Lilach Lerman

Summary

Affiliation: Mayo Clinic
Country: USA

Publications

  1. pmc Diet-induced increase in plasma oxidized LDL promotes early fibrosis in a renal porcine auto-transplantation model
    Nicolas Chatauret
    INSERM, U1082, Ischémie reperfusion en transplantation rénale, Universite de Poitiers, Faculte de Medecine et de Pharmacie, Poitiers 86000, France
    J Transl Med 12:76. 2014
  2. pmc Predictive role of renal resistive index for clinical outcome after revascularization in hypertensive patients with atherosclerotic renal artery stenosis: a monocentric observational study
    Rosa Maria Bruno
    Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy
    Cardiovasc Ultrasound 12:9. 2014
  3. pmc Combined effect of hyperfiltration and renin angiotensin system activation on development of chronic kidney disease in diabetic db/db mice
    Stella P Hartono
    Department of Laboratory Medicine and Pathology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    BMC Nephrol 15:58. 2014
  4. pmc Mesenchymal stem cells improve medullary inflammation and fibrosis after revascularization of swine atherosclerotic renal artery stenosis
    Behzad Ebrahimi
    Division of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota, United States of America
    PLoS ONE 8:e67474. 2013
  5. pmc Angiotensin receptor blockade has protective effects on the poststenotic porcine kidney
    Xin Zhang
    Division of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota, USA
    Kidney Int 84:767-75. 2013
  6. pmc Evolution of cardiac and renal impairment detected by high-field cardiovascular magnetic resonance in mice with renal artery stenosis
    Behzad Ebrahimi
    Division of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota, USA
    J Cardiovasc Magn Reson 15:98. 2013
  7. pmc Increased circulating inflammatory endothelial cells in blacks with essential hypertension
    Alfonso Eirin
    Division of Nephrology and Hypertension, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
    Hypertension 62:585-91. 2013
  8. pmc Obesity-metabolic derangement preserves hemodynamics but promotes intrarenal adiposity and macrophage infiltration in swine renovascular disease
    Xin Zhang
    Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN, USA
    Am J Physiol Renal Physiol 305:F265-76. 2013
  9. pmc Endothelial outgrowth cells shift macrophage phenotype and improve kidney viability in swine renal artery stenosis
    Alfonso Eirin
    Division of Nephrology and Hypertension, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
    Arterioscler Thromb Vasc Biol 33:1006-13. 2013
  10. pmc Chronic renovascular hypertension is associated with elevated levels of neutrophil gelatinase-associated lipocalin
    Alfonso Eirin
    Division of Nephrology and Hypertension, Department of Internal Medicine, Mayo Clinic, Rochester, MN, USA
    Nephrol Dial Transplant 27:4153-61. 2012

Research Grants

Detail Information

Publications105 found, 100 shown here

  1. pmc Diet-induced increase in plasma oxidized LDL promotes early fibrosis in a renal porcine auto-transplantation model
    Nicolas Chatauret
    INSERM, U1082, Ischémie reperfusion en transplantation rénale, Universite de Poitiers, Faculte de Medecine et de Pharmacie, Poitiers 86000, France
    J Transl Med 12:76. 2014
    ..This study aimed to characterize the effects of hypercholesterolemia on renal graft outcome, investigating the role of oxidized low-density lipoprotein (OxLDL)...
  2. pmc Predictive role of renal resistive index for clinical outcome after revascularization in hypertensive patients with atherosclerotic renal artery stenosis: a monocentric observational study
    Rosa Maria Bruno
    Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy
    Cardiovasc Ultrasound 12:9. 2014
    ....
  3. pmc Combined effect of hyperfiltration and renin angiotensin system activation on development of chronic kidney disease in diabetic db/db mice
    Stella P Hartono
    Department of Laboratory Medicine and Pathology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    BMC Nephrol 15:58. 2014
    ..We tested the hypothesis that renovascular hypertension accelerates angiotensin-II-dependent kidney damage and inflammation in the db/db mouse, a model of type II diabetes...
  4. pmc Mesenchymal stem cells improve medullary inflammation and fibrosis after revascularization of swine atherosclerotic renal artery stenosis
    Behzad Ebrahimi
    Division of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota, United States of America
    PLoS ONE 8:e67474. 2013
    ..This study supports development of cell-based strategies for renal protection in ARAS...
  5. pmc Angiotensin receptor blockade has protective effects on the poststenotic porcine kidney
    Xin Zhang
    Division of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota, USA
    Kidney Int 84:767-75. 2013
    ..Thus, Valsartan did not decrease stenotic kidney GFR, but improved cortical perfusion and microcirculation. These beneficial effects may partly offset the hemodynamic GFR reduction in renal artery stenosis and preserve kidney function. ..
  6. pmc Evolution of cardiac and renal impairment detected by high-field cardiovascular magnetic resonance in mice with renal artery stenosis
    Behzad Ebrahimi
    Division of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota, USA
    J Cardiovasc Magn Reson 15:98. 2013
    ..We hypothesized that cardiovascular magnetic resonance (CMR) is capable of detecting progressive cardiac and renal dysfunction in mice with RAS and monitoring the progression of the disease longitudinally...
  7. pmc Increased circulating inflammatory endothelial cells in blacks with essential hypertension
    Alfonso Eirin
    Division of Nephrology and Hypertension, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
    Hypertension 62:585-91. 2013
    ..Thus, increased release of cytokines and IECs in black EH patients may impair EPC reparative capacity and aggravate vascular damage, and accelerate hypertension-related complications. ..
