Arthur E Warrington

Summary

Affiliation: Mayo Clinic
Country: USA

Publications

  1. ncbi Human monoclonal IgM antibody promotes CNS myelin repair independent of Fc function
    Bogoljub Ciric
    Department of Immunology, Mayo Medical and Graduate Schools, Mayo Clinic Rochester, Minn 55905, USA
    Brain Pathol 13:608-16. 2003
  2. ncbi A recombinant human IgM promotes myelin repair after a single, very low dose
    Arthur E Warrington
    Department of Neurology, Mayo Clinic College of Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Neurosci Res 85:967-76. 2007
  3. pmc Method of identifying natural antibodies for remyelination
    Arthur E Warrington
    Department of Neurology, Guggenheim 401, Mayo Clinic, Rochester, MN 55905, USA
    J Clin Immunol 30:S50-5. 2010
  4. ncbi Remyelination-promoting antibodies activate distinct Ca2+ influx pathways in astrocytes and oligodendrocytes: relationship to the mechanism of myelin repair
    M Mateo Paz Soldan
    Program in Molecular Neuroscience, Mayo Medical and Graduate Schools, 200 First Street SW, Rochester, MN 55905, USA
    Mol Cell Neurosci 22:14-24. 2003
  5. pmc Therapeutics to promote CNS repair: a natural human neuron-binding IgM regulates membrane-raft dynamics and improves motility in a mouse model of multiple sclerosis
    Xiaohua Xu
    Department of Neurology, Mayo Clinic and Foundation, Rochester, MN 55905, USA
    J Clin Immunol 33:S50-6. 2013
  6. ncbi Neuron-binding human monoclonal antibodies support central nervous system neurite extension
    Arthur E Warrington
    Department of Neurology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    J Neuropathol Exp Neurol 63:461-73. 2004
  7. pmc A single dose of neuron-binding human monoclonal antibody improves spontaneous activity in a murine model of demyelination
    Aleksandar Denic
    Department of Neurology, Mayo Clinic, Rochester, Minnesota, United States of America
    PLoS ONE 6:e26001. 2011
  8. ncbi A human antibody that promotes remyelination enters the CNS and decreases lesion load as detected by T2-weighted spinal cord MRI in a virus-induced murine model of MS
    Istvan Pirko
    Department of Neurology, Mayo Clinic, Rochester, Minnesota 55905, USA
    FASEB J 18:1577-9. 2004
  9. pmc A human IgM signals axon outgrowth: coupling lipid raft to microtubules
    Xiaohua Xu
    Department of Neurology, Mayo Clinic and Foundation, Rochester, MN 55905, USA
    J Neurochem 119:100-12. 2011
  10. doi Naturally Occurring Monoclonal Antibodies and Their Therapeutic Potential for Neurologic Diseases
    Bharath Wootla
    Department of Neurology, Mayo Clinic, Rochester, Minnesota2Mayo Clinic Center for Multiple Sclerosis and Autoimmune Neurology, Mayo Clinic, Rochester, Minnesota
    JAMA Neurol 72:1346-53. 2015

