Mary M Machulda

Summary

Affiliation: Mayo Clinic
Country: USA

Publications

  1. ncbi request reprint Mayo's Older Americans Normative Studies: Visual Form Discrimination and copy trial of the Rey-Osterrieth Complex Figure
    M M Machulda
    Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MN 55905, USA
    J Clin Exp Neuropsychol 29:377-84. 2007
  2. pmc Identification of an atypical variant of logopenic progressive aphasia
    Mary M Machulda
    Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MN, United States Electronic address
    Brain Lang 127:139-44. 2013
  3. pmc Functional magnetic resonance imaging changes in amnestic and nonamnestic mild cognitive impairment during encoding and recognition tasks
    Mary M Machulda
    Department of Psychiatry and Psychology, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Int Neuropsychol Soc 15:372-82. 2009
  4. pmc Effect of APOE ε4 status on intrinsic network connectivity in cognitively normal elderly subjects
    Mary M Machulda
    Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MN 55905, USA
    Arch Neurol 68:1131-6. 2011
  5. pmc Clinical and MRI models predicting amyloid deposition in progressive aphasia and apraxia of speech
    Jennifer L Whitwell
    Department of Radiology, Mayo Clinic, Rochester, MN, USA
    Neuroimage Clin 11:90-8. 2016
  6. pmc Elevated occipital β-amyloid deposition is associated with widespread cognitive impairment in logopenic progressive aphasia
    Jennifer L Whitwell
    Department of Radiology, Mayo Clinic, Rochester, Minnesota, USA
    J Neurol Neurosurg Psychiatry 84:1357-64. 2013
  7. pmc Influence of amyloid and APOE on cognitive performance in a late middle-aged cohort
    Michelle M Mielke
    Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA Department of Neurology, Mayo Clinic, Rochester, MN, USA Electronic address
    Alzheimers Dement 12:281-91. 2016
  8. doi request reprint Characterizing White Matter Tract Degeneration in Syndromic Variants of Alzheimer's Disease: A Diffusion Tensor Imaging Study
    Ajay Madhavan
    Department of Radiology, Mayo Clinic, Rochester, MN, USA
    J Alzheimers Dis 49:633-43. 2016
  9. pmc Transition rates between amyloid and neurodegeneration biomarker states and to dementia: a population-based, longitudinal cohort study
    Clifford R Jack
    Department of Radiology, Mayo Clinic and Foundation, Rochester, MN, USA Electronic address
    Lancet Neurol 15:56-64. 2016
  10. pmc Association of Elevated Amyloid Levels With Cognition and Biomarkers in Cognitively Normal People From the Community
    Ronald C Petersen
    Department of Neurology, Mayo Clinic and Foundation, Rochester, Minnesota2Department of Health Sciences Research, Mayo Clinic and Foundation, Rochester, Minnesota
    JAMA Neurol 73:85-92. 2016

Collaborators

Detail Information

Publications69

  1. ncbi request reprint Mayo's Older Americans Normative Studies: Visual Form Discrimination and copy trial of the Rey-Osterrieth Complex Figure
    M M Machulda
    Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MN 55905, USA
    J Clin Exp Neuropsychol 29:377-84. 2007
    ..Limitations and unique features of the MOANS normative data are also discussed...
  2. pmc Identification of an atypical variant of logopenic progressive aphasia
    Mary M Machulda
    Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MN, United States Electronic address
    Brain Lang 127:139-44. 2013
    ..The mild atypical group also showed mild neuropsychological impairment. The subjects with mild aphasia and neuropsychological impairment despite long disease duration may represent a slowly progressive variant of lvPPA. ..
  3. pmc Functional magnetic resonance imaging changes in amnestic and nonamnestic mild cognitive impairment during encoding and recognition tasks
    Mary M Machulda
    Department of Psychiatry and Psychology, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Int Neuropsychol Soc 15:372-82. 2009
    ..The diminished parietal and frontal activation in naMCI may reflect compromised ability to perform nonmemory (i.e., attention/executive, visuospatial function) components of the task...
  4. pmc Effect of APOE ε4 status on intrinsic network connectivity in cognitively normal elderly subjects
    Mary M Machulda
    Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MN 55905, USA
    Arch Neurol 68:1131-6. 2011
    ..To examine default mode and salience network functional connectivity as a function of APOE ε4 status in a group of cognitively normal age-, sex-, and education-matched older adults...
