Dennis A Wigle

Summary

Affiliation: Mayo Clinic
Country: USA

Publications

  1. doi request reprint Current readings: management of N2 disease for lung cancer
    Dennis A Wigle
    Division of General Thoracic Surgery, Department of Surgery, Mayo Clinic College of Medicine Rochester, Minnesota Electronic address
    Semin Thorac Cardiovasc Surg 26:67-70. 2014
  2. doi request reprint Biologic approaches to drug selection and targeted therapy: hype or clinical reality?
    Dennis A Wigle
    Thoracic Surgery, Mayo Clinic, 200 First Street, Southwest, Rochester, MN 55905, USA
    Thorac Surg Clin 23:421-8. 2013
  3. doi request reprint Does surgeon workload per day affect outcomes after pulmonary lobectomies?
    Mathew Thomas
    Division of General Thoracic Surgery, Mayo Clinic Rochester, Rochester, Minnesota 55905, USA
    Ann Thorac Surg 94:966-72. 2012
  4. doi request reprint Surgical management of congenital cystic lung malformations in older patients
    Zeena Makhija
    Division of General Thoracic Surgery, Mayo Clinic, Rochester, Minnesota 55905, USA
    Ann Thorac Surg 91:1568-73; discussion 1573. 2011
  5. doi request reprint Long-term outcome after laparoscopic myotomy for achalasia
    Pradheep Krishnamohan
    Division of General Thoracic Surgery, Department of Surgery, Mayo Clinic, Rochester, Minn
    J Thorac Cardiovasc Surg 147:730-6; Discussion 736-7. 2014
  6. pmc Complete pathologic response after neoadjuvant chemoradiotherapy for esophageal cancer is associated with enhanced survival
    James M Donahue
    Division of General Thoracic Surgery, Mayo Clinic, Rochester, Minnesota 55905, USA
    Ann Thorac Surg 87:392-8; discussion 398-9. 2009
  7. doi request reprint Is lymph node dissection required in pulmonary metastasectomy for colorectal adenocarcinoma?
    Masatsugu Hamaji
    Division of General Thoracic Surgery, Mayo Clinic, Rochester, Minnesota 55905, USA
    Ann Thorac Surg 94:1796-800. 2012
  8. doi request reprint Oncologic efficacy of anatomic segmentectomy in stage IA lung cancer patients with T1a tumors
    James M Donahue
    Division of General Thoracic Surgery, William J von Liebig Transplant Center, Mayo Clinic, Rochester, Minnesota 55905, USA
    Ann Thorac Surg 93:381-7; discussion 387-8. 2012
  9. doi request reprint A comprehensive review of anastomotic technique in 432 esophagectomies
    Theolyn N Price
    Division of General Thoracic Surgery, Mayo Clinic, Rochester, Minnesota 55905, USA
    Ann Thorac Surg 95:1154-60; discussion 1160-1. 2013
  10. doi request reprint Surgical treatment of metachronous second primary lung cancer after complete resection of non-small cell lung cancer
    Masatsugu Hamaji
    Division of General Thoracic Surgery, Mayo Clinic, Rochester, MN 55905, USA
    J Thorac Cardiovasc Surg 145:683-90; discussion 690-1. 2013

Detail Information

Publications67

  1. doi request reprint Current readings: management of N2 disease for lung cancer
    Dennis A Wigle
    Division of General Thoracic Surgery, Department of Surgery, Mayo Clinic College of Medicine Rochester, Minnesota Electronic address
    Semin Thorac Cardiovasc Surg 26:67-70. 2014
    ..We review recent literature in this area and its impact. ..
  2. doi request reprint Biologic approaches to drug selection and targeted therapy: hype or clinical reality?
    Dennis A Wigle
    Thoracic Surgery, Mayo Clinic, 200 First Street, Southwest, Rochester, MN 55905, USA
    Thorac Surg Clin 23:421-8. 2013
    ..This article reviews key advances, with commentary and perspective for the practicing thoracic surgical oncologist. ..
