activation and inflammation induced by amadori-glycated albumin in a rat model of diabetes
    Ahmed S Ibrahim
    epartment of Ophthalmology, Medical College of Georgia, Augusta, Georgia, USA
    Diabetes 60:1122-33. 2011
  9. doi request reprint Potential roles of adenosine deaminase-2 in diabetic retinopathy
    Nehal M Elsherbiny
    Department of Ophthalmology, Georgia Regents University, Augusta, GA, United States
    Biochem Biophys Res Commun 436:355-61. 2013
  10. pmc NAD(P)H oxidase-dependent regulation of CCL2 production during retinal inflammation
    Wenbo Zhang
    VA Medical Center, Augusta, Georgia, USA
    Invest Ophthalmol Vis Sci 50:3033-40. 2009

Collaborators

Detail Information

Publications33

  1. pmc Neuroprotective and blood-retinal barrier-preserving effects of cannabidiol in experimental diabetes
    Azza B el-Remessy
    Department of Pharmacology and Toxicology, Medical College of Georgia, 1120 15th St, Augusta, GA 30912, USA
    Am J Pathol 168:235-44. 2006
    ..These results demonstrate that CBD treatment reduces neurotoxicity, inflammation, and BRB breakdown in diabetic animals through activities that may involve inhibition of p38 MAP kinase...
  2. ncbi request reprint HGF regulation of RPE proliferation in an IL-1beta/retinal hole-induced rabbit model of PVR
    Gregory I Liou
    Department of Ophthalmology, Medical College of Georgia, Augusta, GA 30912, USA
    Mol Vis 8:494-501. 2002
    ..To understand molecular events that lead to retinal pigment epithelial (RPE) cell proliferation and migration during the early phases of proliferative vitreoretinopathy (PVR) in a rabbit model...
  3. ncbi request reprint MAP kinase and beta-catenin signaling in HGF induced RPE migration
    Gregory I Liou
    Department of Ophthalmology, Medical College of Georgia, Augusta, GA 30912, USA
    Mol Vis 8:483-93. 2002
    ..The aim of this study is to investigate HGF induced signaling pathways that lead to RPE cell migration...
  4. ncbi request reprint Alternative splicing of the APC gene in the neural retina and retinal pigment epithelium
    Gregory I Liou
    Department of Ophthalmology, Medical College of Georgia, Augusta, GA 30912, USA
    Mol Vis 10:383-91. 2004
    ..Distinctive APC isoforms exist in different cell types due to alternative splicing of the APC transcripts. We hypothesize that differences in expression patterns of APC protein isoforms are critical to RPE proliferation/differentiation...
  5. doi request reprint ABT-702, an adenosine kinase inhibitor, attenuates inflammation in diabetic retinopathy
    Nehal M Elsherbiny
    Department of Ophthalmology, Georgia Regents University, 30909, USA
    Life Sci 93:78-88. 2013
    ..Here we demonstrate that AKI-enhanced adenosine signaling provides protection from DR in mice...
  6. doi request reprint Potential role of A2A adenosine receptor in traumatic optic neuropathy
    Saif Ahmad
    Department of Ophthalmology, Georgia Regents University GRU, Augusta, GA, USA Departmet of Biological Sciences, College of Science and Arts, King Abdulaziz University, Rabigh, Saudi Arabia Electronic address
    J Neuroimmunol 264:54-64. 2013
    ....
  7. pmc Role of IL-6 in angiotensin II-induced retinal vascular inflammation
    Modesto Rojas
    VA Medical Center, Augusta, Georgia, USA
    Invest Ophthalmol Vis Sci 51:1709-18. 2010
    ..The present study was an investigation of the role of interleukin (IL)-6 in angiotensin II-induced retinopathy...
