Joseph Edward Kerschner

Summary

Affiliation: Medical College of Wisconsin
Country: USA

Publications

  1. pmc Differential response of gel-forming mucins to pathogenic middle ear bacteria
    Joseph E Kerschner
    Division of Pediatric Otolaryngology, Children s Hospital of Wisconsin, 9000 W Wisconsin Avenue, Milwaukee, Wisconsin 53226, USA Department of Otolaryngology and Communication Sciences, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, Wisconsin 53226, USA Electronic address
    Int J Pediatr Otorhinolaryngol 78:1368-73. 2014
  2. pmc A novel model of spontaneous otitis media with effusion (OME) in the Oxgr1 knock-out mouse
    Joseph E Kerschner
    Division of Pediatric Otolaryngology, 9000 West Wisconsin Avenue, Milwaukee, WI 53226, United States
    Int J Pediatr Otorhinolaryngol 77:79-84. 2013
  3. ncbi request reprint Signaling pathways in interleukin-1beta-mediated middle ear mucin secretion
    Joseph E Kerschner
    Division of Pediatric Otolaryngology and the Department of Otolaryngology and Communication Sciences, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Laryngoscope 116:207-11. 2006
  4. ncbi request reprint Mucin gene cDNA sequence characterization in chinchilla middle ear epithelium
    Joseph E Kerschner
    Division of Pediatric Otolaryngology, Medical College of Wisconsin, 9000 W Wisconsin Avenue, Milwaukee, WI 53226, USA
    Int J Pediatr Otorhinolaryngol 70:1449-56. 2006
  5. ncbi request reprint Mucin gene expression in human middle ear epithelium
    Joseph Edward Kerschner
    Division of Pediatric Otolaryngology, Department of Otolaryngology and Communication Sciences, Medical College of Wisconsin, Children s Hospital of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Laryngoscope 117:1666-76. 2007
  6. pmc Bench and bedside advances in otitis media
    Joseph E Kerschner
    Division of Pediatric Otolaryngology, Department of Otolaryngology and Communication Sciences, MedicalCollege of Wisconsin, Children s Hospital of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Curr Opin Otolaryngol Head Neck Surg 16:543-7. 2008
  7. pmc Gene expression differences in infected and noninfected middle ear complementary DNA libraries
    Joseph E Kerschner
    Department of Otolaryngology and Communications Disorders, Children s Hospital of Wisconsin, 9000 W Wisconsin Ave, Milwaukee, WI 53226, USA
    Arch Otolaryngol Head Neck Surg 135:33-9. 2009
  8. pmc Mucin gene 19 (MUC19) expression and response to inflammatory cytokines in middle ear epithelium
    Joseph E Kerschner
    Division of Pediatric Otolaryngology, Medical College of Wisconsin, Children s Hospital of Wisconsin, 9000 W Wisconsin Avenue, Milwaukee, WI, 53226, USA
    Glycoconj J 26:1275-84. 2009
  9. pmc Extending the chinchilla middle ear epithelial model for mucin gene investigation
    Joseph E Kerschner
    Division of Pediatric Otolaryngology, Medical College of Wisconsin, Children s Hospital of Wisconsin, 9000 W Wisconsin Avenue, Milwaukee, WI 53226, USA
    Int J Pediatr Otorhinolaryngol 74:980-5. 2010
  10. pmc MUC5AC expression in human middle ear epithelium of patients with otitis media
    Joseph E Kerschner
    Division of Pediatric Otolaryngology, Children s Hospital of Wisconsin, 9000 W Wisconsin Ave, Milwaukee, WI 53226, USA
    Arch Otolaryngol Head Neck Surg 136:819-24. 2010

