Paul J Lockhart

Summary

Affiliation: Mayo Clinic
Country: USA

Publications

  1. ncbi request reprint The human sideroflexin 5 (SFXN5) gene: sequence, expression analysis and exclusion as a candidate for PARK3
    Paul J Lockhart
    Mayo Clinic Jacksonville, Birdsall Building, 4500 San Pablo Road, Jacksonville, FL 32224, USA
    Gene 285:229-37. 2002
  2. doi request reprint Regional and cellular localisation of Parkin co-regulated gene in developing and adult mouse brain
    Kate M Brody
    Bruce Lefroy Centre for Genetic Health Research, Murdoch Childrens Research Institute, Melbourne, Victoria, 3052, Australia
    Brain Res 1201:177-86. 2008
  3. ncbi request reprint Lack of mutations in DJ-1 in a cohort of Taiwanese ethnic Chinese with early-onset parkinsonism
    Paul J Lockhart
    Department of Neuroscience, Birdsall Building, Mayo Clinic Jacksonville, Florida 32224, USA
    Mov Disord 19:1065-9. 2004
  4. ncbi request reprint Multiplication of the alpha-synuclein gene is not a common disease mechanism in Lewy body disease
    Paul J Lockhart
    Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA
    J Mol Neurosci 24:337-42. 2004
  5. ncbi request reprint Identification of a novel gene linked to parkin via a bi-directional promoter
    Andrew B West
    Program for Molecular Neuroscience, Department of Neuroscience, Mayo Clinic Jacksonville, Jacksonville, FL 32224, USA
    J Mol Biol 326:11-9. 2003
  6. ncbi request reprint Identification of the human ubiquitin specific protease 31 (USP31) gene: structure, sequence and expression analysis
    Paul J Lockhart
    Mayo Clinic Jacksonville, 4500 San Pablo Road, Jacksonville, Florida 32224, USA
    DNA Seq 15:9-14. 2004
  7. ncbi request reprint It's a double knock-out! The quaking mouse is a spontaneous deletion of parkin and parkin co-regulated gene (PACRG)
    Paul J Lockhart
    Mayo Clinic Jacksonville, Jacksonville, Florida 32224, USA
    Mov Disord 19:101-4. 2004
  8. ncbi request reprint Biochemical characterization of torsinB
    Casey O'Farrell
    Department of Neuroscience, Mayo Clinic Jacksonville, 4500 San Pablo Road, Jacksonville, FL 32224, USA
    Brain Res Mol Brain Res 127:1-9. 2004
  9. ncbi request reprint Parkin protects against the toxicity associated with mutant alpha-synuclein: proteasome dysfunction selectively affects catecholaminergic neurons
    Leonard Petrucelli
    Neurogenetics Laboratory, Mayo Clinic Jacksonville, Jacksonville, FL 32224, USA
    Neuron 36:1007-19. 2002
  10. ncbi request reprint Parkin genetics: one model for Parkinson's disease
    Ignacio F Mata
    Laboratories of Neurogenetics, Department of Neuroscience, Mayo Clinic Jacksonville, FL, USA
    Hum Mol Genet 13:R127-33. 2004

