Ann C McKee

Summary

Country: USA

Publications

  1. pmc The spectrum of disease in chronic traumatic encephalopathy
    Ann C McKee
    United States Department of Veterans Affairs, VA Boston Healthcare System, Boston, MA 02130, USA
    Brain 136:43-64. 2013
  2. pmc The neuropathology of sport
    Ann C McKee
    VA Boston Healthcare System, 150 South Huntington Ave, Boston, MA, 02130, USA
    Acta Neuropathol 127:29-51. 2014
  3. pmc Helmets and mouth guards: the role of personal equipment in preventing sport-related concussions
    Daniel H Daneshvar
    Department of Neurology, Boston University School of Medicine, Center for the Study of Traumatic Encephalopathy, 72 East Concord Street, B7800, Boston, MA 02118, USA
    Clin Sports Med 30:145-63, x. 2011
  4. doi request reprint Long-term consequences of repetitive brain trauma: chronic traumatic encephalopathy
    Robert A Stern
    Center for Study of Traumatic Encephalopathy, Boston University School of Medicine, Boston University, 72 East Concord St, 7380, Boston, MA 02118, USA
    PM R 3:S460-7. 2011
  5. pmc Profile of self-reported problems with executive functioning in college and professional football players
    Daniel R Seichepine
    Boston University Alzheimer s Disease Center, Boston University School of Medicine, Boston University, Boston, Massachusetts, USA
    J Neurotrauma 30:1299-304. 2013
  6. pmc The Framingham Brain Donation Program: neuropathology along the cognitive continuum
    Rhoda Au
    Department of Neurology, Boston University School of Medicine, 715 Albany Street, Boston, MA 02118, USA
    Curr Alzheimer Res 9:673-86. 2012
  7. pmc Chronic traumatic encephalopathy in athletes: progressive tauopathy after repetitive head injury
    Ann C McKee
    Department of Neurology, Center for the Study of Traumatic Encephalopathy, Boston University School of Medicine, Boston, MA, USA
    J Neuropathol Exp Neurol 68:709-35. 2009
  8. doi request reprint Clinical appraisal of chronic traumatic encephalopathy: current perspectives and future directions
    Brandon E Gavett
    Center for the Study of Traumatic Encephalopathy, Boston University, and Brigham and Women s Hospital, Boston, Massachusetts 02118, USA
    Curr Opin Neurol 24:525-31. 2011
  9. pmc Long-term consequences: effects on normal development profile after concussion
    Daniel H Daneshvar
    Department of Neurology, Center for the Study of Traumatic Encephalopathy, Boston University School of Medicine, Boston 02118, MA, USA
    Phys Med Rehabil Clin N Am 22:683-700, ix. 2011
  10. pmc Association between neuropathology and brain volume in the Framingham Heart Study
    Berneet Kaur
    Department of Neurology, University of California, Davis, Sacramento, CA Department of Neurology, Boston University School of Medicine, Framingham Heart Study Department of Biostatistics, Boston University School of Public Health, Boston, MA
    Alzheimer Dis Assoc Disord 28:219-25. 2014

