Karl Nath

Summary

Affiliation: Mayo Clinic
Country: USA

Publications

  1. pmc ß-Catenin is markedly induced in a murine model of an arteriovenous fistula: the effect of metalloproteinase inhibition
    Karl A Nath
    Division of Nephrology and Hypertension, Department of Physiology and Biomedical Engineering, Mayo Clinic, Guggenheim 542, 200 First St, SW, Rochester, MN 55905, USA
    Am J Physiol Renal Physiol 299:F1270-7. 2010
  2. pmc Functioning of an arteriovenous fistula requires heme oxygenase-2
    Lu Kang
    Mayo Clinic, Guggenheim 542, 200 First St SW, Rochester, MN 55905
    Am J Physiol Renal Physiol 305:F545-52. 2013
  3. pmc Age sensitizes the kidney to heme protein-induced acute kidney injury
    Karl A Nath
    Division of Nephrology and Hypertension, Mayo Clinic, Guggenheim 542, 200 First St, SW, Rochester, MN 55905, USA
    Am J Physiol Renal Physiol 304:F317-25. 2013
  4. pmc Increased production of superoxide anion contributes to dysfunction of the arteriovenous fistula
    Mykola V Tsapenko
    Mayo Clinic, 200 First St SW, Guggenheim 542, Rochester, MN 55905
    Am J Physiol Renal Physiol 303:F1601-7. 2012
  5. pmc Vasculature and kidney complications in sickle cell disease
    Karl A Nath
    Division of Nephrology and Hypertension, Internal Medicine, Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN 55905, USA
    J Am Soc Nephrol 23:781-4. 2012
  6. pmc Preservation of the kidney by carbon monoxide: a black swan phenomenon
    Karl A Nath
    Division of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota 55905, USA
    Kidney Int 74:989-91. 2008
  7. ncbi request reprint Intracellular targets in heme protein-induced renal injury
    K A Nath
    Nephrology Research Unit, Mayo Clinic Foundation, Rochester, Minnesota, USA
    Kidney Int 53:100-11. 1998
  8. ncbi request reprint An analysis of the DOCA-salt model of hypertension in HO-1-/- mice and the Gunn rat
    Karl A Nath
    Division of Nephrology and Hypertension, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA
    Am J Physiol Heart Circ Physiol 293:H333-42. 2007
  9. ncbi request reprint The perfusion paradox and vascular instability in sickle cell disease
    Karl A Nath
    Division of Nephrology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Microcirculation 11:179-93. 2004
  10. ncbi request reprint Renal response to repeated exposure to endotoxin: implications for acute kidney injury
    K A Nath
    Division of Nephrology and Hypertension, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Kidney Int 71:477-9. 2007

Collaborators

Detail Information

Publications68

  1. pmc ß-Catenin is markedly induced in a murine model of an arteriovenous fistula: the effect of metalloproteinase inhibition
    Karl A Nath
    Division of Nephrology and Hypertension, Department of Physiology and Biomedical Engineering, Mayo Clinic, Guggenheim 542, 200 First St, SW, Rochester, MN 55905, USA
    Am J Physiol Renal Physiol 299:F1270-7. 2010
    ..This study provides the first exploration of β-catenin in an AVF, demonstrating substantial upregulation of this mitogenic signaling molecule and uncovering possible mechanisms that may account for such upregulation...
  2. pmc Functioning of an arteriovenous fistula requires heme oxygenase-2
    Lu Kang
    Mayo Clinic, Guggenheim 542, 200 First St SW, Rochester, MN 55905
    Am J Physiol Renal Physiol 305:F545-52. 2013
    ..HO-2 deficiency also led to lower AVF blood flow when AVFs were created in uremia, the latter induced by subtotal nephrectomy. We conclude that HO-2 critically contributes to the adequacy of AVF blood flow and function. ..
  3. pmc Age sensitizes the kidney to heme protein-induced acute kidney injury
    Karl A Nath
    Division of Nephrology and Hypertension, Mayo Clinic, Guggenheim 542, 200 First St, SW, Rochester, MN 55905, USA
    Am J Physiol Renal Physiol 304:F317-25. 2013
    ..Age thus markedly augments the sensitivity of the kidney to heme proteins, and HO-2 confers resistance to such insults...