  3. doi request reprint Does surgeon workload per day affect outcomes after pulmonary lobectomies?
    Mathew Thomas
    Division of General Thoracic Surgery, Mayo Clinic Rochester, Rochester, Minnesota 55905, USA
    Ann Thorac Surg 94:966-72. 2012
    ..Our aim was to evaluate whether the workload of a surgeon, including number of operations, operative time, or number of rooms per day, influenced patient morbidity or mortality after pulmonary lobectomy...
  4. doi request reprint Surgical management of congenital cystic lung malformations in older patients
    Zeena Makhija
    Division of General Thoracic Surgery, Mayo Clinic, Rochester, Minnesota 55905, USA
    Ann Thorac Surg 91:1568-73; discussion 1573. 2011
    ..It is controversial whether surgical management in older patients requires more extensive lung resection. The aim of our study was to analyze the outcomes of surgical management in older patients...
  5. doi request reprint Long-term outcome after laparoscopic myotomy for achalasia
    Pradheep Krishnamohan
    Division of General Thoracic Surgery, Department of Surgery, Mayo Clinic, Rochester, Minn
    J Thorac Cardiovasc Surg 147:730-6; Discussion 736-7. 2014
    ..Achalasia has a variety of therapeutic options. We sought to determine the long-term outcome of laparoscopic myotomy in a large group of patients...
  6. pmc Complete pathologic response after neoadjuvant chemoradiotherapy for esophageal cancer is associated with enhanced survival
    James M Donahue
    Division of General Thoracic Surgery, Mayo Clinic, Rochester, Minnesota 55905, USA
    Ann Thorac Surg 87:392-8; discussion 398-9. 2009
    ..Neoadjuvant chemoradiotherapy followed by esophagogastrectomy has become the standard of care for patients with locally advanced esophageal cancer. This report analyzes our experience with this treatment approach...
  7. doi request reprint Is lymph node dissection required in pulmonary metastasectomy for colorectal adenocarcinoma?
    Masatsugu Hamaji
    Division of General Thoracic Surgery, Mayo Clinic, Rochester, Minnesota 55905, USA
    Ann Thorac Surg 94:1796-800. 2012
    ..The aim of this study was to clarify the clinical outcome and significance of mediastinal lymph node dissection (LND) during pulmonary resection of metastases from colorectal adenocarcinoma...
  8. doi request reprint Oncologic efficacy of anatomic segmentectomy in stage IA lung cancer patients with T1a tumors
    James M Donahue
    Division of General Thoracic Surgery, William J von Liebig Transplant Center, Mayo Clinic, Rochester, Minnesota 55905, USA
    Ann Thorac Surg 93:381-7; discussion 387-8. 2012
    ..Segmentectomy provides an anatomic, parenchymal-sparing strategy for patients with limited lung function. Recently, interest has been renewed in segmentectomy for the treatment of early stage lung cancer...
  9. doi request reprint A comprehensive review of anastomotic technique in 432 esophagectomies
    Theolyn N Price
    Division of General Thoracic Surgery, Mayo Clinic, Rochester, Minnesota 55905, USA
    Ann Thorac Surg 95:1154-60; discussion 1160-1. 2013
    ..This report analyzes outcomes of these anastomotic techniques...
  10. doi request reprint Surgical treatment of metachronous second primary lung cancer after complete resection of non-small cell lung cancer
    Masatsugu Hamaji
    Division of General Thoracic Surgery, Mayo Clinic, Rochester, MN 55905, USA
    J Thorac Cardiovasc Surg 145:683-90; discussion 690-1. 2013
    ..To clarify the perioperative and oncologic outcome of pulmonary resection for a metachronous second primary lung cancer (MSPLC) following resection of an initial non-small cell lung cancer (NSCLC)...
  11. pmc An alternative postoperative pathway reduces length of hospitalisation following oesophagectomy
    Sandra C Tomaszek
    Division of General Thoracic Surgery, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Eur J Cardiothorac Surg 37:807-13. 2010
    ..As part of our ongoing quality improvement effort, we evaluated our conventional approach to post-oesophagectomy management by comparing it to an alternative postoperative management pathway...