Collaborators

Detail Information

Publications37

  1. ncbi Human monoclonal IgM antibody promotes CNS myelin repair independent of Fc function
    Bogoljub Ciric
    Department of Immunology, Mayo Medical and Graduate Schools, Mayo Clinic Rochester, Minn 55905, USA
    Brain Pathol 13:608-16. 2003
    ....
  2. ncbi A recombinant human IgM promotes myelin repair after a single, very low dose
    Arthur E Warrington
    Department of Neurology, Mayo Clinic College of Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Neurosci Res 85:967-76. 2007
    ..We propose that the specificity of rHIgM22 for myelin on living tissue targets the antibody to demyelinated lesions, initiating a long-term reparative effect on the central nervous system...
  3. pmc Method of identifying natural antibodies for remyelination
    Arthur E Warrington
    Department of Neurology, Guggenheim 401, Mayo Clinic, Rochester, MN 55905, USA
    J Clin Immunol 30:S50-5. 2010
    ....
  4. ncbi Remyelination-promoting antibodies activate distinct Ca2+ influx pathways in astrocytes and oligodendrocytes: relationship to the mechanism of myelin repair
    M Mateo Paz Soldan
    Program in Molecular Neuroscience, Mayo Medical and Graduate Schools, 200 First Street SW, Rochester, MN 55905, USA
    Mol Cell Neurosci 22:14-24. 2003
    ..These findings support the hypothesis that remyelination-promoting antibodies are acting directly at the surface of glial cells to induce calcium-dependent physiologic reparative function...
  5. pmc Therapeutics to promote CNS repair: a natural human neuron-binding IgM regulates membrane-raft dynamics and improves motility in a mouse model of multiple sclerosis
    Xiaohua Xu
    Department of Neurology, Mayo Clinic and Foundation, Rochester, MN 55905, USA
    J Clin Immunol 33:S50-6. 2013
    ..Our work demonstrates that a natural human neuron-binding IgM can regulate membrane domain dynamics. This antibody has the potential to improve neurologic disease...
  6. ncbi Neuron-binding human monoclonal antibodies support central nervous system neurite extension
    Arthur E Warrington
    Department of Neurology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    J Neuropathol Exp Neurol 63:461-73. 2004
    ..Both human mAbs were isolated from individuals with monoclonal gammopathy. Each individual has carried high mAb titers in circulation for years without detriment. sHIgM12 and sHIgM42 are therefore unlikely to be systemically pathogenic...
  7. pmc A single dose of neuron-binding human monoclonal antibody improves spontaneous activity in a murine model of demyelination
    Aleksandar Denic
    Department of Neurology, Mayo Clinic, Rochester, Minnesota, United States of America
    PLoS ONE 6:e26001. 2011
    ..rHIgM12 did not alter activity of normal, uninfected mice. This study supports the hypothesis that treatment with a neuron-binding IgM not only protects neurons in vitro, but also influences functional motor improvement...
  8. ncbi A human antibody that promotes remyelination enters the CNS and decreases lesion load as detected by T2-weighted spinal cord MRI in a virus-induced murine model of MS
    Istvan Pirko
    Department of Neurology, Mayo Clinic, Rochester, Minnesota 55905, USA
    FASEB J 18:1577-9. 2004
    ..The reduction in high signal T2-weighted lesion volume may be an important outcome measure in future clinical trials in humans...
  9. pmc A human IgM signals axon outgrowth: coupling lipid raft to microtubules
    Xiaohua Xu
    Department of Neurology, Mayo Clinic and Foundation, Rochester, MN 55905, USA
    J Neurochem 119:100-12. 2011
    ..We propose that the pentameric structure of the IgM is critical to cross-link membrane lipids and proteins resulting in signaling cascades...
  10. doi Naturally Occurring Monoclonal Antibodies and Their Therapeutic Potential for Neurologic Diseases
    Bharath Wootla
    Department of Neurology, Mayo Clinic, Rochester, Minnesota2Mayo Clinic Center for Multiple Sclerosis and Autoimmune Neurology, Mayo Clinic, Rochester, Minnesota
    JAMA Neurol 72:1346-53. 2015
    ..Modulating the immune system does not reverse long-term disability in neurologic disorders. Better neuroregenerative and neuroprotective treatment strategies are needed for neuroinflammatory and neurodegenerative diseases...
  11. pmc Cellular targets and mechanistic strategies of remyelination-promoting IgMs as part of the naturally occurring autoantibody repertoire
    Jens O Watzlawik
    Departments of Neurology and Immunology, Mayo Clinic, College of Medicine, 200 First Street, S W, Rochester, MN 55905, USA
    Expert Rev Neurother 13:1017-29. 2013
    ..However, accumulating evidence also suggests involvement of other antigens in stimulation of remyelination, which will be discussed in the text. ..
  12. pmc A patterned recombinant human IgM guides neurite outgrowth of CNS neurons
    Xiaohua Xu
    Department of Neurology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Sci Rep 3:2267. 2013
