Malayannan Subramaniam

Summary

Affiliation: Mayo Clinic
Country: USA

Publications

  1. pmc Functional role of KLF10 in multiple disease processes
    Malayannan Subramaniam
    Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN 55905, USA
    Biofactors 36:8-18. 2010
  2. pmc TGFbeta inducible early gene-1 directly binds to, and represses, the OPG promoter in osteoblasts
    M Subramaniam
    Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN 55905, USA
    Biochem Biophys Res Commun 392:72-6. 2010
  3. pmc TIEG1 null mouse-derived osteoblasts are defective in mineralization and in support of osteoclast differentiation in vitro
    Malayannan Subramaniam
    Department of Biochemistry and Molecular Biology, 1601B Guggenheim Bldg, Mayo Clinic College of Medicine, 200 First Street S W, Rochester, MN 55905, USA
    Mol Cell Biol 25:1191-9. 2005
  4. pmc Estrogen receptor beta isoform-specific induction of transforming growth factor beta-inducible early gene-1 in human osteoblast cells: an essential role for the activation function 1 domain
    John R Hawse
    Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Mol Endocrinol 22:1579-95. 2008
  5. pmc Estrogen receptor-beta sensitizes breast cancer cells to the anti-estrogenic actions of endoxifen
    Xianglin Wu
    Department of Biochemistry and Molecular Biology, Mayo Clinic, 200 1stStreet SW, Rochester, MN 55905, USA
    Breast Cancer Res 13:R27. 2011
  6. pmc Endoxifen's molecular mechanisms of action are concentration dependent and different than that of other anti-estrogens
    John R Hawse
    Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota, USA
    PLoS ONE 8:e54613. 2013
  7. ncbi request reprint Estrogen receptor isoform-specific regulation of the retinoblastoma-binding protein 1 (RBBP1) gene: roles of AF1 and enhancer elements
    David G Monroe
    Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    J Biol Chem 281:28596-604. 2006
  8. pmc Development, characterization, and applications of a novel estrogen receptor beta monoclonal antibody
    Xianglin Wu
    Department of Biochemistry and Molecular Biology, Mayo Clinic, 200 1st Street SW, Rochester, Minnesota 55905, USA
    J Cell Biochem 113:711-23. 2012
  9. pmc TIEG1/KLF10 modulates Runx2 expression and activity in osteoblasts
    John R Hawse
    Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota, United States of America
    PLoS ONE 6:e19429. 2011
  10. ncbi request reprint Differential gene expression of TGF beta inducible early gene (TIEG), Smad7, Smad2 and Bard1 in normal and malignant breast tissue
    Monica M Reinholz
    Division of Experimental Pathology, Department of Biochemistry, Mayo Clinic College of Medicine, Rochester, MN, USA
    Breast Cancer Res Treat 86:75-88. 2004