  12. doi request reprint Routine anticoagulation is not indicated for postoperative general thoracic surgical patients with new-onset atrial fibrillation
    Zeena Makhija
    Division of General Thoracic Surgery, Mayo Clinic, Rochester, Minnesota 55905, USA
    Ann Thorac Surg 92:421-6; discussion 426-7. 2011
    ..We analyzed new-onset AF in patients after a general thoracic operation to determine the benefit of anticoagulation on prevention of stroke and its impact on postoperative outcome...
  13. doi request reprint External validation of the recalibrated thoracic revised cardiac risk index for predicting the risk of major cardiac complications after lung resection
    Alessandro Brunelli
    Division of General Thoracic Surgery, Mayo Clinic, Rochester, Minnesota, USA
    Ann Thorac Surg 92:445-8. 2011
    ..The objective of this study was to validate the ThRCRI in an external population of candidates having undergone major lung resections to assess its reliability for cardiac risk stratification across different samples...
  14. pmc N2 disease in T1 non-small cell lung cancer
    Sebastian A Defranchi
    Division of General Thoracic Surgery, Mayo Clinic, Rochester, Minnesota 55905, USA
    Ann Thorac Surg 88:924-8. 2009
    ..The true prevalence of mediastinal lymph node metastases (N2 disease) in resected pathologic T1 (pT1) NSCLC must be known to define the role of invasive mediastinal staging in these patients...
  15. doi request reprint Bronchial resection margin length and clinical outcome in non-small cell lung cancer
    Sandra C Tomaszek
    Division of General Thoracic Surgery, Mayo Clinic, 200 First Street SW, Rochester, Minnesota 55905, USA
    Eur J Cardiothorac Surg 40:1151-6. 2011
    ..However, the impact of the length of the bronchial margin remains unknown. This study aimed to determine whether an increased bronchial resection margin length is correlated with an improved disease-free and overall survival rate...
  16. doi request reprint Bullectomy for symptomatic or complicated giant lung bullae
    Pradheep Krishnamohan
    Division of General Thoracic Surgery, Department of Surgery, Mayo Clinic, Rochester, Minnesota
    Ann Thorac Surg 97:425-31. 2014
    ..Giant bullae of the lung are rare. Little is known about functional results after surgical treatment...
  17. doi request reprint Mediastinoscopy in patients with lung cancer and negative endobronchial ultrasound guided needle aspiration
    Sebastian A Defranchi
    Division of General Thoracic Surgery, Mayo Clinic, Rochester, Minnesota 55905, USA
    Ann Thorac Surg 90:1753-7. 2010
    ..We evaluated the negative predictive value of EBUS-TBNA in lung cancer patients suspected of having N2 nodal metastases...
  18. pmc Clinical outcomes of video-assisted thoracoscopic lobectomy
    Sandra C Tomaszek
    Division of General Thoracic Surgery, Mayo Clinic, Rochester, MN 55905, USA
    Mayo Clin Proc 84:509-13. 2009
    ..To review our experience with video-assisted thoracoscopic (VATS) lobectomy with respect to morbidity, mortality, and short-term outcome...
  19. pmc Cell proliferation and epidermal growth factor signaling in non-small cell lung adenocarcinoma cell lines are dependent on Rin1
    Jin C Tomshine
    Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN 55905, USA
    J Biol Chem 284:26331-9. 2009
    ..These data demonstrate that proper internalization and endocytic trafficking are critical for EGFR-mediated signaling in A549 cells and suggest that up-regulation of Rin1 in A549 cell lines may contribute to their proliferative nature...
  20. doi request reprint The sensitivity of 18F-fluorodeoxyglucose positron emission tomography in the evaluation of metastatic pulmonary nodules
    Daniel L Fortes
    Division of General Thoracic Surgery, Department of Surgery, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA
    Eur J Cardiothorac Surg 34:1223-7. 2008
    ..The aims of the study were to determine the accuracy of FDG-PET in detecting pulmonary metastasis and identify factors affecting sensitivity...