Research Grants

Collaborators

Detail Information

Publications46

  1. pmc Differential response of gel-forming mucins to pathogenic middle ear bacteria
    Joseph E Kerschner
    Division of Pediatric Otolaryngology, Children s Hospital of Wisconsin, 9000 W Wisconsin Avenue, Milwaukee, Wisconsin 53226, USA Department of Otolaryngology and Communication Sciences, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, Wisconsin 53226, USA Electronic address
    Int J Pediatr Otorhinolaryngol 78:1368-73. 2014
    ....
  2. pmc A novel model of spontaneous otitis media with effusion (OME) in the Oxgr1 knock-out mouse
    Joseph E Kerschner
    Division of Pediatric Otolaryngology, 9000 West Wisconsin Avenue, Milwaukee, WI 53226, United States
    Int J Pediatr Otorhinolaryngol 77:79-84. 2013
    ..As a primary component of interest in OME, mucin expression was examined in this model to assess expression as compared to wild type animals and suitability as a murine model of OME...
  3. ncbi request reprint Signaling pathways in interleukin-1beta-mediated middle ear mucin secretion
    Joseph E Kerschner
    Division of Pediatric Otolaryngology and the Department of Otolaryngology and Communication Sciences, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Laryngoscope 116:207-11. 2006
    ....
  4. ncbi request reprint Mucin gene cDNA sequence characterization in chinchilla middle ear epithelium
    Joseph E Kerschner
    Division of Pediatric Otolaryngology, Medical College of Wisconsin, 9000 W Wisconsin Avenue, Milwaukee, WI 53226, USA
    Int J Pediatr Otorhinolaryngol 70:1449-56. 2006
    ....
  5. ncbi request reprint Mucin gene expression in human middle ear epithelium
    Joseph Edward Kerschner
    Division of Pediatric Otolaryngology, Department of Otolaryngology and Communication Sciences, Medical College of Wisconsin, Children s Hospital of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Laryngoscope 117:1666-76. 2007
    ....
  6. pmc Bench and bedside advances in otitis media
    Joseph E Kerschner
    Division of Pediatric Otolaryngology, Department of Otolaryngology and Communication Sciences, MedicalCollege of Wisconsin, Children s Hospital of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Curr Opin Otolaryngol Head Neck Surg 16:543-7. 2008
    ..The present review aims to discuss recent and important publications related to otitis media and present an analysis of some of these findings...
  7. pmc Gene expression differences in infected and noninfected middle ear complementary DNA libraries
    Joseph E Kerschner
    Department of Otolaryngology and Communications Disorders, Children s Hospital of Wisconsin, 9000 W Wisconsin Ave, Milwaukee, WI 53226, USA
    Arch Otolaryngol Head Neck Surg 135:33-9. 2009
    ..A comprehensive assessment of these genetic differences using the techniques of complementary DNA (cDNA) library creation has not been performed...
  8. pmc Mucin gene 19 (MUC19) expression and response to inflammatory cytokines in middle ear epithelium
    Joseph E Kerschner
    Division of Pediatric Otolaryngology, Medical College of Wisconsin, Children s Hospital of Wisconsin, 9000 W Wisconsin Avenue, Milwaukee, WI, 53226, USA
    Glycoconj J 26:1275-84. 2009
    ..The large size, gel-forming properties and up-regulation in response to important inflammatory cytokines of MUC19 suggest that it has significant potential to play a role in both physiology and pathophysiology of the ME...
  9. pmc Extending the chinchilla middle ear epithelial model for mucin gene investigation
    Joseph E Kerschner
    Division of Pediatric Otolaryngology, Medical College of Wisconsin, Children s Hospital of Wisconsin, 9000 W Wisconsin Avenue, Milwaukee, WI 53226, USA
    Int J Pediatr Otorhinolaryngol 74:980-5. 2010
    ..To investigate the expression of recently identified human mucin genes in an in vivo model of the chinchilla middle ear epithelium (CMEE)...
  10. pmc MUC5AC expression in human middle ear epithelium of patients with otitis media
    Joseph E Kerschner