Collaborators

Detail Information

Publications15

  1. ncbi request reprint The human sideroflexin 5 (SFXN5) gene: sequence, expression analysis and exclusion as a candidate for PARK3
    Paul J Lockhart
    Mayo Clinic Jacksonville, Birdsall Building, 4500 San Pablo Road, Jacksonville, FL 32224, USA
    Gene 285:229-37. 2002
    ..Sequence analysis of 2p13 linked individuals affected with PD did not reveal any potentially pathogenic mutations within SFXN5, suggesting SFXN5 does not correspond to PARK3...
  2. doi request reprint Regional and cellular localisation of Parkin co-regulated gene in developing and adult mouse brain
    Kate M Brody
    Bruce Lefroy Centre for Genetic Health Research, Murdoch Childrens Research Institute, Melbourne, Victoria, 3052, Australia
    Brain Res 1201:177-86. 2008
    ..These results suggest that the transcriptional co-regulation of Pacrg and parkin leads to a similar regional protein distribution in mouse brain, which may have functional significance for the two proteins...
  3. ncbi request reprint Lack of mutations in DJ-1 in a cohort of Taiwanese ethnic Chinese with early-onset parkinsonism
    Paul J Lockhart
    Department of Neuroscience, Birdsall Building, Mayo Clinic Jacksonville, Florida 32224, USA
    Mov Disord 19:1065-9. 2004
    ..Our results and previous studies suggest that alterations to DJ-1 are not a common cause of early-onset Parkinson's disease and other causes, genetic and/or environmental, remain to be identified...
  4. ncbi request reprint Multiplication of the alpha-synuclein gene is not a common disease mechanism in Lewy body disease
    Paul J Lockhart
    Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA
    J Mol Neurosci 24:337-42. 2004
    ..We examined a large collection of pathologically confirmed LBD cases and found no evidence for multiplication of the alpha-synuclein gene, suggesting that this mechanism is not a common cause of LBD...
  5. ncbi request reprint Identification of a novel gene linked to parkin via a bi-directional promoter
    Andrew B West
    Program for Molecular Neuroscience, Department of Neuroscience, Mayo Clinic Jacksonville, Jacksonville, FL 32224, USA
    J Mol Biol 326:11-9. 2003
    ..Although PACRG protein lacks known functional domains, in silico prediction suggests a potential link to the ubiquitin/proteasome system...
  6. ncbi request reprint Identification of the human ubiquitin specific protease 31 (USP31) gene: structure, sequence and expression analysis
    Paul J Lockhart
    Mayo Clinic Jacksonville, 4500 San Pablo Road, Jacksonville, Florida 32224, USA
    DNA Seq 15:9-14. 2004
    ..Northern blot analysis revealed a single USP31 transcript of approximately 4 kb, which was primarily expressed in the testis and lung...
  7. ncbi request reprint It's a double knock-out! The quaking mouse is a spontaneous deletion of parkin and parkin co-regulated gene (PACRG)
    Paul J Lockhart
    Mayo Clinic Jacksonville, Jacksonville, Florida 32224, USA
    Mov Disord 19:101-4. 2004
    ..Homozygous Quaking mice show a complete loss of PRKN and PACRG mRNA and protein. These mice will constitute a useful additional model for studies of the molecular role of parkin and PACRG in neurodegeneration...
  8. ncbi request reprint Biochemical characterization of torsinB
    Casey O'Farrell
    Department of Neuroscience, Mayo Clinic Jacksonville, 4500 San Pablo Road, Jacksonville, FL 32224, USA
    Brain Res Mol Brain Res 127:1-9. 2004
    ..These results show that torsins A and B are similar proteins, although there are differences in the abundance of the two homologues and in their recruitment into Lewy bodies...
  9. ncbi request reprint Parkin protects against the toxicity associated with mutant alpha-synuclein: proteasome dysfunction selectively affects catecholaminergic neurons
    Leonard Petrucelli
    Neurogenetics Laboratory, Mayo Clinic Jacksonville, Jacksonville, FL 32224, USA
    Neuron 36:1007-19. 2002
    ..Therefore, parkin and alpha-synuclein are linked by common effects on a pathway associated with selective cell death in catecholaminergic neurons...
  10. ncbi request reprint Parkin genetics: one model for Parkinson's disease
    Ignacio F Mata
    Laboratories of Neurogenetics, Department of Neuroscience, Mayo Clinic Jacksonville, FL, USA
    Hum Mol Genet 13:R127-33. 2004
    ..Herein, we compare and contrast PD and AR-JP and discuss the implications of recent data about parkin's genomic organization, regulation and function...
  11. ncbi request reprint Accurate determination of ataxin-2 polyglutamine expansion in patients with intermediate-range repeats
    Jennifer Hussey
    Department of Neuroscience, Mayo Clinic Jacksonville, Jacksonville, FL 32224, USA
    Genet Test 6:217-20. 2002
    ..Using cloning and sequencing methods, we have constructed a ladder of ATX2 alleles of known size and sequence composition. This freely available size ladder will facilitate future quantification of expansions of the ATX2 locus...
  12. ncbi request reprint Functional association of the parkin gene promoter with idiopathic Parkinson's disease
    Andrew B West
    Laboratories of Neurogenetics, Department of Neuroscience, Mayo Clinic Jacksonville, FL 32224, USA
    Hum Mol Genet 11:2787-92. 2002
    ..Our results further implicate the parkin gene in the development of Parkinson's disease...
  13. ncbi request reprint RING finger 1 mutations in Parkin produce altered localization of the protein
    Mark R Cookson
    Laboratory of Neurogenetics, National Institute on Aging, Bethesda, MD 20892, USA
    Hum Mol Genet 12:2957-65. 2003
    ..We have replicated this observation in primary cultured neurons and demonstrate, by the accumulation/co-localization of cytoskeletal protein vimentin, that the inclusion bodies are aggresomes, a cellular response to misfolded protein...
  14. ncbi request reprint Oligomeric alpha-synuclein inhibits tubulin polymerization
    Leo Chen
    Department of Pathology, University of Washington School of Medicine, Seattle, WA, USA
    Biochem Biophys Res Commun 356:548-53. 2007
    ..Finally, we demonstrated that neurotoxicity induced by oligomeric alpha-synuclein was largely prevented by overexpressing the neuroprotective protein, DJ-1...
  15. ncbi request reprint Parkin Co-Regulated Gene (PACRG) is regulated by the ubiquitin-proteasomal system and is present in the pathological features of Parkinsonian diseases
    Juliet M Taylor
    Bruce Lefroy Centre for Genetic Health Research, Murdoch Children s Research Institute, Melbourne, Victoria 3052, Australia
    Neurobiol Dis 27:238-47. 2007
    ..Together, these results demonstrate that PACRG is regulated by the ubiquitin-proteasomal system and may play a role in the pathogenesis of Parkinson's disease...