M Rodriguez

Summary

Affiliation: Mayo Clinic
Country: USA

Publications

  1. pmc Cellular sources and targets of IFN-gamma-mediated protection against viral demyelination and neurological deficits
    Paul D Murray
    Department of Immunology, Mayo Clinic and Foundation, Rochester, MN 55905, USA
    Eur J Immunol 32:606-15. 2002
  2. ncbi Tryptophan Metabolites and Their Impact on Multiple Sclerosis Progression
    Jens O Watzlawik
    Departments of Neurology and Immunology, Mayo Clinic College of Medicine, 200 1st Street SW, Rochester, Minnesota 55905, U S A
    Curr Pharm Des . 2015
  3. ncbi Multiple Sclerosis, Gut Microbiota and Permeability: Role of Tryptophan Catabolites, Depression and the Driving Down of Local Melatonin
    Moses Rodriguez
    Guggenheim 4 42B, 200 1st Street SW, Mayo Clinic, Rochester, MN 55905, USA
    Curr Pharm Des 22:6134-6141. 2016
  4. ncbi Tryptophan Catabolites and Their Impact on Multiple Sclerosis Progression
    Jens O Watzlawik
    Departments of Neurology and Immunology, Mayo Clinic College of Medicine, 200 1st Street SW, Rochester, Minnesota 55905, USA
    Curr Pharm Des 22:1049-59. 2016
  5. pmc Genetic deletion of a single immunodominant T-cell response confers susceptibility to virus-induced demyelination
    Kevin D Pavelko
    Department of Immunology, Mayo Clinic College of Medicine, Rochester, MN, USA
    Brain Pathol 17:184-96. 2007
  6. pmc Evidence for the role of B cells and immunoglobulins in the pathogenesis of multiple sclerosis
    Bharath Wootla
    Department of Neurology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Neurol Res Int 2011:780712. 2011
  7. pmc A single dose of neuron-binding human monoclonal antibody improves spontaneous activity in a murine model of demyelination
    Aleksandar Denic
    Department of Neurology, Mayo Clinic, Rochester, Minnesota, United States of America
    PLoS ONE 6:e26001. 2011
  8. pmc Is multiple sclerosis an autoimmune disease?
    Bharath Wootla
    Departments of Neurology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Autoimmune Dis 2012:969657. 2012
  9. pmc PDGF is required for remyelination-promoting IgM stimulation of oligodendrocyte progenitor cell proliferation
    Jens O Watzlawik
    Departments of Neurology and Immunology, Mayo Clinic College of Medicine, Rochester, Minnesota, United States of America
    PLoS ONE 8:e55149. 2013
  10. pmc CD8(+) T cells in multiple sclerosis
    Aleksandar Denic
    Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA
    Expert Opin Ther Targets 17:1053-66. 2013

Research Grants

  1. IMMUNE PROMOTION OF REMYELINATION
    Moses Rodriguez; Fiscal Year: 2008
  2. T cell Function in Murine Model of Multiple Sclerosis
    Moses Rodriguez; Fiscal Year: 2010

Collaborators

Detail Information

Publications148 found, 100 shown here

  1. pmc Cellular sources and targets of IFN-gamma-mediated protection against viral demyelination and neurological deficits
    Paul D Murray
    Department of Immunology, Mayo Clinic and Foundation, Rochester, MN 55905, USA
    Eur J Immunol 32:606-15. 2002
    ..We demonstrate that IFN-gamma receptor must be present on central nervous system glia, but not bone marrow-derived lymphocytes, in order to maintain resistance to TMEV-induced demyelination...
  2. ncbi Tryptophan Metabolites and Their Impact on Multiple Sclerosis Progression
    Jens O Watzlawik
    Departments of Neurology and Immunology, Mayo Clinic College of Medicine, 200 1st Street SW, Rochester, Minnesota 55905, U S A
    Curr Pharm Des . 2015
    ..The availability of potential KP modulators approved for MS may shed some light into the therapeutic potential of KP antagonists for the treatment of MS patients...
  3. ncbi Multiple Sclerosis, Gut Microbiota and Permeability: Role of Tryptophan Catabolites, Depression and the Driving Down of Local Melatonin
    Moses Rodriguez
    Guggenheim 4 42B, 200 1st Street SW, Mayo Clinic, Rochester, MN 55905, USA
    Curr Pharm Des 22:6134-6141. 2016
    ..Alterations in gut microbiota, coupled to increased gut permeability are now widely recognized as having a role in the etiology, course and treatment of many medical conditions, including autoimmune and neurodegenerative disorders...
  4. ncbi Tryptophan Catabolites and Their Impact on Multiple Sclerosis Progression
    Jens O Watzlawik
    Departments of Neurology and Immunology, Mayo Clinic College of Medicine, 200 1st Street SW, Rochester, Minnesota 55905, USA
    Curr Pharm Des 22:1049-59. 2016
    ..The availability of potential KP modulators approved for MS may shed some light into the therapeutic potential of KP antagonists for the treatment of MS patients. ..
  5. pmc Genetic deletion of a single immunodominant T-cell response confers susceptibility to virus-induced demyelination
    Kevin D Pavelko
    Department of Immunology, Mayo Clinic College of Medicine, Rochester, MN, USA
    Brain Pathol 17:184-96. 2007
    ..This model will be important for understanding the mechanisms involved in antigen-specific T-cell deletion and the contribution of this response to CNS pathology...