    Division of Pediatric Otolaryngology, Children s Hospital of Wisconsin, 9000 W Wisconsin Ave, Milwaukee, WI 53226, USA
    Arch Otolaryngol Head Neck Surg 136:819-24. 2010
    ..Mucin gene 5AC has been identified as a major secretory mucin in the ME and is fundamentally important in the development of ME mucoid effusions, hearing loss and also provides ME mucosal protection and bacterial clearance...
  11. pmc Mucin gene expression and mouse middle ear epithelium
    Joseph E Kerschner
    Division of Pediatric Otolaryngology, Medical College of Wisconsin, Children s Hospital of Wisconsin, 9000 W Wisconsin Avenue, Milwaukee, WI 53226, United States
    Int J Pediatr Otorhinolaryngol 74:864-8. 2010
    ..To investigate the expression of recently identified human mucin genes in an in vitro model of cultured mouse middle ear epithelial cells (MMEEC)...
  12. ncbi request reprint Comparison of caregiver otitis media risk factor knowledge in suburban and urban primary care environments
    Joseph E Kerschner
    Children s Hospital of Wisconsin, Department of Otolaryngology and Communication Sciences, Medical College of Wisconsin, 9000 W Wisconsin Avenue, Milwaukee, WI 53226, USA
    Int J Pediatr Otorhinolaryngol 69:49-56. 2005
    ..The purpose of this study is to assess caregiver knowledge deficits about risk factors associated with otitis media and their willingness to modify behaviors associated with those risks...
  13. ncbi request reprint Chinchilla middle ear epithelial mucin gene expression in response to inflammatory cytokines
    Joseph E Kerschner
    Division of Pediatric Otolaryngology, Department of Otolaryngology and Communication Sciences, Medical College of Wisconsin, 9000 W Wisconsin Avenue, Milwaukee, WI 53226, USA
    Arch Otolaryngol Head Neck Surg 130:1163-7. 2004
    ....
  14. ncbi request reprint Mediastinitis associated with foreign body erosion of the esophagus in children
    J E Kerschner
    Department of Otolaryngology and Communication Sciences, Medical College of Wisconsin, Children s Hospital of Wisconsin, 9000 West Wisconsin Avenue, Box 1997, Milwaukee, WI 53021, USA
    Int J Pediatr Otorhinolaryngol 59:89-97. 2001
    ..This review was performed to examine our experience with this uncommon complication of esophageal foreign bodies...
  15. ncbi request reprint Uvulopalatopharyngoplasty with tonsillectomy and adenoidectomy as a treatment for obstructive sleep apnea in neurologically impaired children
    Joseph E Kerschner
    Division of Pediatric Otolaryngology, Childrens Hospital of Wisconsin, Medical College of Wisconsin, 9000 West Wisconsin Avenue, Milwaukee 53226, USA
    Int J Pediatr Otorhinolaryngol 62:229-35. 2002
    ..This study was performed to examine the effectiveness of using adenotonsillectomy and uvulopalatopharyngoplasty (UPPP) in resolving obstructive apnea (OA) in patients with neurologic impairment...
  16. ncbi request reprint Middle ear epithelial mucin production in response to interleukin-6 exposure in vitro
    Joseph E Kerschner
    Division of Pediatric Otolaryngology, Medical College of Wisconsin, 9000 West Wisconsin Avenue, Milwaukee, WI 53226, USA
    Cytokine 26:30-6. 2004
    ..To investigate the role of the inflammatory cytokine interleukin-6 (IL-6) in the regulation of mucin secretion by middle ear epithelia...
  17. ncbi request reprint Middle ear epithelial mucin production in response to interleukin 1beta exposure in vitro
    Joseph E Kerschner
    Department of Otolaryngology and Communication Sciences, Medical College of Wisconsin, USA
    Otolaryngol Head Neck Surg 129:128-35. 2003
    ..Mucin secretion was characterized by exclusion chromatography and liquid scintillation...
  18. ncbi request reprint Voluntary progress toward universal newborn hearing screening
    Joseph E Kerschner
    Division of Pediatric Otolaryngology, Department of Otolaryngology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Int J Pediatr Otorhinolaryngol 68:165-74. 2004
    ....