  8. pmc Obesity-metabolic derangement preserves hemodynamics but promotes intrarenal adiposity and macrophage infiltration in swine renovascular disease
    Xin Zhang
    Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN, USA
    Am J Physiol Renal Physiol 305:F265-76. 2013
    ..Increased adiposity and MØ-accentuated inflammation induced by an ObM diet may contribute to structural injury in the post-STK kidney. ..
  9. pmc Endothelial outgrowth cells shift macrophage phenotype and improve kidney viability in swine renal artery stenosis
    Alfonso Eirin
    Division of Nephrology and Hypertension, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
    Arterioscler Thromb Vasc Biol 33:1006-13. 2013
    ..Inflammation aggravates kidney injury in renal artery stenosis (RAS), and may account for its persistence upon revascularization. We hypothesized that EOC would decrease inflammatory (M1) macrophages and improve renal recovery in RAS...
  10. pmc Chronic renovascular hypertension is associated with elevated levels of neutrophil gelatinase-associated lipocalin
    Alfonso Eirin
    Division of Nephrology and Hypertension, Department of Internal Medicine, Mayo Clinic, Rochester, MN, USA
    Nephrol Dial Transplant 27:4153-61. 2012
    ..We hypothesized that chronic RVH would be associated with increased renal and circulating NGAL levels...
  11. doi request reprint A mitochondrial permeability transition pore inhibitor improves renal outcomes after revascularization in experimental atherosclerotic renal artery stenosis
    Alfonso Eirin
    Division of Nephrology and Hypertension, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
    Hypertension 60:1242-9. 2012
    ..Potent antiapoptotic and antioxidant effects provide Bendavia a novel therapeutic potential for improving kidney outcomes after PTRA in experimental ARAS...
  12. pmc Addition of endothelial progenitor cells to renal revascularization restores medullary tubular oxygen consumption in swine renal artery stenosis
    Behzad Ebrahimi
    Division of Nephrology and Hypertension, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
    Am J Physiol Renal Physiol 302:F1478-85. 2012
    ..These results support further development of cell-based therapy as an adjunct to revascularization of RAS...
  13. pmc Transition from obesity to metabolic syndrome is associated with altered myocardial autophagy and apoptosis
    Zi Lun Li
    Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN 55905, USA
    Arterioscler Thromb Vasc Biol 32:1132-41. 2012
    ..We tested the hypothesis that development of insulin resistance and MetS is associated with impaired myocardial cellular turnover...
  14. pmc Age-dependent renal cortical microvascular loss in female mice
    Victor H Urbieta-Caceres
    Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN 55905, USA
    Am J Physiol Endocrinol Metab 302:E979-86. 2012
    ..However, estrogen may play a role in protecting the kidney by decreasing oxidative stress and attenuating mechanisms linked to renal interstitial fibrosis...
  15. pmc Determinations of renal cortical and medullary oxygenation using blood oxygen level-dependent magnetic resonance imaging and selective diuretics
    Lizette Warner
    Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN 55905, USA
    Invest Radiol 46:41-7. 2011
    ..Therefore, the adjunct use of diuretics that inhibit Na reabsorption selectively in PT and TAL, Az and furosemide, respectively, may help discern tubular function by using BOLD MRI to detect changes in tissue oxygenation...
  16. ncbi request reprint Increased oxidative stress in experimental renovascular hypertension
    L O Lerman
    Department of Internal Medicine, Division of Hypertension, Mayo Clinic, Rochester, Minnesota, USA
    Hypertension 37:541-6. 2001
    ..Moreover, oxidation-sensitive mechanisms may influence ischemic and hypertensive parenchymal renal injury...
  17. ncbi request reprint Functional assessment of the circulation of the single kidney
    L O Lerman
    Department of Internal Medicine, Division of Hypertension, Mayo Clinic, Rochester, Minnesota, USA
    Hypertension 38:625-9. 2001
    ..Such assessments of the function of the renal circulation can assist in evaluation of patients with systemic or renal disease for early detection and monitoring of renovascular injury...
  18. ncbi request reprint Atherosclerotic process, renovascular disease and outcomes from bench to bedside
    Lilach O Lerman
    Department of Internal Medicine, Division of Nephrology and Hypertension, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Curr Opin Nephrol Hypertens 15:583-7. 2006
    ..Its presence increases cardiovascular morbidity and mortality independent of other atherosclerotic risk factors. Therefore, novel renoprotective strategies are needed to decrease the impact of this disease...
  19. ncbi request reprint Noninvasive evaluation of a novel swine model of renal artery stenosis
    L O Lerman
    Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Am Soc Nephrol 10:1455-65. 1999
    ..Electron-beam computerized tomography shows promise to noninvasively quantify, follow-up, and study changes in concurrent, in vivo intrarenal hemodynamics and segmental tubular function in renovascular hypertension...
  20. pmc Mechanisms of tissue injury in renal artery stenosis: ischemia and beyond
    Lilach O Lerman
    Department of Internal Medicine, Division of Nephrology and Hypertension, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Prog Cardiovasc Dis 52:196-203. 2009
    ..Identification of specific pathways producing progressive renal injury may enable development of targeted interventions to block these pathways and preserve the stenotic kidney...
  21. ncbi request reprint Animal models of hypertension: an overview
    Lilach O Lerman
    Division of Nephrology and Hypertension, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA
    J Lab Clin Med 146:160-73. 2005
    ..Nevertheless, a cautious approach is mandatory when experimental findings in these models are extrapolated to human hypertension...