  4. pmc Increased production of superoxide anion contributes to dysfunction of the arteriovenous fistula
    Mykola V Tsapenko
    Mayo Clinic, 200 First St SW, Guggenheim 542, Rochester, MN 55905
    Am J Physiol Renal Physiol 303:F1601-7. 2012
    ....
  5. pmc Vasculature and kidney complications in sickle cell disease
    Karl A Nath
    Division of Nephrology and Hypertension, Internal Medicine, Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN 55905, USA
    J Am Soc Nephrol 23:781-4. 2012
    ..From these perspectives the renal complications of sickle cell disease are discussed and classified...
  6. pmc Preservation of the kidney by carbon monoxide: a black swan phenomenon
    Karl A Nath
    Division of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota 55905, USA
    Kidney Int 74:989-91. 2008
    ....
  7. ncbi request reprint Intracellular targets in heme protein-induced renal injury
    K A Nath
    Nephrology Research Unit, Mayo Clinic Foundation, Rochester, Minnesota, USA
    Kidney Int 53:100-11. 1998
    ..The presence of TUNEL-positive cells in the distal nephron but not at proximal sites in vivo underscores the increasing appreciation of the distinct responses of these nephron sites to nephrotoxic insults...
  8. ncbi request reprint An analysis of the DOCA-salt model of hypertension in HO-1-/- mice and the Gunn rat
    Karl A Nath
    Division of Nephrology and Hypertension, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA
    Am J Physiol Heart Circ Physiol 293:H333-42. 2007
    ..DOCA salt stimulated vascular production of superoxide anion in wild-type but not in Gunn rats. We suggest that HO-1 and the product bilirubin may exert a countervailing effect in the DOCA-salt model of systemic hypertension...
  9. ncbi request reprint The perfusion paradox and vascular instability in sickle cell disease
    Karl A Nath
    Division of Nephrology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Microcirculation 11:179-93. 2004
    ..Finally, the possibility that the induction of heme oxygenase-1, recently described in SCD, may confer a protective response in the vasculature and other tissues is discussed...
  10. ncbi request reprint Renal response to repeated exposure to endotoxin: implications for acute kidney injury
    K A Nath
    Division of Nephrology and Hypertension, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Kidney Int 71:477-9. 2007
    ..These novel findings are discussed mainly from the perspective of acute kidney injury and its prevention by preconditioning and the elicitation of cytoprotective pathways...
  11. ncbi request reprint Heme oxygenase-1: a provenance for cytoprotective pathways in the kidney and other tissues
    K A Nath
    Department of Medicine, Division of Nephrology and Hypertension, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Kidney Int 70:432-43. 2006
    ..Studies of HO in other tissues are discussed insofar as they aid in elucidating the physiologic and pathophysiologic significance of the HO system in the kidney...
  12. pmc The role of Sirt1 in renal rejuvenation and resistance to stress
    Karl A Nath
    Division of Nephrology and Hypertension, Department of Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Clin Invest 120:1026-8. 2010
    ..Sirt1 is thus an important participant in renal cytoprotective responses to aging and stress...
  13. pmc Heme oxygenase activity as a determinant of the renal hemodynamic response to low-dose ANG II
    Karl A Nath
    Division of Nephrology and Hypertension, Mayo Clinic, Guggenheim 542, 200 First St, SW, Rochester, MN 55905, USA
    Am J Physiol Regul Integr Comp Physiol 299:R1183-91. 2010
    ..These findings may be germane to conditions attended by heightened ANG II levels, ineffective renal perfusion, and susceptibility to acute kidney injury...
  14. pmc Increased venous proinflammatory gene expression and intimal hyperplasia in an aorto-caval fistula model in the rat
    Karl A Nath
    Division of Nephrology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Am J Pathol 162:2079-90. 2003
    ....