  21. pmc MicroRNA-mRNA interactions in a murine model of hyperoxia-induced bronchopulmonary dysplasia
    Jie Dong
    Division of General Thoracic Surgery, Department of Surgery, Mayo Clinic, Rochester, MN, USA
    BMC Genomics 13:204. 2012
    ..There is increasing evidence that microRNAs (miRNAs) regulate translation of messenger RNAs (mRNAs) during lung organogenesis. The potential role of miRNAs in the pathogenesis of BPD is unclear...
  22. doi request reprint Stage IIIA non-small cell lung cancer: morbidity and mortality of three distinct multimodality regimens
    Christopher W Seder
    Division of General Thoracic Surgery, Mayo Clinic, Rochester, MN 55905, USA
    Ann Thorac Surg 95:1708-16. 2013
    ..We examined morbidity and mortality associated with 3 multimodality treatment regimens for stage IIIA disease...
  23. pmc c-Myc regulates self-renewal in bronchoalveolar stem cells
    Jie Dong
    Division of General Thoracic Surgery, Department of Surgery, Mayo Clinic, Rochester, Minnesota, United States of America
    PLoS ONE 6:e23707. 2011
    ..The mechanisms directing self-renewal in BASCs are poorly understood...
  24. doi request reprint A novel use of human acellular dermis for conduit salvage after esophagectomy
    Mathew Thomas
    Division of General Thoracic Surgery, Mayo Clinic, Rochester, Minnesota
    Ann Thorac Surg 97:1459-63. 2014
    ..We describe a technique in which human acellular dermis (AlloDerm) is used to repair the conduit, and report a series of 3 patients with significant anastomotic dehiscence whose conduits were salvaged using this technique. ..
  25. doi request reprint The role of surgical management in recurrent thymic tumors
    Masatsugu Hamaji
    Division of General Thoracic Surgery, Mayo Clinic, Rochester, Minnesota 55905, USA
    Ann Thorac Surg 94:247-54; discussion 254. 2012
    ..There are few data on outcomes after surgical treatment for recurrent thymic tumors. The aim of this study is to analyze and compare long-term outcomes of treatments for recurrent thymic tumors...
  26. doi request reprint Prospects for molecular staging of non-small-cell lung cancer from genomic alterations
    Sandra C Tomaszek
    Division of General Thoracic Surgery, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Expert Rev Respir Med 4:499-508. 2010
    ..Here we review some of the successes, frustrations and obstacles that exist to further progress in the field...
  27. doi request reprint Patient-centered quality indicators for pulmonary resection
    Stephen D Cassivi
    Division of General Thoracic Surgery, Mayo Clinic, Rochester, Minnesota 55905, USA
    Ann Thorac Surg 86:927-32. 2008
    ..Quality of care is increasingly scrutinized. However, no standard quality measures exist for surgical care of patients undergoing pulmonary resection...
  28. pmc Thoracic metastasectomy for thyroid malignancies
    John Roland Porterfield
    Division of General Thoracic Surgery, Mayo Clinic, Rochester, Minnesota, USA
    Eur J Cardiothorac Surg 36:155-8. 2009
    ..To better define early and long-term outcomes of patients undergoing thoracic metastasectomy for thyroid cancer...
  29. doi request reprint Surgical management of lung cancer
    Sandra C Tomaszek
    Division of General Thoracic Surgery, Mayo Clinic, Rochester, Minnesota 55905, USA
    Semin Respir Crit Care Med 32:69-77. 2011
    ..Surgical management of early-stage non-small-cell lung cancer and its role in more advanced disease are discussed in this review...
  30. doi request reprint Hiatal hernia after esophagectomy: analysis of 2,182 esophagectomies from a single institution
    Theolyn N Price
    Division of General Thoracic Surgery, Mayo Clinic, Rochester, Minnesota 55905, USA
    Ann Thorac Surg 92:2041-5. 2011
    ..Esophageal resection is a complex operation often associated with morbidity. Hiatal hernia after esophagectomy is an unusual complication. We reviewed our experience with this complication...
