John C Morris

Summary

Affiliation: Mayo Clinic
Country: USA

Publications

  1. pmc A probasin promoter, conditionally replicating adenovirus that expresses the sodium iodide symporter (NIS) for radiovirotherapy of prostate cancer
    M A Trujillo
    Department of Internal Medicine, Division of Endocrinology, Diabetes, Metabolism, Nutrition, Mayo Clinic, Rochester, MN 55905, USA
    Gene Ther 17:1325-32. 2010
  2. pmc A steep radioiodine dose response scalable to humans in sodium-iodide symporter (NIS)-mediated radiovirotherapy for prostate cancer
    M A Trujillo
    Department of Internal Medicine, Division of Endocrinology, Diabetes, Metabolism, Nutrition, Mayo Clinic, Rochester, MN 55905, USA
    Cancer Gene Ther 19:839-44. 2012
  3. pmc Viral dose, radioiodide uptake, and delayed efflux in adenovirus-mediated NIS radiovirotherapy correlates with treatment efficacy
    M A Trujillo
    Division of Endocrinology, Diabetes, Metabolism, Nutrition, Mayo Clinic, Rochester, MN 55905, USA
    Gene Ther 20:567-74. 2013
  4. doi request reprint How do you approach the problem of TSH elevation in a patient on high-dose thyroid hormone replacement?
    John C Morris
    Division of Endocrinology, Mayo Clinic, Rochester, MN 55905, USA
    Clin Endocrinol (Oxf) 70:671-3. 2009
  5. pmc Noninvasive imaging and radiovirotherapy of prostate cancer using an oncolytic measles virus expressing the sodium iodide symporter
    Pavlos Msaouel
    Department of Molecular Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA
    Mol Ther 17:2041-8. 2009
  6. ncbi request reprint Interaction of measles virus vectors with Auger electron emitting radioisotopes
    David Dingli
    Molecular Medicine Program, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Biochem Biophys Res Commun 337:22-9. 2005
  7. pmc Construction of an MUC-1 promoter driven, conditionally replicating adenovirus that expresses the sodium iodide symporter for gene therapy of breast cancer
    Miguel A Trujillo
    Department of Internal Medicine, Division of Endocrinology, Diabetes, Metabolism, Nutrition, Mayo Clinic Rochester, 200 First Street SW, Rochester, MN 55905, USA
    Breast Cancer Res 11:R53. 2009
  8. ncbi request reprint Adenovirus-mediated and targeted expression of the sodium-iodide symporter permits in vivo radioiodide imaging and therapy of pancreatic tumors
    Roisin M Dwyer
    Department of Endocrinology, Mayo Clinic, Rochester, MN 55905, USA
    Hum Gene Ther 17:661-8. 2006
  9. ncbi request reprint Combined I-124 positron emission tomography/computed tomography imaging of NIS gene expression in animal models of stably transfected and intravenously transfected tumor
    David Dingli
    Molecular Medicine Program, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Mol Imaging Biol 8:16-23. 2006
  10. pmc Engineered measles virus as a novel oncolytic therapy against prostate cancer
    Pavlos Msaouel
    Department of Molecular Medicine, Mayo Clinic, Rochester, Minnesota, USA
    Prostate 69:82-91. 2009

Detail Information

Publications40

  1. pmc A probasin promoter, conditionally replicating adenovirus that expresses the sodium iodide symporter (NIS) for radiovirotherapy of prostate cancer
    M A Trujillo
    Department of Internal Medicine, Division of Endocrinology, Diabetes, Metabolism, Nutrition, Mayo Clinic, Rochester, MN 55905, USA
    Gene Ther 17:1325-32. 2010
    ..This construct may allow multimodal therapy, combining cytolytic virotherapy with radioiodine treatment, to be developed as a novel treatment for prostate cancer...
  2. pmc A steep radioiodine dose response scalable to humans in sodium-iodide symporter (NIS)-mediated radiovirotherapy for prostate cancer
    M A Trujillo
    Department of Internal Medicine, Division of Endocrinology, Diabetes, Metabolism, Nutrition, Mayo Clinic, Rochester, MN 55905, USA
    Cancer Gene Ther 19:839-44. 2012
    ..We also show that the radioiodine doses needed to achieve this increase scaled well within the current doses used for treatment of thyroid cancer in humans...