  22. ncbi request reprint Distinct renal injury in early atherosclerosis and renovascular disease
    Alejandro R Chade
    Department of Internal Medicine, Division of Hypertension, Mayo Clinic, Rochester, Minn 55905, USA
    Circulation 106:1165-71. 2002
    ..This study was designed to test the hypothesis that concurrent early atherosclerosis and hypoperfusion might have greater early deleterious effects on the function and structure of the stenotic kidney...
  23. ncbi request reprint Early experimental obesity is associated with coronary endothelial dysfunction and oxidative stress
    Offer Galili
    Department of Cardiovascular Diseases, Mayo Clinic College of Medicine, Rochester, Minnesota, USA
    Am J Physiol Heart Circ Physiol 292:H904-11. 2007
    ..Vascular dysfunction is therefore an early manifestation of obesity and might contribute to the increased cardiovascular risk, independently of insulin resistance...
  24. ncbi request reprint The porcine remnant kidney model of chronic renal insufficiency
    Sanjay Misra
    Department of Radiology, Division of Vascular Surgery, Mayo Clinic, Rochester, Minnesota 55905
    J Surg Res 135:370-9. 2006
    ..The purpose of the present study was to develop and characterize a porcine model of chronic renal insufficiency created by renal artery embolization...
  25. ncbi request reprint Antioxidant intervention attenuates myocardial neovascularization in hypercholesterolemia
    Xiang Yang Zhu
    Department of Internal Medicine, Division of Hypertension, Mayo Clinic College of Medicine, Rochester, Minn 55905, USA
    Circulation 109:2109-15. 2004
    ..We tested the hypothesis that chronic antioxidant intervention in HC would attenuate neovascularization and preserve the expression of hypoxia-inducible factor (HIF)-1alpha and vascular endothelial growth factor (VEGF)...
  26. ncbi request reprint Antioxidant intervention prevents renal neovascularization in hypercholesterolemic pigs
    Alejandro R Chade
    Department of Internal Medicine Division of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Am Soc Nephrol 15:1816-25. 2004
    ..Chronic antioxidant supplementation may preserve the kidney in HC...
  27. ncbi request reprint Hypercholesterolemia and hypertension have synergistic deleterious effects on coronary endothelial function
    Martin Rodriguez-Porcel
    Department of Internal Medicine, Division of Cardiovascular Diseases, Mayo Clinic, 200 First St SW, Rochester, Minn 55905, USA
    Arterioscler Thromb Vasc Biol 23:885-91. 2003
    ..However, pathogenic mechanisms are poorly understood. Here we studied the effects of coexisting HC and HT on coronary endothelial function...
  28. pmc Simvastatin decreases endothelial progenitor cell apoptosis in the kidney of hypertensive hypercholesterolemic pigs
    Ronit Lavi
    Division of Nephrology and Hypertension, Department of Internal Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Arterioscler Thromb Vasc Biol 30:976-83. 2010
    ..We hypothesized that simvastatin improves the survival of endothelial progenitor cells (EPC) in the renal microenvironment imposed by concurrent renovascular hypertension and dietary hypercholesterolemia (HTC)...
  29. ncbi request reprint Beneficial effects of antioxidant vitamins on the stenotic kidney
    Alejandro R Chade
    Division of Hypertension, Department of Internal Medicine, Mayo Clinic, Rochester, Minn 55905, USA
    Hypertension 42:605-12. 2003
    ..These observations underscore the involvement of oxidative stress in renal injury in RAS and support a role for antioxidant vitamins in preserving the ischemic kidney...
  30. pmc Renovascular hypertension and ischemic nephropathy
    Stephen C Textor
    Mayo Clinic, Rochester, Minnesota, USA
    Am J Hypertens 23:1159-69. 2010
    ..Until additional staging tools become available, clinicians will be forced to individualize therapy carefully to optimize the potential benefits regarding both blood pressure and renal function for such patients...
  31. pmc Phase-contrast MRI-based elastography technique detects early hypertensive changes in ex vivo porcine aortic wall
    David A Woodrum
    Radiology Department, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Magn Reson Imaging 29:583-7. 2009
    ..To measure the elastic properties of ex vivo porcine aortas in control and hypertensive groups using a phase contrast magnetic resonance imaging (MRI)-based elastography technique...
  32. ncbi request reprint Simvastatin promotes angiogenesis and prevents microvascular remodeling in chronic renal ischemia
    Alejandro R Chade
    Department of Internal Medicine, Division of Nephrology and Hypertension, Mayo Clinic College of Medicine, 200 First St S W, Rochester, Minnesota 55905, USA
    FASEB J 20:1706-8. 2006
    ..These novel renoprotective effects suggest a role for simvastatin in preserving the ischemic kidney in chronic RAS...
  33. pmc Regional decreases in renal oxygenation during graded acute renal arterial stenosis: a case for renal ischemia
    Lizette Warner
    Department of Physiology and Biomedical Engineering, Mayo Clinic, ST 7, 200 First St SW, Rochester, MN 55905, USA
    Am J Physiol Regul Integr Comp Physiol 296:R67-71. 2009
    ..Furthermore, the notion that arteriovenous shunting and increased stoichiometric energy requirements are potential contributors toward ensuing hypoxia with graded and progressive acute RAS cannot be excluded...
  34. doi request reprint Potential role of the ubiquitin-proteasome system in atherosclerosis: aspects of a protein quality disease
    Joerg Herrmann
    Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Am Coll Cardiol 51:2003-10. 2008
    ..This review summarizes these recent findings with a focus on atherosclerosis. In particular, this paper reflects on the viewpoint of atherosclerosis as a protein quality disease...