  31. doi request reprint The prognosis of pulmonary metastasectomy depends on the location of the primary colorectal cancer
    Jong Ho Cho
    Division of General Thoracic Surgery, Mayo Clinic, Rochester, Minnesota
    Ann Thorac Surg 98:1231-7. 2014
    ..Rectal cancer has a higher risk of developing lung metastasis compared with colon cancer. It is unclear whether the prognosis after pulmonary metastasectomy for these distinct tumors is different...
  32. doi request reprint Primary and prosthetic repair of acquired chest wall hernias: a 20-year experience
    Christopher W Seder
    Division of General Thoracic Surgery, Mayo Clinic, Rochester, Minnesota
    Ann Thorac Surg 98:484-9. 2014
    ..Chest wall herniation has been described after thoracotomy, trauma, and violent coughing episodes. Few studies have examined risk factors associated with chest wall herniation or predictors of complications after surgical repair...
  33. doi request reprint Outcomes in patients requiring mechanical ventilation following pneumonectomy
    Masatsugu Hamaji
    Division of General Thoracic Surgery, Mayo Clinic, Rochester, MN, USA
    Eur J Cardiothorac Surg 46:e14-9. 2014
    ..The aim of this study was to clarify the outcomes of patients who require post-pneumonectomy mechanical ventilation (PPMV)...
  34. doi request reprint Laparoscopic conversion from Nissen to partial fundoplication for refractory dysphagia
    Stephen H McKellar
    Division of General Thoracic Surgery, Mayo Clinic, Rochester, Minnesota 55905, USA
    Ann Thorac Surg 91:932-4. 2011
    ..There were no perioperative deaths and no fundoplication-related complications. In short-term follow-up, all patients reported improvement of dysphagia symptoms...
  35. doi request reprint The outcome of pulmonary resection for invasive fungal infection complicating haematological malignancy
    Masatsugu Hamaji
    Division of General Thoracic Surgery, Mayo Clinic, Rochester, MN, USA
    Eur J Cardiothorac Surg 45:e1-5. 2014
    ..The aim of this study was to clarify clinical outcomes of pulmonary resection of invasive fungal infection (IFI) complicating haematological malignancy...
  36. pmc A randomized controlled trial of bupivacaine through intracostal catheters for pain management after thoracotomy
    Mark S Allen
    Division of General Thoracic Surgery, Mayo Clinic School of Medicine, Rochester, Minnesota 55905, USA
    Ann Thorac Surg 88:903-10. 2009
    ..To address this issue, we performed a randomized, double-blinded, controlled trial of infusion of bupivacaine versus placebo through intercostal and subcutaneous catheters after thoracotomy...
  37. doi request reprint Surgical management of acquired nonmalignant tracheoesophageal and bronchoesophageal fistulae
    K Robert Shen
    Division of General Thoracic Surgery, Mayo Clinic, Rochester, Minnesota 55905, USA
    Ann Thorac Surg 90:914-8; discussion 919. 2010
    ..Acquired nonmalignant fistulae between the airway and esophagus (tracheoesophageal fistulae [TEF]) are rare life-threatening conditions. Several management approaches have been proposed, while the optimal strategy remains controversial...
  38. doi request reprint Minimally invasive resection for mediastinal ectopic parathyroid glands
    Sameh M Said
    Division of General Thoracic Surgery, Mayo Clinic, Rochester, Minnesota
    Ann Thorac Surg 96:1229-33. 2013
    ..We reviewed our experience with ectopic mediastinal parathyroidectomy...
  39. doi request reprint Salvage resections for recurrent or persistent cancer of the proximal esophagus after chemoradiotherapy
    Colin Schieman
    Division of General Thoracic Surgery, Mayo Clinic, Rochester, Minnesota 55905, USA
    Ann Thorac Surg 95:459-63. 2013
    ..The benefit of so-called salvage surgical resection in this group of patients remains unclear and is the focus of this article...