  3. pmc Viral dose, radioiodide uptake, and delayed efflux in adenovirus-mediated NIS radiovirotherapy correlates with treatment efficacy
    M A Trujillo
    Division of Endocrinology, Diabetes, Metabolism, Nutrition, Mayo Clinic, Rochester, MN 55905, USA
    Gene Ther 20:567-74. 2013
    ..Our results have important implications regarding the desirable and undesirable characteristics of vectors for clinical translation of virus-mediated NIS transfer therapy...
  4. doi request reprint How do you approach the problem of TSH elevation in a patient on high-dose thyroid hormone replacement?
    John C Morris
    Division of Endocrinology, Mayo Clinic, Rochester, MN 55905, USA
    Clin Endocrinol (Oxf) 70:671-3. 2009
    ..In the compliant patient, however, multiple aetiologies are possible and a methodological and stepwise approach to the patient's problem will uniformly identify a cause, or at least a resolution...
  5. pmc Noninvasive imaging and radiovirotherapy of prostate cancer using an oncolytic measles virus expressing the sodium iodide symporter
    Pavlos Msaouel
    Department of Molecular Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA
    Mol Ther 17:2041-8. 2009
    ..The NIS transgene allows viral localization and monitoring by noninvasive imaging which can facilitate dose optimization in a clinical setting...
  6. ncbi request reprint Interaction of measles virus vectors with Auger electron emitting radioisotopes
    David Dingli
    Molecular Medicine Program, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Biochem Biophys Res Commun 337:22-9. 2005
    ..MV-NICE does not replicate faster in the presence of radiation. Auger electron emitting isotopes effectively stop propagation of MV vectors expressing NIS in vitro. Additional work is necessary to translate these observations in vivo...
  7. pmc Construction of an MUC-1 promoter driven, conditionally replicating adenovirus that expresses the sodium iodide symporter for gene therapy of breast cancer
    Miguel A Trujillo
    Department of Internal Medicine, Division of Endocrinology, Diabetes, Metabolism, Nutrition, Mayo Clinic Rochester, 200 First Street SW, Rochester, MN 55905, USA
    Breast Cancer Res 11:R53. 2009
    ....
  8. ncbi request reprint Adenovirus-mediated and targeted expression of the sodium-iodide symporter permits in vivo radioiodide imaging and therapy of pancreatic tumors
    Roisin M Dwyer
    Department of Endocrinology, Mayo Clinic, Rochester, MN 55905, USA
    Hum Gene Ther 17:661-8. 2006
    ..0001). The ability to target NIS expression to pancreatic cancer, which has such limited treatment options, may be highly beneficial and warrants further investigation...
  9. ncbi request reprint Combined I-124 positron emission tomography/computed tomography imaging of NIS gene expression in animal models of stably transfected and intravenously transfected tumor
    David Dingli
    Molecular Medicine Program, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Mol Imaging Biol 8:16-23. 2006
    ..We evaluated the potential of I-124 positron emission tomography (PET)/computed tomography (CT) imaging in gene therapy animal models utilizing the sodium iodide symporter (NIS) and compared the findings to I-123 gamma camera imaging...
  10. pmc Engineered measles virus as a novel oncolytic therapy against prostate cancer
    Pavlos Msaouel
    Department of Molecular Medicine, Mayo Clinic, Rochester, Minnesota, USA
    Prostate 69:82-91. 2009
    ..In this study, we investigated the antitumor potential of recombinant MV-Edm derivatives as novel oncolytic agents against prostate cancer...
  11. ncbi request reprint A preclinical large animal model of adenovirus-mediated expression of the sodium-iodide symporter for radioiodide imaging and therapy of locally recurrent prostate cancer
    Roisin M Dwyer
    Department of Endocrinology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Mol Ther 12:835-41. 2005
    ..The results presented provide further evidence of the safety and efficacy of NIS as a therapeutic gene and support translation of this work into the clinical setting...
  12. pmc Characterization of infectivity-enhanced conditionally replicating adenovectors for prostate cancer radiovirotherapy
    Michael J Oneal
    Department of Molecular Medicine, Mayo Clinic, Rochester, MN 55904, USA
    Hum Gene Ther 23:951-9. 2012
    ..001), but the benefit of radiovirotherapy was not statistically significant compared with virotherapy alone in this model. These results show the potential of Ad5/3PB-ADP-hNIS as a vector for treatment of prostate cancer...
