John M Arthur

Summary

Affiliation: Medical University of South Carolina
Country: USA

Publications

  1. pmc An open-source representation for 2-DE-centric proteomics and support infrastructure for data storage and analysis
    Romesh Stanislaus
    The University of Texas M, d, Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    BMC Bioinformatics 9:4. 2008
  2. pmc An XML standard for the dissemination of annotated 2D gel electrophoresis data complemented with mass spectrometry results
    Romesh Stanislaus
    Department of Biostatistics, Bioinformatics and Epidemiology, Medical University of South Carolina, Charleston, South Carolina, USA
    BMC Bioinformatics 5:9. 2004
  3. doi request reprint Diagnostic and prognostic biomarkers in acute renal failure
    John M Arthur
    Ralph H Johnson VA Medical Center and Medical University of South Carolina, Charleston, SC 29425, USA
    Contrib Nephrol 160:53-64. 2008
  4. ncbi request reprint Differential expression of proteins in renal cortex and medulla: a proteomic approach
    John M Arthur
    Department of Medicine, University of Louisville, Louisville, KY, USA
    Kidney Int 62:1314-21. 2002
  5. pmc Prediction of urinary protein markers in lupus nephritis
    Jim C Oates
    Department of Medicine, Medical University of South Carolina and Ralph H Johnson VA Medical Center, Charleston, Charleston, SC 29425, USA
    Kidney Int 68:2588-92. 2005
  6. pmc Urine haptoglobin levels predict early renal functional decline in patients with type 2 diabetes
    Nishant M Bhensdadia
    Department of Medicine, Medical University of South Carolina, Charleston, South Carolina, USA
    Kidney Int 83:1136-43. 2013
  7. pmc Angiotensin I is largely converted to angiotensin (1-7) and angiotensin (2-10) by isolated rat glomeruli
    Juan Carlos Q Velez
    Ralph H Johnson Veterans Affairs Medical Center, Division of Nephrology, Medical University of South Carolina, Charleston, SC 29425, USA
    Hypertension 53:790-7. 2009
  8. pmc Urine biomarkers predict the cause of glomerular disease
    Sanju A Varghese
    Department of Medicine, Division of Nephrology, Medical University of South Carolina, 96 Jonathan Lucas Street, P O Box 250623, Charleston, SC 29425, USA
    J Am Soc Nephrol 18:913-22. 2007
  9. pmc Enzymatic processing of angiotensin peptides by human glomerular endothelial cells
    Juan Carlos Q Velez
    Division of Nephrology, Department of Medicine, Medical University of South Carolina, Charleston, South Carolina, USA
    Am J Physiol Renal Physiol 302:F1583-94. 2012
  10. pmc Identification of diagnostic urinary biomarkers for acute kidney injury
    Sanju A Varghese
    Department of Medicine, Division of Nephrology, Medical University of South Carolina, Charleston, SC 29425, USA
    J Investig Med 58:612-20. 2010