  15. pmc Oxidative stress and induction of heme oxygenase-1 in the kidney in sickle cell disease
    K A Nath
    Nephrology Research Unit, Mayo Clinic Foundation, 200 First St SW, 542 Guggenheim Bldg, Rochester, MN 55905, USA
    Am J Pathol 158:893-903. 2001
    ..Additionally, the oxidant-inducible, heme-degrading enzyme, HO-1, is induced regionally in the murine and human sickle kidney, and systemically, in circulating endothelial cells in sickle patients...
  16. ncbi request reprint Renal response to repetitive exposure to heme proteins: chronic injury induced by an acute insult
    K A Nath
    Nephrology Research Unit, Mayo Clinic Foundation, Rochester, Minnesota 55905, USA
    Kidney Int 57:2423-33. 2000
    ..We questioned whether acute, reversible, renal insults may be induced to incite a chronic scarring process, employing as an acute insult the glycerol model of heme protein-induced renal injury...
  17. pmc The indispensability of heme oxygenase-1 in protecting against acute heme protein-induced toxicity in vivo
    K A Nath
    Nephrology Research Unit, Mayo Clinic Foundation, Rochester, Minnesota 55905, USA
    Am J Pathol 156:1527-35. 2000
    ..We conclude that the induction of HO-1 is an indispensable response in protecting against acute heme protein toxicity in vivo...
  18. ncbi request reprint Redox regulation of renal DNA synthesis, transforming growth factor-beta1 and collagen gene expression
    K A Nath
    Department of Medicine, Mayo Clinic Foundation, Rochester, Minnesota 55905, USA
    Kidney Int 53:367-81. 1998
    ..Oxidants also induce collagen III, collagen IV and TGF-beta1 mRNA in vitro...
  19. pmc Transgenic sickle mice are markedly sensitive to renal ischemia-reperfusion injury
    Karl A Nath
    Division of Nephrology, Mayo Clinic College of Medicine, 200 First St, SW, Guggenheim 542, Rochester, MN 55905, USA
    Am J Pathol 166:963-72. 2005
    ..We conclude that tissues in SCD exhibit heightened vascular congestion and sensitivity to ischemia and that clinically apparent or silent episodes of ischemia may contribute to the complications of SCD...
  20. pmc MCP-1 contributes to arteriovenous fistula failure
    Julio P Juncos
    Mayo Clinic, Guggenheim 542, 200 First Street, SW, Rochester, MN 55905, USA
    J Am Soc Nephrol 22:43-8. 2011
    ..In summary, marked upregulation of MCP-1 occurs in the venous segment of an arteriovenous fistula in rodents, and this vasculopathic chemokine contributes to failure of the fistula...
  21. ncbi request reprint Mechanisms of aging-induced impairment of endothelium-dependent relaxation: role of tetrahydrobiopterin
    Katherine A Blackwell
    Department of Anesthesia Research and Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Am J Physiol Heart Circ Physiol 287:H2448-53. 2004
    ..Oxidation of BH4 does not appear to be an important mechanism underlying vasomotor dysfunction in aged mouse arteries...
  22. ncbi request reprint The hyperbilirubinemic Gunn rat is resistant to the pressor effects of angiotensin II
    Axel Pflueger
    Division of Nephrology, Department of Internal Medicine, Mayo Clinic, 200 First St, SW, Guggenheim 542, Rochester, MN 55905, USA
    Am J Physiol Renal Physiol 288:F552-8. 2005
    ..We conclude that the pressor and prooxidant effects of ANG II are attenuated in the hyperbilirubinemic Gunn rat, an effect which, we speculate, may reflect, at least in part, the scavenging of superoxide anion by bilirubin...
  23. ncbi request reprint Increased blood flow causes coordinated upregulation of arterial eNOS and biosynthesis of tetrahydrobiopterin
    Chen Fuh Lam
    Dept of Anesthesiology, Mayo Clinic College of Medicine, 200 First St SW, Rochester, MN 55905, USA
    Am J Physiol Heart Circ Physiol 290:H786-93. 2006
    ..This induction of GTPCH I increases BH4 production, thereby optimizing the generation of NO by eNOS and thus the adaptive, vasorelaxant response required in sustaining increased blood flow...