  8. pmc Retinal microglial activation and inflammation induced by amadori-glycated albumin in a rat model of diabetes
    Ahmed S Ibrahim
    epartment of Ophthalmology, Medical College of Georgia, Augusta, Georgia, USA
    Diabetes 60:1122-33. 2011
    ..The mechanism by which diabetes activates microglia to release those inflammatory mediators is unclear and was therefore elucidated...
  9. doi request reprint Potential roles of adenosine deaminase-2 in diabetic retinopathy
    Nehal M Elsherbiny
    Department of Ophthalmology, Georgia Regents University, Augusta, GA, United States
    Biochem Biophys Res Commun 436:355-61. 2013
    ..These results suggest that retinal inflammation in DR is mediated by ADA2, and that the anti-inflammatory activity of A(2A)AR signaling is impaired in diabetes due to increased ADA2 activity...
  10. pmc NAD(P)H oxidase-dependent regulation of CCL2 production during retinal inflammation
    Wenbo Zhang
    VA Medical Center, Augusta, Georgia, USA
    Invest Ophthalmol Vis Sci 50:3033-40. 2009
    ..The authors had previously found that the blockade of NAD(P)H oxidase in turn blocks leukocyte adhesion to retinal vessels during diabetes and uveitis. In this study, the role of NAD(P)H oxidase in CCL2 production was assessed...
  11. ncbi request reprint Neuroprotective and intraocular pressure-lowering effects of (-)Delta9-tetrahydrocannabinol in a rat model of glaucoma
    James Crandall
    Department of Ophthalmology, Medical College of Georgia, Augusta, GA 30912, USA
    Ophthalmic Res 39:69-75. 2007
    ..The RGC loss in the operated eyes of the THC-treated animals was reduced to 10-20%. These results demonstrate that THC is a neuroprotectant that preserves RGCs in an experimental model of glaucoma, possibly through a reduction in IOP...
  12. doi request reprint Tyrosine kinase inhibitor, genistein, reduces renal inflammation and injury in streptozotocin-induced diabetic mice
    Ahmed A Elmarakby
    Department of Oral Biology, Georgia Health Sciences University, Augusta, GA 30912, United States
    Vascul Pharmacol 55:149-56. 2011
    ..Collectively, the results suggest that the reno-protective effect of genistein likely relates to reduced renal inflammation, oxidative stress and apoptosis in diabetic mice...
  13. doi request reprint Loss of thioredoxin function in retinas of mice overexpressing amyloid β
    Folami Lamoke
    Department of Pharmacology and Toxicology, Georgia Health Sciences University, Augusta, GA 30912, USA
    Free Radic Biol Med 53:577-88. 2012
    ..Our data suggest that Aβ-mediated retinal neurotoxicity involves impairment of the thioredoxin system and enhanced oxidative stress, potentially implicating this mechanism in the pathogenesis of ARMD and glaucoma...
  14. pmc Mediation of cannabidiol anti-inflammation in the retina by equilibrative nucleoside transporter and A2A adenosine receptor
    Gregory I Liou
    Department of Ophthalmology, Medical College of Georgia, Augusta, Georgia 30912, USA
    Invest Ophthalmol Vis Sci 49:5526-31. 2008
    ..However, the protective mechanism of this anti-inflammatory cannabinoid is not completely understood. The goal of this study is to determine the role of adenosine signaling in retinal inflammation and its potential modulation by CBD...
  15. doi request reprint Peroxynitrite mediates retinal neurodegeneration by inhibiting nerve growth factor survival signaling in experimental and human diabetes
    Tayyeba K Ali
    Program in Clinical and Experimental Therapeutics, College of Pharmacy, University of Georgia, Augusta, GA 30912, USA
    Diabetes 57:889-98. 2008
    ..However, the causal role of peroxynitrite and the impact of tyrosine nitration on diabetes-induced retinal neurodegeneration and NGF survival signaling have not been elucidated...
