Meghan E McGee-Lawrence

Summary

Affiliation: Mayo Clinic
Country: USA

Publications

  1. pmc Histone deacetylases in skeletal development and bone mass maintenance
    Meghan E McGee-Lawrence
    Mayo Clinic, Rochester, MN 55905, USA
    Gene 474:1-11. 2011
  2. pmc Runx2 protein represses Axin2 expression in osteoblasts and is required for craniosynostosis in Axin2-deficient mice
    Meghan E McGee-Lawrence
    Mayo Clinic, Rochester, Minnesota 55905, USA
    J Biol Chem 288:5291-302. 2013
  3. pmc Runx2 is required for early stages of endochondral bone formation but delays final stages of bone repair in Axin2-deficient mice
    Meghan E McGee-Lawrence
    Mayo Clinic, Rochester, MN, USA
    Bone 66:277-86. 2014
  4. pmc Suberoylanilide hydroxamic acid (SAHA; vorinostat) causes bone loss by inhibiting immature osteoblasts
    Meghan E McGee-Lawrence
    Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Bone 48:1117-26. 2011
  5. pmc Hdac-mediated control of endochondral and intramembranous ossification
    Elizabeth W Bradley
    Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Crit Rev Eukaryot Gene Expr 21:101-13. 2011
  6. pmc Sclerostin deficient mice rapidly heal bone defects by activating β-catenin and increasing intramembranous ossification
    Meghan E McGee-Lawrence
    Department of Orthopedic Surgery, Mayo Clinic College of Medicine, Mayo Clinic, 200 1st St, Southwest, Rochester, MN 55905, USA
    Biochem Biophys Res Commun 441:886-90. 2013
  7. pmc Histone deacetylase 3 is required for maintenance of bone mass during aging
    Meghan E McGee-Lawrence
    Department of Orthopedic Surgery Orthopedic Research, Mayo Clinic, Rochester, MN 55905, USA
    Bone 52:296-307. 2013
  8. pmc Histone deacetylase inhibition destabilizes the multi-potent state of uncommitted adipose-derived mesenchymal stromal cells
    Amel Dudakovic
    Department of Orthopedic Surgery, Mayo Clinic, Rochester, Minnesota
    J Cell Physiol 230:52-62. 2015
  9. pmc Update on Wnt signaling in bone cell biology and bone disease
    David G Monroe
    Department of Medicine Endocrine Research Unit, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Gene 492:1-18. 2012
  10. pmc Histone Deacetylases in Bone Development and Skeletal Disorders
    Elizabeth W Bradley
    Mayo Clinic, Departments of Orthopedic Surgery and of Biochemistry and Molecular Biology, and Mayo Graduate School, Rochester, Minnesota and Georgia Regents University, Department of Cellular Biology and Anatomy, Augusta, Georgia
    Physiol Rev 95:1359-81. 2015