  19. ncbi request reprint Neonatal hearing screening: to do or not to do
    Joseph E Kerschner
    Division of Pediatric Otolaryngology, Department of Otolaryngology and Communication Sciences, Medical College of Wisconsin, 9000 West Wisconsin Avenue, Milwaukee, WI 53226, USA
    Pediatr Clin North Am 51:725-36, x. 2004
    ....
  20. pmc Mucin gene polymorphisms in otitis media patients
    Matthew L Ubell
    Department of Otolaryngology and Communication Sciences, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Laryngoscope 120:132-8. 2010
    ..Mucin genes MUC2, MUC5AC, and MUC5B have been identified as major gel-forming mucins in the middle ear (ME). This study compared polymorphisms in MUC2, MUC5AC, and MUC5B genes in otitis media (OM) patients and controls...
  21. ncbi request reprint Mucin gene expression in human laryngeal epithelia: effect of laryngopharyngeal reflux
    Tina L Samuels
    Department of Otolaryngology and Communication Sciences, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Ann Otol Rhinol Laryngol 117:688-95. 2008
    ..We also investigated the effect of low pH with or without pepsin on mucin messenger RNA levels in vitro...
  22. pmc Partial characterization of normal and Haemophilus influenzae-infected mucosal complementary DNA libraries in chinchilla middle ear mucosa
    Joseph E Kerschner
    Department of Otolaryngology and Communication Sciences, Medical College of Wisconsin, Children s Hospital of Wisconsin, Milwaukee 53226, USA
    Ann Otol Rhinol Laryngol 119:270-8. 2010
    ....
  23. pmc MUC2 expression in human middle ear epithelium of patients with otitis media
    Matthew L Ubell
    Division of Pediatric Otolaryngology, Department of Otolaryngology and Communication Sciences, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Arch Otolaryngol Head Neck Surg 134:39-44. 2008
    ..To compare levels of expression of mucin gene 2 (MUC2), a major secretory mucin, in the middle ear of patients with otitis media (OM) and control patients...
  24. pmc Cytokine regulation of mucin secretion in a human middle ear epithelial model
    Erica A Samuel
    Division of Pediatric Otolaryngology, Department of Otolaryngology and Communication Sciences, Medical College of Wisconsin, 9000 W Wisconsin Avenue, Milwaukee, WI 53226, USA
    Cytokine 41:38-43. 2008
    ....
  25. doi request reprint PHACES syndrome: a review
    David A Hartemink
    Department of Otolaryngology and Communication Science, Medical College of Wisconsin, Milwaukee, WI, USA
    Int J Pediatr Otorhinolaryngol 73:181-7. 2009
    ..Large, segmental, cervicofacial hemangiomas are often associated with anomalies of intracranial, cardiovascular, and ophthalmic systems as well as ventral development...
  26. doi request reprint Association of hearing loss with PHACE syndrome
    Kelly J Duffy
    Department of Pediatric Dermatology, Medical College of Wisconsin, Milwaukee, WI, USA
    Arch Dermatol 146:1391-6. 2010
    ..To our knowledge, the potential association of ipsilateral hearing loss and PHACE syndrome has not been previously emphasized...
  27. ncbi request reprint The impact of gender and age on voice related quality of life in children: normative data
    Joel H Blumin
    Division of Laryngology and Professional Voice, Department of Otolaryngology and Communication Sciences, Medical College of Wisconsin, Milwaukee, WI 53226, United States
    Int J Pediatr Otorhinolaryngol 72:229-34. 2008
    ....
  28. doi request reprint Otomicroscope in the emergency department management of pediatric ear foreign bodies
    Christopher A Cederberg
    Medical College of Wisconsin, Department of Otolaryngology and Communication Sciences, 9200 West Wisconsin Ave, Wauwatosa, WI 53226, United States
    Int J Pediatr Otorhinolaryngol 73:589-91. 2009
    ..To determine the effect of a dedicated otomicroscope in the emergency department (ED) management of complex ear foreign bodies (FB)...
  29. ncbi request reprint The use of injectable collagen in the management of pediatric vocal unilateral fold paralysis