Collaborators

Detail Information

Publications38

  1. pmc Functional role of KLF10 in multiple disease processes
    Malayannan Subramaniam
    Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN 55905, USA
    Biofactors 36:8-18. 2010
    ....
  2. pmc TGFbeta inducible early gene-1 directly binds to, and represses, the OPG promoter in osteoblasts
    M Subramaniam
    Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN 55905, USA
    Biochem Biophys Res Commun 392:72-6. 2010
    ..Taken together, these results confirm that TIEG directly binds to and inhibits OPG promoter activity in OBs, partially explaining the inability of TIEG KO OBs to fully support osteoclast differentiation...
  3. pmc TIEG1 null mouse-derived osteoblasts are defective in mineralization and in support of osteoclast differentiation in vitro
    Malayannan Subramaniam
    Department of Biochemistry and Molecular Biology, 1601B Guggenheim Bldg, Mayo Clinic College of Medicine, 200 First Street S W, Rochester, MN 55905, USA
    Mol Cell Biol 25:1191-9. 2005
    ..We conclude from these data that TIEG1 expression in OBs is critical for both osteoblast-mediated mineralization and osteoblast support of osteoclast differentiation...
  4. pmc Estrogen receptor beta isoform-specific induction of transforming growth factor beta-inducible early gene-1 in human osteoblast cells: an essential role for the activation function 1 domain
    John R Hawse
    Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Mol Endocrinol 22:1579-95. 2008
    ....
  5. pmc Estrogen receptor-beta sensitizes breast cancer cells to the anti-estrogenic actions of endoxifen
    Xianglin Wu
    Department of Biochemistry and Molecular Biology, Mayo Clinic, 200 1stStreet SW, Rochester, MN 55905, USA
    Breast Cancer Res 13:R27. 2011
    ..Here, we characterize the molecular actions of endoxifen in breast cancer cells expressing ERβ and examine its effectiveness as an anti-estrogenic agent in these cell lines...
  6. pmc Endoxifen's molecular mechanisms of action are concentration dependent and different than that of other anti-estrogens
    John R Hawse
    Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota, USA
    PLoS ONE 8:e54613. 2013
    ....
  7. ncbi request reprint Estrogen receptor isoform-specific regulation of the retinoblastoma-binding protein 1 (RBBP1) gene: roles of AF1 and enhancer elements
    David G Monroe
    Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    J Biol Chem 281:28596-604. 2006
    ..These results describe an E2-dependent, ER isoform-specific transcriptional activation of the RBBP1 gene, which in part, is explained by the differential activity of ER AF1 and enhancer element binding...
  8. pmc Development, characterization, and applications of a novel estrogen receptor beta monoclonal antibody
    Xianglin Wu
    Department of Biochemistry and Molecular Biology, Mayo Clinic, 200 1st Street SW, Rochester, Minnesota 55905, USA
    J Cell Biochem 113:711-23. 2012
    ..The use of the MC10 antibody, in combination with highly specific antibodies targeting only full-length ERβ, is likely to provide additional discriminatory features in breast cancers that may be useful in predicting response to therapy...
  9. pmc TIEG1/KLF10 modulates Runx2 expression and activity in osteoblasts
    John R Hawse
    Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota, United States of America
    PLoS ONE 6:e19429. 2011
    ....
  10. ncbi request reprint Differential gene expression of TGF beta inducible early gene (TIEG), Smad7, Smad2 and Bard1 in normal and malignant breast tissue
    Monica M Reinholz
    Division of Experimental Pathology, Department of Biochemistry, Mayo Clinic College of Medicine, Rochester, MN, USA
    Breast Cancer Res Treat 86:75-88. 2004
    ..Further investigation is necessary to validate the ability of these genes to discriminate between different populations of breast cancer patients...
  11. pmc Retinoblastoma binding protein-1 (RBP1) is a Runx2 coactivator and promotes osteoblastic differentiation
    David G Monroe
    Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    BMC Musculoskelet Disord 11:104. 2010
    ..Since the function of RBP1 in osteoblastic differentiation and mineralization is unknown, we investigated the role of RBP1 in these processes...
  12. ncbi request reprint TGFbeta inducible early gene-1 knockout mice display defects in bone strength and microarchitecture
    Sabine F Bensamoun
    Department of Orthopedic Research, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Bone 39:1244-51. 2006
    ..In summary, an important role for TIEG in skeletal development and/or homeostasis is indicated...
  13. ncbi request reprint Transcriptional regulation of Smad2 is required for enhancement of TGFbeta/Smad signaling by TGFbeta inducible early gene
    Steven A Johnsen
    Department of Biochemistry and Molecular Biology, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
    J Cell Biochem 87:233-41. 2002
    ..Thus we propose a new model whereby TIEG enhances Smad signaling by a dual mechanism involving both the repression of the inhibitory Smad7 as well as the activation of Smad2...