  13. ncbi request reprint In vivo radioiodide imaging and treatment of breast cancer xenografts after MUC1-driven expression of the sodium iodide symporter
    Roisin M Dwyer
    Department of Endocrinology, Mayo Clinic, 200 First Street Southwest, Rochester, MN 55905, USA
    Clin Cancer Res 11:1483-9. 2005
    ..The aim of this study was to create a construct containing NIS under the control of the MUC1 promoter to target expression specifically to MUC1-positive breast cancer cells...
  14. ncbi request reprint Dynamic iodide trapping by tumor cells expressing the thyroidal sodium iodide symporter
    David Dingli
    Molecular Medicine Program, Mayo Clinic and Mayo Foundation, 200 First Street SW, Rochester, MN 55905, USA
    Biochem Biophys Res Commun 325:157-66. 2004
    ..Iodide organification was insignificant. In vivo studies in tumors composed of mixed cell populations confirmed these observations...
  15. ncbi request reprint Image-guided radiovirotherapy for multiple myeloma using a recombinant measles virus expressing the thyroidal sodium iodide symporter
    David Dingli
    Molecular Medicine Program, Mayo Clinic and Foundation, Rochester, MN 55905, USA
    Blood 103:1641-6. 2004
    ..Testing in other radiosensitive cancers is warranted...
  16. ncbi request reprint Development of a multidisciplinary, multicampus subspecialty practice in endocrine cancers
    Keith C Bible
    Mayo Clinic, Rochester, MN 55905, USA
    Am J Manag Care 18:e162-7. 2012
    ..We therefore sought to build interest in endocrine cancers, improve physician experience, and develop innovative approaches to treating patients with these neoplasms...
  17. doi request reprint Sodium iodide symporter (hNIS) permits molecular imaging of gene transduction in cardiac transplantation
    Vinay P Rao
    William J von Liebig Transplant Center, Department of Surgery, Division of Cardiovascular Surgery, Mayo Clinic, Rochester, MN, USA
    Transplantation 84:1662-6. 2007
    ....
  18. ncbi request reprint In vivo imaging and tumor therapy with the sodium iodide symporter
    David Dingli
    Molecular Medicine Program, Mayo Clinic and Mayo Foundation, 200 First Street SW, Rochester, Minnesota 55905, USA
    J Cell Biochem 90:1079-86. 2003
    ..In this review, we discuss the role of the sodium iodide symporter (NIS) as a reporter and therapeutic gene for cancer gene therapy when combined with various radioactive isotopes...
  19. doi request reprint Enhanced survival in locoregionally confined anaplastic thyroid carcinoma: a single-institution experience using aggressive multimodal therapy
    Robert L Foote
    Endocrine Malignancies Disease Oriented Group, Mayo Clinic Comprehensive Cancer Center, Rochester, Minnesota, USA
    Thyroid 21:25-30. 2011
    ....
  20. ncbi request reprint Probasin promoter (ARR(2)PB)-driven, prostate-specific expression of the human sodium iodide symporter (h-NIS) for targeted radioiodine therapy of prostate cancer
    Hideaki Kakinuma
    Department of Endocrinology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Cancer Res 63:7840-4. 2003
    ..These results indicate that Ad-ARR(2)PB/hNIS can be used to achieve high-magnitude and tissue-specific expression of h-NIS in prostate tissue and is a promising candidate for cancer gene therapy of prostate cancer...
  21. doi request reprint Application of shear wave imaging and shear wave dispersion ultrasound vibrometry in assessing viscoelastic properties of human thyroid: In vivo pilot study
    Mohammad Mehrmohammadi
    Physiol and Biomedical Eng, Mayo Clinic, 200 First St SW, Rochester, MN
    J Acoust Soc Am 134:4009. 2013
    ..Further studies on a large population of patients is required to better evaluate the role of the combination of elasticity and viscosity properties of tissue in differentiating various thyroid nodules. ..