  40. doi request reprint Surgical Resection of Rare Esophageal Cancers
    Sahar A Saddoughi
    Division of General Thoracic Surgery, Department of Surgery, Mayo Clinic, Rochester, Minnesota
    Ann Thorac Surg 101:311-5. 2016
    ..The aim of this study was to examine the treatment of rare malignant esophageal cancers and to evaluate the survival of these patients...
  41. pmc External validation of the Ferguson pulmonary risk score for predicting major pulmonary complications after oesophagectomy†
    J Matthew Reinersman
    Division of General Thoracic Surgery, Department of Surgery, Mayo Clinic, Rochester, MN, USA
    Eur J Cardiothorac Surg 49:333-8. 2016
    ..Risk screening tools assist in patient stratification. Ferguson proposed a risk score system to predict major pulmonary complications after oesophagectomy. Our objective was to externally validate this risk score system...
  42. pmc MicroRNA networks in mouse lung organogenesis
    Jie Dong
    Division of General Thoracic Surgery, Mayo Clinic Cancer Center, Mayo Clinic, Rochester, Minnesota, USA
    PLoS ONE 5:e10854. 2010
    ..MiRNA networks and their regulation of messenger RNA (mRNA) translation and protein expression in specific biological processes are poorly understood...
  43. doi request reprint Generation and sequencing of pulmonary carcinoid tumor cell lines
    Michael K Asiedu
    Division of General Thoracic Surgery, Department of Surgery, Mayo Clinic College of Medicine, Rochester, MN Thoracic Diseases Research Unit, Division of Pulmonary, Critical Care, and Internal Medicine, Department of Medicine Department of Laboratory Medicine and Pathology and Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, MN
    J Thorac Oncol 9:1763-71. 2014
    ..We report the generation and characterization of human pulmonary carcinoid tumor cell lines to study underlying biology, and to provide models for testing novel chemotherapeutic agents...
  44. doi request reprint Laparoscopic repair for failed antireflux procedures
    George Makdisi
    Division of General Thoracic Surgery, Mayo Clinic College of Medicine, Rochester, Minnesota
    Ann Thorac Surg 98:1261-6. 2014
    ..Minimally invasive procedures have become common, and more reoperations for failed antireflux procedures are performed laparoscopically. We wanted to study the outcomes of laparoscopic reoperations for reflux...
  45. doi request reprint Navigating the pathway to robotic competency in general thoracic surgery
    Christopher W Seder
    Division of General Thoracic Surgery, Mayo Clinic, Rochester, MN 55905, USA
    Innovations (Phila) 8:184-9. 2013
    ..We report our initial robotic surgery experience and propose a structured, competency-based pathway for the development of robotic skills...
  46. pmc Solitary fibrous tumors of the pleura: results of surgical treatment and long-term prognosis
    Karen M Harrison-Phipps
    Division of General Thoracic Surgery, Mayo Clinic, Rochester, Minn 55905, USA
    J Thorac Cardiovasc Surg 138:19-25. 2009
    ..We sought to define the long-term outcome of surgically treated solitary fibrous tumors of the pleura...
  47. doi request reprint Outcome of lung transplantation in elderly recipients
    Sandra C Tomaszek
    William J von Liebig Transplant Center, Mayo Clinic, Rochester, MN 55905, USA
    Eur J Cardiothorac Surg 39:726-31. 2011
    ..With demographic trends showing an increasing proportion of patients over 60 years old, we evaluated our outcomes with lung transplantation in this older cohort...
  48. doi request reprint Comparison of Two National Databases for General Thoracic Surgery
    Mark S Allen
    Division of General Thoracic Surgery, Department of Surgery, Mayo Clinic, Rochester, Minnesota Electronic address
    Ann Thorac Surg 100:1155-61; discussion 1161-2. 2015
    ....
  49. doi request reprint Non-overlapping and non-cell-type-specific gene expression signatures predict lung cancer survival
    Zhifu Sun
    Department of Health Sciences Research, College of Medicine, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
    J Clin Oncol 26:877-83. 2008
    ..This study applied multivariate approaches to identify and evaluate value-added gene expression signatures in two types of NSCLC...