  5. pmc Clinical and MRI models predicting amyloid deposition in progressive aphasia and apraxia of speech
    Jennifer L Whitwell
    Department of Radiology, Mayo Clinic, Rochester, MN, USA
    Neuroimage Clin 11:90-8. 2016
    ....
  6. pmc Elevated occipital β-amyloid deposition is associated with widespread cognitive impairment in logopenic progressive aphasia
    Jennifer L Whitwell
    Department of Radiology, Mayo Clinic, Rochester, Minnesota, USA
    J Neurol Neurosurg Psychiatry 84:1357-64. 2013
    ....
  7. pmc Influence of amyloid and APOE on cognitive performance in a late middle-aged cohort
    Michelle M Mielke
    Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA Department of Neurology, Mayo Clinic, Rochester, MN, USA Electronic address
    Alzheimers Dement 12:281-91. 2016
    ..Few studies have examined the effects of amyloid and apolipoprotein E (APOE) genotype on cognition among middle-aged individuals...
  8. doi request reprint Characterizing White Matter Tract Degeneration in Syndromic Variants of Alzheimer's Disease: A Diffusion Tensor Imaging Study
    Ajay Madhavan
    Department of Radiology, Mayo Clinic, Rochester, MN, USA
    J Alzheimers Dis 49:633-43. 2016
    ..Different clinical syndromes can arise from Alzheimer's disease (AD) neuropathology, including dementia of the Alzheimer's type (DAT), logopenic primary progressive aphasia (lvPPA), and posterior cortical atrophy (PCA)...
  9. pmc Transition rates between amyloid and neurodegeneration biomarker states and to dementia: a population-based, longitudinal cohort study
    Clifford R Jack
    Department of Radiology, Mayo Clinic and Foundation, Rochester, MN, USA Electronic address
    Lancet Neurol 15:56-64. 2016
    ..In this longitudinal study, we aimed to estimate rates of transition from a less to a more abnormal biomarker state by age in individuals without dementia, as well as to assess rates of transition to dementia from an abnormal state...
  10. pmc Association of Elevated Amyloid Levels With Cognition and Biomarkers in Cognitively Normal People From the Community
    Ronald C Petersen
    Department of Neurology, Mayo Clinic and Foundation, Rochester, Minnesota2Department of Health Sciences Research, Mayo Clinic and Foundation, Rochester, Minnesota
    JAMA Neurol 73:85-92. 2016
    ..The presence of amyloid has become a prerequisite for enrollment in several secondary prevention trials for AD, yet the precise effect of elevated amyloid levels on subsequent clinical and biomarker events is less certain...
  11. pmc Practice effects and longitudinal cognitive change in normal aging vs. incident mild cognitive impairment and dementia in the Mayo Clinic Study of Aging
    Mary M Machulda
    a Department of Psychiatry and Psychology, College of Medicine, Mayo Clinic, Rochester, MN, USA
    Clin Neuropsychol 27:1247-64. 2013
    ..Modeling cognitive change in an epidemiologic sample may serve as a useful benchmark for evaluating cognitive change in future intervention studies. ..
  12. pmc Microbleeds in the logopenic variant of primary progressive aphasia
    Jennifer L Whitwell
    Department of Radiology, Mayo Clinic, Rochester, MN, USA Electronic address
    Alzheimers Dement 10:62-6. 2014
    ..We aimed to assess the presence and clinical correlates of microbleeds in lvPPA...
  13. pmc Distinct regional anatomic and functional correlates of neurodegenerative apraxia of speech and aphasia: an MRI and FDG-PET study
    Jennifer L Whitwell
    Department of Radiology, Mayo Clinic, Rochester, MN 55905, USA
    Brain Lang 125:245-52. 2013
    ..Progressive agrammatic aphasia and AOS have non-overlapping regional correlations, suggesting that these are dissociable clinical features that have different neuroanatomical underpinnings...
  14. pmc Syndromes dominated by apraxia of speech show distinct characteristics from agrammatic PPA
    Keith A Josephs
    Department of Neurology Behavioral Neurology, Mayo Clinic, Rochester, MN, USA
    Neurology 81:337-45. 2013
    ..We assessed whether clinical and imaging features of subjects with apraxia of speech (AOS) more severe than aphasia (dominant AOS) are more similar to agrammatic primary progressive aphasia (agPPA) or to primary progressive AOS (PPAOS)...