  24. pmc Anomalous renal effects of tin protoporphyrin in a murine model of sickle cell disease
    Julio P Juncos
    Division of Nephrology and Hypertension, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Am J Pathol 169:21-31. 2006
    ..These findings suggest that induction of HO-1, at least as assessed by this approach, may contribute to renal injury in this murine model of SCD and uncover an experimental maneuver that protects the kidney in murine SCD...
  25. ncbi request reprint Essential role of endothelial nitric oxide synthase in vascular effects of erythropoietin
    Livius V d'Uscio
    Department of Anesthesiology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Hypertension 49:1142-8. 2007
    ..05). Our results demonstrate that EPO prevents aberrant remodeling of the injured carotid artery. The protective effects of EPO are critically dependent on activation of eNOS...
  26. pmc Vascular protection by tetrahydrobiopterin: progress and therapeutic prospects
    Zvonimir S Katusic
    Department of Anesthesiology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Trends Pharmacol Sci 30:48-54. 2009
    ..This review also addresses the emerging roles of BH4 in the regulation of endothelial function and their therapeutic implications...
  27. pmc Induction of heme oxygenase-1 and ferritin in the kidney in warm antibody hemolytic anemia
    Fernando C Fervenza
    Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN 55905, USA
    Am J Kidney Dis 52:972-7. 2008
    ..Finally, this case report documents that nephrotic-range proteinuria can occur in patients with autoimmune hemolytic anemia complicated by hemoglobinuria...
  28. pmc Early and prominent alterations in hemodynamics, signaling, and gene expression following renal ischemia in sickle cell disease
    Julio P Juncos
    Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Am J Physiol Renal Physiol 298:F892-9. 2010
    ..We speculate that such sensitivity of the kidney to ischemia in SCD may underlie the occurrence of acute kidney injury in patients with SCD and may set the stage for the emergence of chronic kidney disease in SCD...
  29. pmc A promising approach for treatment of tumor-induced bone diseases: utilizing bisphosphonate derivatives of nucleoside antimetabolites
    Monica M Reinholz
    Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55906, USA
    Bone 47:12-22. 2010
    ..53). These results demonstrate that MBC-11 decreases bone tumor burden, maintains bone structure, and may increase overall survival, warranting further investigation as a treatment for TIBD...
  30. ncbi request reprint Nitric oxide synthase gene transfer as a tool to study biology of endothelial cells
    Zvonimir S Katusic
    Department of Anesthesiology and Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, 200 First St SW, Rochester, Minn 55905, USA
    Arterioscler Thromb Vasc Biol 23:1990-4. 2003
    ..In this review, we will use nitric oxide synthase gene transfer as a paradigm to illustrate how gene transfer technology can be used to address key issues in the vascular biology of endothelium...
  31. ncbi request reprint Vitamin E prevents renal dysfunction induced by experimental chronic bile duct ligation
    M Clara Ortiz
    Department of Physiology and Biophysics, Mayo School of Medicine, Mayo Clinic, Rochester, Minnesota, USA
    Kidney Int 64:950-61. 2003
    ..g., F2-isoprostanes) and endothelin (ET). We investigated whether antioxidant therapy prevents chronic bile duct ligation (CBDL)-induced alterations in systemic and renal hemodynamics, and reduces F2-isoprostane and ET levels...
  32. pmc n-3 Fatty acids block TNF-α-stimulated MCP-1 expression in rat mesangial cells
    Montserrat M Diaz Encarnacion
    Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA
    Am J Physiol Renal Physiol 300:F1142-51. 2011
    ..We speculate that such effects may contribute to the salutary effect of fish oil in renal and vascular disease...
  33. pmc Characterization of a model of an arteriovenous fistula in the rat: the effect of L-NAME
    Anthony J Croatt
    Division of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota 55905, USA
    Am J Pathol 176:2530-41. 2010
    ....
  34. ncbi request reprint Proteinuria as a determinant of renal expression of heme oxygenase-1: studies in models of glomerular and tubular proteinuria in the rat
    José Pedraza-Chaverri
    Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN 55905, USA
    Am J Physiol Renal Physiol 290:F196-204. 2006
    ....