  6. pmc Evidence for the role of B cells and immunoglobulins in the pathogenesis of multiple sclerosis
    Bharath Wootla
    Department of Neurology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Neurol Res Int 2011:780712. 2011
    ..In this paper, we discuss both the deleterious and the beneficial roles of B cells and immunoglobulins in MS lesions. We provide alternative hypotheses to explain both damaging and protective antibody responses...
  7. pmc A single dose of neuron-binding human monoclonal antibody improves spontaneous activity in a murine model of demyelination
    Aleksandar Denic
    Department of Neurology, Mayo Clinic, Rochester, Minnesota, United States of America
    PLoS ONE 6:e26001. 2011
    ..rHIgM12 did not alter activity of normal, uninfected mice. This study supports the hypothesis that treatment with a neuron-binding IgM not only protects neurons in vitro, but also influences functional motor improvement...
  8. pmc Is multiple sclerosis an autoimmune disease?
    Bharath Wootla
    Departments of Neurology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Autoimmune Dis 2012:969657. 2012
    ..We show the evidence that both supports and refutes the autoimmune hypothesis. In addition, we present an alternate hypothesis based on virus infection to explain the pathogenesis of MS...
  9. pmc PDGF is required for remyelination-promoting IgM stimulation of oligodendrocyte progenitor cell proliferation
    Jens O Watzlawik
    Departments of Neurology and Immunology, Mayo Clinic College of Medicine, Rochester, Minnesota, United States of America
    PLoS ONE 8:e55149. 2013
    ..It is also unknown whether astrocytes or microglia play a functional role in IgM-mediated lesion repair...
  10. pmc CD8(+) T cells in multiple sclerosis
    Aleksandar Denic
    Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA
    Expert Opin Ther Targets 17:1053-66. 2013
    ..In this article, we discuss the theoretical roles of different CD8(+) T-cell subsets in MS...
  11. ncbi The CD4-mediated immune response is critical in determining the outcome of infection using Theiler's viruses with VP1 capsid protein point mutations
    M Rodriguez
    Department of Immunology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Virology 275:9-19. 2000
    ..Therefore, the nondemyelinating phenotype observed with DA-VP1-99(Ser) and DA-VP1-100(Asp) viruses is dependent in part on the CD4-mediated host immune response...
  12. pmc Gamma interferon is critical for neuronal viral clearance and protection in a susceptible mouse strain following early intracranial Theiler's murine encephalomyelitis virus infection
    Moses Rodriguez
    Department of Immunology, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Virol 77:12252-65. 2003
    ..These data support the hypothesis that IFN-gamma plays a critical role in protecting spinal cord neurons from persistent infection and death...
  13. ncbi Disability profile of MS did not change over 10 years in a population-based prevalence cohort
    S J Pittock
    Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA
    Neurology 62:601-6. 2004
    ..To assess whether the level of multiple sclerosis (MS) -related disability in the Olmsted County population has changed over a decade, and to evaluate how the rate of initial progression to moderate disability impacts further disability...
  14. ncbi STAT4- and STAT6-signaling molecules in a murine model of multiple sclerosis
    Moses Rodriguez
    Department of Neurology, Mayo Clinic, Rochester, Minnesota 55905, USA
    FASEB J 20:343-5. 2006
    ..Thus, virus infection of STAT4-/- mice results in a model that may allow for dissection of the immune events predisposing to late-onset demyelination in MS...
  15. ncbi Effectors of demyelination and remyelination in the CNS: implications for multiple sclerosis
    Moses Rodriguez
    Department of Neurology and Immunology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Brain Pathol 17:219-29. 2007
    ..These are models in which the effector molecules for demyelination and remyelination have been most precisely evaluated...
  16. pmc Human HLA-DR transgenes protect mice from fatal virus-induced encephalomyelitis and chronic demyelination
    Moses Rodriguez
    Department of Neurology, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
    J Virol 82:3369-80. 2008
    ..The mechanism of protection appears to be the result of cytokines released by CD4(+) T cells...
  17. pmc Tumor necrosis factor alpha is reparative via TNFR2 [corrected] in the hippocampus and via TNFR1 [corrected] in the striatum after virus-induced encephalitis
    Moses Rodriguez
    Department of Immunology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Brain Pathol 19:12-26. 2009
    ..TNFR2 [corrected] mediated hippocampal pathology resolution whereas TNFR1 [corrected] mediated striatal healing. These findings indicate the role of TNFalpha in resolution of sublethal hippocampal and striatal injury...
  18. pmc Invited article: human natural autoantibodies in the treatment of neurologic disease
    Moses Rodriguez
    Department of Immunology and Neurology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Neurology 72:1269-76. 2009
    ..Natural human auto mAbs are a potentially important therapeutic technique in combating a wide spectrum of disease processes...
  19. ncbi Perforin-dependent neurologic injury in a viral model of multiple sclerosis
    P D Murray
    Department of Immunology, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
    J Neurosci 18:7306-14. 1998
    ..These studies implicate perforin release by CD8(+) T cells as a potential mechanism by which neurologic deficits are induced after demyelination...
  20. ncbi Spontaneous remyelination following extensive demyelination is associated with improved neurological function in a viral model of multiple sclerosis
    P D Murray
    Departments of Neurology and Immunology, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
    Brain 124:1403-16. 2001
    ..Of greater importance, functional recovery occurred despite previous severe demyelination and spinal cord atrophy...