Collaborators

Detail Information

Publications18

  1. pmc Histone deacetylases in skeletal development and bone mass maintenance
    Meghan E McGee-Lawrence
    Mayo Clinic, Rochester, MN 55905, USA
    Gene 474:1-11. 2011
    ..Here we review the progress that has been made in the last decade in understanding how Hdacs contribute to bone development and maintenance...
  2. pmc Runx2 protein represses Axin2 expression in osteoblasts and is required for craniosynostosis in Axin2-deficient mice
    Meghan E McGee-Lawrence
    Mayo Clinic, Rochester, Minnesota 55905, USA
    J Biol Chem 288:5291-302. 2013
    ....
  3. pmc Runx2 is required for early stages of endochondral bone formation but delays final stages of bone repair in Axin2-deficient mice
    Meghan E McGee-Lawrence
    Mayo Clinic, Rochester, MN, USA
    Bone 66:277-86. 2014
    ..Taken together, our data demonstrate a dominant role for Runx2 in chondrocyte maturation, but implicate Axin2 as an important modulator of the terminal stages of endochondral bone formation. ..
  4. pmc Suberoylanilide hydroxamic acid (SAHA; vorinostat) causes bone loss by inhibiting immature osteoblasts
    Meghan E McGee-Lawrence
    Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Bone 48:1117-26. 2011
    ..These studies suggest that clinical use of SAHA and other Hdac inhibitors to treat cancer, epilepsy or other conditions may potentially compromise skeletal structure and function...
  5. pmc Hdac-mediated control of endochondral and intramembranous ossification
    Elizabeth W Bradley
    Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Crit Rev Eukaryot Gene Expr 21:101-13. 2011
    ..In this review, we summarize the roles of class I and class II Hdacs in chondrocytes and osteoblasts. The effects of small molecule Hdac inhibitors on the skeleton are also discussed...
  6. pmc Sclerostin deficient mice rapidly heal bone defects by activating β-catenin and increasing intramembranous ossification
    Meghan E McGee-Lawrence
    Department of Orthopedic Surgery, Mayo Clinic College of Medicine, Mayo Clinic, 200 1st St, Southwest, Rochester, MN 55905, USA
    Biochem Biophys Res Commun 441:886-90. 2013
    ....
  7. pmc Histone deacetylase 3 is required for maintenance of bone mass during aging
    Meghan E McGee-Lawrence
    Department of Orthopedic Surgery Orthopedic Research, Mayo Clinic, Rochester, MN 55905, USA
    Bone 52:296-307. 2013
    ..Osteoblasts and osteocytes from Hdac3 CKO(OCN) mice showed increased DNA damage and reduced functional activity in vivo and in vitro. Thus, Hdac3 expression in osteoblasts and osteocytes is essential for bone maintenance during aging...
  8. pmc Histone deacetylase inhibition destabilizes the multi-potent state of uncommitted adipose-derived mesenchymal stromal cells
    Amel Dudakovic
    Department of Orthopedic Surgery, Mayo Clinic, Rochester, Minnesota
    J Cell Physiol 230:52-62. 2015
    ..Furthermore, AMSCs grown in platelet lysate may provide a useful biological model for screening of new HDAC inhibitors that control the biological fate of human mesenchymal stromal cells...
  9. pmc Update on Wnt signaling in bone cell biology and bone disease
    David G Monroe
    Department of Medicine Endocrine Research Unit, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Gene 492:1-18. 2012
    ..Emphasis is placed on the plethora of genetic studies in mouse models and genome wide association studies that reveal the requirement for and crucial roles of Wnt pathway components during skeletal development and disease...
  10. pmc Histone Deacetylases in Bone Development and Skeletal Disorders
    Elizabeth W Bradley
    Mayo Clinic, Departments of Orthopedic Surgery and of Biochemistry and Molecular Biology, and Mayo Graduate School, Rochester, Minnesota and Georgia Regents University, Department of Cellular Biology and Anatomy, Augusta, Georgia
    Physiol Rev 95:1359-81. 2015
    ..g., osteoblasts and chondrocytes) and bone resorbing osteoclasts. Finally, we offer predictions on future research in this area and the utility of this knowledge for orthopedic applications and bone tissue engineering. ..
  11. pmc Histone deacetylase 3 depletion in osteo/chondroprogenitor cells decreases bone density and increases marrow fat
    David F Razidlo
    Department of Orthopedic Surgery, Mayo Clinic, Rochester, Minnesota, United States of America
    PLoS ONE 5:e11492. 2010
    ..Thus, Hdac3 depletion in osterix-expressing progenitor cells interferes with bone formation and promotes bone marrow adipocyte differentiation. These results demonstrate that Hdac3 inhibition is detrimental to skeletal health...
  12. pmc Hdac3 Deficiency Increases Marrow Adiposity and Induces Lipid Storage and Glucocorticoid Metabolism in Osteochondroprogenitor Cells
    Meghan E McGee-Lawrence
    Department of Orthopedic Surgery, Mayo Clinic, Rochester, MN, USA
    J Bone Miner Res 31:116-28. 2016
    ..2015 American Society for Bone and Mineral Research. ..
  13. pmc Deletion of Estrogen Receptor Beta in Osteoprogenitor Cells Increases Trabecular but Not Cortical Bone Mass in Female Mice
    Kristy M Nicks
    Mayo Clinic College of Medicine, Rochester, MN, USA
    J Bone Miner Res 31:606-14. 2016
    ..These findings suggest that pharmacological inhibition of ERβ in bone may provide a novel approach to treat osteoporosis. © 2015 American Society for Bone and Mineral Research. ..
  14. pmc RUNX3 facilitates growth of Ewing sarcoma cells
    Krista L Bledsoe
    Mayo Graduate School, Mayo Clinic, Rochester, Minnesota
    J Cell Physiol 229:2049-56. 2014
    ..These results demonstrate an important role for RUNX3 in Ewing sarcoma...
  15. pmc Thirteen-lined ground squirrels (Ictidomys tridecemlineatus) show microstructural bone loss during hibernation but preserve bone macrostructural geometry and strength
    Meghan E McGee-Lawrence
    Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    J Exp Biol 214:1240-7. 2011
    ....
  16. pmc Conditional deletion of Hdac3 in osteoprogenitor cells attenuates diet-induced systemic metabolic dysfunction
    Meghan E McGee-Lawrence
    Mayo Clinic, Rochester, MN, United States Electronic address
    Mol Cell Endocrinol 410:42-51. 2015
    ..Thus, Hdac3 is a new player in the emerging paradigm that the skeleton influences systemic energy metabolism. ..
  17. pmc Aberrant bone density in aging mice lacking the adenosine transporter ENT1
    David J Hinton
    Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic College of Medicine, Rochester, Minnesota, United States of America Neurobiology of Disease Program, Mayo Clinic College of Medicine, Rochester, Minnesota, United States of America
    PLoS ONE 9:e88818. 2014
    ..Overall, our study suggests that ENT1-regulated adenosine signaling plays an essential role in lumbar spine and femur bone density. ..
  18. pmc The Ewing's sarcoma fusion protein, EWS-FLI, binds Runx2 and blocks osteoblast differentiation
    Xiaodong Li
    Mayo Clinic, Rochester, Minnesota 55905, USA
    J Cell Biochem 111:933-43. 2010
    ..These results demonstrate that EWS-FLI blocks the ability of Runx2 to induce osteoblast specification of a mesenchymal progenitor cell. Disrupting interactions between Runx2 and EWS-FLI1 may promote differentiation of the tumor cell...