  50. pmc USP44 regulates centrosome positioning to prevent aneuploidy and suppress tumorigenesis
    Ying Zhang
    Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Clin Invest 122:4362-74. 2012
    ..These functions required direct binding to the centriole protein centrin. Our data reveal a new role for the ubiquitin system in mitotic spindle regulation and underscore the importance of USP44 in the pathogenesis of human cancer...
  51. doi request reprint Pretreatment assessment for the optimal management of early-stage lung cancer
    Sandra C Tomaszek
    From the Division of General Thoracic Surgery, Mayo Clinic, Rochester, MN 55905, USA
    Cancer J 17:11-7. 2011
    ..We review the clinical approach to suspected early-stage lung cancer based on a tumor and patient-centered stratification of risk and benefit...
  52. pmc Hyperoxia-induced changes in estradiol metabolism in postnatal airway smooth muscle
    Yvette N Martin
    Department of Anesthesiology, Mayo Clinic, Rochester, Minnesota
    Am J Physiol Lung Cell Mol Physiol 308:L141-6. 2015
    ....
  53. pmc Lung cancer: developmental networks gone awry?
    Jie Dong
    Division of General Thoracic Surgery, Mayo Clinic Cancer Center, Mayo Clinic, Rochester, MN 55905, USA
    Cancer Biol Ther 8:312-8. 2009
    ..This review summarizes our understanding of the potential overlapping mechanisms involved in lung development and lung tumorigenesis...
  54. doi request reprint Manubrial-clavicular-chest wall explantation to expose the anterior thoracic inlet
    Christopher W Seder
    Division of General Thoracic Surgery, Mayo Clinic, Rochester, Minnesota
    Ann Thorac Surg 97:350-2. 2014
    ..This approach represents an alternative technique that provides excellent visualization of the entire anterior thoracic inlet. ..
  55. pmc Metastasectomy and surgical resection of the primary tumor in patients with stage IV breast cancer: time for a second look?
    Barbara A Pockaj
    Department of Surgery, Mayo Clinic, Scottsdale, AZ, USA
    Ann Surg Oncol 17:2419-26. 2010
    ..It is time to conduct a carefully designed randomized trial to see whether surgery in stage IV breast cancer does indeed warrant a second look...
  56. pmc A comparative genomic approach for identifying synthetic lethal interactions in human cancer
    Raamesh Deshpande
    Authors Affiliations Department of Computer Science and Engineering Program in Biomedical Informatics and Computational Biology, University of Minnesota, Minneapolis Department of Surgery, Mayo Clinic, Rochester, Minnesota Department of Laboratory Medicine and Pathology, Molecular Genetics Lab, Mayo Clinic, Rochester, Minnesota Department of Molecular Genetics, Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Ontario, Canada Chemical Genomics Research Group, RIKEN Advance Science Institute, Saitama, Japan and Great Lakes Bioenergy Research Center, University of Wisconsin, Madison, Wisconsin
    Cancer Res 73:6128-36. 2013
    ..These results suggest therapeutic targets for cancers harboring mutations in SMARCB1 or ASPSCR1 and highlight the potential of a targeted, cross-species strategy for identifying synthetic lethal interactions relevant to human cancer...
  57. pmc Genomic rearrangements define lineage relationships between adjacent lepidic and invasive components in lung adenocarcinoma
    Stephen J Murphy
    Authors Affiliations Departments of Molecular Medicine, General Thoracic Surgery, Pulmonary and Critical Care Medicine, Health Sciences Research, and Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota
    Cancer Res 74:3157-67. 2014
    ..Our results offer a perspective on the genetic pathogenesis underlying adenocarcinoma development and its clinical management...
  58. pmc Impact of sample acquisition and linear amplification on gene expression profiling of lung adenocarcinoma: laser capture micro-dissection cell-sampling versus bulk tissue-sampling
    Eric W Klee
    Department of Molecular Medicine, Mayo Clinic, Rochester, MN, USA
    BMC Med Genomics 2:13. 2009
    ..Consequently, LCM may enable investigators to obtain additional information in microarray studies not easily found using bulk tissue samples, but it is of critical importance that potential amplification biases are controlled for...