  35. pmc A major role for carbon monoxide as an endogenous hyperpolarizing factor in the gastrointestinal tract
    Gianrico Farrugia
    Enteric Neuroscience Program, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Proc Natl Acad Sci U S A 100:8567-70. 2003
    ..Our results suggest that CO is a critical hyperpolarizing factor required for the maintenance of intestinal smooth muscle membrane potential and gradient...
  36. ncbi request reprint TGF-beta1 is an autocrine mediator of renal tubular epithelial cell growth and collagen IV production
    Joseph P Grande
    Renal Pathophysiology Laboratory, Department of Laboratory Medicine and Pathology, and Division of Nephrology, Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA
    Exp Biol Med (Maywood) 227:171-81. 2002
    ..These studies provide evidence that autocrine production of TGF-beta1 may play a critical role in regulation of growth and basal collagen IV production by renal tubular epithelial cells...
  37. ncbi request reprint TGF-beta1 stimulates monocyte chemoattractant protein-1 expression in mesangial cells through a phosphodiesterase isoenzyme 4-dependent process
    Jingfei Cheng
    Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, 200 First St SW, Stabile 7, Rochester, Minnesota 55905, USA
    Am J Physiol Cell Physiol 289:C959-70. 2005
    ..Rp, by preventing TGF-beta1-stimulated MCP-1 production, may offer a therapeutic approach in retarding the progression of renal disease...
  38. ncbi request reprint Functional adaptation and remodeling of pulmonary artery in flow-induced pulmonary hypertension
    Chen Fuh Lam
    Dept of Anesthesiology, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
    Am J Physiol Heart Circ Physiol 289:H2334-41. 2005
    ..Increased eNOS and phosphorylated eNOS are most likely the adaptive changes in response to an increase in PA pressure secondary to high blood flow...
  39. pmc Induction of heme oxygenase-1 is a beneficial response in a murine model of venous thrombosis
    Michal J Tracz
    Division of Nephrology and Hypertension, Department of Pathology, Mayo Clinic, Rochester, MN 55905, USA
    Am J Pathol 173:1882-90. 2008
    ....
  40. pmc Neoangiogenesis and the presence of progenitor cells in the venous limb of an arteriovenous fistula in the rat
    Noel M Caplice
    Division of Cardiovascular Disease, Mayo Clinic College of Medicine, 200 First St, SW, Guggenheim 542, Rochester, MN 55905, USA
    Am J Physiol Renal Physiol 293:F470-5. 2007
    ....
  41. ncbi request reprint In vivo stimulatory effect of erythropoietin on endothelial nitric oxide synthase in cerebral arteries
    Anantha Vijay R Santhanam
    Department of Anesthesiology, Mayo Clinic College of Medicine, 200 First St SW, Rochester, MN 55905, USA
    Am J Physiol Heart Circ Physiol 291:H781-6. 2006
    ..Our studies suggest that in cerebral circulation, Epo enhances endothelium-dependent vasodilatation mediated by NO. This effect could play an important role in the vascular protective effect of Epo...
  42. pmc Signaling pathways modulated by fish oil in salt-sensitive hypertension
    Montserrat M Diaz Encarnacion
    Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, 200 First St SW, Rochester, MN 55905, USA
    Am J Physiol Renal Physiol 294:F1323-35. 2008
    ..05). We propose that FO ameliorates renal injury in Dahl salt-sensitive rats through the inhibition of ERK, decreased NF-kappaB activation, inhibition of COX-2 expression, and decreased NADPH oxidase activation...
  43. ncbi request reprint Low-dose angiotensin II enhances pressor responses without causing sustained hypertension
    Laura I Pelaez
    Department of Family Medicine, Mayo School of Medicine, Mayo Clinic, Rochester, Minn 55905, USA
    Hypertension 42:798-801. 2003
    ....