  15. pmc Association Between Olfactory Dysfunction and Amnestic Mild Cognitive Impairment and Alzheimer Disease Dementia
    Rosebud O Roberts
    Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota2Department of Neurology, Mayo Clinic, Rochester, Minnesota
    JAMA Neurol 73:93-101. 2016
    ..Olfactory impairment may be an important clinical marker and predictor of these conditions and may help identify persons at increased risk...
  16. pmc Head trauma and in vivo measures of amyloid and neurodegeneration in a population-based study
    Michelle M Mielke
    From the Divisions of Epidemiology M M Mielke, R O R, R C P, Y E G and Biomedical Statistics and Informatics H J W, S D W, Department of Health Sciences Research Departments of Neurology R S, D S K, R O R, R C P, Psychiatry and Psychology M M Machulda, and Radiology P V, V J L, C R J, Mayo Clinic, Rochester, MN and Departments of Psychiatry, Psychology, and Neurology Y E G, Mayo Clinic, Scottsdale, AZ
    Neurology 82:70-6. 2014
    ..We determined whether head trauma was associated with amyloid deposition and neurodegeneration among individuals who were cognitively normal (CN) or had mild cognitive impairment (MCI)...
  17. pmc Evolution of neurodegeneration-imaging biomarkers from clinically normal to dementia in the Alzheimer disease spectrum
    David S Knopman
    Department of Neurology, Mayo Clinic and Foundation, Rochester, MN, USA Mayo Clinic Alzheimer s Disease Research Center, Mayo Clinic and Foundation, Rochester, MN, USA Electronic address
    Neurobiol Aging 46:32-42. 2016
    ..Expansion of regional involvement and faster rate of neurodegeneration characterizes progression in the AD pathway. ..
  18. pmc Defining imaging biomarker cut points for brain aging and Alzheimer's disease
    Clifford R Jack
    Department of Radiology, Mayo Clinic, Rochester, MN, USA Electronic address
    Alzheimers Dement . 2016
    ..Our goal was to develop cut points for amyloid positron emission tomography (PET), tau PET, flouro-deoxyglucose (FDG) PET, and MRI cortical thickness...
  19. pmc Age and neurodegeneration imaging biomarkers in persons with Alzheimer disease dementia
    David S Knopman
    From the Departments of Neurology D S K, P V, M M Mielke, R O R, B F B, D T J, R C P and Radiology C R J, V J L, K K, J L G, M L S, D T J, Mayo Clinic Alzheimer s Disease Research Center D S K, C R J, B F B, D T J, R C P, Division of Biomedical Statistics and Informatics, Department of Health Sciences Research H J W, S D W, Division of Epidemiology, Department of Health Sciences Research M M Mielke, R O R, R C P, and Department of Psychiatry, Division of Psychology M M Machulda, Mayo Clinic and Foundation, Rochester, MN
    Neurology 87:691-8. 2016
    ..To examine neurodegenerative imaging biomarkers in Alzheimer disease (AD) dementia from middle to old age...
  20. pmc Multimorbidity and neuroimaging biomarkers among cognitively normal persons
    Maria Vassilaki
    From the Departments of Health Sciences Research M V, J A A, M M Mielke, Y E G, W K K, R C P, R O R and Neurology M M Mielke, Y E G, R E A, D S K, R C P, R O R, Mayo Clinic, Rochester, MN Departments of Psychiatry and Psychology and Neurology Y E G, Mayo Clinic, Scottsdale, AZ Mayo Clinic Graduate School of Medicine R E A, Rochester, MN and Departments of Psychiatry and Psychology M M Machulda and Radiology V J L, C R J, Mayo Clinic, Rochester, MN
    Neurology 86:2077-84. 2016
    ..To assess the cross-sectional association between multimorbidity and imaging biomarkers of brain pathology in the population-based Mayo Clinic Study of Aging (MCSA)...