  16. pmc MicroRNA-146b-3p regulates retinal inflammation by suppressing adenosine deaminase-2 in diabetes
    Sadanand Fulzele
    Department of Orthopedics, Georgia Regents University, Augusta, GA, USA
    Biomed Res Int 2015:846501. 2015
    ..These results suggest a regulatory role of miR-146b-3p in diabetes related retinal inflammation by suppressing ADA2. ..
  17. doi request reprint Regulation of vitamin C transporter in the type 1 diabetic mouse bone and bone marrow
    Rajnikumar Sangani
    Departments of Orthopaedic Surgery, Georgia Regents University, Augusta, GA 30912, United States
    Exp Mol Pathol 95:298-306. 2013
    ..This study has provided evidence that the regulation of the SVCT2 transporter plays an important role not only in T1D osteoporosis but also in other oxidative stress-related musculoskeletal complications...
  18. pmc Genistein attenuates retinal inflammation associated with diabetes by targeting of microglial activation
    Ahmed S Ibrahim
    Department of Ophthalmology, Medical College of Georgia, Augusta, GA 30912, USA
    Mol Vis 16:2033-42. 2010
    ....
  19. pmc A(₂A) adenosine receptor (A(₂A)AR) as a therapeutic target in diabetic retinopathy
    Ahmed S Ibrahim
    Department of Ophthalmology, Medical College of Georgia, Augusta, Georgia, USA
    Am J Pathol 178:2136-45. 2011
    ....
  20. pmc Neuroprotective effect of (-)Delta9-tetrahydrocannabinol and cannabidiol in N-methyl-D-aspartate-induced retinal neurotoxicity: involvement of peroxynitrite
    Azza B el-Remessy
    Department of Pharmacology and Toxicology, Medical College of Georgia, 1120 15th Street, Augusta, GA 30912, USA
    Am J Pathol 163:1997-2008. 2003
    ..The effect of THC was in part mediated by the cannabinoid receptor CB1. These results suggest the potential use of CBD as a novel topical therapy for the treatment of glaucoma...
  21. doi request reprint Inhibition of adenosine kinase attenuates inflammation and neurotoxicity in traumatic optic neuropathy
    Saif Ahmad
    Department of Ophthalmology, School of Medicine, Georgia Regents University GRU, Augusta, GA, USA Departmet of Biological Sciences, Rabigh College of Science and Arts, King Abdulaziz University, Rabigh, Saudi Arabia Electronic address
    J Neuroimmunol 277:96-104. 2014
    ....
  22. pmc Adenosine kinase inhibition protects the kidney against streptozotocin-induced diabetes through anti-inflammatory and anti-oxidant mechanisms
    Chelsey Pye
    Department of Oral Biology, Georgia Regents University, Augusta, GA 30912, United States
    Pharmacol Res 85:45-54. 2014
    ..Collectively, the results suggest that the reno-protective effects of ABT702 could be attributed to the reduction in renal inflammation and oxidative stress in diabetic mice. ..
  23. pmc Opioid receptor activation: suppression of ischemia/reperfusion-induced production of TNF-α in the retina
    Shahid Husain
    Hewitt Laboratory, Ola B Williams Glaucoma Center, Department of Ophthalmology, Storm Eye Institute, Medical University of South Carolina, 167 Ashley Avenue, Charleston, SC 29425, USA
    Invest Ophthalmol Vis Sci 52:2577-83. 2011
    ..The detrimental role of TNF-α in ischemia-induced tissue damage is known. The authors study examined whether opioid receptor activation alters TNF-α levels in the postischemic retina...
  24. pmc Receptor interacting protein kinase-mediated necrosis contributes to cone and rod photoreceptor degeneration in the retina lacking interphotoreceptor retinoid-binding protein
    Kota Sato
    Department of Ophthalmology and Neuroscience Center of Excellence, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112, Electron Microscope Laboratory, Tulane University, New Orleans, Louisiana 70118, Department of Ophthalmology, Georgia Health Sciences University, Augusta, Georgia 30912, and Jules Stein Eye Institute, The University of California, Los Angeles School of Medicine, Los Angeles, California 90095
    J Neurosci 33:17458-68. 2013
    ....