  44. pmc Renal hemodynamic, inflammatory, and apoptotic responses to lipopolysaccharide in HO-1-/- mice
    Michal J Tracz
    Division of Nephrology and Hypertension, Department of Pathology, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA
    Am J Pathol 170:1820-30. 2007
    ..Because polymorphisms in the HO-1 gene with diminished HO activity predispose to human disease, we speculate that our findings may be relevant to the clinical outcome in patients with sepsis syndromes...
  45. ncbi request reprint IL-10-deficiency unmasks unique immune system defects and reveals differential regulation of organ-specific autoimmunity in non-obese diabetic mice
    Govindarajan Rajagopalan
    Department of Immunology, Mayo Clinic College of Medicine, Rochester, MN, USA
    Cytokine 34:85-95. 2006
    ..This was accompanied by a heightened systemic inflammatory cytokine response and mortality following in vivo challenge with a toll-like receptor 9 agonist, CpG-containing DNA...
  46. pmc Temporal analysis of signaling pathways activated in a murine model of two-kidney, one-clip hypertension
    Jingfei Cheng
    Department of Experimental Pathology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Am J Physiol Renal Physiol 297:F1055-68. 2009
    ..Notably, an unexpected proliferative response occurs in the stenotic kidney that undergoes atrophy...
  47. ncbi request reprint Heme: a novel inducer of MCP-1 through HO-dependent and HO-independent mechanisms
    Sharan K R Kanakiriya
    Division of Nephrology, Mayo Clinic Foundation, Rochester, Minnesota 55905, USA
    Am J Physiol Renal Physiol 284:F546-54. 2003
    ....
  48. pmc Dendritic cells facilitate accumulation of IL-17 T cells in the kidney following acute renal obstruction
    Xiangyang Dong
    Division of Nephrology and Hypertension, Department of Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota, USA
    Kidney Int 74:1294-309. 2008
    ....
  49. pmc A systems biology consideration of the vasculopathy of sickle cell anemia: the need for multi-modality chemo-prophylaxsis
    Robert P Hebbel
    Vascular Biology Center and Division of Hematology Oncology Transplantation, Department of Medicine, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    Cardiovasc Hematol Disord Drug Targets 9:271-92. 2009
    ..It is proposed here that the specific combination of a statin with suberoylanilide hydroxamic acid would provide a suitable, broad, multi-modality approach to chemo-prophylaxis for sickle vasculopathy...
  50. ncbi request reprint MCP-1 is up-regulated in unstressed and stressed HO-1 knockout mice: Pathophysiologic correlates
    Siobhan T Pittock
    Department of Pediatric and Adolescent Medicine, Division of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota 55905, USA
    Kidney Int 68:611-22. 2005
    ..The present study was stimulated by the hypothesis that expression of MCP-1 is suppressed by HO-1, and analyzed the effect of HO-1 on the expression of MCP-1 in stressed and unstressed conditions...
  51. ncbi request reprint Antigen presentation by dendritic cells in renal lymph nodes is linked to systemic and local injury to the kidney
    Xiangyang Dong
    Division of Nephrology and Hypertension, Department of Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Kidney Int 68:1096-108. 2005
    ..The normal kidney contains an extensive population of interstitial DCs but their role in the pathogenesis of acute renal injury is not known...
  52. ncbi request reprint Renal upregulation of HO-1 reduces albumin-driven MCP-1 production: implications for chronic kidney disease
    Narayana S Murali
    Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Am J Physiol Renal Physiol 292:F837-44. 2007
    ..These findings suggest that the induction of HO-1 in the proximal tubule, as occurs in chronic kidney disease, may be a countervailing response that reduces albumin-stimulated production of cytokines such as MCP-1...
  53. ncbi request reprint Physiology and pathophysiology of heme: implications for kidney disease
    Michal J Tracz
    Mayo Clinic, 200 First Street, SW, Guggenheim 542, Rochester, MN 55905, USA
    J Am Soc Nephrol 18:414-20. 2007
    ..Finally, current views regarding the molecular basis for heme-induced upregulation of HO-1 are discussed...
  54. pmc The Modulatory Role of Heme Oxygenase on Subpressor Angiotensin II-Induced Hypertension and Renal Injury
    Kiran Chandrashekar
    Division of Nephrology, Department of Medicine, University of Mississippi Medical Center, Jackson, MS 39216, USA
    Int J Hypertens 2012:392890. 2012
    ....