  21. ncbi Change in MS-related disability in a population-based cohort: a 10-year follow-up study
    S J Pittock
    Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA
    Neurology 62:51-9. 2004
    ..S: To study the change in disability over 10 years in individual patients constituting the 1991 Olmsted County, MN, multiple sclerosis (MS) prevalence cohort...
  22. pmc Cytotoxic T cells isolated from the central nervous systems of mice infected with Theiler's virus
    M D Lindsley
    Department of Immunology, Mayo Medical School, Rochester, Minnesota 55905
    J Virol 65:6612-20. 1991
    ..Anti-TMEV CTLs in the CNS of chronically infected SJL/J mice may play a role in demyelination through their ability to lyse TMEV-infected glial cells...
  23. pmc CD4(+) and CD8(+) T cells make discrete contributions to demyelination and neurologic disease in a viral model of multiple sclerosis
    P D Murray
    Departments of Immunology, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
    J Virol 72:7320-9. 1998
    ....
  24. ncbi Preservation of motor function by inhibition of CD8+ virus peptide-specific T cells in Theiler's virus infection
    A J Johnson
    Departments of, Immunology and, Neurology, Mayo Graduate and Medical Schools, Rochester, Minnesota 55901, USA
    FASEB J 15:2760-2. 2001
    ....
  25. ncbi Immunosuppression promotes CNS remyelination in chronic virus-induced demyelinating disease
    M Rodriguez
    Department of Neurology, Mayo Medical School, Rochester, MN
    Neurology 42:348-57. 1992
    ..Interference with the function of immune T cells enhances CNS remyelination by oligodendrocytes. Similar depletion of immune T cells may allow for enhanced remyelination in the CNS of patients with chronic multiple sclerosis...
  26. ncbi Abrogation of resistance to Theiler's virus-induced demyelination in H-2b mice deficient in beta 2-microglobulin
    M Rodriguez
    Department of Neurology, Mayo Clinic, Rochester, MN 55901
    J Immunol 151:266-76. 1993
    ..Development of chronic neurologic deficits as observed in immunocompetent susceptible strains of mice may be dependent on the presence of class I MHC and CD8+ T cells...
  27. ncbi Theiler's virus infection of genetically susceptible mice induces central nervous system-infiltrating CTLs with no apparent viral or major myelin antigenic specificity
    X Lin
    Department of Immunology, Mayo Clinic, Rochester, MN 55905, USA
    J Immunol 160:5661-8. 1998
    ....
  28. pmc Demyelinated axons and motor function are protected by genetic deletion of perforin in a mouse model of multiple sclerosis
    Chandra Deb
    Departments of Neurology, Mayo Clinic, Rochester, Minnesota
    J Neuropathol Exp Neurol 68:1037-48. 2009
    ..These results suggest that perforin is a key mediator of axon injury and lend additional support to the hypothesis that CD8 T cells are primarily responsible for axon damage in multiple sclerosis...
  29. ncbi Coexpression of class I major histocompatibility antigen and viral RNA in central nervous system of mice infected with Theiler's virus: a model for multiple sclerosis
    M D Lindsley
    Section of Clinical Microbiology, Mayo Clinic, Rochester, MN 55905
    Mayo Clin Proc 67:829-38. 1992
    ..These results support the hypothesis that a class I-restricted immune response directed against virus-infected cells may be important in the mechanism of demyelination...
  30. ncbi Role of natural killer cells as immune effectors in encephalitis and demyelination induced by Theiler's virus
    C V Paya
    Division of Infectious Diseases, Mayo Medical School, Rochester, MN 55905
    J Immunol 143:95-102. 1989
    ..1- NK cells, or other activated lymphocytes may be critical in resistance/susceptibility to demyelination...
  31. ncbi Differential expression of H-2K and H-2D in the central nervous system of mice infected with Theiler's virus
    A Altintas
    Department of Immunology, Mayo Medical School, Rochester, MN 55905
    J Immunol 151:2803-12. 1993
    ..These findings are consistent with the hypothesis that differences in gene regulation may account for different roles of the K and D loci play in determining resistance and susceptibility to TMEV-induced demyelinating disease...
  32. ncbi Preferential expression of myelencephalon-specific protease by oligodendrocytes of the adult rat spinal cord white matter
    I A Scarisbrick
    Department of Biochemistry and Molecular Biology, Mayo Medical and Graduate Schools, Rochester, Minnesota 55905, USA
    Glia 30:219-30. 2000
    ..These findings suggest that the enzymatic activity of MSP is likely to be important in the biology of oligodendrocytes and/or in the maintenance of the nerve fiber tracts of the adult spinal cord...
  33. ncbi Expression of human HLA-B27 transgene alters susceptibility to murine Theiler's virus-induced demyelination
    M Rodriguez
    Department of Neurology, Mayo Clinic, Rochester, MN 55905
    J Immunol 146:2596-602. 1991
    ..These experiments demonstrate that expression of a human class I MHC gene can modulate a virus-induced demyelinating disease process in the mouse...
  34. ncbi A quantitative analysis of oligodendrocytes in multiple sclerosis lesions. A study of 113 cases
    C Lucchinetti
    Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA
    Brain 122:2279-95. 1999
    ..The profound heterogeneity in extent and topography of OG destruction in active demyelinating lesions suggests that in subsets of multiple sclerosis patients, myelin, mature OGs and possibly OG progenitors are differentially affected...
