Affiliation: Medical College of Ohio
- A model of anti-angiogenesis: differential transcriptosome profiling of microvascular endothelial cells from diffuse systemic sclerosis patientsBetti Giusti
Department of Medical and Surgical Critical Care DENOTHE, University of Florence, Florence, Italy
Arthritis Res Ther 8:R115. 2006..These observations indicate that microvascular endothelial cells of patients with SSc show abnormalities in a variety of genes that are able to account for defective angiogenesis...
- Assessment of vascular involvementB Kahaleh
Division of Rheumatology and Immunology, Medical College of Ohio, USA
Clin Exp Rheumatol 21:S9-14. 2003..The subcommittee also however recognizes that there exists a promising set of vascular variable that still needs further investigation...
- Raynaud phenomenon and the vascular disease in sclerodermaM Bashar Kahaleh
Division of Rheumatology, Department of Medicine, Medical College of Ohio, 1321 Glendale Avenue, Toledo, OH 43617, USA
Curr Opin Rheumatol 16:718-22. 2004....
- Progress in research into systemic sclerosisBashar Kahaleh
Department of Medicine, Division of Rheumatology, Medical College of Ohio, Toledo, OH 43614, USA
Lancet 364:561-2. 2004
- Marinobufagenin induces increases in procollagen expression in a process involving protein kinase C and Fli-1: implications for uremic cardiomyopathyJihad Elkareh
Department of Medicine, University of Toledo College of Medicine, Toledo, Ohio, USA
Am J Physiol Renal Physiol 296:F1219-26. 2009..Should these findings be confirmed, we speculate that this pathway may represent a therapeutic target for uremic cardiomyopathy as well as other conditions associated with excessive fibrosis...
- Effects of cardiotonic steroids on dermal collagen synthesis and wound healingNasser El-Okdi
Department of Medicine, University of Toledo College of Medicine, 3000 Arlington Ave, Mail Stop 1186, Toledo, OH 43614 2598, USA
J Appl Physiol (1985) 105:30-6. 2008..01). The data suggest that cardiotonic steroids induce increases in collagen synthesis by dermal fibroblasts, as could potentially be exploited to accelerate wound healing...
- Vascular disease in scleroderma: mechanisms of vascular injuryBashar Kahaleh
Division of Rheumatology and Immunology, University of Toledo Medical Center, 3120 Glendale Avenue, Toledo, OH 43617, USA
Rheum Dis Clin North Am 34:57-71; vi. 2008..Current hypotheses in SSc vascular disease suggest a possible chemical or infectious trigger...
- Epigenetics, the holy grail in the pathogenesis of systemic sclerosisNezam Altorok
Division of Rheumatology and Immunology and Department of Internal Medicine, University of Toledo Medical Center, Toledo, OH, USA
Rheumatology (Oxford) 54:1759-70. 2015..Additional longitudinal and comprehensive epigenetic studies designed to evaluate the effect of environmental epigenetic factors on disease pathogenesis are needed. ..
- Association between enhanced type I collagen expression and epigenetic repression of the FLI1 gene in scleroderma fibroblastsYoungqing Wang
Medical University of Ohio, Division of Rheumatology and Immunology, 3120 Glendale Avenue, Toledo, OH 43614, USA
Arthritis Rheum 54:2271-9. 2006..We undertook this study to investigate the possibility that epigenetic mechanisms mediate the emergence and persistence of the altered SSc fibroblast phenotype...
- Outcome measurements in scleroderma: results from a delphi exerciseHashim Gazi
Division of Rheumatology, Department of Medicine, The University of Western Ontario, London, Ontario, Canada
J Rheumatol 34:501-9. 2007..To obtain a consensus on the minimal clinically relevant treatment effect in various scleroderma disease outcome measures to be used in future clinical trials...
- Epigenetics and systemic sclerosisNezam Altorok
Division of Rheumatology, Department of Internal Medicine, University of Toledo Medical Center, 3000 Arlington Ave, Mailstop 1186, Toledo, OH, 43614, USA
Semin Immunopathol 37:453-62. 2015..In this review, we will summarize the work that has been done in the field of epigenetic regulation in SSc, and we will discuss possible factors and mechanisms that may lead to epigenetic dysregulation in SSc. ..
- Endothelial dysfunction in systemic sclerosisNezam Altorok
Division of Rheumatology and Immunology, Department of Internal Medicine, University of Toledo Medical Center, Toledo, Ohio, USA
Curr Opin Rheumatol 26:615-20. 2014..We aim to provide the reader with an update regarding the role of MVECs in the pathogenesis of SSc and the mechanisms for MVECs dysfunction in the disease...
- Epigenetic repression of bone morphogenetic protein receptor II expression in sclerodermaYongqing Wang
Division of Rheumatology and Immunology, University of Toledo, Toledo, OH, USA
J Cell Mol Med 17:1291-9. 2013..The role of BMPRII underexpression in the pathogenesis of SSc vasculopathy is suggested and should be investigated further. ..
- Marinobufagenin stimulates fibroblast collagen production and causes fibrosis in experimental uremic cardiomyopathyJihad Elkareh
Department of Medicine, University of Toledo College of Medicine, 3120 Glendale Ave, Toledo, OH 43614 5809, USA
Hypertension 49:215-24. 2007..Based on these findings, we propose that MBG directly induces increases in collagen expression by fibroblasts, and we suggest that this may be important in the cardiac fibrosis seen with experimental renal failure...
- The microvascular endothelium in sclerodermaB Kahaleh
Division of Rheumatology and Immunology, University of Toledo College of Medicine, 3120 Glendale Ave, Toledo, OH 43617, USA
Rheumatology (Oxford) 47:v14-5. 2008..Knowledge of the initial trigger of immune activation in SSc may offer an opportunity to develop a multiple step strategy for therapeutic intervention...
- Central role for the cardiotonic steroid marinobufagenin in the pathogenesis of experimental uremic cardiomyopathyDavid J Kennedy
Department of Medicine, Medical University of Ohio, Toledo, OH 43614 5809, USA
Hypertension 47:488-95. 2006..These data suggest that the increased concentrations of MBG are important in the cardiac disease and oxidant stress state seen with renal failure...
- Development of a provisional core set of response measures for clinical trials of systemic sclerosisD Khanna
Division of Rheumatology, Department of Medicine, David Geffen School of Medicine, University of California at Los Angeles, California 90095, USA
Ann Rheum Dis 67:703-9. 2008..To develop a provisional core set of response measures for clinical trials of systemic sclerosis (SSc)...