  25. ncbi request reprint Vascular endothelial growth factor and diabetic retinopathy: role of oxidative stress
    Ruth B Caldwell
    Vascular Biology Center, The Medical College of Georgia, Augusta, 30912, USA
    Curr Drug Targets 6:511-24. 2005
    ..Potential therapeutic strategies for preventing VEGF overexpression or blocking its pathological actions in the diabetic retina are considered...
  26. pmc Role of adenosine in diabetic retinopathy
    Gregory I Liou
    Department of Ophthalmology, Georgia Health Sciences University, 1120 15th Street, Augusta, GA 30912 USA
    J Ocul Biol Dis Infor 4:19-24. 2011
    ....
  27. pmc Exaggerated eye growth in IRBP-deficient mice in early development
    Jeffrey Wisard
    Department of Ophthalmology, Emory University, Atlanta, Georgia 30322, USA
    Invest Ophthalmol Vis Sci 52:5804-11. 2011
    ..Because interphotoreceptor retinoid-binding protein (IRBP) is expressed before being needed in its presumptive role in the visual cycle, we tested whether it controls eye growth during development...
  28. ncbi request reprint Sequence analysis of the mouse IRBP gene and cDNA
    R Keith Shuler
    Department of Ophthalmology, Emory University, Atlanta, GA 30322, USA
    Curr Eye Res 24:354-67. 2002
    ..To compare the levels of expression of IRBP RNA in normal and knockout mice...
  29. pmc An immunologically privileged retinal antigen elicits tolerance: major role for central selection mechanisms
    Dody Avichezer
    Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 198:1665-76. 2003
    ..Thus, uveitis-susceptible individuals display a detectable and functionally significant tolerance to their target antigen, in which central mechanisms play a prominent role...
  30. pmc Endogenous IRBP can be dispensable for generation of natural CD4+CD25+ regulatory T cells that protect from IRBP-induced retinal autoimmunity
    Rafael S Grajewski
    Laboratory of Immunology, National Eye Institute, National Institutes of Health NIH, Bethesda, MD 20892, USA
    J Exp Med 203:851-6. 2006
    ..Our data also provide the first evidence that generation of specific T reg cells to a native autoantigen in a mouse with a diverse T cell repertoire requires a cognate interaction...
  31. pmc Spontaneous autoimmunity prevented by thymic expression of a single self-antigen
    Jason DeVoss
    Diabetes Center and Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA
    J Exp Med 203:2727-35. 2006
    ..These results suggest that failure of thymic expression of selective single self-antigens can be sufficient to cause organ-specific autoimmune disease, even in otherwise self-tolerant individuals...
  32. ncbi request reprint Interphotoreceptor retinoid-binding protein (IRBP)-deficient C57BL/6 mice have enhanced immunological and immunopathogenic responses to IRBP and an altered recognition of IRBP epitopes
    Dody Avichezer
    Laboratory of Immunology, Section of Immunoregulation, National Institutes of Health, 10 Center Drive, 10 10N222, Bethesda, MD 20892 1857, USA
    J Autoimmun 21:185-94. 2003
    ..Furthermore, endogenous expression of IRBP is directly responsible for lowering the threshold of susceptibility to uveitic disease...
  33. pmc Repertoire analysis and new pathogenic epitopes of IRBP in C57BL/6 (H-2b) and B10.RIII (H-2r) mice
    Lizette M Cortes
    Laboratory of Immunology, National Eye Institute, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA
    Invest Ophthalmol Vis Sci 49:1946-56. 2008
    ..The purpose of this study was to identify and characterize additional uveitogenic epitopes in B10.RIII and C57BL/6 mice and to compare epitope recognition in wild-type versus IRBP-deficient mice on both backgrounds...