  35. ncbi Role of T cells in resistance to Theiler's virus infection
    M Rodriguez
    Department of Neurology, Mayo Clinic, Rochester, MN 55905
    Microb Pathog 11:269-81. 1991
    ..However, subsequent spinal cord demyelination, to the extent observed in susceptible mice, depends on the presence of virus antigen persistence and a competent cellular immune response...
  36. ncbi Immunoglobulins stimulate central nervous system remyelination: electron microscopic and morphometric analysis of proliferating cells
    M Rodriguez
    Department of Neurology, Mayo Clinic, Rochester, Minnesota
    Lab Invest 64:358-70. 1991
    ..These experiments suggest that immunoglobulins to a spinal cord antigen may induce proliferation of cells in the central nervous system to promote remyelination...
  37. ncbi Persistent infection of a glioma cell line generates a Theiler's virus variant which fails to induce demyelinating disease in SJL/J mice
    A K Patick
    Department of Immunology, Mayo Clinic, Rochester, Minnesota 55905
    J Gen Virol 71:2123-32. 1990
    ..Characterization of the biochemical and molecular determinants of the variant will lead to a better understanding of determinants important in viral persistence...
  38. ncbi Abrogation of resistance to Theiler's virus-induced demyelination in C57BL mice by total body irradiation
    M Rodriguez
    Department of Neurology, Mayo Clinic and Research Foundation, Rochester, MN 55905
    J Neuroimmunol 26:189-99. 1990
    ....
  39. ncbi Human class I major histocompatibility complex transgene prevents virus-induced demyelination in susceptible mutant B10.D2dml mice
    M Rodriguez
    Department of Neurology, Mayo Medical School, Rochester, MN 55905
    Ann Neurol 33:208-12. 1993
    ..These experiments demonstrate that transgenic expression of a human class I major histocompatibility complex locus molecule can prevent demyelination induced by a virus in mutant mice...
  40. ncbi Progressive depletion of peripheral B lymphocytes in 4-1BB (CD137) ligand/I-Ealpha)-transgenic mice
    G Zhu
    Department of Immunology, Mayo Graduate and Medical Schools, Mayo Clinic, Rochester, MN 55905, USA
    J Immunol 167:2671-6. 2001
    ..Our results reveal unexpected functions of 4-1BBL in the regulation of humoral immune responses and Ag presentation...
  41. ncbi Immunoglobulin-mediated CNS repair
    A E Warrington
    Department of Neurology, Mayo Clinic Medical and Graduate School, Rochester, MN 55905, USA
    J Allergy Clin Immunol 108:S121-5. 2001
    ..They challenge the assertion that an immune response to CNS antigens is pathogenic. Treatment with CNS-reactive human mAbs following CNS disease may facilitate CNS regeneration...
  42. ncbi Membrane lymphotoxin is required for resistance to Theiler's virus infection
    Xiaoqi Lin
    Department of Neurology, University of Chicago, Chicago, IL 60637, USA
    Int Immunol 15:955-62. 2003
    ..There was relatively little demyelination associated with inflammation in LT-alpha(-/-) and LT-beta-R(-/-) mice compared to susceptible SJL mice, suggesting the possibility that LT plays a role in mediating demyelination...
  43. ncbi The potential for oligodendrocyte proliferation during demyelinating disease
    N Prayoonwiwat
    Department of Neurology, Mayo Clinic, Rochester, Minnesota 55905
    J Neuropathol Exp Neurol 52:55-63. 1993
    ..These experiments support the hypothesis that factors within a demyelinating lesion promote the proliferation and differentiation of cells within the oligodendroglial lineage...
  44. ncbi A randomized trial of plasma exchange in acute central nervous system inflammatory demyelinating disease
    B G Weinshenker
    Department of Neurology, Mayo Clinic and Mayo Foundation, Rochester, MN 55902, USA
    Ann Neurol 46:878-86. 1999
    ..Plasma exchange leads to functionally important neurological recovery in an important proportion of severely disabled patients with acute attacks of idiopathic inflammatory demyelinating disease...
  45. pmc Major histocompatibility complex-conferred resistance to Theiler's virus-induced demyelinating disease is inherited as a dominant trait in B10 congenic mice
    A K Patick
    Department of Neurology, Mayo Medical School and Research Foundation, Rochester, Minnesota 55905
    J Virol 64:5570-6. 1990
    ....
  46. ncbi Characterization of the inflammatory response in the central nervous system of mice susceptible or resistant to demyelination by Theiler's virus
    M D Lindsley
    Department of Immunology, Mayo Clinic and Research Foundation, Rochester, MN 55905
    J Immunol 142:2677-82. 1989
    ..These results provide further evidence that Lyt-2+ lymphocytes are important in the mechanism of susceptibility/resistance to Theiler's murine encephalomyelitis virus-induced demyelination...
  47. ncbi Potential scope of action of tissue kallikreins in CNS immune-mediated disease
    I A Scarisbrick
    Department of Physical Medicine and Rehabilitation, Mayo Medical and Graduate Schools, Rochester, MN 55905, USA
    J Neuroimmunol 178:167-76. 2006
    ..The patterns of co-expression and co-regulation described point to novel effector roles for select tissue kallikreins in neurological disorders involving T cells, such as multiple sclerosis...