Research Grants

Collaborators

Detail Information

Publications38

  1. pmc An open-source representation for 2-DE-centric proteomics and support infrastructure for data storage and analysis
    Romesh Stanislaus
    The University of Texas M, d, Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    BMC Bioinformatics 9:4. 2008
    ....
  2. pmc An XML standard for the dissemination of annotated 2D gel electrophoresis data complemented with mass spectrometry results
    Romesh Stanislaus
    Department of Biostatistics, Bioinformatics and Epidemiology, Medical University of South Carolina, Charleston, South Carolina, USA
    BMC Bioinformatics 5:9. 2004
    ..This paper proposes a data structure based on XML standards to fill the void that exists between data generated by proteomics experiments and storing of data...
  3. doi request reprint Diagnostic and prognostic biomarkers in acute renal failure
    John M Arthur
    Ralph H Johnson VA Medical Center and Medical University of South Carolina, Charleston, SC 29425, USA
    Contrib Nephrol 160:53-64. 2008
    ..Combinations of urine proteins can be used to predict which patients will require RRT...
  4. ncbi request reprint Differential expression of proteins in renal cortex and medulla: a proteomic approach
    John M Arthur
    Department of Medicine, University of Louisville, Louisville, KY, USA
    Kidney Int 62:1314-21. 2002
    ..However, only a few proteins can be studied in each experiment by Western blot. We have used proteomic tools to construct protein maps of rat kidney cortex and medulla...
  5. pmc Prediction of urinary protein markers in lupus nephritis
    Jim C Oates
    Department of Medicine, Medical University of South Carolina and Ralph H Johnson VA Medical Center, Charleston, Charleston, SC 29425, USA
    Kidney Int 68:2588-92. 2005
    ..Renal biopsy is currently the only way to accurately predict class and activity and chronicity indices. We propose to use patterns of abundance of urine proteins to identify class and disease indices...
  6. pmc Urine haptoglobin levels predict early renal functional decline in patients with type 2 diabetes
    Nishant M Bhensdadia
    Department of Medicine, Medical University of South Carolina, Charleston, South Carolina, USA
    Kidney Int 83:1136-43. 2013
    ..Thus, the haptoglobin to creatinine ratio may be useful to predict patients with type 2 diabetes at risk of nephropathy before the development of macroalbuminuria or reduced glomerular filtration rate...
  7. pmc Angiotensin I is largely converted to angiotensin (1-7) and angiotensin (2-10) by isolated rat glomeruli
    Juan Carlos Q Velez
    Ralph H Johnson Veterans Affairs Medical Center, Division of Nephrology, Medical University of South Carolina, Charleston, SC 29425, USA
    Hypertension 53:790-7. 2009
    ..Formation of these alternative Ang peptides may be critical to counterbalance the local actions of Ang II. Enhancement of these enzymatic activities may constitute potential therapeutic targets for Ang II-mediated glomerular diseases...
  8. pmc Urine biomarkers predict the cause of glomerular disease
    Sanju A Varghese
    Department of Medicine, Division of Nephrology, Medical University of South Carolina, 96 Jonathan Lucas Street, P O Box 250623, Charleston, SC 29425, USA
    J Am Soc Nephrol 18:913-22. 2007
    ..The fingerprint of urine protein charge forms identifies the glomerular disease. The identified proteins are candidate biomarkers that can be tested in assays that are more amenable to clinical testing...
  9. pmc Enzymatic processing of angiotensin peptides by human glomerular endothelial cells
    Juan Carlos Q Velez
    Division of Nephrology, Department of Medicine, Medical University of South Carolina, Charleston, South Carolina, USA
    Am J Physiol Renal Physiol 302:F1583-94. 2012
    ..Injury to specific cell types within the glomeruli may alter the intrarenal RAS balance...
  10. pmc Identification of diagnostic urinary biomarkers for acute kidney injury
    Sanju A Varghese
    Department of Medicine, Division of Nephrology, Medical University of South Carolina, Charleston, SC 29425, USA
    J Investig Med 58:612-20. 2010
    ..Plasma retinol-binding protein was identified in 1 spot and a fragment of albumin and plasma retinol-binding protein in the other. These proteins are candidate markers for diagnostic assays of AKI...
  11. pmc Evaluation of 32 urine biomarkers to predict the progression of acute kidney injury after cardiac surgery
    John M Arthur
    1 Medical Service, Ralph H Johnson VA Medical Center, Charleston, South Carolina, USA 2 Department of Medicine, Medical University of South Carolina, Charleston, South Carolina, USA