  55. ncbi request reprint Transplantation of circulating endothelial progenitor cells restores endothelial function of denuded rabbit carotid arteries
    Tongrong He
    Mayo Clinic of Medicine, Rochester, Minn 55905, USA
    Stroke 35:2378-84. 2004
    ..The present study was designed to determine the effect of EPCs transplantation on the regeneration of endothelium and recovery of endothelial function in denuded carotid arteries...
  56. ncbi request reprint Intranasal exposure to staphylococcal enterotoxin B elicits an acute systemic inflammatory response
    Govindarajan Rajagopalan
    Department of Immunology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Shock 25:647-56. 2006
    ..Thus, we have shown, for the first time, that intranasal administration of SEB can cause systemic immune activation...
  57. ncbi request reprint Proapoptotic, antimigratory, antiproliferative, and antiangiogenic effects of commercial C-reactive protein on various human endothelial cell types in vitro: implications of contaminating presence of sodium azide in commercial preparation
    Chunsheng Liu
    Division of Cardiovascular Diseases, Mayo Clinic College of Medicine, Rochester, MN, USA
    Circ Res 97:135-43. 2005
    ..This study has implications for interpretation of in vitro studies using CRP preparations containing azide at equivalent or higher concentrations...
  58. ncbi request reprint Accommodation in ABO-incompatible kidney allografts, a novel mechanism of self-protection against antibody-mediated injury
    Walter D Park
    Department of Surgery, Mayo Clinic, Rochester, MN, USA
    Am J Transplant 3:952-60. 2003
    ..This self-protection against antibody-mediated damage may involve several novel mechanisms including the disruption of normal signal transduction, attenuation of cellular adhesion and the prevention of apoptosis...
  59. ncbi request reprint Heme: a determinant of life and death in renal tubular epithelial cells
    Luis Gonzalez-Michaca
    Division of Nephrology, Mayo Clinic Foundation, Rochester, Minnesota 55905, USA
    Am J Physiol Renal Physiol 286:F370-7. 2004
    ..We suggest that these effects of heme may influence the nature of, and recovery from, ischemic and nephrotoxic insults to the kidney...
  60. ncbi request reprint Endothelial progenitor cells stimulate cerebrovascular production of prostacyclin by paracrine activation of cyclooxygenase-2
    Anantha Vijay R Santhanam
    Department of Anesthesiology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Circ Res 100:1379-88. 2007
    ..This effect appears to be mediated by activation of arachidonic acid metabolism via stimulation of cyclooxygenase-2/PGI(2) synthase pathway...
  61. ncbi request reprint Heart failure increases protein expression and enzymatic activity of heme oxygenase-1 in the lung
    Chen F Lam
    Departments of Anesthesiology, Mayo Clinic and Foundation, Rochester, MN, USA
    Cardiovasc Res 65:203-10. 2005
    ..We hypothesized that the HF-induced increase in the concentration of heme up-regulates the expression and enzymatic activity of heme oxygenase (HO)-1 in the lung...
  62. pmc Regional and systemic hemodynamic responses following the creation of a murine arteriovenous fistula
    Lu Kang
    Division of Nephrology and Hypertension, Mayo Clinic, Rochester 55905, USA
    Am J Physiol Renal Physiol 301:F845-51. 2011
    ..We suggest that these findings support the utility of this model in investigating the basis for and the consequences of hemodynamic stress, including shear stress, and the pathobiology of hemodialysis AVF dysfunction...
  63. pmc Outcomes of arteriovenous fistula creation after the Fistula First Initiative
    Carrie A Schinstock
    Mayo Clinic, Guggenheim 542, 200 1st Street SW, Rochester, MN 55905, USA
    Clin J Am Soc Nephrol 6:1996-2002. 2011
    ..There is no clear consensus on predictors of AVF patency. This study determined AVF outcomes and patency predictors at Mayo Clinic Rochester following the Fistula First Initiative...