  21. pmc Role of β-Amyloidosis and Neurodegeneration in Subsequent Imaging Changes in Mild Cognitive Impairment
    David S Knopman
    Department of Neurology, Mayo Clinic and Foundation, Rochester, Minnesota2Mayo Clinic Alzheimer s Disease Research Center, Mayo Clinic and Foundation, Rochester, Minnesota
    JAMA Neurol 72:1475-83. 2015
    ..To understand how a model of Alzheimer disease pathophysiology based on β-amyloidosis and neurodegeneration predicts the regional anatomic expansion of hypometabolism and atrophy in persons with mild cognitive impairment (MCI)...
  22. pmc Classification and clinicoradiologic features of primary progressive aphasia (PPA) and apraxia of speech
    Hugo Botha
    Department of Neurology Behavioural Neurology, Mayo Clinic, Rochester, MN, USA
    Cortex 69:220-36. 2015
    ..Our findings support consideration of an alternative way of identifying and categorizing subtypes of degenerative speech and language disorders. ..
  23. pmc Sample size calculations for clinical trials targeting tauopathies: a new potential disease target
    Jennifer L Whitwell
    Department of Radiology, Mayo Clinic, Rochester, MN, 55905, USA
    J Neurol 262:2064-72. 2015
    ..The small sample size estimates demonstrate feasibility for including progressive apraxia of speech in future clinical treatment trials targeting tau...
  24. pmc Working memory and language network dysfunctions in logopenic aphasia: a task-free fMRI comparison with Alzheimer's dementia
    Jennifer L Whitwell
    Department of Radiology, Mayo Clinic, Rochester, MN, USA Electronic address
    Neurobiol Aging 36:1245-52. 2015
    ..Patterns of network dysfunction differ across these 2 clinical variants of Alzheimer's disease, with lvPPA particularly associated with disruptions in the language and left working memory networks. ..
  25. pmc FDG PET and MRI in logopenic primary progressive aphasia versus dementia of the Alzheimer's type
    Ajay Madhavan
    Department of Radiology, Mayo Clinic, Rochester, Minnesota, United States of America
    PLoS ONE 8:e62471. 2013
    ....
  26. pmc Tau-PET uptake: Regional variation in average SUVR and impact of amyloid deposition
    Prashanthi Vemuri
    Department of Radiology, Mayo Clinic, Rochester, MN, USA
    Alzheimers Dement (Amst) 6:21-30. 2017
    ..e., amyloid sensitive) tau-PET changes in individuals aged 50+ years...
  27. pmc Decline in Weight and Incident Mild Cognitive Impairment: Mayo Clinic Study of Aging
    Rabe E Alhurani
    Mayo Clinic Graduate School of Medicine, Rochester, Minnesota2Department of Neurology, Mayo Clinic, Rochester, Minnesota
    JAMA Neurol 73:439-46. 2016
    ..Because mild cognitive impairment (MCI) is a prodromal stage for dementia, we sought to evaluate whether changes in weight and body mass index (BMI) may predict incident MCI...
  28. pmc FDG-PET and Neuropsychiatric Symptoms among Cognitively Normal Elderly Persons: The Mayo Clinic Study of Aging
    Janina Krell-Roesch
    Mayo Clinic Translational Neuroscience and Aging Program, Mayo Clinic, Scottsdale, AZ, USA
    J Alzheimers Dis 53:1609-16. 2016
    ..These findings indicate that NPS, even in community-based samples, can be an important additional tool to the biomarker-based investigation of presymptomatic AD. ..
  29. pmc [Formula: see text]Practice effects and longitudinal cognitive change in clinically normal older adults differ by Alzheimer imaging biomarker status
    Mary M Machulda
    a Division of Neurocognitive Disorders, Department of Psychiatry and Psychology, College of Medicine, Mayo Clinic, Rochester, MN, USA
    Clin Neuropsychol 31:99-117. 2017
    ..The objective of this study was to examine practice effects and longitudinal cognitive change in 190 clinically normal elderly classified according to a two-feature biomarker model for Alzheimer's disease...
  30. pmc Tracking the development of agrammatic aphasia: A tensor-based morphometry study
    Jennifer L Whitwell
    Department of Radiology, Mayo Clinic, Rochester, MN, USA Electronic address
    Cortex . 2016
    ..Clinical and neuroimaging abnormalities were also present before the onset of agrammatism that could help improve prognosis in these subjects...