    Kidney Int 85:431-8. 2014
    ..93 to predict AKIN 3 or death. Thus, a combination of IL-18 and KIM-1 would result in improved identification of high-risk patients for enrollment in clinical trials. ..
  12. pmc Association of elevated urinary concentration of renin-angiotensin system components and severe AKI
    Joseph L Alge
    Medical University of South Carolina, Charleston, South Carolina, University of Tennessee College of Medicine in Chattanooga, Chattanooga, Tennessee, George Washington University, Washington, DC, Duke University, Durham, North Carolina, Durham Veterans Affairs Medical Center, Durham, North Carolina, Ralph H Johnson Veterans Affairs Medical Center, Charleston, South Carolina
    Clin J Am Soc Nephrol 8:2043-52. 2013
    ..The study hypothesis is that urinary renin could also predict AKI severity and that in combination angiotensinogen and renin would be a strong predictor of prognosis at the time of AKI diagnosis...
  13. ncbi request reprint Proteomics in renal research
    Michael G Janech
    Medical University of South Carolina, Ralph H Johnson Veterans Affairs Medical Center, Charleston, SC 29425 2220, USA
    Am J Physiol Renal Physiol 292:F501-12. 2007
    ..The rapid rate of development of the technologies along with the combination of classic physiological and biochemical techniques with proteomics will enable new discoveries...
  14. doi request reprint Network modeling reveals steps in angiotensin peptide processing
    John H Schwacke
    Medical University of South Carolina, Charleston, SC 29425, USA
    Hypertension 61:690-700. 2013
    ....
  15. ncbi request reprint Sodium loading changes urinary protein excretion: a proteomic analysis
    Visith Thongboonkerd
    Core Proteomics Laboratory, Kidney Disease Program, Department of Medicine, University of Louisville, KY 40202, USA
    Am J Physiol Renal Physiol 284:F1155-63. 2003
    ..Some of these proteins have previously been shown to be associated with tubular transport. These data indicate that alterations in the excretion of several urinary proteins occur during acute sodium loading...
  16. ncbi request reprint Proteomic identification of a large complement of rat urinary proteins
    Visith Thongboonkerd
    Core Proteomics Laboratory, Kidney Disease Program, Department of Medicine, University of Louisville, Louisville, KY 40202, USA
    Nephron Exp Nephrol 95:e69-78. 2003
    ..This approach may lead to better understanding of renal physiology and pathophysiology, and to biomarker discovery...
  17. doi request reprint Proteomic analysis of cerebrospinal fluid in California sea lions (Zalophus californianus) with domoic acid toxicosis identifies proteins associated with neurodegeneration
    Benjamin A Neely
    Department of Medicine, Division of Nephrology, Medical University of South Carolina, Charleston, SC, USA
    Proteomics 15:4051-63. 2015
    ..All MS data have been deposited in the ProteomeXchange with identifier PXD002105 (http://proteomecentral.proteomexchange.org/dataset/PXD002105). ..
  18. pmc Lack of renoprotective effect of chronic intravenous angiotensin-(1-7) or angiotensin-(2-10) in a rat model of focal segmental glomerulosclerosis
    Juan Carlos Q Velez
    Division of Nephrology, Department of Medicine, Medical University of South Carolina, Charleston, South Carolina, United States of America Medical Service, Ralph H Johnson Veterans Affairs Medical Center, Charleston, South Carolina, United States of America
    PLoS ONE 9:e110083. 2014
    ....
  19. pmc Sources of variability among replicate samples separated by two-dimensional gel electrophoresis
    Alison M Bland
    Medical University of South Carolina, Charleston, South Carolina 29425, USA
    J Biomol Tech 21:3-8. 2010
    ..This study demonstrates that spot identification and characterization make major contributions to variability seen with 2DE. Methods to highlight why measured protein spot abundance is different could reduce these errors...
  20. doi request reprint Changes in protein profiles during course of experimental glomerulonephritis
    Khurram Nazeer
    Div of Nephrology, Dept of Medicine, Medical Univ of South Carolina, 96 Jonathan Lucas St, PO Box 250623, Charleston, SC 29425, USA
    Am J Physiol Renal Physiol 296:F186-93. 2009
    ..Isoforms Tm4 and Tm5 remained unchanged in the course of this model of experimental glomerulonephritis. Characterization of Tm isoform abundance in the course of clinical glomerulonephritis may identify disease-specific markers...