  35. pmc The use of magnetic resonance to evaluate tissue oxygenation in renal artery stenosis
    Stephen C Textor
    Division of Nephrology and Hypertension, Departments of Physiology and Pathology, Center for Magnetic Imaging Research and Department of Radiology, Mayo Clinic, W19, Rochester, MN 55905, USA
    J Am Soc Nephrol 19:780-8. 2008
    ..These results suggest that BOLD MR coupled with a method to suppress tubular oxygen consumption can be used to evaluate regional tissue oxygenation in the human kidney affected by vascular occlusive disease...
  36. ncbi request reprint Chronic proteasome inhibition contributes to coronary atherosclerosis
    Joerg Herrmann
    Division of Cardiovascular Diseases, Mayo Clinic and College of Medicine, Rochester, MN 55905, USA
    Circ Res 101:865-74. 2007
    ..These findings support the significance of the proteasome and related protein quality control for vascular biology and pathology...
  37. ncbi request reprint Endothelin-a receptor blockade improves renal microvascular architecture and function in experimental hypercholesterolemia
    Alejandro R Chade
    Department of Internal Medicine, Division of Nephrology and Hypertension, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    J Am Soc Nephrol 17:3394-403. 2006
    ..This study suggests novel renoprotective effects of ET-A blockers and supports further exploration of strategies that target the ET pathway in HC and atherosclerosis...
  38. ncbi request reprint Role of renal cortical neovascularization in experimental hypercholesterolemia
    Alejandro R Chade
    Division of Nephrology and Hypertension, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Hypertension 50:729-36. 2007
    ..This study, therefore, suggests that neovascularization in the hypercholesterolemic kidney is a compensatory mechanism that sustains basal renal vascular function...
  39. ncbi request reprint Early changes in coronary artery wall structure detected by microcomputed tomography in experimental hypercholesterolemia
    Xiang Yang Zhu
    Division of Nephrology and Hypertension, Department of Internal Medicine, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Am J Physiol Heart Circ Physiol 293:H1997-2003. 2007
    ..Therefore, this technique can be a useful tool in atherosclerosis research...
  40. pmc Antioxidants improve early survival of cardiomyoblasts after transplantation to the myocardium
    Martin Rodriguez-Porcel
    Division of Cardiovascular Diseases, Department of Internal Medicine, Mayo Clinic College of Medicine, Rochester, MN, USA
    Mol Imaging Biol 12:325-34. 2010
    ..We tested the hypothesis that modulation of the microenvironment (using antioxidants) will increase stem cell survival in hypoxia and after transplantation to the myocardium...
  41. doi request reprint Coronary endothelial dysfunction is associated with a reduction in coronary artery compliance and an increase in wall shear stress
    Takuro Takumi
    Division of Cardiovascular Disease, Mayo Clinic, 200 First Street SW, Rochester, Minnesota 55905, USA
    Heart 96:773-8. 2010
    ..The purpose of this study was to investigate the association between coronary endothelial dysfunction, coronary artery compliance and wall shear stress in patients with early atherosclerosis...
  42. pmc Early atherosclerosis aggravates the effect of renal artery stenosis on the swine kidney
    Victor H Urbieta-Caceres
    Division of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota 55905, USA
    Am J Physiol Renal Physiol 299:F135-40. 2010
    ..These observations underscore the direct intrarenal effect of atherogenic factors on the kidneys...
  43. pmc Association of kidney function and metabolic risk factors with density of glomeruli on renal biopsy samples from living donors
    Andrew D Rule
    Division of Nephrology and Hypertension, Mayo Clinic, 200 First St SW, Rochester, MN 55905
    Mayo Clin Proc 86:282-90. 2011
    ..To test the hypothesis that kidney function and metabolic risk factors are associated with glomerular density on renal biopsy samples from healthy adults...
  44. ncbi request reprint Role of oxidative stress in remodeling of the myocardial microcirculation in hypertension
    Xiang Yang Zhu
    Department of Internal Medicine, Division of Nephrology and Hypertension, Mayo Clinic, 200 First Street SW, Rochester, Minnesota 55905, USA
    Arterioscler Thromb Vasc Biol 26:1746-52. 2006
    ..We tested the hypothesis that in early hypertension (HT), increased oxidative stress leads to myocardial microvascular remodeling...
  45. ncbi request reprint Review--3D micro CT imaging of renal micro-structural changes
    Mario Gossl
    Division of Cardiovascular Diseases, Mayo Clinic College of Medicine, Rochester, Minn 55901, USA
    Nephron Clin Pract 103:c66-70. 2006
    ..Future developments will be needed to establish the place of 3D micro CT in developing, directing, and monitoring the treatment of chronic kidney diseases...
  46. ncbi request reprint Chronic endothelin receptor antagonism prevents coronary vasa vasorum neovascularization in experimental hypercholesterolemia
    Joerg Herrmann
    Division of Cardiovascular Diseases, Mayo Clinic Rochester, Rochester, Minnesota 55905, USA
    J Am Coll Cardiol 39:1555-61. 2002
    ..The purpose of this study was to test the hypothesis that endothelin (ET) receptor antagonism reduces coronary vasa vasorum neovascularization in experimental hypercholesterolemia...
  47. ncbi request reprint Oxidative stress-related increase in ubiquitination in early coronary atherogenesis
    Joerg Hermann
    Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN 55905, USA
    FASEB J 17:1730-2. 2003
    ..These results demonstrate that the UPS is functionally active in early atherogenesis despite increase in oxidative stress with important repercussions in the pathophysiology and therapy of cardiovascular diseases...