    Nalin J Patel
    Department of Otolaryngology and Communication Sciences, Division of Pediatric Otolaryngology, Medical College of Wisconsin, Milwaukebe, WI 53045, USA
    Int J Pediatr Otorhinolaryngol 67:1355-60. 2003
    ..Collagen augmentation can be used in the acute setting to decrease aspiration, possibly avoiding a tracheotomy or gastrostomy tube placement, or to augment patients with a tracheotomy who are still severely aspirating...
  30. ncbi request reprint STAT3 activation in recurrent respiratory papillomatosis
    Nalin J Patel
    Division of Laryngology, Department of Otolaryngology and Communication Sciences, Medical College of Wisconsin, Milwaukee, USA
    Arch Otolaryngol Head Neck Surg 130:1043-5. 2004
    ....
  31. doi request reprint Prevalence of dysplasia in juvenile-onset recurrent respiratory papillomatosis
    Javad A Sajan
    Departments of Otolaryngology and Communication Sciences, Medical College of Wisconsin, Milwaukee, USA
    Arch Otolaryngol Head Neck Surg 136:7-11. 2010
    ..To quantify the prevalence of dysplasia and to evaluate the impact of use of cidofovir in recurrent respiratory papilloma biopsy specimens obtained from a pediatric population...
  32. ncbi request reprint Disease severity in patients referred to pediatric otolaryngologists with a diagnosis of otitis media
    David M Poetker
    Department of Otolaryngology and Communication Sciences, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Int J Pediatr Otorhinolaryngol 70:311-7. 2006
    ..This study evaluated disease severity of children referred to a pediatric otolaryngology practice with a diagnosis of otitis media (OM) before and after tympanostomy tube (TT) placement...
  33. ncbi request reprint Role of extra-esophageal reflux in chronic otitis media with effusion
    Matthew Crapko
    Department of Otolaryngology and Communication Sciences, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Laryngoscope 117:1419-23. 2007
    ..The objective of this study was to confirm that children with OME have EER into the middle ear as measured by the presence of pepsin in middle ear effusions (MEE) removed during tympanostomy tube (TT) placement...
  34. ncbi request reprint Microbiology of middle ear effusions from 292 patients undergoing tympanostomy tube placement for middle ear disease
    David M Poetker
    Division of Pediatric Otolaryngology, Department of Otolaryngology and Communication Sciences, Medical College of Wisconsin, 9200 West Wisconsin Avenue, Milwaukee, WI 53226, USA
    Int J Pediatr Otorhinolaryngol 69:799-804. 2005
    ....
  35. ncbi request reprint Pediatric Voice-Related Quality of Life: findings in healthy children and in common laryngeal disorders
    Albert L Merati
    Division of Laryngology and Professional Voice, Department of Otolaryngology and Communication Sciences, Medical College of Wisconsin, Milwaukee, Wisconsin, USA
    Ann Otol Rhinol Laryngol 117:259-62. 2008
    ....
  36. doi request reprint Cidofovir modulated gene expression in recurrent respiratory papillomatosis
    David M Poetker
    Department of Otolaryngology and Communication Sciences, Medical College of Wisconsin, Milwaukee, WI 53226, United States
    Int J Pediatr Otorhinolaryngol 72:1385-92. 2008
    ..Cidofovir, an antiviral drug, has demonstrated efficacy in slowing and/or reducing RRP recurrence. This investigation examined the differential gene expression of RPP before and after cidofovir use in vivo...
  37. ncbi request reprint Vocal fold medialization in children: injection laryngoplasty, thyroplasty, or nerve reinnervation?
    J Andrew Sipp
    Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Boston, MA 02114, USA
    Arch Otolaryngol Head Neck Surg 133:767-71. 2007
    ..To review surgical interventions for pediatric unilateral vocal fold immobility (UVFI)...
  38. ncbi request reprint Self-reported voice-related quality of life in adolescents with paradoxical vocal fold dysfunction
    Karolyn L Mirasola