  21. pmc Comparison of variability associated with sample preparation in two-dimensional gel electrophoresis of cardiac tissue
    Alison M Bland
    Medical University of South Carolina, Charleston, USA
    J Biomol Tech 17:195-9. 2006
    ..Sample preparation should be optimized to minimize variability as well as to maximize the number of spots seen...
  22. pmc Urinary angiotensinogen and risk of severe AKI
    Joseph L Alge
    Medical University of South Carolina, Charleston, SC 29425, USA
    Clin J Am Soc Nephrol 8:184-93. 2013
    ..Biomarkers of AKI that can predict which patients will develop severe renal disease at the time of diagnosis will facilitate timely intervention in populations at risk of adverse outcomes...
  23. ncbi request reprint Proteomic analysis of normal human urinary proteins isolated by acetone precipitation or ultracentrifugation
    Visith Thongboonkerd
    Core Proteomics Laboratory and Molecular Signaling Group, Kidney Disease Program, Department of Medicine, University of Louisville, 570 South Preston Street, Louisville, KY 40202, USA
    Kidney Int 62:1461-9. 2002
    ..We constructed a proteome map of normal human urine as a reference protein database by using two differential fractionated techniques to isolate the proteins...
  24. pmc Proteomic Analysis of Plasma from California Sea Lions (Zalophus californianus) Reveals Apolipoprotein E as a Candidate Biomarker of Chronic Domoic Acid Toxicosis
    Benjamin A Neely
    Department of Medicine, Division of Nephrology, Medical University of South Carolina, Charleston, SC, United States of America
    PLoS ONE 10:e0123295. 2014
    ..Although this analysis is specifically focused on blood biomarkers and routine clinical data, the results demonstrate promise for future studies combining additional variables in multidimensional space to create robust classifiers. ..
  25. pmc Diabetes-induced renal injury in rats is attenuated by suramin
    Midhun C Korrapati
    Department of Pharmaceutical and Biomedical Sciences, Medical University of South Carolina, Charleston, SC 29425, USA
    J Pharmacol Exp Ther 343:34-43. 2012
    ..These results support the potential use of suramin in DN...
  26. pmc Proteomic analysis of murine bone marrow niche microenvironment identifies thioredoxin as a novel agent for radioprotection and for enhancing donor cell reconstitution
    Ningfei An
    Division of Hematology Oncology, Medical University of South Carolina, Charleston, SC, USA
    Exp Hematol 41:944-56. 2013
    ..Identifying these factors provides clues on potential novel targets that can be used to enhance hematologic recovery in hematopoietic stem cell transplan`tation...
  27. pmc Overcoming the effects of matrix interference in the measurement of urine protein analytes
    Timothy P Taylor
    Medical University of South Carolina, Department of Medicine, Division of Nephrology, 96 Jonathan Lucas St, 829 Clinical Science Building, Charleston, SC 29425
    Biomark Insights 7:1-8. 2012
    ..Therefore, dilution can be used as an effective technique for over-coming urine matrix effects in urine immunoassays. These results may be applicable to other biological fluids in which matrix components interfere with assay performance...
  28. ncbi request reprint Normalization and analysis of residual variation in two-dimensional gel electrophoresis for quantitative differential proteomics
    Jonas S Almeida
    Department of Biometry and Epidemiology, Medical University of South Carolina, Charleston, SC, USA
    Proteomics 5:1242-9. 2005
    ..The model described is being used to assign confidence values to observed variations in arbitrary 2-DE gels in order to quantify the degree of over-expression and under-expression of protein spots...
  29. ncbi request reprint Characterization of renin-angiotensin system enzyme activities in cultured mouse podocytes
    Juan Carlos Q Velez
    Department of Research, Ralph H Johnson Veterans Affairs Medical Center, Charleston, South Carolina, USA
    Am J Physiol Renal Physiol 293:F398-407. 2007
    ..These findings may reflect a specific role of POD in maintenance of intraglomerular renin-angiotensin system balance...
  30. doi request reprint Comparison of the Rate of Renal Function Decline in NonProteinuric Patients With and Without Diabetes
    Liliane Hobeika
    Department of Internal Medicine, Division of Nephrology LH, Department of Internal Medicine, University of Louisville, Louisville, Kentucky Department of Public Health Sciences KJH, Medical University of South Carolina, Charleston, South Carolina Ralph H Johnson VA Medical Center KJH, Charleston, South Carolina Division of Nephrology BAN, Department of Internal Medicine, Medical University of South Carolina, Charleston, South Carolina Division of Nephrology JMA, Department of Internal Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas and Central Arkansas Veterans Healthcare System JMA, Little Rock, AR