  64. pmc Hemolysis and acute kidney failure
    Qi Qian
    Department of Medicine, Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN 55905, USA
    Am J Kidney Dis 56:780-4. 2010
    ..We conclude that tubular injury resulting from heme proteins should be considered as a cause of decreased kidney function in all patients with a cardiac valvular disease or prosthesis...
  65. pmc Endogenous superantigens shape response to exogenous superantigens
    Govindarajan Rajagopalan
    Department of Immunology, Mayo Clinic College of Medicine, Mayo Clinic, SW, Rochester, MN 55905, USA
    Clin Diagn Lab Immunol 12:1119-22. 2005
    ..Consequently, the magnitude of immune response to exogenous superantigen staphylococcal enterotoxin B, which activates TCR Vbeta8(+) T cells, was significantly reduced and conferred protection from superantigen-induced mortality...
  66. ncbi request reprint Smooth muscle progenitor cells in vascular disease
    Chunsheng Liu
    Division of Cardiovascular Diseases, Molecular Pharmacology and Experimental Therapeutics, Department of Internal Medicine and the Molecular Medicine Program, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA
    Trends Cardiovasc Med 14:288-93. 2004
    ..These observations provide a platform for re-evaluation of smooth muscle cell heterogeneity and progenitor biology in atherosclerosis, with implications for diagnosis and therapy of vascular disease...
  67. ncbi request reprint Heme activates the heme oxygenase-1 gene in renal epithelial cells by stabilizing Nrf2
    Jawed Alam
    Department of Molecular Genetics, Ochsner Clinic Foundation, New Orleans 70121, USA
    Am J Physiol Renal Physiol 284:F743-52. 2003
    ..These results indicate that heme promotes stabilization of Nrf2, leading to accumulation of Nrf2. MafG dimers that bind to StREs to activate the ho-1 gene...
  68. ncbi request reprint Provenance of the protective property of p21
    Karl A Nath
    Am J Physiol Renal Physiol 289:F512-3. 2005

Research Grants12

  1. RENAL INJURY AND ADAPTATION TO HEME PROTEINS
    Karl Nath; Fiscal Year: 2007
    ..This application seeks to understand how a protein called heme oxygenase-1 protects the kidney against different types of diseases. This understanding may facilitate the development of new therapies for kidney disease. ..
  2. Mechanism of Dialysis Arteriovenous Fistula Dysfunction
    Karl Nath; Fiscal Year: 2007
    ..In aggregate, these studies will determine the basis for and the pathogenetic significance of such upregulation of MCP-1, and may suggest strategies for preventing dysfunction of AVFs. ..
  3. Mechanism of Dialysis Arteriovenous Fistula Dysfunction
    Karl Nath; Fiscal Year: 2006
    ..In aggregate, these studies will determine the basis for and the pathogenetic significance of such upregulation of MCP-1, and may suggest strategies for preventing dysfunction of AVFs. ..
  4. RENAL INJURY AND ADAPTATION TO HEME PROTEINS
    Karl Nath; Fiscal Year: 2001
    ..Our proposed application thus continues to pursue the functionality of HO-1, as it utilized a new strategy, transgenic mice, and as it defines a new area of involvement namely, renal inflammation. ..
  5. RENAL INJURY AND ADAPTATION TO HEME PROTEINS
    Karl Nath; Fiscal Year: 2000
    ..Our proposed application thus continues to pursue the functionality of HO-1, as it utilized a new strategy, transgenic mice, and as it defines a new area of involvement namely, renal inflammation. ..
  6. RENAL INJURY AND ADAPTATION TO HEME PROTEINS
    Karl Nath; Fiscal Year: 1999
    ..Our proposed application thus continues to pursue the functionality of HO-1, as it utilized a new strategy, transgenic mice, and as it defines a new area of involvement namely, renal inflammation. ..
  7. Mechanism of Dialysis Arteriovenous Fistula Dysfunction
    Karl Nath; Fiscal Year: 2009
    ..In aggregate, these studies will determine the basis for and the pathogenetic significance of such upregulation of MCP-1, and may suggest strategies for preventing dysfunction of AVFs. ..