  59. pmc Endoscopic and surgical treatment of mucosal (T1a) esophageal adenocarcinoma in Barrett's esophagus
    Ganapathy A Prasad
    Barrett s Esophagus Unit, Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, Minnesota, USA
    Gastroenterology 137:815-23. 2009
    ..Long-term outcomes of patients treated endoscopically and surgically for mucosal EAC are unknown. We compared long-term outcomes of patients with mucosal EAC treated endoscopically and surgically...
  60. doi request reprint Cooperative group clinical trials in general thoracic surgery: report from the 2012 Robert Ginsberg Clinical Trials Meeting of the General Thoracic Surgical Club
    Mark S Allen
    Division of General Thoracic Surgery, Department of Surgery, Mayo Clinic, Rochester, Minnesota 55905, USA
    Ann Thorac Surg 95:750-6. 2013
    ..The purpose of this review is to centralize the information to assist surgeons enrolling patients into oncologic clinical trials in thoracic surgery...
  61. ncbi request reprint Early experience with robotic-assisted lung resection
    Daniel L Fortes
    Division of General Thoracic Surgery, Mayo Clinic, Rochester, MN, USA
    Innovations (Phila) 6:237-42. 2011
    ..Few reports have been published to date regarding clinical experience with this technology. We describe our first consecutive case experience with robotic-assisted lung resection...
  62. doi request reprint Analysis of ErbB receptors in pulmonary carcinoid tumors
    Otis B Rickman
    Thoracic Diseases Research Unit, Division of Pulmonary, Critical Care and Internal Medicine, Department of Medicine, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Clin Cancer Res 15:3315-24. 2009
    ....
  63. ncbi request reprint Lung cancer in octogenarians: factors affecting long-term survival following resection
    Alberto Dominguez-Ventura
    Division of General Thoracic Surgery, Mayo Clinic, 200 First Street, S W, Rochester, MN 55905, USA
    Eur J Cardiothorac Surg 32:370-4. 2007
    ..To identify factors associated with long-term survival following pulmonary resection for lung cancer in patients 80 years of age or older...
  64. doi request reprint 5-year survival after multiple repeat metastasectomy for pulmonary artery angiosarcoma
    Sameh M Said
    Division of General Thoracic Surgery, Mayo Clinic, Rochester, Minnesota 55905, USA
    Ann Thorac Surg 91:e49-51. 2011
    ..We report a case of a 39-year-old woman without evidence of disease 5 years after initial diagnosis and after multiple metastasectomies and pulmonary artery tumor endarterectomy...
  65. pmc Preoperative gabapentin for acute post-thoracotomy analgesia: a randomized, double-blinded, active placebo-controlled study
    Michelle A O Kinney
    Department of Anesthesiology, College of Medicine Mayo Clinic, Rochester, Minnesota, USA
    Pain Pract 12:175-83. 2012
    ..Patients undergoing thoracotomy benefit from epidural analgesia but still may experience significant postoperative pain. We examined the effect of preoperative gabapentin in thoracotomy patients...
  66. doi request reprint Robust and efficient identification of biomarkers by classifying features on graphs
    TaeHyun Hwang
    Department of Computer Science and Engineering, University of Minnesota, Twin Cities, Bioinformatics Core, Mayo Clinic College of Medicine, Rochester, MN, USA
    Bioinformatics 24:2023-9. 2008
    ..In addition, although designed for classifying features, our algorithm can also simultaneously classify test samples for disease prognosis/diagnosis...
  67. pmc Thymomas: review of current clinical practice
    Sandra Tomaszek
    Division of General Thoracic Surgery, Mayo Clinic, Rochester, Minnesota, USA
    Ann Thorac Surg 87:1973-80. 2009
    ..Here we review the literature for current clinical practice in the diagnosis, management, and treatment of thymomas...