  48. ncbi Direct comparison of demyelinating disease induced by the Daniel's strain and BeAn strain of Theiler's murine encephalomyelitis virus
    Laurie J Zoecklein
    Department of Immunology, Mayo Medical and Graduate Schools, Rochester, Minn, USA
    Brain Pathol 13:291-308. 2003
    ..Functional deficits as measured by Rotarod were more severe in DA infected versus BeAn infected mice. These findings indicate that the diseases induced by DA or BeAn are distinct...
  49. ncbi In vivo magnetic resonance imaging of immune cells in the central nervous system with superparamagnetic antibodies
    Istvan Pirko
    Department of Neurology, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
    FASEB J 18:179-82. 2004
    ..Because superparamagnetic antibodies similar to those used in the study are approved for human use, the in vivo MRI technique we have described could be developed for human use...
  50. ncbi A 40-cM region on chromosome 14 plays a critical role in the development of virus persistence, demyelination, brain pathology and neurologic deficits in a murine viral model of multiple sclerosis
    Shunya Nakane
    Department of Neurology, Mayo Clinic and Foundation, Rochester, Minn 55905, USA
    Brain Pathol 13:519-33. 2003
    ..D2 Chr.14D2 mice as determined by quantitative real-time RT-PCR. These results indicate that the 40-cM region on chromosome 14 of DBA/2 mice contributes to viral persistence, subsequent demyelination, and loss of neurological function...
  51. ncbi Inability of bm14 mice to respond to Theiler's murine encephalomyelitis virus is caused by defective antigen presentation, not repertoire selection
    Matthew S Block
    Department of Immunology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    J Immunol 174:2756-62. 2005
    ..Although previous work suggests a correlation between the ability to present an Ag and the ability to generate a repertoire responsive to that Ag, we show that the two functions of MHC class I are independent...
  52. ncbi Antigen-specific CD8+ T cells mediate a peptide-induced fatal syndrome
    Aaron J Johnson
    Department of Immunology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    J Immunol 174:6854-62. 2005
    ..Susceptibility to the syndrome is genetically determined, is mediated by CD8(+) T cells, and requires expression of perforin. These findings raise concerns about the use of peptides and MHC tetramers in therapeutic schemes...
  53. ncbi Theiler's murine encephalomyelitis: a model of demyelination and persistence of virus
    M Rodriguez
    Mayo Medical School, Rochester, Minnesota
    Crit Rev Immunol 7:325-65. 1987
    ....
  54. pmc Immunomodulation using the recombinant monoclonal human B7-DC cross-linking antibody rHIgM12
    V P Van Keulen
    Department of Immunology, Mayo Clinic of Medicine, Mayo Clinic, Rochester, MN 55905, USA
    Clin Exp Immunol 143:314-21. 2006
    ..Furthermore, cell lines expressing this recombinant form of the human antibody provide the basis for developing this reagent for clinical application...
  55. pmc Clinical course, pathological correlations, and outcome of biopsy proved inflammatory demyelinating disease
    S J Pittock
    Department of Neurology, Mayo Clinic, 200 First Street SW, Rochester, MN, USA
    J Neurol Neurosurg Psychiatry 76:1693-7. 2005
    ..Mechanisms of demyelination in early MS may differ among the subgroups. Previous studies on biopsied MS have lacked clinicopathological correlation and follow up. Critics argue that observations are not generalisable to prototypic MS...
  56. ncbi Role of T cell receptor V beta genes in Theiler's virus-induced demyelination of mice
    M Rodriguez
    Department of Neurology, Mayo Clinic, Rochester, MN 55905
    J Immunol 148:921-7. 1992
    ..These experiments provide strong evidence that the structural diversity at the TCR beta-complex can influence susceptibility to virus-induced demyelination...
  57. ncbi Theiler's virus-associated antigens on the surfaces of cultured glial cells
    M Rodriguez
    Department of Neurology, Mayo Clinic, Rochester, Minnesota 55905
    Virology 166:463-74. 1988
    ..The finding is consistent with the hypothesis that demyelination follows damage of infected oligodendrocytes by immune cells or immunoglobulins that recognize surface virus antigen...
  58. ncbi Expression of T cell receptor V beta transcripts in central nervous system of mice susceptible and resistant to Theiler's virus-induced demyelination
    M Rodriguez
    Department of Neurology, Mayo Clinic, Rochester, MN 55905
    J Neuroimmunol 47:95-100. 1993
    ....
  59. ncbi Incidence and prevalence of multiple sclerosis in Olmsted County, Minnesota, 1985-2000
    W T Mayr
    Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA
    Neurology 61:1373-7. 2003
    ..Epidemiologic data for multiple sclerosis (MS) in Olmsted County, MN, have been recorded for almost 100 years and have indicated that the increasing prevalence rate was likely due in part to an increasing incidence rate...
  60. ncbi Interleukin-6 protects anterior horn neurons from lethal virus-induced injury
    Kevin D Pavelko
    Department of Immunology, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Neurosci 23:481-92. 2003
    ..These data support the hypothesis that IL-6 plays a critical role in protecting specific populations of neurons from irreversible injury...