    ..Comparison between rHIgM12 and rHIgM22 suggested the biochemistry that facilitates anchoring the neuronal surfaces is a prerequisite for the function of IgM, and spatial properties cooperate in guiding the assembly of neuronal networks. ..
  13. pmc Remyelination induced by a DNA aptamer in a mouse model of multiple sclerosis
    Branislav Nastasijevic
    Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, Rochester, Minnesota, United States of America
    PLoS ONE 7:e39595. 2012
    ..Relative to monoclonal antibodies, DNA aptamers are small, stable, and non-immunogenic, suggesting new possibilities for MS treatment...
  14. doi Naturally occurring antibodies as therapeutics for neurologic disease: can human monoclonal IgMs replace the limited resource IVIG?
    Arthur E Warrington
    Department of Neurology and Immunology, Mayo Clinic, Rochester, Minnesota, USA
    Adv Exp Med Biol 750:44-55. 2012
    ..A long-term solution is to identify the functional component of IVIG and test whether a recombinant human monoclonal can replicate its efficacy...
  15. pmc Recent Advances in Monoclonal Antibody Therapies for Multiple Sclerosis
    Bharath Wootla
    a Department of Neurology, Mayo Clinic, Rochester, MN, USA
    Expert Opin Biol Ther 16:827-39. 2016
    ..Existing immunomodulatory and immunosuppressive approaches lower the number of relapses but do not cure or reverse existing deficits nor improve long-term disability in MS patients...
  16. pmc Antibody Binding Specificity for Kappa (Vκ) Light Chain-containing Human (IgM) Antibodies: Polysialic Acid (PSA) Attached to NCAM as a Case Study
    Jens O Watzlawik
    Department of Neurology, Mayo Clinic Mayo Clinic Center for Multiple Sclerosis and Autoimmune Neurology, Mayo Clinic Center for Regenerative Medicine, Neuroregeneration, Mayo Clinic
    J Vis Exp . 2016
    ..Further enzymatic digestion of CNS tissue and cultured CNS cells using endoneuraminidases led us to identify PSA as the specific binding epitope for HIgM12. ..
  17. pmc A natural human IgM that binds to gangliosides is therapeutic in murine models of amyotrophic lateral sclerosis
    Xiaohua Xu
    Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA
    Dis Model Mech 8:831-42. 2015
    ..Because rHIgM12 improves three different models of neurological disease, we propose that the IgM might act late in the cascade of neuronal stress and/or death by a broad mechanism. ..
  18. pmc Polysialic acid as an antigen for monoclonal antibody HIgM12 to treat multiple sclerosis and other neurodegenerative disorders
    Jens O Watzlawik
    Department of Neurology, Mayo Clinic College of Medicine, Rochester, Minnesota, USA
    J Neurochem 134:865-78. 2015
    ..These findings indicate a new strategy for the treatment of neuro-motor disorders including multiple sclerosis...
  19. pmc PDGF is required for remyelination-promoting IgM stimulation of oligodendrocyte progenitor cell proliferation
    Jens O Watzlawik
    Departments of Neurology and Immunology, Mayo Clinic College of Medicine, Rochester, Minnesota, United States of America
    PLoS ONE 8:e55149. 2013
    ..It is also unknown whether astrocytes or microglia play a functional role in IgM-mediated lesion repair...
  20. ncbi Antiapoptotic signaling by a remyelination-promoting human antimyelin antibody
    Charles L Howe
    Department of Neurology, Mayo Clinic and Foundation, Rochester, MN 55905, USA
    Neurobiol Dis 15:120-31. 2004
    ....
  21. ncbi Direct evidence that a human antibody derived from patient serum can promote myelin repair in a mouse model of chronic-progressive demyelinating disease
    Yoshihiro Mitsunaga
    Department of Neurology, Mayo Medical and Graduate Schools, Mayo Clinic, Rochester, Minnesota 55905, USA
    FASEB J 16:1325-7. 2002
    ..The rHIgM22 antibody provides a new venue for the analysis of mechanisms governing remyelination and may prove useful in the treatment of demyelinating diseases...
  22. pmc Human class I major histocompatibility complex alleles determine central nervous system injury versus repair
    Bharath Wootla
    Department of Neurology, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA
    J Neuroinflammation 13:293. 2016
    ..We investigated the role of human HLA class I molecules in persistent central nervous system (CNS) injury versus repair following virus infection of the CNS...
  23. pmc Antiviral Protection via RdRP-Mediated Stable Activation of Innate Immunity
    Meghan M Painter
    Mayo Graduate School of Medicine, Mayo Clinic, Rochester, Minnesota, United States of America
    PLoS Pathog 11:e1005311. 2015
    ..These results provide a foundation for augmenting innate immunity to achieve broad-spectrum antiviral protection. ..
  24. pmc Need for a paradigm shift in therapeutic approaches to CNS injury
    Bharath Wootla
    Department of Neurology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Expert Rev Neurother 12:409-20. 2012
    ..We have developed recombinant autoreactive natural human IgM antibodies with the therapeutic potential for CNS repair in several neurologic diseases...