  22. ncbi request reprint Comparison of thyrotropin-receptor antibodies measured by four commercially available methods with a bioassay that uses Fisher rat thyroid cells
    Carol M Preissner
    Department of Laboratory Medicine and Pathology, Mayo Clinic, 200 1st Street S W, Rochester, MN 55905
    Clin Chem 49:1402-4. 2003
  23. ncbi request reprint Mild cognitive impairment as a clinical entity and treatment target
    Ronald C Petersen
    Alzheimer s Disease Research Center, Mayo Clinic College of Medicine, Rochester, Minn 55905, USA
    Arch Neurol 62:1160-3; discussion 1167. 2005
  24. pmc The Impact of Subclinical Disease and Mechanism of Detection on the Rise in Thyroid Cancer Incidence: A Population-Based Study in Olmsted County, Minnesota During 1935 Through 2012
    Juan P Brito
    1 Division of Diabetes, Endocrinology, Metabolism, and Nutrition, Department of Medicine, Mayo Clinic, Rochester, Minnesota
    Thyroid 25:999-1007. 2015
    ..An ongoing epidemic of thyroid carcinoma (TC) has affected Americans since 1975. Understanding the contribution of subclinical disease and the mechanism of such disease detection may help to alter the course of this epidemic...
  25. doi request reprint Restricting ultrasound thyroid fine needle aspiration biopsy by nodule size: which tumors are we missing? A population-based study
    Juan P Brito
    Division of Endocrinology, Diabetes, Metabolism and Nutrition, Department of Medicine and Knowledge and Evaluation Research Unit, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA
    Endocrine 51:499-505. 2016
    ..Thus, if further discrimination is desired, for example, to avoid overdiagnosis, features other than size at presentation need to be evaluated. ..
  26. doi request reprint Low risk papillary thyroid cancer
    Juan P Brito
    Division of Endocrinology, Diabetes, Metabolism, and Nutrition, Mayo Clinic, Rochester, MN, USA Knowledge and Evaluation Research Unit, Mayo Clinic, Rochester, MN 55905, USA
    BMJ 348:g3045. 2014
    ....
  27. ncbi request reprint Genetically targeted radiotherapy for multiple myeloma
    David Dingli
    Mayo Clinic and Foundation, Rochester, MN, USA
    Blood 102:489-96. 2003
    ..We conclude that lentivectors can be transcriptionally targeted for myeloma cells and the use of hNIS as a therapeutic gene for myeloma in combination with 131I needs further exploration...
  28. pmc Mild physical impairment predicts future diagnosis of dementia of the Alzheimer's type
    Consuelo H Wilkins
    Division of Geriatrics and Nutritional Science, Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri, USA
    J Am Geriatr Soc 61:1055-9. 2013
    ..To determine whether mildly impaired physical function (based on performance-based assessment) is associated with development of dementia of the Alzheimer's type (DAT) in cognitively normal older adults...
  29. ncbi request reprint Comparison of ultrasound-guided fine-needle aspiration biopsy with core-needle biopsy in the evaluation of thyroid nodules
    Teck Kim Khoo
    Division of Endocrinology and Metabolism, Mayo Clinic, Rochester, Minnesota, USA
    Endocr Pract 14:426-31. 2008
    ..To compare the diagnostic rate of ultra-sound-guided fine-needle aspiration biopsy (FNAB) with the diagnostic rate of combined FNAB and core-needle biopsy in the evaluation of nodular thyroid disease...
  30. pmc Serial PIB and MRI in normal, mild cognitive impairment and Alzheimer's disease: implications for sequence of pathological events in Alzheimer's disease
    Clifford R Jack
    Clifford R Jack, Mayo Clinic, Diagnostic Radiology, 200 First Street SW, Rochester, MN 55905, USA
    Brain 132:1355-65. 2009
    ..This model implies a complimentary role for MRI and PIB imaging in Alzheimer's disease, with each reflecting one of the major pathologies, amyloid dysmetabolism and neurodegeneration...
  31. pmc Efficacy of pazopanib in progressive, radioiodine-refractory, metastatic differentiated thyroid cancers: results of a phase 2 consortium study
    Keith C Bible
    Division of Medical Oncology, Mayo Clinic, Rochester, MN, USA
    Lancet Oncol 11:962-72. 2010
    ..We investigated the safety and efficacy of pazopanib...
  32. doi request reprint The Value of Repeat Thyroid Fine-Needle Aspiration Biopsy in Patients with a Previously Benign Result: How Often Does It Alter Management?
    Naykky Singh Ospina
    1 Division of Endocrinology, Diabetes, Metabolism, and Nutrition and Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota
    Thyroid 25:1121-6. 2015
    ..The objective of this study was to evaluate the clinical relevance of a repeat fine-needle aspiration (rFNA) in patients with an initial benign fine-needle aspiration biopsy (iFNA)...