    Am J Med Sci 350:447-52. 2015
    ..It was hypothesized that if this is true, the rate of renal function decline should be similar among nonproteinuric patients with and without diabetes...
  31. pmc Urinary ATP Synthase Subunit β Is a Novel Biomarker of Renal Mitochondrial Dysfunction in Acute Kidney Injury
    Ryan M Whitaker
    Department of Drug Discovery and Biomedical Sciences, Medical University of South Carolina, Charleston, South Carolina 29425, Department of Medicine, Division of Nephrology, Medical University of South Carolina, Charleston, South Carolina 29425 and Ralph H Johnson Veterans Administration Medical Center, Charleston, South Carolina 29425
    Toxicol Sci 145:108-17. 2015
    ....
  32. doi request reprint Intravenous conivaptan for the treatment of hyponatraemia caused by the syndrome of inappropriate secretion of antidiuretic hormone in hospitalized patients: a single-centre experience
    Juan Carlos Q Velez
    Medical and Research Services, Ralph H Johnson, VA Medical Center, Charleston, South Carolina, USA
    Nephrol Dial Transplant 25:1524-31. 2010
    ..Moreover, while there is reasonable concern for overcorrection, no pre-treatment variables are known to be helpful to identify patients at risk for rapid correction...
  33. ncbi request reprint Proteomic analysis reveals alterations in the renal kallikrein pathway during hypoxia-induced hypertension
    Visith Thongboonkerd
    Core Proteomics Laboratory, Kidney Disease Program, Department of Medicine, University of Louisville, Louisville, Kentucky 40202, USA
    J Biol Chem 277:34708-16. 2002
    ..Transgenic hKLK1 animals were protected from EH-induced hypertension. We conclude that EH-induced hypertension may result, at least in part, from altered regulation of the renal kallikrein system...
  34. pmc Cilia movement regulates expression of the Raf-1 kinase inhibitor protein
    Kelli M Sas
    Ralph H Johnson Veterans Affairs Medical Center, Medical University of South Carolina, Charleston, 29425, USA
    Am J Physiol Renal Physiol 300:F1163-70. 2011
    ..In terms of polycystic kidney disease, loss of cilia and therefore sensitivity to flow may lead to reduced RKIP levels, activation of the MAPK pathway, and contribute to the formation of cysts...
  35. ncbi request reprint Identification of proteins in slow continuous ultrafiltrate by reversed-phase chromatography and proteomics
    David M Lefler
    Medical University of South Carolina and Ralph H Johnson VA Medical Center, Charleston, SC 29425, USA
    J Proteome Res 3:1254-60. 2004
    ..The physiological significance of this protein removal is unclear. Identification of these proteins will lead to better understanding of the role of protein removal in continuous renal replacement therapy...
  36. ncbi request reprint Proteomics
    John M Arthur
    Department of Medicine, Medical University of South Carolina, Charleston, South Carolina, USA
    Curr Opin Nephrol Hypertens 12:423-30. 2003
    ..This review will highlight the technologies available, outline the capabilities, advantages and disadvantages of each and briefly describe applications in nephrology...
  37. doi request reprint Kidney glycosphingolipids are elevated early in diabetic nephropathy and mediate hypertrophy of mesangial cells
    Marimuthu Subathra
    Department of Pharmacology and Toxicology, James Graham Brown Cancer Center, University of Louisville, Louisville, Kentucky
    Am J Physiol Renal Physiol 309:F204-15. 2015
    ..Thus, hyperglycemia in type II diabetes leads to renal dysfunction at least in part by inducing accumulation of HexCers and LacCers in mesangial cells, resulting in fibrosis, extracellular matrix production, and hypertrophy. ..
  38. doi request reprint Changes in protein expression in Burkholderia vietnamiensis PR1 301 at pH 5 and 7 with and without nickel
    Joy D Van Nostrand
    Marine Biomedicine and Environmental Sciences Center, Medical University of South Carolina, 221 Fort Johnson Rd, Charleston, SC 29412, USA
    Microbiology 154:3813-24. 2008
    ..These findings suggest that changes in membrane structure and function may be involved in the ability of PR1 to grow at higher concentrations of Ni at pH 5 than at pH 7...

Research Grants1

  1. REGULATION OF RENAL CALCIUM TRANSPORT BY CALCIUM
    John Arthur; Fiscal Year: 2002
    ....