  31. ncbi request reprint Varying Degrees of Temporoparietal Hypometabolism on FDG-PET Reveal Amyloid-Positive Logopenic Primary Progressive Aphasia is not a Homogeneous Clinical Entity
    Kamini Krishnan
    Department of Psychiatry and Psychology Neuropsychology, Mayo Clinic, Rochester, MN, USA
    J Alzheimers Dis 55:1019-1029. 2017
    ..LvPPA is strongly associated with amyloid deposition, yet there is question as to whether it is a homogeneous clinical entity...
  32. pmc Different definitions of neurodegeneration produce similar amyloid/neurodegeneration biomarker group findings
    Clifford R Jack
    1 Department of Radiology, Mayo Clinic and Foundation, 200 First Street SW, Rochester, MN 55905, USA
    Brain 138:3747-59. 2015
    ....
  33. pmc APOE ε4 influences β-amyloid deposition in primary progressive aphasia and speech apraxia
    Keith A Josephs
    Division of Behavioral Neurology, Department of Neurology, Mayo Clinic, Rochester, MN, USA Division of Movement Disorders, Department of Neurology, Mayo Clinic, Rochester, MN, USA Electronic address
    Alzheimers Dement 10:630-6. 2014
    ..Apolipoprotein E ε4 (APOE ε4) is a risk factor for β-amyloid deposition in Alzheimer's disease dementia. Its influence on β-amyloid deposition in speech and language disorders, including primary progressive aphasia (PPA), is unclear...
  34. pmc Dominant frontotemporal dementia mutations in 140 cases of primary progressive aphasia and speech apraxia
    Eoin P Flanagan
    Division of Behavioral Neurology, Mayo Clinic, Rochester, Minn, USA
    Dement Geriatr Cogn Disord 39:281-6. 2015
    ..Progressive apraxia of speech (PAOS) is a type of FTD characterized by speech production deficits without a known cause...
  35. doi request reprint Microbleeds in atypical presentations of Alzheimer's disease: a comparison to dementia of the Alzheimer's type
    Jennifer L Whitwell
    Department of Radiology, Mayo Clinic, Rochester, MN, USA
    J Alzheimers Dis 45:1109-17. 2015
    ..However, little is known about the frequency or distribution of microbleeds in subjects with AD that present with atypical clinical presentations...
  36. pmc Clinical and neuroimaging biomarkers of amyloid-negative logopenic primary progressive aphasia
    Jennifer L Whitwell
    Department of Radiology, Mayo Clinic, Rochester, MN, United States Electronic address
    Brain Lang 142:45-53. 2015
    ..There was very little evidence for clinical differences between the groups. Strikingly asymmetric neuroimaging findings with relatively preserved right hemisphere may provide clues that AD pathology is absent in lvPPA. ..
  37. pmc MRI and MRS predictors of mild cognitive impairment in a population-based sample
    Kejal Kantarci
    Department of Radiology, Mayo Clinic, Rochester, MN, USA
    Neurology 81:126-33. 2013
    ..To investigate MRI and proton magnetic resonance spectroscopy (MRS) predictors of mild cognitive impairment (MCI) in cognitively normal older adults...
  38. pmc Mediterranean diet, micronutrients and macronutrients, and MRI measures of cortical thickness
    Sara C Staubo
    Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA Charles University in Prague, Faculty in Hradec Králové, Hradec Kralove, Czech Republic
    Alzheimers Dement . 2016
    ..The Mediterranean diet (MeDi) is associated with reduced risk of cognitive impairment, but it is unclear whether it is associated with better brain imaging biomarkers...
  39. doi request reprint Excessive daytime sleepiness and fatigue may indicate accelerated brain aging in cognitively normal late middle-aged and older adults
    Diego Z Carvalho
    Department of Neurology, Mayo Clinic, Rochester, MN, USA
    Sleep Med . 2016
    ..5 and 9 additional years of aging, respectively. EDS and fatigue were associated with cortical thickness reduction primarily in regions with increased age-susceptibility, which may indicate accelerated brain aging...
  40. pmc Vascular and amyloid pathologies are independent predictors of cognitive decline in normal elderly
    Prashanthi Vemuri
    1 Department of Radiology, Mayo Clinic, 200 First Street SW, Rochester, MN, USA
    Brain 138:761-71. 2015
    ....
  41. pmc White matter integrity determined with diffusion tensor imaging in older adults without dementia: influence of amyloid load and neurodegeneration
    Kejal Kantarci
    Department of Radiology, Mayo Clinic, Rochester, Minnesota
    JAMA Neurol 71:1547-54. 2014
    ....