  48. ncbi request reprint Long-term antioxidant intervention improves myocardial microvascular function in experimental hypertension
    Martin Rodriguez-Porcel
    Department of Internal Medicine, Division of Cardiovascular Diseases, Mayo Clinic College of Medicine, 200 First St SW, Rochester, Minn 55905, USA
    Hypertension 43:493-8. 2004
    ..These results support the involvement of oxidative stress in myocardial vascular dysfunction in hypertension and suggest a role for antioxidant strategies to preserve the myocardial microvasculature...
  49. ncbi request reprint Comparison of acute and chronic antioxidant interventions in experimental renovascular disease
    Alejandro R Chade
    Div of Hypertension, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
    Am J Physiol Renal Physiol 286:F1079-86. 2004
    ..These suggest that chronic tissue changes play an important role in renal compromise mediated by oxidative stress in RVD...
  50. ncbi request reprint The ubiquitin-proteasome system in cardiovascular diseases-a hypothesis extended
    Joerg Herrmann
    Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN 55905, USA
    Cardiovasc Res 61:11-21. 2004
    ..This review summarizes recent findings regarding the ubiquitin-proteasome system in cardiovascular diseases and discusses the potential use of proteasome inhibitors in cardiovascular therapy...
  51. ncbi request reprint Simvastatin preserves the structure of coronary adventitial vasa vasorum in experimental hypercholesterolemia independent of lipid lowering
    Stephanie H Wilson
    Divisions of Cardiovascular Diseases, Mayo Clinic, Rochester, MN 55905, USA
    Circulation 105:415-8. 2002
    ..We aimed to determine the effect of simvastatin on coronary VV neovascularization, in the absence of cholesterol lowering...
  52. ncbi request reprint KLF11-mediated repression antagonizes Sp1/sterol-responsive element-binding protein-induced transcriptional activation of caveolin-1 in response to cholesterol signaling
    Sheng Cao
    Gastroenterology Research Unit and Tumor Biology Program, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    J Biol Chem 280:1901-10. 2005
    ....
  53. ncbi request reprint Experimental hypercholesterolemia differentially affects adventitial vasa vasorum and vessel structure of the left internal thoracic and coronary arteries
    Offer Galili
    Division of Cardiovascular Diseases, Mayo College of Medicine, Rochester, MN 55905, USA
    J Thorac Cardiovasc Surg 129:767-72. 2005
    ..Hence the current study was designed to characterize and compare the structure of the adventitial vasa vasorum in the left internal thoracic and coronary arteries...
  54. ncbi request reprint The ubiquitin-proteasome system--micro target for macro intervention?
    Joerg Herrmann
    Division of Cardiovascular Diseases Mayo Clinic, Rochester, MN 55905, USA
    Int J Cardiovasc Intervent 7:5-13. 2005
    ....
  55. ncbi request reprint Simvastatin preserves myocardial perfusion and coronary microvascular permeability in experimental hypercholesterolemia independent of lipid lowering
    Piero O Bonetti
    Division of Cardiovascular Diseases, Department of Internal Medicine, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
    J Am Coll Cardiol 40:546-54. 2002
    ....
  56. pmc The uncertain value of renal artery interventions: where are we now?
    Stephen C Textor
    Department of Medicine, Division of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota, USA
    JACC Cardiovasc Interv 2:175-82. 2009
    ....
  57. ncbi request reprint Vascular responses in vivo to 8-epi PGF(2alpha) in normal and hypercholesterolemic pigs
    James D Krier
    Department of Internal Medicine, Division of Hypertension, Mayo Clinic, Rochester, Minnesota 55905, USA
    Am J Physiol Regul Integr Comp Physiol 283:R303-8. 2002
    ....
  58. ncbi request reprint Antioxidant vitamins induce angiogenesis in the normal pig kidney
    Elena Daghini
    Division of Nephrology and Hypertension, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
    Am J Physiol Renal Physiol 293:F371-81. 2007
    ..Antioxidant vitamin supplementation can increase tissue oxidative redox and microvascular proliferation in the normal kidney, probably due to a biphasic effect that depends on basal redox balance...
  59. pmc Prevention of vasa vasorum neovascularization attenuates early neointima formation in experimental hypercholesterolemia
    Mario Gossl
    Division of Cardiovascular Diseases, Mayo Clinic College of Medicine, Rochester, MN, USA
    Basic Res Cardiol 104:695-706. 2009
    ..Serum levels of hs-CRP and TNF-alpha did not differ among the groups. Our study supports a role of VV neovascularization in the development of and a therapeutic potential for anti-angiogenic intervention in early atherosclerosis...
  60. ncbi request reprint Chronic antioxidant supplementation attenuates nuclear factor-kappa B activation and preserves endothelial function in hypercholesterolemic pigs
    Martin Rodriguez-Porcel
    Department of Internal Medicine, Division of Cardiovascular Diseases, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Cardiovasc Res 53:1010-8. 2002
    ..The physiological significance of in vivo chronic antioxidant intervention on HC-induced NF-kappa B activation and coronary endothelial function remains unclear...
  61. pmc On to the road to degradation: atherosclerosis and the proteasome
    Joerg Herrmann
    Department of Internal Medicine, Division of Cardiovascular Diseases, Mayo Clinic Rochester, 200 First Street SW, Rochester, MN 55905, USA
    Cardiovasc Res 85:291-302. 2010
    ..It will conclude with the integration of the available information in a synoptic view of the involvement of the UPS in atherosclerosis...
