Leigh Ann Callahan

Summary

Affiliation: Medical College of Georgia
Country: USA

Publications

  1. ncbi request reprint Sepsis induces diaphragm electron transport chain dysfunction and protein depletion
    Leigh A Callahan
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Medical College of Georgia, Augusta GA 30912 3135, USA
    Am J Respir Crit Care Med 172:861-8. 2005
  2. ncbi request reprint Downregulation of diaphragm electron transport chain and glycolytic enzyme gene expression in sepsis
    Leigh Ann Callahan
    Div of Pulmonary and Critical Care Medicine, 1120 15th St, Rm BBR 5513, Medical College of Georgia, Augusta, GA 30912 3135, USA
    J Appl Physiol (1985) 99:1120-6. 2005
  3. ncbi request reprint Diaphragm and cardiac mitochondrial creatine kinases are impaired in sepsis
    Leigh A Callahan
    Pulmonary and Critical Care Division, Department of Medicine, Medical College of Georgia, Augusta, Georgia, USA
    J Appl Physiol (1985) 102:44-53. 2007
  4. pmc Calpain activation contributes to endotoxin-induced diaphragmatic dysfunction
    Gerald S Supinski
    Department of Medicine, 740 South Limestone, University of Kentucky, Lexington, KY 40536 0284, USA
    Am J Respir Cell Mol Biol 42:80-7. 2010
  5. pmc p38 Mitogen-activated protein kinase modulates endotoxin-induced diaphragm caspase activation
    Gerry S Supinski
    Department of Medicine, 740 South Limestone, K 528, Lexington, KY 40536 0284, USA
    Am J Respir Cell Mol Biol 43:121-7. 2010

Collaborators

Detail Information

Publications5

  1. ncbi request reprint Sepsis induces diaphragm electron transport chain dysfunction and protein depletion
    Leigh A Callahan
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Medical College of Georgia, Augusta GA 30912 3135, USA
    Am J Respir Crit Care Med 172:861-8. 2005
    ..Sepsis significantly alters skeletal muscle mitochondrial function, but the mechanisms responsible for this abnormality are unknown...
  2. ncbi request reprint Downregulation of diaphragm electron transport chain and glycolytic enzyme gene expression in sepsis
    Leigh Ann Callahan
    Div of Pulmonary and Critical Care Medicine, 1120 15th St, Rm BBR 5513, Medical College of Georgia, Augusta, GA 30912 3135, USA
    J Appl Physiol (1985) 99:1120-6. 2005
    ....
  3. ncbi request reprint Diaphragm and cardiac mitochondrial creatine kinases are impaired in sepsis
    Leigh A Callahan
    Pulmonary and Critical Care Division, Department of Medicine, Medical College of Georgia, Augusta, Georgia, USA
    J Appl Physiol (1985) 102:44-53. 2007
    ..001 and P = 0.009, respectively, comparing sepsis to control conditions). Our data indicate that endotoxin markedly impairs the MtCK-ATP transporter system; this phenomenon may have significant effects on diaphragm and cardiac function...
  4. pmc Calpain activation contributes to endotoxin-induced diaphragmatic dysfunction
    Gerald S Supinski
    Department of Medicine, 740 South Limestone, University of Kentucky, Lexington, KY 40536 0284, USA
    Am J Respir Cell Mol Biol 42:80-7. 2010
    ..Moreover, calpain inhibition attenuates endotoxin-induced diaphragm weakness, suggesting that such inhibitors may be a potential treatment to improve respiratory muscle function in infected patients...
  5. pmc p38 Mitogen-activated protein kinase modulates endotoxin-induced diaphragm caspase activation
    Gerry S Supinski
    Department of Medicine, 740 South Limestone, K 528, Lexington, KY 40536 0284, USA
    Am J Respir Cell Mol Biol 43:121-7. 2010
    ..001). p38 inhibitors also prevented endotoxin-induced diaphragm weakness (P < 0.001). p38 modulates cytokine-induced skeletal muscle caspase activation...