  42. pmc Independent comparison of CogState computerized testing and a standard cognitive battery with neuroimaging
    Michelle M Mielke
    Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA Department of Neurology, Mayo Clinic, Rochester, MN, USA Electronic address
    Alzheimers Dement 10:779-89. 2014
    ..Inexpensive, non-invasive tools for assessing Alzheimer-type pathophysiologies are needed. Computerized cognitive assessments are prime candidates...
  43. pmc Quantitative application of the primary progressive aphasia consensus criteria
    Meredith R Wicklund
    From the Division of Behavioral Neurology M R W, K A J, Speech Pathology, Department of Neurology J R D, E A S, Division of Neurocognitive Disorders, Department of Psychiatry and Psychology M M M, and Division of Radiology Research, Department of Radiology J L W, Mayo Clinic, Rochester, MN
    Neurology 82:1119-26. 2014
    ..To determine how well the consensus criteria could classify subjects with primary progressive aphasia (PPA) using a quantitative speech and language battery that matches the test descriptions provided by the consensus criteria...
  44. pmc Occupational differences between Alzheimer's and aphasic dementias: implication for teachers
    Keith A Josephs
    Department of Neurology Behavioral Neurology, Mayo Clinic, Rochester, MN 55905, USA
    Am J Alzheimers Dis Other Demen 28:612-6. 2013
    ..We identified an association between progressive SLDs and the occupation of teaching. Since teaching is a communication demanding occupation, teachers may be more sensitive to the development of speech and language impairments. ..
  45. pmc Progranulin-associated PiB-negative logopenic primary progressive aphasia
    Keith A Josephs
    Department of Neurology Division of Behavioral Neurology, Mayo Clinic, Rochester, MN, USA
    J Neurol 261:604-14. 2014
    ..Identification of such patients, however, should prompt testing for GRN mutations, since GRN-positive patients do not have distinctive features, yet account for 50 % of this patient population...
  46. pmc Performance of the CogState computerized battery in the Mayo Clinic Study on Aging
    Michelle M Mielke
    Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA Department of Neurology, Mayo Clinic, Rochester, MN, USA Electronic address
    Alzheimers Dement 11:1367-76. 2015
    ..The feasibility and validity of brief computerized cognitive batteries at the population-level are unknown...
  47. pmc Spectrum of cognition short of dementia: Framingham Heart Study and Mayo Clinic Study of Aging
    David S Knopman
    From the Department of Neurology, Mayo Alzheimer s Disease Research Center D S K, B F B, R C P, R O R, W A R, Division of Epidemiology, Department of Health Sciences Research R O R, M M Mielke, W A R, R C P, Division of Biostatistics and Bioinformatics, Department of Health Sciences Research V S P, J A, R H C, and Department of Psychiatry and Psychology, Division of Neurocognitive Disorders R J I, M M Machulda, J F, College of Medicine, Mayo Clinic, Rochester, MN and Departments of Neurology A B, S D, R A, S A, P A W, S S and Biostatistics A B, Boston University Schools of Medicine and Public Health, MA
    Neurology 85:1712-21. 2015
    ..To understand the neuropsychological basis of dementia risk among persons in the spectrum including cognitive normality and mild cognitive impairment...
  48. pmc Risk and protective factors for cognitive impairment in persons aged 85 years and older
    Rosebud O Roberts
    From the Divisions of Epidemiology R O R, M M Mielke, Y E G, R C P and Biomedical Statistics and Informatics R H C, Department of Health Sciences Research, the Department of Neurology R O R, B F B, D S K, R C P, and the Department of Psychiatry and Psychology M M Machulda, Mayo Clinic, Rochester, MN and the Departments of Psychiatry and Psychology and Neurology Y E G, Mayo Clinic, Scottsdale, AZ
    Neurology 84:1854-61. 2015
    ..To determine risk and protective factors for mild cognitive impairment (MCI) among persons 85 years and older...
  49. pmc The evolution of primary progressive apraxia of speech
    Keith A Josephs
    1 Department of Neurology Behavioural Neurology, Mayo Clinic, Rochester, MN 55905, USA 2 Department of Neurology Movement Disorders, Mayo Clinic, Rochester, MN 55905, USA
    Brain 137:2783-95. 2014
    ..These findings help improve our understanding of primary progressive apraxia of speech and provide some important prognostic guidelines...