  33. doi request reprint An independent study of a gene expression classifier (Afirma) in the evaluation of cytologically indeterminate thyroid nodules
    Bryan McIver
    Department of Head and Neck, and Endocrine Oncology B M, Moffitt Cancer Center, Tampa, Florida 33612 Division of Endocrinology M R C, J C M, L K, Mayo Clinic, Rochester, Minnesota 55905 Division of Endocrinology V B, R S, Mayo Clinic, Jacksonville, Florida 32216 Department of Surgical Pathology M H, Mayo Clinic, Rochester, Minnesota 55905 and Prevention Genetics H R, Marshfield, Wisconsin 54449
    J Clin Endocrinol Metab 99:4069-77. 2014
    ..However, there are currently no independent studies of the performance of this assay...
  34. pmc A multicenter phase 2 trial of pazopanib in metastatic and progressive medullary thyroid carcinoma: MC057H
    Keith C Bible
    Division of Medical Oncology K C B, J R M, J R, K S, J K B, K P W, C R I, C E, Division of Biomedical Statistics and Informatics V J S, Division of Endocrinology J C M, B M, I H, V F, Mayo Clinic, Rochester, Minnesota 55905 Division of Endocrinology R C S, Division of Medical Oncology W J M, M E M, C B, Mayo Clinic Florida, Jacksonville, Florida 32224 Division of Medical Oncology N K, Mayo Clinic Arizona, Scottsdale, Arizona 85259 Carbone Cancer Center A M T, University of Wisconsin, Madison Wisconsin 53705 Minnesota Oncology Hematology P J F, PA, Minneapolis, Minnesota 55407 National University Hospital C G, Singapore 119228 and Cancer Therapy Evaluation Program P H, National Cancer Institute, Bethesda, Maryland 20892
    J Clin Endocrinol Metab 99:1687-93. 2014
    ....
  35. ncbi request reprint Thyrotropin-axis adaptation in aging and chronic disease
    Marius Stan
    Division of Endocrinology, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA
    Endocrinol Metab Clin North Am 34:973-92, x. 2005
  36. pmc In vivo thyroid vibro-acoustography: a pilot study
    Azra Alizad
    Department of Physiology and Biomedical Engineering, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    BMC Med Imaging 13:12. 2013
    ..The purpose of this study was to evaluate the utility of a noninvasive ultrasound-based method, vibro-acoustography (VA), for thyroid imaging and determine the feasibility and challenges of VA in detecting nodules in thyroid...
  37. pmc Predictors of malignancy in patients with cytologically suspicious thyroid nodules
    M Regina Castro
    Division of Endocrinology and Metabolism, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55905, USA
    Thyroid 21:1191-8. 2011
    ..We aimed to identify clinical predictors of malignancy in the subset of patients with suspicious FNA cytology...
  38. pmc The accuracy of thyroid nodule ultrasound to predict thyroid cancer: systematic review and meta-analysis
    Juan P Brito
    Departments of Diabetes, Metabolism, and Nutrition J P B, M N S, J C M, V M M, Pediatric Endocrinology and Metabolism A A N, and Radiology C R, M C, Knowledge and Evaluation Research Unit J P B, M R G, K R B, A L L, T A E, L J P, M H M, V M M, Mayo Graduate School M R G, and Division of Preventive Medicine M H M, Mayo Clinic, Rochester, Minnesota 55905
    J Clin Endocrinol Metab 99:1253-63. 2014
    ..Significant uncertainty remains surrounding the diagnostic accuracy of sonographic features used to predict the malignant potential of thyroid nodules...
  39. pmc Interleukin-15 biology and its therapeutic implications in cancer
    Jason C Steel
    Division of Hematology Oncology, Department of Internal Medicine, University of Cincinnati, Cincinnati, OH 45267 0562, USA
    Trends Pharmacol Sci 33:35-41. 2012
    ..We also discuss preclinical models in which IL-15 has demonstrated antitumor activity and highlight ongoing clinical trials of IL-15 in patients with cancer and HIV infection...
  40. ncbi request reprint Phantoms in the assay tube: heterophile antibody interferences in serum thyroglobulin assays
    Carol M Preissner
    Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Clin Endocrinol Metab 88:3069-74. 2003
    ..Unless a Tg assay is confirmed to be free of HAB interference or uses additional blocking steps, as ours now does, HAB interference should be suspected if Tg results do not fit the clinical picture...