  25. pmc Autoantibodies with enzymatic properties in human autoimmune diseases
    Bharath Wootla
    Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA
    J Autoimmun 37:144-50. 2011
    ..The therapeutic relevance of these findings is discussed...
  26. pmc Cellular mechanisms of central nervous system repair by natural autoreactive monoclonal antibodies
    Brent R Wright
    Department of Neurology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Arch Neurol 66:1456-9. 2009
    ..Natural autoreactive monoclonal antibodies directed against CNS cells represent novel therapeutic molecules to induce repair of the nervous system...
  27. pmc Importance of oligodendrocyte protection, BBB breakdown and inflammation for remyelination
    Jens Watzlawik
    Departments of Neurology and Immunology, Mayo Clinic College of Medicine, 200 First Street, SW, Rochester, MN 55905, USA
    Expert Rev Neurother 10:441-57. 2010
    ....
  28. pmc Invited article: human natural autoantibodies in the treatment of neurologic disease
    Moses Rodriguez
    Department of Immunology and Neurology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Neurology 72:1269-76. 2009
    ..Natural human auto mAbs are a potentially important therapeutic technique in combating a wide spectrum of disease processes...
  29. pmc Antibody-Mediated Oligodendrocyte Remyelination Promotes Axon Health in Progressive Demyelinating Disease
    Bharath Wootla
    Departments of Neurology, Mayo Clinic, 200 1st Street SW, Rochester, MN, 55905, USA
    Mol Neurobiol 53:5217-28. 2016
    ..This is direct validation that remyelination preserves spinal cord axons and protects functional axon integrity. ..
  30. pmc A single dose of a neuron-binding human monoclonal antibody improves brainstem NAA concentrations, a biomarker for density of spinal cord axons, in a model of progressive multiple sclerosis
    Bharath Wootla
    Department of Neurology, Mayo Clinic, 200 1st Street SW, Rochester, MN, 55905, USA
    J Neuroinflammation 12:83. 2015
    ..In this study, we examined IgM-mediated changes in brainstem NAA concentrations and central nervous system (CNS) pathology...
  31. pmc Quantitative PCR analysis of DNA aptamer pharmacokinetics in mice
    Katherine Perschbacher
    1 Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, Rochester, Minnesota
    Nucleic Acid Ther 25:11-9. 2015
    ..These data help to interpret the previously observed effectiveness of aptamer conjugates, as opposed to free aptamers, in stimulating central nervous system remyelination in a mouse model of multiple sclerosis. ..
  32. pmc Evidence for the role of B cells and immunoglobulins in the pathogenesis of multiple sclerosis
    Bharath Wootla
    Department of Neurology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Neurol Res Int 2011:780712. 2011
    ..In this paper, we discuss both the deleterious and the beneficial roles of B cells and immunoglobulins in MS lesions. We provide alternative hypotheses to explain both damaging and protective antibody responses...
  33. ncbi STAT4- and STAT6-signaling molecules in a murine model of multiple sclerosis
    Moses Rodriguez
    Department of Neurology, Mayo Clinic, Rochester, Minnesota 55905, USA
    FASEB J 20:343-5. 2006
    ..Thus, virus infection of STAT4-/- mice results in a model that may allow for dissection of the immune events predisposing to late-onset demyelination in MS...
  34. pmc The relevance of animal models in multiple sclerosis research
    Aleksandar Denic
    Molecular Neuroscience Program, Mayo Clinic, Rochester, MN, USA
    Pathophysiology 18:21-9. 2011
    ..Despite their limitations, the rational utilization and application of these models to address specific research questions will remain one of the most useful tools in studies of human demyelinating diseases...
  35. pmc A monoclonal natural human IgM protects axons in the absence of remyelination
    Bharath Wootla
    Department of Neurology, Mayo Clinic College of Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA
    J Neuroinflammation 13:94. 2016
    ....
  36. pmc Enhancing CNS repair in neurological disease: challenges arising from neurodegeneration and rewiring of the network
    Xiaohua Xu
    Department of Neurology, Mayo Clinic and Foundation, Rochester, Minnesota, USA
    CNS Drugs 25:555-73. 2011
    ..Finally, we discuss recent progress in developing human monoclonal IgMs that regulate CNS homeostasis and promote neural regeneration...
  37. pmc Concomitant Use of Neuroprotective Drugs in Neuro Rehabilitation of Multiple Sclerosis
    Harika Dasari
    Department of Neurology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA Mayo Clinic Center for Multiple Sclerosis and Autoimmune Neurology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Int J Phys Med Rehabil 4:. 2016
    ..Inclusion of these drugs as a multifaceted approach may further enhance the efficacy of neurorehabilitation in neuroinflammatory and neurodegenerative disorders...