  50. pmc Nonverbal oral apraxia in primary progressive aphasia and apraxia of speech
    Hugo Botha
    From the Departments of Neurology H B, J R D, E A S, K A J, Psychology and Psychiatry M M M, and Radiology J L W, Mayo Clinic, Rochester, MN
    Neurology 82:1729-35. 2014
    ....
  51. pmc Aphasia with left occipitotemporal hypometabolism: a novel presentation of posterior cortical atrophy?
    Meredith R Wicklund
    Division of Behavioral Neurology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    J Clin Neurosci 20:1237-40. 2013
    ..Posterior cortical atrophy may present focally with left occipitotemporal metabolism characterized clinically with a progressive fluent aphasia and prominent ventral visuospatial deficits with loss of insight. ..
  52. pmc Characterizing a neurodegenerative syndrome: primary progressive apraxia of speech
    Keith A Josephs
    Behavioural Neurology and Movement Disorders, Mayo Clinic, 200 1st Street S W, Rochester, MN 55905, USA
    Brain 135:1522-36. 2012
    ..A syndrome characterized by progressive pure apraxia of speech clearly exists, with a neuroanatomic correlate of superior lateral premotor and supplementary motor atrophy, making this syndrome distinct from primary progressive aphasia...
  53. pmc Comparison of Gait Parameters for Predicting Cognitive Decline: The Mayo Clinic Study of Aging
    Rodolfo Savica
    Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA
    J Alzheimers Dis 55:559-567. 2017
    ..However, the predictive value of other gait parameters for cognitive decline is unclear...
  54. pmc Multimorbidity and Risk of Mild Cognitive Impairment
    Maria Vassilaki
    Department of Neurology, Mayo Clinic, Rochester, Minnesota
    J Am Geriatr Soc 63:1783-90. 2015
    ..To determine the association between multiple chronic conditions and risk of incident mild cognitive impairment (MCI) and dementia...
  55. pmc Clinical, FDG and amyloid PET imaging in posterior cortical atrophy
    Tarun D Singh
    Department of Neurology, Mayo Clinic, 200 First St SW, Rochester, MN, USA
    J Neurol 262:1483-92. 2015
    ..Many of the classic features of PCA show associated focal, but not widespread, areas of involvement of these posterior hemispheric regions. Simultanagnosia appears to be the most common and hence sensitive feature of early PCA...
  56. pmc Non-stationarity in the "resting brain's" modular architecture
    David T Jones
    Department of Neurology, Mayo Clinic, Rochester, Minnesota, United States of America
    PLoS ONE 7:e39731. 2012
    ..DMN dwell time in specific modular configurations may also underlie the TF-fMRI findings that have been described in mild cognitive impairment and cognitively normal subjects who are at risk for Alzheimer's dementia...
  57. doi request reprint Neuropsychological Profiles Differ among the Three Variants of Primary Progressive Aphasia
    Alissa M Butts
    1Department of Psychiatry and Psychology Neuropsychology, Mayo Clinic, Rochester, Minnesota
    J Int Neuropsychol Soc 21:429-35. 2015
    ....
  58. pmc Neuropsychiatric symptoms, APOE ε4, and the risk of incident dementia: a population-based study
    Anna Pink
    From Mayo Clinic Translational Neuroscience and Aging Program A P, J K R, J I A, Y E G, and Departments of Psychiatry and Psychology Y E G and Neurology Y E G, Mayo Clinic, Scottsdale, AZ Departments of Neurology M M B, D S K, R C P and Psychiatry and Psychology M M Machulda, Divisions of Epidemiology R O R, M M Mielke, R C P, Y E G and Biomedical Statistics and Informatics T J C, V S P, Department of Health Sciences Research, Mayo Clinic, Rochester, MN International Clinical Research Center A P, G B S, O S, J K R, Y E G, Brno, Czech Republic and Paracelsus Medical University A P, Salzburg, Austria
    Neurology 84:935-43. 2015
    ..To investigate the population-based interaction between a biological variable (APOE ε4), neuropsychiatric symptoms, and the risk of incident dementia among subjects with prevalent mild cognitive impairment (MCI)...