  62. pmc Disparate effects of simvastatin on angiogenesis during hypoxia and inflammation
    Xiang Yang Zhu
    Department of Internal Medicine, Division of Nephrology and Hypertension, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, United States
    Life Sci 83:801-9. 2008
    ..This study tested the hypothesis that the angiogenic potential of simvastatin is related to the microenvironmental conditions...
  63. ncbi request reprint Increased ubiquitin immunoreactivity in unstable atherosclerotic plaques associated with acute coronary syndromes
    Joerg Herrmann
    Division of Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Am Coll Cardiol 40:1919-27. 2002
    ..The current study was designed to examine whether ubiquitin expression is higher in unstable than in stable lesions of patients with acute coronary syndrome (ACS)...
  64. ncbi request reprint Lipid-lowering-independent effects of simvastatin on the kidney in experimental hypercholesterolaemia
    Stephanie H Wilson
    Division of Hypertension, Mayo Clinic, Rochester, MN 55905, USA
    Nephrol Dial Transplant 18:703-9. 2003
    ..HMG-CoA-reductase inhibitors are commonly used in HC, but their effects on renal haemodynamics and function in HC are poorly understood...
  65. ncbi request reprint Chronic antioxidant supplementation impairs coronary endothelial function and myocardial perfusion in normal pigs
    Daniele Versari
    Division of Cardiovascular Diseases, Mayo Clinic College of Medicine, Rochester, MN, USA
    Hypertension 47:475-81. 2006
    ....
  66. ncbi request reprint Antioxidant intervention blunts renal injury in experimental renovascular disease
    Alejandro R Chade
    Department of Internal Medicine, Division of Hypertension, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    J Am Soc Nephrol 15:958-66. 2004
    ..This study supports critical pathogenic contribution of increased oxidative stress to renal injury and scarring in RVD and suggests a role for antioxidant strategies in preserving the atherosclerotic and ischemic kidney...
  67. pmc Preserved oxygenation despite reduced blood flow in poststenotic kidneys in human atherosclerotic renal artery stenosis
    Monika L Gloviczki
    Department of Nephrology and Hypertension, Mayo Clinic, Rochester, MN 55905, USA
    Hypertension 55:961-6. 2010
    ..1+/-2.2 versus 58.1+/-1.2; P=0.006). These data indicate that, although stenosis reduced blood flow and volume, cortical and medullary oxygenation was preserved under these conditions...
  68. ncbi request reprint Relation of depression to coronary endothelial function
    Eric H Yang
    Center of Coronary Physiology and Imaging, Division of Cardiovascular Diseases, Mayo College of Medicine, Rochester, Minnesota, USA
    Am J Cardiol 99:1134-6. 2007
    ..It is, however, associated with a cluster of cardiac risk factors that are linked to the progression of atherosclerotic disease...
  69. ncbi request reprint Endothelin-1 receptor blockade prevents renal injury in experimental hypercholesterolemia
    Alejandro R Chade
    Department of Internal Medicine, Division of Hypertension, Mayo Clinic, Rochester, Minnesota, USA
    Kidney Int 64:962-9. 2003
    ..However, the involvement of endothelin (ET) in this disease process is yet unknown...
  70. ncbi request reprint Smoking is associated with epicardial coronary endothelial dysfunction and elevated white blood cell count in patients with chest pain and early coronary artery disease
    Shahar Lavi
    Division of Cardiovascular Diseases, Mayo College of Medicine, Rochester, MN 55905, USA
    Circulation 115:2621-7. 2007
    ..The present study was designed to test the hypothesis that smoking is associated with epicardial coronary endothelial dysfunction and inflammation...
  71. ncbi request reprint Mechanisms of renal structural alterations in combined hypercholesterolemia and renal artery stenosis
    Alejandro R Chade
    Department of Internal Medicine, Division of Hypertension, Mayo Clinic, Rochester, Minn 55905, USA
    Arterioscler Thromb Vasc Biol 23:1295-301. 2003
    ..We tested the hypothesis that coexistence of atherosclerosis and RAS interferes with renal tissue remodeling...
  72. ncbi request reprint Hypertension exacerbates the effect of hypercholesterolemia on the myocardial microvasculature
    Martin Rodriguez-Porcel
    Department of Internal Medicine, Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN, USA
    Cardiovasc Res 58:213-21. 2003
    ..HC and HT are individually associated with abnormal myocardial vascular function, but whether HT exacerbates the HC-induced myocardial vascular dysfunction remains unclear...
  73. pmc Increased hypoxia and reduced renal tubular response to furosemide detected by BOLD magnetic resonance imaging in swine renovascular hypertension
    Sabas I Gomez
    Department of Physiology and Biomedical Engineering, Rochester, MN 55905, USA
    Am J Physiol Renal Physiol 297:F981-6. 2009
    ..This approach may allow more detailed physiologic evaluation of poststenotic kidneys in renovascular hypertension than previously possible...
  74. pmc Monocyte chemoattractant proteins mediate myocardial microvascular dysfunction in swine renovascular hypertension
    Jing Lin
    Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN 55905, USA
    Arterioscler Thromb Vasc Biol 29:1810-6. 2009
    ..This study tested the hypothesis that MCPs regulate cardiac microvascular function and structure in experimental HTN...
  75. pmc Comparison of 1.5 and 3 T BOLD MR to study oxygenation of kidney cortex and medulla in human renovascular disease
    Monika L Gloviczki
    Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN 55905, USA
    Invest Radiol 44:566-71. 2009
    ..We sought to define the differences between regions within kidneys and to optimize selection of regions of interest for study with 1.5 and 3 Tesla systems...