Collaborators

Detail Information

Publications28

  1. pmc The spectrum of disease in chronic traumatic encephalopathy
    Ann C McKee
    United States Department of Veterans Affairs, VA Boston Healthcare System, Boston, MA 02130, USA
    Brain 136:43-64. 2013
    ....
  2. pmc The neuropathology of sport
    Ann C McKee
    VA Boston Healthcare System, 150 South Huntington Ave, Boston, MA, 02130, USA
    Acta Neuropathol 127:29-51. 2014
    ..Other sports associated with CTE include ice hockey, professional wrestling, soccer, rugby, and baseball...
  3. pmc Helmets and mouth guards: the role of personal equipment in preventing sport-related concussions
    Daniel H Daneshvar
    Department of Neurology, Boston University School of Medicine, Center for the Study of Traumatic Encephalopathy, 72 East Concord Street, B7800, Boston, MA 02118, USA
    Clin Sports Med 30:145-63, x. 2011
    ..Improving coach and player education about proper concussion management, encouraging neck-strengthening exercises, and minimizing high-risk impacts may reduce concussions in sports...
  4. doi request reprint Long-term consequences of repetitive brain trauma: chronic traumatic encephalopathy
    Robert A Stern
    Center for Study of Traumatic Encephalopathy, Boston University School of Medicine, Boston University, 72 East Concord St, 7380, Boston, MA 02118, USA
    PM R 3:S460-7. 2011
    ..Research also will provide policy makers with the scientific knowledge to make appropriate guidelines regarding the prevention and treatment of brain trauma in all levels of athletic involvement as well as the military theater...
  5. pmc Profile of self-reported problems with executive functioning in college and professional football players
    Daniel R Seichepine
    Boston University Alzheimer s Disease Center, Boston University School of Medicine, Boston University, Boston, Massachusetts, USA
    J Neurotrauma 30:1299-304. 2013
    ..The findings are in accord with a growing body of evidence that participation in football is associated with the development of cognitive changes and dementia as observed in CTE...
  6. pmc The Framingham Brain Donation Program: neuropathology along the cognitive continuum
    Rhoda Au
    Department of Neurology, Boston University School of Medicine, 715 Albany Street, Boston, MA 02118, USA
    Curr Alzheimer Res 9:673-86. 2012
    ..We observed that an aggregate ischemic injury score was significantly higher in persons with a CDR score of 0.5 than in normal controls...
  7. pmc Chronic traumatic encephalopathy in athletes: progressive tauopathy after repetitive head injury
    Ann C McKee
    Department of Neurology, Center for the Study of Traumatic Encephalopathy, Boston University School of Medicine, Boston, MA, USA
    J Neuropathol Exp Neurol 68:709-35. 2009
    ..Deposition of beta-amyloid, most commonly as diffuse plaques, occurs in fewer than half the cases. Chronic traumatic encephalopathy is a neuropathologically distinct slowly progressive tauopathy with a clear environmental etiology...
  8. doi request reprint Clinical appraisal of chronic traumatic encephalopathy: current perspectives and future directions
    Brandon E Gavett
    Center for the Study of Traumatic Encephalopathy, Boston University, and Brigham and Women s Hospital, Boston, Massachusetts 02118, USA
    Curr Opin Neurol 24:525-31. 2011
    ..This review provides an update on recent literature pertaining to clinically relevant procedures that--presently or in the future--may be useful for the in-vivo detection, characterization, and/or prediction of CTE...
  9. pmc Long-term consequences: effects on normal development profile after concussion
    Daniel H Daneshvar
    Department of Neurology, Center for the Study of Traumatic Encephalopathy, Boston University School of Medicine, Boston 02118, MA, USA
    Phys Med Rehabil Clin N Am 22:683-700, ix. 2011
    ..Effective diagnoses, treatments, and education plans are required to reduce the future burden and incidence of long-term effects of head injuries...
  10. pmc Association between neuropathology and brain volume in the Framingham Heart Study
    Berneet Kaur
    Department of Neurology, University of California, Davis, Sacramento, CA Department of Neurology, Boston University School of Medicine, Framingham Heart Study Department of Biostatistics, Boston University School of Public Health, Boston, MA
    Alzheimer Dis Assoc Disord 28:219-25. 2014
    ....
  11. pmc The epidemiology of sport-related concussion
    Daniel H Daneshvar
    Department of Neurology, Boston University School of Medicine, Center for the Study of Traumatic Encephalopathy, 72 East Concord Street, B7800, Boston, MA 02118, USA
    Clin Sports Med 30:1-17, vii. 2011
    ..With this knowledge can come improved techniques and rule changes to minimize the rate and severity of concussions in sports. This article identifies the factors that affect concussion rate...
  12. pmc Chronic traumatic encephalopathy: a potential late effect of sport-related concussive and subconcussive head trauma
    Brandon E Gavett
    Center for the Study of Traumatic Encephalopathy and Alzheimer s Disease Center, Boston University School of Medicine, 72 East Concord Street, B 7800, Boston, MA 02118, USA
    Clin Sports Med 30:179-88, xi. 2011
    ..No formal clinical or pathologic diagnostic criteria for CTE currently exist, but the distinctive neuropathologic profile of the disorder lends promise for future research into its prevention, diagnosis, and treatment...
  13. doi request reprint Post-traumatic neurodegeneration and chronic traumatic encephalopathy
    Daniel H Daneshvar
    Boston University Chronic Traumatic Encephalopathy Program, Boston University School of Medicine, 72 E Concord St, Boston, MA 02118, USA Boston University Alzheimer s Disease Center, Boston University School of Medicine, 72 E Concord St, Boston, MA 02118, USA Department of Neurology, Boston University School of Medicine, 72 E Concord St, Boston, MA 02118, USA
    Mol Cell Neurosci 66:81-90. 2015
    ..This article is part of a Special Issue entitled 'Traumatic Brain Injury'...
  14. pmc Beta-amyloid deposition in chronic traumatic encephalopathy