  59. pmc Neuropsychiatric symptoms in primary progressive aphasia and apraxia of speech
    Tarun D Singh
    Department of Neurology, Mayo Clinic, Rochester, Minn, USA
    Dement Geriatr Cogn Disord 39:228-38. 2015
    ....
  60. pmc Assessing the temporal relationship between cognition and gait: slow gait predicts cognitive decline in the Mayo Clinic Study of Aging
    Michelle M Mielke
    Department of Health Sciences Research, Division of Epidemiology, Mayo Clinic, 200 First Street S W, Rochester, MN 55905, USA
    J Gerontol A Biol Sci Med Sci 68:929-37. 2013
    ..The association between gait speed and cognition has been reported; however, there is limited knowledge about the temporal associations between gait slowing and cognitive decline among cognitively normal individuals...
  61. ncbi request reprint Alzheimer's disease patients' cognitive status and course years prior to symptom recognition
    Jane H Cerhan
    Mayo Clinic College of Medicine Rochester, Minnesota, USA
    Neuropsychol Dev Cogn B Aging Neuropsychol Cogn 14:227-35. 2007
    ..A significant interaction (but no group effect) was seen for verbal comprehension...
  62. doi request reprint Resolution of neuropsychological and FDG-PET abnormalities in a patient with neuropsychiatric systemic lupus erythematosus
    Anahita Adeli
    Departments of Neurology Psychiatry and Psychology, Mayo Clinic, Rochester, MN
    Cogn Behav Neurol 26:161-6. 2013
    ..F-18 fluorodeoxyglucose positron emission tomography shows promise in the diagnosis and treatment monitoring of patients who have lupus with neuropsychiatric involvement. ..
  63. ncbi request reprint Altered functional MR imaging language activation in elderly individuals with cerebral leukoaraiosis
    Kirk M Welker
    Department of Radiology, Division of Neuroradiology, Mayo Clinic, 200 First St SW, Charlton 2 X ray, Rochester, MN 55902, USA
    Radiology 265:222-32. 2012
    ..To test the hypothesis that leukoaraiosis alters functional activation during a semantic decision language task...
  64. pmc Characterization of frontotemporal dementia and/or amyotrophic lateral sclerosis associated with the GGGGCC repeat expansion in C9ORF72
    Bradley F Boeve
    Department of Neurology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Brain 135:765-83. 2012
    ..While variability exists, most cases with this mutation have a characteristic spectrum of demographic, clinical, neuropsychological, neuroimaging and especially neuropathological findings...
  65. doi request reprint Retrospective Analysis of Interobserver Spatial Variability in the Localization of Broca's and Wernicke's Areas Using Three Different fMRI Language Paradigms
    David F Black
    Department of Radiology, Mayo Clinic, Rochester, MN
    J Neuroimaging 25:626-33. 2015
    ..To determine interobserver spatial variability in language area localization using three commonly employed language tasks...
  66. pmc Late-onset Alzheimer's risk variants in memory decline, incident mild cognitive impairment, and Alzheimer's disease
    Minerva M Carrasquillo
    Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA
    Neurobiol Aging 36:60-7. 2015
    ..Discovery of biologically functional variants at these loci may uncover stronger effects on memory and incident disease. ..
  67. ncbi request reprint A plateau in pre-Alzheimer memory decline: evidence for compensatory mechanisms?
    G E Smith
    Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MN 55905, USA
    Neurology 69:133-9. 2007
    ..To compare logistic and bilogistic models to describe the pattern of cognitive decline in the preclinical phase of Alzheimer disease (AD)...
  68. pmc Comparison of memory fMRI response among normal, MCI, and Alzheimer's patients
    M M Machulda
    Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MN 55905, USA
    Neurology 61:500-6. 2003
    ..To determine whether an fMRI memory encoding task distinguishes among cognitively normal elderly individuals, patients with mild cognitive impairment (MCI), and patients with early Alzheimer's disease (AD)...
  69. pmc Functional inferences vary with the method of analysis in fMRI
    M M Machulda
    Department of Radiology, Magnetic Resonance Research, Mayo Clinic, Rochester, Minnesota 55905, USA
    Neuroimage 14:1122-7. 2001
    ..Using data processing methods that are independent of the arbitrary selection of cutoff values for thresholding activation maps may reduce the likelihood of obtaining spurious results...