  76. pmc Myocardial microvascular function during acute coronary artery stenosis: effect of hypertension and hypercholesterolaemia
    Xiang Yang Zhu
    Division of Nephrology and Hypertension, Department of Internal Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Cardiovasc Res 83:371-80. 2009
    ..We tested the hypothesis that new microvessels that proliferate in early atherosclerosis may be associated with myocardial protection during acute subtotal coronary artery obstruction (CAO)...
  77. ncbi request reprint Blood oxygen level-dependent measurement of acute intra-renal ischemia
    Laurent Juillard
    Department of Physiology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Kidney Int 65:944-50. 2004
    ..This study was therefore designed to test if BOLD can detect the characteristic of renal hypoxia induced by RAS...
  78. ncbi request reprint Dysregulation of the ubiquitin-proteasome system in human carotid atherosclerosis
    Daniele Versari
    Division of Cardiovascular Diseases, Mayo Clinic Rochester, 200 First St SW, Rochester, MN 55905, USA
    Arterioscler Thromb Vasc Biol 26:2132-9. 2006
    ..The aim of this study was to evaluate the activity of ubiquitin-proteasome system in human carotid artery plaques in relation to oxidative stress and clinical manifestation...
  79. ncbi request reprint Redox-sensitive myocardial remodeling and dysfunction in swine diet-induced experimental hypercholesterolemia
    Xiang Yang Zhu
    Department of Internal Medicine, Division of Nephrology and Hypertension, Mayo Clinic College of Medicine, Rochester, MN 55905, United States
    Atherosclerosis 193:62-9. 2007
    ....
  80. ncbi request reprint Plasma 8-iso-prostaglandin F2alpha, a marker of oxidative stress, is increased in patients with acute myocardial infarction
    Ahmad A Elesber
    The Division of Cardiovascular Diseases, Mayo Clinic and Foundation, Rochester, MN 55905, USA
    Free Radic Res 40:385-91. 2006
    ..The aim of our study is to examine whether the plasma 8-iso-prostaglandin F(2alpha) level, a marker of oxidative stress, is elevated in patients with acute myocardial infarction...
  81. ncbi request reprint Pathways of renal fibrosis and modulation of matrix turnover in experimental hypercholesterolemia
    Alejandro R Chade
    Division of Nephrology, Department of Internal Medicine, Mayo Clinic College of Medicine, Rochester, MN, USA
    Hypertension 46:772-9. 2005
    ..Notably, many of these pathways may be reversible in hypercholesterolemia, and crucial targets could potentially be identified for early interventions to preserve the kidney...
  82. ncbi request reprint Non-invasive evaluation of bilateral renal regional blood flow and tubular dynamics during acute unilateral ureteral obstruction
    Laura I Pelaez
    Department of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Nephrol Dial Transplant 20:83-8. 2005
    ..The advent of electron beam computerized tomography (EBCT) now allows us to evaluate non-invasively intrarenal haemodynamics and tubular fluid dynamics in vivo...
  83. ncbi request reprint Angiotensin II AT1 receptor blockade improves renal perfusion in hypercholesterolemia
    Alejandro R Chade
    Department of Internal Medicine, Division of Hypertension, Mayo Clinic, Rochester, Minnesota 55905, USA
    Am J Hypertens 16:111-5. 2003
    ..This study tested the hypothesis that AT1 receptor blockade improved renal perfusion and functional responses in hypercholesterolemic pigs...
  84. ncbi request reprint Assessment of renal hemodynamics and function in pigs with 64-section multidetector CT: comparison with electron-beam CT
    Elena Daghini
    Department of Medicine, Division of Nephrology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Radiology 243:405-12. 2007
    ..To prospectively evaluate the feasibility of obtaining reliable measurements of renal hemodynamics and function by using 64-section multidetector CT...
  85. pmc Increased glomerular filtration rate in early metabolic syndrome is associated with renal adiposity and microvascular proliferation
    Zilun Li
    Department of Internal Medicine, Division of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota 55905, USA
    Am J Physiol Renal Physiol 301:F1078-87. 2011
    ..Renal adiposity and proliferative microvessels may represent novel therapeutic targets for preserving renal function in early MetS...
  86. pmc Early experimental hypertension preserves the myocardial microvasculature but aggravates cardiac injury distal to chronic coronary artery obstruction
    Victor Hugo Urbieta Caceres
    Division of Nephrology and Hypertension, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
    Am J Physiol Heart Circ Physiol 300:H693-701. 2011
    ..HT modulates cardiac adaptive responses to CAS and bears cardiac functional consequences...
  87. pmc Persistent kidney dysfunction in swine renal artery stenosis correlates with outer cortical microvascular remodeling
    Alfonso Eirin
    Department of Internal Medicine, Division of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota 55905, USA
    Am J Physiol Renal Physiol 300:F1394-401. 2011
    ..MV loss and fibrosis in swine ARAS might account for persistent renal dysfunction after PTRS and underscore the need to assess renal parenchymal disease before revascularization...
  88. ncbi request reprint c-Myc oncoprotein: cell cycle-related events and new therapeutic challenges in cancer and cardiovascular diseases
    Filomena de Nigris
    Department of Pharmacological Sciences, University of Salerno, Salerno, Italy
    Cell Cycle 2:325-8. 2003
    ..In general, the increased biologic understanding of the participation of cell cycle events and targeting these events may enable to attenuate or prevent some of the complications of vascular and neoplastic diseases...