    Thor D Stein
    VA Boston Healthcare System, Boston, MA, 02130, USA
    Acta Neuropathol 130:21-34. 2015
    ..Overall, these findings suggest that Aβ deposition is altered and accelerated in a cohort of CTE subjects compared to normal aging and that Aβ is associated with both pathological and clinical progression of CTE independent of age...
  15. pmc Increased expression of TrkB and Capzb2 accompanies preserved cognitive status in early Alzheimer disease pathology
    Patricia F Kao
    Department of Pathology and Laboratory Medicine, Boston University School of Medicine, Boston, MA 02118, USA
    J Neuropathol Exp Neurol 71:654-64. 2012
    ..In subsequent stages of AD, the higher levels of TrkB and Capzb2 expression achieved may not be sufficient to prevent cognitive decline...
  16. pmc Mild traumatic brain injury: a risk factor for neurodegeneration
    Brandon E Gavett
    Department of Neurology, Boston University School of Medicine, 72 East Concord St, B 7800, Boston, MA 02118, USA
    Alzheimers Res Ther 2:18. 2010
    ....
  17. pmc Assessing clinicopathological correlation in chronic traumatic encephalopathy: rationale and methods for the UNITE study
    Jesse Mez
    Alzheimer s Disease Center, Boston University School of Medicine, 72 East Concord Street, B 7800, Boston, MA, 02118, USA
    Alzheimers Res Ther 7:62. 2015
    ..Here, we present the rationale and methodology for UNITE...
  18. pmc R-flurbiprofen improves tau, but not Aß pathology in a triple transgenic model of Alzheimer's disease
    Isabel Carreras
    Research GRECC, VA Boston Healthcare System, Boston, MA, USA Department of Biochemistry, Boston University School of Medicine, Boston, MA, USA
    Brain Res 1541:115-27. 2013
    ..Glutamine and glutamate, neurochemicals that shuttles between neurons and astrocytes to maintain glutamate homeostasis in the synapses, deserve further attention as MR markers of cognitive function. ..
  19. pmc Chronic traumatic encephalopathy: where are we and where are we going?
    Jesse Mez
    Boston University Alzheimer s Disease Center, Boston University School of Medicine, 72 E Concord Street, Suite 7800, Boston, MA, 02118, USA
    Curr Neurol Neurosci Rep 13:407. 2013
    ..We conclude by suggesting seven essential areas for future CTE research. ..
  20. pmc Concussion in Chronic Traumatic Encephalopathy
    Thor D Stein
    VA Boston Healthcare System, Boston, MA, 02130, USA
    Curr Pain Headache Rep 19:47. 2015
    ..In fact, amyloid β peptide deposition is altered and accelerated in CTE and is associated with worse disease. Here, we review the current exposure, clinical, and pathological associations of CTE...
  21. pmc The neuropathology of chronic traumatic encephalopathy
    Ann C McKee
    VA Boston Healthcare System, Boston University, Boston, MA Department of Pathology and Laboratory Science, Boston University School of Medicine, Boston University, Boston, MA Department of Neurology, Boston University School of Medicine, Boston University, Boston, MA Boston University Alzheimer s Disease Center, Boston University, Boston, MA Chronic Traumatic Encephalopathy Center Program, Boston University, Boston, MA
    Brain Pathol 25:350-64. 2015
    ....
  22. pmc Chronic traumatic encephalopathy in blast-exposed military veterans and a blast neurotrauma mouse model
    Lee E Goldstein
    Molecular Aging and Development Laboratory, Boston University School of Medicine, Boston, MA 02118, USA
    Sci Transl Med 4:134ra60. 2012
    ....
  23. pmc Diagnostic value of lobar microbleeds in individuals without intracerebral hemorrhage
    Sergi Martínez-Ramírez
    Neurology Department, J Philip Kistler Stroke Research Center, Massachusetts General Hospital, Boston, MA, USA Escola de Postgrau, Autonomous University of Barcelona, Barcelona, Spain Electronic address
    Alzheimers Dement 11:1480-8. 2015
    ..We assessed the accuracy of these criteria in individuals with lobar microbleeds (MBs) without ICH...
  24. pmc The first NINDS/NIBIB consensus meeting to define neuropathological criteria for the diagnosis of chronic traumatic encephalopathy
    Ann C McKee
    Department of Neurology, Boston University School of Medicine, 72 East Concord Street, Boston, MA, 02118, USA
    Acta Neuropathol 131:75-86. 2016
    ..This study provides the first step towards the development of validated neuropathological criteria for CTE and will pave the way towards future clinical and mechanistic studies. ..
  25. pmc The neuropathology of traumatic brain injury
    Ann C McKee
    VA Boston HealthCare System Center for the Study of Traumatic Encephalopathy, Alzheimer s Disease Center, and Departments of Neurology and Pathology, Boston University School of Medicine, Boston, MA, USA Electronic address
    Handb Clin Neurol 127:45-66. 2015
    ....
  26. pmc Early-life sodium exposure unmasks susceptibility to stroke in hyperlipidemic, hypertensive heterozygous Tg25 rats transgenic for human cholesteryl ester transfer protein
    Julius L Decano
    Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA 02118, USA
    Circulation 119:1501-9. 2009
    ..Early-life risk factor exposure increases aortic atherosclerosis and blood pressure in humans and animal models; however, limited insight has been gained as to end-organ complications...
  27. doi request reprint Response to comment on "chronic traumatic encephalopathy in blast-exposed military veterans and a blast neurotrauma mouse model"
    Lee E Goldstein
    College of Engineering and Photonics Center, Boston University Alzheimer s Disease Center, Boston University School of Medicine, Boston, MA 02118, USA
    Sci Transl Med 4:157lr5. 2012
    ..Goldstein and McKee respond to points raised in two letters about their study of tau neuropathology in postmortem brain tissue samples from blast-exposed military veterans with traumatic brain injury...
  28. pmc Association of distinct variants in SORL1 with cerebrovascular and neurodegenerative changes related to Alzheimer disease
    Karen T Cuenco
    Genetics Program, Department of Medicine, Room L320, Boston University School of Medicine, 715 Albany St, Boston, MA 02118, USA
    Arch Neurol 65:1640-8. 2008
    ....