- 2,3,7,8-tetrachlorodibenzo-p-dioxin increases reactive oxygen species production in human endothelial cells via induction of cytochrome P4501A1P G Kopf
Department of Pharmaceutical Science, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA
Toxicol Appl Pharmacol 245:91-9. 2010..97+/-0.03; p=0.481) (siCYP1A1: Cont=1.00+/-0.03; TCDD=0.92+/-0.03; p=0.034), while siRNA targeting CYP1B1 did not. These data suggest that TCDD-induced increase in ROS is AhR-dependent and may be mediated, in part, by CYP1A1 induction...