  14. doi request reprint The tamoxifen metabolite, endoxifen, is a potent antiestrogen that targets estrogen receptor alpha for degradation in breast cancer cells
    Xianglin Wu
    Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Cancer Res 69:1722-7. 2009
    ..These results support the theory that endoxifen is the primary metabolite responsible for the overall effectiveness of tamoxifen in the treatment of ER-positive breast cancer...
  15. pmc TGF-β inducible early gene 1 regulates osteoclast differentiation and survival by mediating the NFATc1, AKT, and MEK/ERK signaling pathways
    Muzaffer Cicek
    Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, Rochester, Minnesota, United States of America
    PLoS ONE 6:e17522. 2011
    ..Together, these data provide evidence that TIEG1 controls osteoclast differentiation by reducing NFATc1 pathway activation and reduces osteoclast survival by suppressing AKT and MEK/ERK signaling...
  16. ncbi request reprint TGFbeta inducible early gene enhances TGFbeta/Smad-dependent transcriptional responses
    Steven A Johnsen
    Department of Biochemistry and Molecular Biology, Mayo Clinic and Foundation, Rochester, Minnesota, MN 55905, USA
    Oncogene 21:5783-90. 2002
    ..In conclusion, these results describe a novel mechanism for the potentiation of TGFbeta/Smad signaling via repression of the inhibitory Smad7 gene by TIEG...
  17. ncbi request reprint Estrogen receptor alpha and beta heterodimers exert unique effects on estrogen- and tamoxifen-dependent gene expression in human U2OS osteosarcoma cells
    David G Monroe
    Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, 1601C Guggenheim, 200 1st Street Southwest, Rochester, Minnesota 55905, USA
    Mol Endocrinol 19:1555-68. 2005
    ..These results suggest that the expression of both ER isoforms, forming functional ERalpha/beta heterodimers, result in unique patterns of gene regulation, many of which are distinct from the genes regulated by the ER homodimers...
  18. ncbi request reprint Role of TIEG1 in biological processes and disease states
    Malayannan Subramaniam
    Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    J Cell Biochem 102:539-48. 2007
    ..This review outlines TIEG1's molecular functions and roles in skeletal disease (osteopenia/osteoporosis), heart disease (hypertrophic cardiomyopathy), and cancer (breast and prostate)...
  19. pmc ERβ1: characterization, prognosis, and evaluation of treatment strategies in ERα-positive and -negative breast cancer
    Jordan M Reese
    Department of Biochemistry and Molecular Biology, Mayo Clinic, 16 01B Guggenheim Building, 200 First St, SW, Rochester, MN 55905, USA
    BMC Cancer 14:749. 2014
    ....
  20. pmc The effects of a novel hormonal breast cancer therapy, endoxifen, on the mouse skeleton
    Anne Gingery
    Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota, United States of America
    PLoS ONE 9:e98219. 2014
    ....
  21. pmc Runx2 protein represses Axin2 expression in osteoblasts and is required for craniosynostosis in Axin2-deficient mice
    Meghan E McGee-Lawrence
    Mayo Clinic, Rochester, Minnesota 55905, USA
    J Biol Chem 288:5291-302. 2013
    ....
  22. doi request reprint 2-methoxyestradiol-mediated anti-tumor effect increases osteoprotegerin expression in osteosarcoma cells
    Michaela B Benedikt
    Department of Orthopedics, College of Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Cell Biochem 109:950-6. 2010
    ..These findings suggest that OPG is not directly involved in 2-ME-mediated anti-proliferative effects in osteosarcoma cells, but rather participates in anti-resorptive functions of 2-ME in bone tumor environment...
  23. pmc Histone demethylase JARID1B/KDM5B is a corepressor of TIEG1/KLF10
    Joanna Kim
    Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN 55905, USA
    Biochem Biophys Res Commun 401:412-6. 2010
    ..In conclusion, JARID1B is the first TIEG1 corepressor identified, explaining how TIEG1 represses transcription through inducing histone H3 lysine 4 demethylation, which may be important for TIEG1 function in both normal and cancer cells...
  24. pmc TGFβ inducible early gene-1 plays an important role in mediating estrogen signaling in the skeleton
    John R Hawse
    Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN, USA
    J Bone Miner Res 29:1206-16. 2014
    ....
  25. ncbi request reprint Modulation of transforming growth factor beta (TGFbeta)/Smad transcriptional responses through targeted degradation of TGFbeta-inducible early gene-1 by human seven in absentia homologue
    Steven A Johnsen
    Department of Biochemistry and Molecular Biology, Mayo Clinic and Foundation, 200 First Street SW, Rochester, MN 55905, USA
    J Biol Chem 277:30754-9. 2002
    ..In this manner, turnover of TIEG1 may serve to limit the duration and/or magnitude of TGFbeta responses...
  26. ncbi request reprint Age-dependent changes in the mechanical properties of tail tendons in TGF-beta inducible early gene-1 knockout mice
    Sabine F Bensamoun
    Biomechanics Laboratory, Department of Orthopedics, Mayo Clinic Rochester, Rochester, Minnesota 55905, USA
    J Appl Physiol (1985) 101:1419-24. 2006