  61. ncbi Naturally occurring human IgM antibody that binds B7-DC and potentiates T cell stimulation by dendritic cells
    Suresh Radhakrishnan
    Department of Immunology, Mayo Medical and Graduate Schools, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    J Immunol 170:1830-8. 2003
    ..These findings imply that, in addition to known costimulatory roles, B7-DC can function as a receptor for signals delivered by cells expressing B7-DC ligands...
  62. ncbi Remyelination-promoting antibodies activate distinct Ca2+ influx pathways in astrocytes and oligodendrocytes: relationship to the mechanism of myelin repair
    M Mateo Paz Soldan
    Program in Molecular Neuroscience, Mayo Medical and Graduate Schools, 200 First Street SW, Rochester, MN 55905, USA
    Mol Cell Neurosci 22:14-24. 2003
    ..These findings support the hypothesis that remyelination-promoting antibodies are acting directly at the surface of glial cells to induce calcium-dependent physiologic reparative function...
  63. ncbi Human monoclonal IgM antibody promotes CNS myelin repair independent of Fc function
    Bogoljub Ciric
    Department of Immunology, Mayo Medical and Graduate Schools, Mayo Clinic Rochester, Minn 55905, USA
    Brain Pathol 13:608-16. 2003
    ....
  64. pmc Anatomical and cellular requirements for the activation and migration of virus-specific CD8+ T cells to the brain during Theiler's virus infection
    Yanice V Mendez-Fernandez
    Department of Immunology, Mayo Clinic College of Medicine, 200 First Ave SW, Rochester, MN 55905, USA
    J Virol 79:3063-70. 2005
    ....
  65. pmc CD8+ T cells cause disability and axon loss in a mouse model of multiple sclerosis
    Chandra Deb
    Department of Neurology, Mayo Clinic College of Medicine, Rochester, Minnesota, United States of America
    PLoS ONE 5:e12478. 2010
    ..We have previously observed that genetic deletion of the CD8+ T cell effector molecule perforin leads to preservation of motor function and preservation of spinal axons in chronically demyelinated mice...
  66. ncbi Oligodendrocyte-reactive O1, O4, and HNK-1 monoclonal antibodies are encoded by germline immunoglobulin genes
    K Asakura
    Department of Neurology, Mayo Clinic and Foundation, Rochester, MN 55905, USA
    Brain Res Mol Brain Res 34:283-93. 1995
    ..O1 and O4, but not A2B5 were polyreactive against multiple antigens by direct ELISA. Therefore, O1, O4 and HNK-1 Igs are encoded by germline genes, and have the genotype and phenotype of natural autoantibodies...
  67. ncbi Preservation of neurologic function during inflammatory demyelination correlates with axon sparing in a mouse model of multiple sclerosis
    D R Ure
    Department of Immunology, Mayo Medical and Graduate School, 428 Guggenheim Building, 200 1st Street SW, Rochester, MN 55905, USA
    Neuroscience 111:399-411. 2002
    ..Additionally, the data suggest that axonal injury obligatorily results from chronic inflammatory demyelination and significantly contributes to neurological deficits...
  68. pmc Pathogenesis of early and late disease in mice infected with Theiler's virus, using intratypic recombinant GDVII/DA viruses
    M Rodriguez
    Department of Neurology, Mayo Medical School, Rochester, Minnesota 55905
    J Virol 66:217-25. 1992
    ..However, quantitative analysis of demyelination produced by recombinant GDVII/DA viruses suggest that multiple gene segments influence the number and extent of demyelinating lesions...
  69. ncbi Immunoglobulins and complement in demyelination induced in mice by Theiler's virus
    M Rodriguez
    Department of Neurology, Mayo Clinic, Rochester, MN 55905
    J Immunol 140:800-6. 1988
    ..However, the humoral immune response directed at TMEV antigens may either limit virus spread or promote virus persistence...
  70. pmc Primary demyelination in transgenic mice expressing interferon-gamma
    M S Horwitz
    Department of Immunology, The Scripps Research Institute, La Jolla, California 92037, USA
    Nat Med 3:1037-41. 1997
    ..These results demonstrate a direct role for IFN-gamma as an inducer of CNS demyelination leading to disease and provide new opportunities for dissecting the mechanism of demyelination...
  71. ncbi MSP, a trypsin-like serine protease, is abundantly expressed in the human nervous system
    I A Scarisbrick
    Department of Biochemistry and Molecular Biology, Mayo Clinic, Jacksonville, Florida 32224, USA
    J Comp Neurol 431:347-61. 2001
    ..The robust expression of MSP in clinically significant regions of the adult human CNS indicates that further study of this protease in terms of both normal brain physiology and neurodegenerative disorders is warranted...
  72. ncbi Remyelination-promoting human IgMs: developing a therapeutic reagent for demyelinating disease
    A E Warrington
    Department of Neurology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Curr Top Microbiol Immunol 318:213-39. 2008
    ..In contrast, remyelination promoting IgMs are the first potential therapeutic molecules designed to induce tissue repair by acting within the CNS at sites of damage on the cells responsible for myelin synthesis...
  73. ncbi Polyreactive antibodies to glatiramer acetate promote myelin repair in murine model of demyelinating disease
    Daren R Ure
    Department of Immunology, Mayo Medical and Graduate School, Rochester, Minnesota 55905, USA
    FASEB J 16:1260-2. 2002
    ..Thus, several mechanisms may have contributed to the promotion of remyelination. These results support the hypothesis that the antibody response in GA-treated patients is beneficial by facilitating repair of demyelinated lesions...