  89. ncbi request reprint Relation of nonperfused myocardial volume and surface area to left ventricular performance in coronary microembolization
    Nasser M Malyar
    Department of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine, Rochester, Minn 55905, USA
    Circulation 110:1946-52. 2004
    ..We hypothesized that the total surface area (SA), rather than the total volume, of NPM is the major determinant of ME-induced LV dysfunction...
  90. doi request reprint Positron-emission tomography imaging of the angiotensin II subtype 1 receptor in swine renal artery stenosis
    Jinsong Xia
    Department of Radiology, Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Hypertension 51:466-73. 2008
    ..The findings support the concept of introducing AT(1)R PET as a diagnostic biomarker of renovascular disease...
  91. ncbi request reprint Effects of proteasome inhibition on the kidney in experimental hypercholesterolemia
    Alejandro R Chade
    Department of Internal Medicine, Division of Nephrology and Hypertension, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA
    J Am Soc Nephrol 16:1005-12. 2005
    ..This study may support a role for the ubiquitin/proteasome system in the kidney in HC and early atherosclerosis...
  92. pmc Functional assessment of the kidney from magnetic resonance and computed tomography renography: impulse retention approach to a multicompartment model
    Jeff L Zhang
    Department of Radiology, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA
    Magn Reson Med 59:278-88. 2008
    ..These results support the reliability and validity of the new model in computing GFR, RPF, and renal mean transit times from MR and CT data...
  93. pmc Functional and structural remodeling of the myocardial microvasculature in early experimental hypertension
    Martin Rodriguez-Porcel
    Department of Internal Medicine, Division of Cardiovascular Disease, Mayo Clinic College of Medicine, 200 First St SW, Rochester, Minnesota 55905, USA
    Am J Physiol Heart Circ Physiol 290:H978-84. 2006
    ..These observations underscore the direct and early effects of HT on the myocardial vasculature...
  94. ncbi request reprint Lipoprotein-associated phospholipase A2 is an independent marker for coronary endothelial dysfunction in humans
    Eric H Yang
    Division of Cardiovascular Diseases, Mayo College of Medicine, Rochester, MN 55905, USA
    Arterioscler Thromb Vasc Biol 26:106-11. 2006
    ..The purpose of the current study was to determine whether lipoprotein-associated phospholipase A2 (Lp-PLA2) is associated with coronary endothelial dysfunction and is a predictor of endothelial dysfunction in humans...
  95. ncbi request reprint Impaired myocardial perfusion reserve in experimental hypercholesterolemia is independent of myocardial neovascularization
    Dallit Mannheim
    Division of Cardiovascular Diseases, Mayo Clinic Rochester, 200 First Street SW, Rochester, MN 55905, USA
    Am J Physiol Heart Circ Physiol 292:H2449-58. 2007
    ..This suggests that the myocardial neovascularization may not contribute to the attenuated myocardial perfusion response in hypercholesterolemia...
  96. ncbi request reprint Evaluation of porcine myocardial microvascular permeability and fractional vascular volume using 64-slice helical computed tomography (CT)
    Elena Daghini
    Department of Medicine, Division of Nephrology and Hypertension, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Invest Radiol 42:274-82. 2007
    ....
  97. ncbi request reprint Comparison of mathematic models for assessment of glomerular filtration rate with electron-beam CT in pigs
    Elena Daghini
    Division of Nephrology and Hypertension and Department of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine, 200 First St SW, Rochester, MN 55905, USA
    Radiology 242:417-24. 2007
    ..To prospectively compare in pigs three mathematic models for assessment of glomerular filtration rate (GFR) on electron-beam (EB) computed tomographic (CT) images, with concurrent inulin clearance serving as the reference standard...
  98. ncbi request reprint Quantification of myocardial microcirculatory function with X-ray CT
    Stefan Mohlenkamp
    Department of Cardiology, University Clinic Essen, Germany
    Ann N Y Acad Sci 972:307-16. 2002
    ..The simulation results also indicate that if the vascular diameters change so that the vascular resistance corresponds to the change in flow, then the empirically observed myocardial B(v)-to-F relationship holds well...
  99. ncbi request reprint Enhanced renal cortical vascularization in experimental hypercholesterolemia
    Michael D Bentley
    Department of Internal Medicine, Division of Hypertension, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Kidney Int 61:1056-63. 2002
    ..In this study, using a novel three-dimensional (3-D) micro computed-tomography technique we tested the hypothesis that hypercholesterolemia was associated with increased microvascular density in the renal cortex...
  100. ncbi request reprint Rethinking primary prevention of atherosclerosis-related diseases
    Claudio Napoli
    Department of General Pathology and Excellence Research Center on Cardiovascular Diseases, 1st School of Medicine, II University of Naples, Complesso S Andrea delle Dame, Naples 80134, Italy
    Circulation 114:2517-27. 2006
  101. ncbi request reprint Renal handling of X-ray contrast media imaging and exploration with electron beam CT
    Andrew D Rule
    Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA
    Ann N Y Acad Sci 972:317-24. 2002
    ..This ability to quantify renal regional attributes may not only shed light on the physiologic mechanisms that the kidney controls, but also assist in detecting subtle impairment in its function...

Research Grants1

  1. MECHANISMS OF RENAL IMPAIRMENT IN HYPERCHOLESTEROLEMIA
    Lilach Lerman; Fiscal Year: 2003
    ..Aim # 4 is to characterize intrarenal morphology in the HC pig model using 3-d x-ray micro-CT of microfil vascular casts and conventional light microscopy histology of tissue sections. ..