    Masters Speech and Hearing Center, Department of Otolaryngology and Communication Sciences, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    J Voice 22:373-8. 2008
    ..The overall PVOS does not show a significant decline in the self-reported VR-QOL. Several cofactors may be associated with the detectable but not significant reduction in the PVOS scores for the females in this study...
  39. doi request reprint Histopathologic and immunophenotypic profile of subglottic hemangioma: multicenter study
    Arunkumar N Badi
    Division of Pediatric Otolaryngology, Medical College of Wisconsin, Children s Hospital of Wisconsin, 9000 W Wisconsin Avenue, Milwaukee, WI 53226, USA
    Int J Pediatr Otorhinolaryngol 73:1187-91. 2009
    ..We present the largest, multi-institutional study, to date, with immunophenotypic characterization of SGH...
  40. ncbi request reprint Fungal causes of otitis externa and tympanostomy tube otorrhea
    Timothy J Martin
    Department of Otolaryngology and Communication Sciences, Division of Pediatric Otolaryngology, Medical College of Wisconsin, 9000 West Wisconsin Avenue, Milwaukee, WI 53226, USA
    Int J Pediatr Otorhinolaryngol 69:1503-8. 2005
    ..To describe the occurrence of fungal organisms in the setting of otitis externa and tympanostomy tube otorrhea, review the treatment course, timing of diagnosis, organism identified and time to resolution with fungal infections...
  41. ncbi request reprint Gradenigo syndrome: a rare but serious complication of otitis media
    Stephanie A Lutter
    Department of Pediatrics, Medical College of Wisconsin and Children s Hospital of Wisconsin, Milwaukee, WI, USA
    Pediatr Emerg Care 21:384-6. 2005
  42. ncbi request reprint Plastic bronchitis: an unusual bronchoscopic challenge associated with congenital heart disease repair
    Stacey Ishman
    Department of Otolaryngology and Communication Sciences, Medical College of Wisconsin, 9200 West Wisconsin Avenue, Milwaukee 53226, USA
    Int J Pediatr Otorhinolaryngol 67:543-8. 2003
    ..In both cases, endoscopic intervention was required to remove these casts. A review of the literature, including the proposed etiologies, diagnosis, and current medical and surgical management, is also undertaken...
  43. ncbi request reprint Immune stimulation for the treatment of papilloma
    David M Poetker
    Department of Otolaryngology and Communication Sciences, Medical College of Wisconsin, Milwaukee, Wisconsin, USA
    Ann Otol Rhinol Laryngol 114:657-61. 2005
    ..We examined the therapeutic effect of CpG oligodeoxynucleotides in the treatment of papillomavirus in a cottontail rabbit model (CRPV)...
  44. ncbi request reprint Ofloxacin otic drops vs neomycin-polymyxin B otic drops as prophylaxis against early postoperative tympanostomy tube otorrhea
    David M Poetker
    Department of Otolaryngology and Communication Sciences, Medical College of Wisconsin, Milwaukee, USA
    Arch Otolaryngol Head Neck Surg 132:1294-8. 2006
    ....
  45. ncbi request reprint Long-term results of Armstrong beveled grommet tympanostomy tubes in children
    D Richard Lindstrom
    Division of Pediatric Otolaryngology, Children s Hospital of Wisconsin and the Medical College of Wisconsin, Milwaukee, WI 53226 0099, USA
    Laryngoscope 114:490-4. 2004
    ..An ideal tube would be easy to insert and would extrude at a predictable interval without complications. This study was performed to assess outcome measures and complication rates of the Armstrong beveled grommet tube...
  46. ncbi request reprint Foreign body granuloma of the external auditory canal
    Kevin C Harris
    Otolaryngology and Communication Sciences, Medical College of Wisconsin, Milwaukee, Wisconsin 53201, USA
    Pediatrics 113:e371-3. 2004
    ..External auditory canal polyps that fail to respond promptly to conservative medical therapy warrant a computed tomography scan and surgical exploration with biopsy...

Research Grants1

  1. Middle Ear Epithelial Response to Cytokine Stimulation
    Joseph Kerschner; Fiscal Year: 2005
    ....