  74. pmc Transgenic expression of Theiler's murine encephalomyelitis virus genes in H-2(b) mice inhibits resistance to virus-induced demyelination
    Xiaoqi Lin
    Department of Neurology, University of Chicago Medical Center, Chicago, Illinois 60637, USA
    J Virol 76:7799-811. 2002
    ..Presented within the context of self-antigens, inactivation of these cells by ubiquitous expression of relevant virus capsid peptides partially inhibited resistance to virus-induced demyelination...
  75. ncbi Antibody-mediated remyelination operates through mechanism independent of immunomodulation
    Bogoljub Ciric
    Department of Immunology, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA
    J Neuroimmunol 146:153-61. 2004
    ..Treatment with rHIgM22 had no effect on demyelination or virus infection in two disease models. These results demonstrate that the remyelination-promoting activity of antibody rHIgM22 is not dependent on immunomodulation...
  76. ncbi HLA DR and DQ interaction in myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis in HLA class II transgenic mice
    Meenakshi Khare
    Department of Immunology, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
    J Neuroimmunol 169:1-12. 2005
    ..The use of defined single and double HLA transgenic mice may reveal the intricate interactions between class II molecules in human disease...
  77. ncbi Disrupted spatial memory is a consequence of picornavirus infection
    Eric J Buenz
    Molecular Neuroscience Program, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Neurobiol Dis 24:266-73. 2006
    ..An important implication of such subclinical virus-induced neurologic deficit is that the injury may accumulate over the lifetime of the individual, eventually leading to the manifestation of clinical cognitive or memory deficits...
  78. ncbi Ultrastructure of multiple sclerosis
    M Rodriguez
    Department of Neurology, Mayo Clinic, Rochester, Minnesota 55905
    Ultrastruct Pathol 18:3-13. 1994
    ..Many were membrane-bound and appeared to arise from the endoplasmic reticulum. We conclude that disturbance of the myelinating function of oligodendrocytes may be a critical event in the pathogenesis of multiple sclerosis...
  79. ncbi Humoral autoimmunity as a mediator of CNS repair
    A J Bieber
    Dept of Neurology, Mayo Clinic and Foundation, Rochester, MN 55905, USA
    Trends Neurosci 24:S39-44. 2001
    ..Autoreactive IgM antibodies might constitute an endogenous system for tissue repair, and therefore these antibodies could be of value as therapeutic reagents...
  80. ncbi Activity of a newly identified serine protease in CNS demyelination
    I A Scarisbrick
    Department of Neurology and Immunology, Mayo Medical and Graduate Schools, Rochester, Minnesota 55905, USA
    Brain 125:1283-96. 2002
    ..These studies support the hypothesis that excess MSP, as is present in inflammatory CNS lesions, promotes demyelination...
  81. ncbi Dynamics of MRI lesion development in an animal model of viral-induced acute progressive CNS demyelination
    Istvan Pirko
    Department of Neurology, Mayo Clinic, Rochester, MN, USA
    Neuroimage 21:576-82. 2004
    ..These novel findings may provide new insights into the pathogenesis of acute fulminant multiple sclerosis (MS)...
  82. ncbi Genetically dominant spinal cord repair in a murine model of chronic progressive multiple sclerosis
    Allan J Bieber
    Department Neurology, Mayo Foundation and College of Medicine, Rochester, Minnesota, USA
    J Neuropathol Exp Neurol 64:46-57. 2005
    ..These results highlight the significant extent to which hereditary factors can control disease course and demonstrate that the switch from a pathogenic to a reparative phenotype can occur even after prolonged inflammatory demyelination...
  83. ncbi Benign multiple sclerosis: a distinct clinical entity with therapeutic implications
    S J Pittock
    Department of Neurology, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA
    Curr Top Microbiol Immunol 318:1-17. 2008
    ..We review the arguments for and against treating all patients with MS. The authors propose an individualized approach to the use of these agents in the MS population...
  84. doi Surgical therapy for multiple sclerosis tremor: a 12-year follow-up study
    A Hassan
    Department of Neurology, Mayo Clinic, Rochester, MN, USA
    Eur J Neurol 19:764-8. 2012
    ..Severe multiple sclerosis (MS) tremor causes disability poorly responsive to medication. Deep brain stimulation (DBS) or thalamotomy can suppress tremor, but long-term outcomes are unclear...
  85. ncbi Inhibition of Theiler's virus-induced demyelination in vivo by tumor necrosis factor alpha
    C V Paya
    Division of Infection Diseases, Mayo Medical School and Research Foundation, Rochester, MN 55905
    Int Immunol 2:909-13. 1990
    ..In vivo administration of TNF-alpha inhibits TMEV-induced demyelination in susceptible SJL/J mice without affecting virus replication in the CNS...
  86. ncbi Mechanisms of virus-induced demyelination and remyelination
    M Rodriguez
    Department of Neurology and Immunology, Mayo Clinic and Research Foundation, Rochester, Minnesota
    Ann N Y Acad Sci 540:240-51. 1988
    ..Isolation, purification, and characterization of factors that promote remyelination and proliferation of oligodendrocytes may provide hope in the treatment of patients with chronic demyelinating disorders...