    ..These data indicate an important role for TIEG in tendon microarchitecture and strength in adult mice...
  27. pmc TGFβ-inducible early gene-1 (TIEG1) mutations in hypertrophic cardiomyopathy
    J Martijn Bos
    Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Cell Biochem 113:1896-903. 2012
    ..Functional assays suggest a role for PTTG1 in the pathogenesis of TIEG1-mediated HCM. Up-regulation of PTTG1 seems to be a common pathway in hypertrophic heart disease, including TIEG1-mediated HCM...
  28. pmc TIEG1 enhances Osterix expression and mediates its induction by TGFβ and BMP2 in osteoblasts
    Malayannan Subramaniam
    Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN 55905, USA
    Biochem Biophys Res Commun 470:528-33. 2016
    ....
  29. pmc WOUND-HEALING PROPERTIES OF TRANSFORMING GROWTH FACTOR β (TGF-β) INDUCIBLE EARLY GENE 1 (TIEG1) KNOCKOUT MICE
    Manabu Taguchi
    Orthopedic Biomechanical Laboratory, Mayo Clinic 200 First Street SW, Rochester, MN 55905, USA
    J Musculoskelet Res 11:63-69. 2008
    ..These results suggest that TIEG1 expression may be an important factor involved in the initiation and support of normal cutaneous wound healing...
  30. ncbi request reprint 15-hydroxy-eicosatetraenoic acid arrests growth of colorectal cancer cells via a peroxisome proliferator-activated receptor gamma-dependent pathway
    George G Chen
    Department of Surgery, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, NT, Hong Kong
    Int J Cancer 107:837-43. 2003
    ..Treatment of colon cancer cells with 15S-HETE inhibits cell proliferation and induces apoptosis in a PPARgamma-dependent pathway involving augmentation of TIEG and reduction of Bcl-2 expression...
  31. pmc Atorvastatin inhibits hypercholesterolemia-induced cellular proliferation and bone matrix production in the rabbit aortic valve
    Nalini M Rajamannan
    Division of Cardiology, Department of Medicine, Northwestern University Medical School, Chicago, Ill 60611, USA
    Circulation 105:2660-5. 2002
    ..We hypothesized that atherosclerosis and early bone matrix expression in the aortic valve occurs secondary to experimental hypercholesterolemia and that treatment with atorvastatin modifies this transformation...
  32. pmc TGFbeta inducible early gene-1 (TIEG1) and cardiac hypertrophy: Discovery and characterization of a novel signaling pathway
    Nalini M Rajamannan
    Division of Cardiology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
    J Cell Biochem 100:315-25. 2007
    ..We present evidence implicating TIEG and possibly its target gene, Pttg1, in the development of cardiac hypertrophy in the TIEG null mouse...
  33. pmc The E3 ubiquitin ligase Itch regulates expression of transcription factor Foxp3 and airway inflammation by enhancing the function of transcription factor TIEG1
    K Venuprasad
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, La Jolla, California 92037, USA
    Nat Immunol 9:245-53. 2008
    ..These results suggest TIEG and Itch contribute to a ubiquitin-dependent nonproteolytic pathway that regulates inducible Foxp3 expression and the control of allergic responses...
  34. pmc Two novel VHL targets, TGFBI (BIGH3) and its transactivator KLF10, are up-regulated in renal clear cell carcinoma and other tumors
    Sergey V Ivanov
    Basic Research Program, SAIC Frederick, Inc, 462 First Avenue, Bellevue Hospital, Room 15N20, NY 10016, USA
    Biochem Biophys Res Commun 370:536-40. 2008
    ..These data provide the molecular basis for the observed VHL effect on TGFBI and stimulate further research into the KLF10 and TGFBI roles in cancer...
  35. pmc Calcified rheumatic valve neoangiogenesis is associated with vascular endothelial growth factor expression and osteoblast-like bone formation
    Nalini M Rajamannan
    Division of Cardiology, Northwestern University, Feinberg School of Medicine, Chicago, Ill, Chicago, IL 60611, USA
    Circulation 111:3296-301. 2005
    ..Despite the high prevalence of this disease, the cellular mechanisms are not well known. We hypothesized that rheumatic valve calcification is associated with an osteoblast bone formation and neoangiogenesis...
  36. pmc Atorvastatin decreases cellular proliferation and bone matrix expression in the hypercholesterolemic mitral valve
    Babu Makkena
    J Am Coll Cardiol 45:631-3. 2005
  37. pmc Human aortic valve calcification is associated with an osteoblast phenotype
    Nalini M Rajamannan
    Division of Cardiology, Northwestern University Feinberg School of Medicine, Northwestern University, 201 East Huron St, Galter Suite 10 240, Chicago, Ill 60611, USA
    Circulation 107:2181-4. 2003
    ..We hypothesized that the mechanism for aortic valve calcification is similar to skeletal bone formation and that this process is mediated by an osteoblast-like phenotype...
  38. pmc Atorvastatin inhibits hypercholesterolemia-induced calcification in the aortic valves via the Lrp5 receptor pathway
    Nalini M Rajamannan
    Division of Cardiology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    Circulation 112:I229-34. 2005
    ..We hypothesize that Lrp5 also plays a role in aortic valve (AV) calcification in experimental hypercholesterolemia...