  87. ncbi IV immunoglobulin does not reverse established weakness in MS
    J H Noseworthy
    Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA
    Neurology 55:1135-43. 2000
    ..Immunoglobulin (Ig) administration induces remyelination in the Theiler's virus model of MS...
  88. ncbi Distinct promoters regulate tissue-specific and differential expression of kallikrein 6 in CNS demyelinating disease
    G P Christophi
    Department of Physical Medicine and Rehabilitation, Mayo Medical and Graduate Schools, Rochester, Minnesota, USA
    J Neurochem 91:1439-49. 2004
    ....
  89. pmc Human remyelination promoting antibody inhibits apoptotic signaling and differentiation through Lyn kinase in primary rat oligodendrocytes
    J Watzlawik
    Department of Neurology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Glia 58:1782-93. 2010
    ..However, their mechanism of action is unknown. This study seeks to identify the cellular mechanism of action of a recombinant human IgM on OL survival...
  90. ncbi A human antibody that promotes remyelination enters the CNS and decreases lesion load as detected by T2-weighted spinal cord MRI in a virus-induced murine model of MS
    Istvan Pirko
    Department of Neurology, Mayo Clinic, Rochester, Minnesota 55905, USA
    FASEB J 18:1577-9. 2004
    ..The reduction in high signal T2-weighted lesion volume may be an important outcome measure in future clinical trials in humans...
  91. ncbi Role of MHC class II expressing CD4+ T cells in proteolipid protein(91-110)-induced EAE in HLA-DR3 transgenic mice
    Ashutosh Mangalam
    Department of Immunology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Eur J Immunol 36:3356-70. 2006
    ....
  92. pmc Transgenic expression of the 3D polymerase inhibits Theiler's virus infection and demyelination
    Jason Kerkvliet
    Departments of Neurology, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Virol 83:12279-89. 2009
    ..Understanding how endogenously overexpressed 3D polymerase inhibits viral replication may lead to new strategies for targeting therapies to all picornaviruses...
  93. doi Novel immunomodulatory approaches for the management of multiple sclerosis
    O H Kantarci
    Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA
    Clin Pharmacol Ther 95:32-44. 2014
    ..In the future, we envision new drugs to enhance remyelination and protect neurons and axons from death in order to promote central nervous system regeneration and repair...
  94. ncbi Surgical therapy for tremor in multiple sclerosis: an evaluation of outcome measures
    J Matsumoto
    Department of Neurology, Mayo Clinic and Foundation, Rochester, MN 55905, USA
    Neurology 57:1876-82. 2001
    ..To assess the reliability, validity, and sensitivity of outcome measures that might be used in a clinical trial of surgery for the treatment of severe tremor associated with MS (MS tremor)...
  95. ncbi Rapid weaning from mechanical ventilator in acute cervical cord multiple sclerosis lesion after steroids
    S J Pittock
    Department of Neurology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Anesth Analg 93:1550-1, table of contents. 2001
    ..Cervical cord or brainstem relapses should be suspected in MS patients with respiratory failure. Identification and management of this critical condition are discussed...
  96. ncbi Contrasting murine models of MS
    A L A Nelson
    Program in Molecular Neuroscience, Mayo Graduate School, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
    Int MS J 11:95-9. 2004
    ..Analysing therapeutic successes and failures with both models may also help the development of more directed, positive treatments for MS that have fewer negative effects...
  97. ncbi Dynamic role of kallikrein 6 in traumatic spinal cord injury
    I A Scarisbrick
    Program for Molecular Neuroscience, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Eur J Neurosci 24:1457-69. 2006
    ..These data support the hypothesis that K6 enzymatic cascades mediate events secondary to spinal cord trauma, including dynamic modification of the capacity for axon outgrowth...
  98. ncbi Prevention of recurrence and prolonged survival in primary central nervous system lymphoma (PCNSL) patients treated with adjuvant high-dose methylprednisolone
    B P O'Neill
    Department of Neurology, Mayo Clinic, and the Mayo Clinic Cancer Center, Rochester, MN 55905, USA
    Med Oncol 16:211-5. 1999
    ....
  99. ncbi A randomized trial of intravenous immunoglobulin in inflammatory demyelinating optic neuritis
    J H Noseworthy
    Department of Neurology, Mayo Clinic and Mayo Foundation, Rochester, MN 55905, USA
    Neurology 56:1514-22. 2001
    ..To determine whether IV immunoglobulin (IVIg) reverses chronic visual impairment in MS patients with optic neuritis (ON)...
  100. ncbi A randomized controlled crossover trial of aspirin for fatigue in multiple sclerosis
    D M Wingerchuk
    Department of Neurology Mayo Clinic, Scottsdale, AZ 85259, USA
    Neurology 64:1267-9. 2005
    ..012). There were no significant adverse effects. The results warrant further study and support a role for ASA-influenced mechanisms, perhaps immunologic, in the generation of MS-related chronic fatigue...

Research Grants2

  1. IMMUNE PROMOTION OF REMYELINATION
    Moses Rodriguez; Fiscal Year: 2008
    ..Our findings are expected to provide new insights into the enhancement of remyelination in diseases such as multiple sclerosis. [unreadable] [unreadable]..
  2. T cell Function in Murine Model of Multiple Sclerosis
    Moses Rodriguez; Fiscal Year: 2010
    ..The findings are expected to provide new insights into the pathogenesis of axonal and neuronal injury in demyelinating disorders such as multiple sclerosis. ..