Hirohito Kita

Summary

Affiliation: Mayo Clinic
Country: USA

Publications

  1. pmc ILC2s and fungal allergy
    Hirohito Kita
    Department of Medicine, Mayo Clinic, Rochester, MN, USA Department of Immunology, Mayo Clinic, Rochester, MN, USA Electronic address
    Allergol Int 64:219-26. 2015
  2. pmc Eosinophils: multifunctional and distinctive properties
    Hirohito Kita
    Division of Allergic Diseases, Departments of Internal Medicine and Immunology, Mayo Clinic, Rochester, MN 55905, USA
    Int Arch Allergy Immunol 161:3-9. 2013
  3. pmc Eosinophils: multifaceted biological properties and roles in health and disease
    Hirohito Kita
    Division of Allergic Diseases, Department of Internal Medicine, Mayo Clinic, Rochester, MN 55905, USA
    Immunol Rev 242:161-77. 2011
  4. ncbi request reprint Does IgE bind to and activate eosinophils from patients with allergy?
    H Kita
    Department of Immunology and Internal Medicine, Mayo Clinic and Mayo Foundation, Rochester, MN 55905, USA
    J Immunol 162:6901-11. 1999
  5. pmc Airway uric acid is a sensor of inhaled protease allergens and initiates type 2 immune responses in respiratory mucosa
    Kenichiro Hara
    Division of Allergic Diseases, Department of Internal Medicine, Mayo Clinic, Rochester, MN 55905
    J Immunol 192:4032-42. 2014
  6. pmc Asthma-related environmental fungus, Alternaria, activates dendritic cells and produces potent Th2 adjuvant activity
    Takao Kobayashi
    Division of Allergic Diseases, Department of Internal Medicine, Mayo Clinic, Rochester, MN 55905, USA
    J Immunol 182:2502-10. 2009
  7. pmc T-bet expression by dendritic cells is required for the repolarization of allergic airway inflammation
    Karin L Heckman
    Department of Immunology, College of Medicine, Mayo Clinic, Rochester, MN 55905, USA
    Eur J Immunol 38:2464-74. 2008
  8. pmc Increased risk of serious pneumococcal disease in patients with atopic conditions other than asthma
    Ji A Jung
    Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN 55905, USA
    J Allergy Clin Immunol 125:217-21. 2010
  9. pmc IL-33-activated dendritic cells induce an atypical TH2-type response
    Matthew A Rank
    Department of Medicine, Division of Allergic Diseases, Mayo Clinic, Rochester, Minn, USA
    J Allergy Clin Immunol 123:1047-54. 2009
  10. pmc IL-33-responsive lineage- CD25+ CD44(hi) lymphoid cells mediate innate type 2 immunity and allergic inflammation in the lungs
    Kathleen R Bartemes
    Division of Allergic Diseases, Department of Internal Medicine, Mayo Clinic, Rochester, MN 55905, USA
    J Immunol 188:1503-13. 2012

Detail Information

Publications106 found, 100 shown here

  1. pmc ILC2s and fungal allergy
    Hirohito Kita
    Department of Medicine, Mayo Clinic, Rochester, MN, USA Department of Immunology, Mayo Clinic, Rochester, MN, USA Electronic address
    Allergol Int 64:219-26. 2015
    ....
  2. pmc Eosinophils: multifunctional and distinctive properties
    Hirohito Kita
    Division of Allergic Diseases, Departments of Internal Medicine and Immunology, Mayo Clinic, Rochester, MN 55905, USA
    Int Arch Allergy Immunol 161:3-9. 2013
    ..Further studies will be necessary to better understand the biology of this extraordinary leukocyte and to reveal the importance of the cell in human health and disease...
  3. pmc Eosinophils: multifaceted biological properties and roles in health and disease
    Hirohito Kita
    Division of Allergic Diseases, Department of Internal Medicine, Mayo Clinic, Rochester, MN 55905, USA
    Immunol Rev 242:161-77. 2011
    ..This review summarizes the emerging concept of the multifaceted immunobiology of eosinophils and discusses the roles of eosinophils in health and disease and the challenges and perspectives in the field...
  4. ncbi request reprint Does IgE bind to and activate eosinophils from patients with allergy?
    H Kita
    Department of Immunology and Internal Medicine, Mayo Clinic and Mayo Foundation, Rochester, MN 55905, USA
    J Immunol 162:6901-11. 1999
    ..Thus, IgG and/or cytokines, such as IL-5, appear to be more important for eosinophil activation in allergic diseases than IgE...
  5. pmc Airway uric acid is a sensor of inhaled protease allergens and initiates type 2 immune responses in respiratory mucosa
    Kenichiro Hara
    Division of Allergic Diseases, Department of Internal Medicine, Mayo Clinic, Rochester, MN 55905
    J Immunol 192:4032-42. 2014
    ..These findings provide mechanistic insights into the development of type 2 immunity to airborne allergens and recognize airway UA as a key player that regulates the process in respiratory mucosa. ..
  6. pmc Asthma-related environmental fungus, Alternaria, activates dendritic cells and produces potent Th2 adjuvant activity
    Takao Kobayashi
    Division of Allergic Diseases, Department of Internal Medicine, Mayo Clinic, Rochester, MN 55905, USA
    J Immunol 182:2502-10. 2009
    ..Such immunogenic properties of certain environmental fungi may explain their strong relationships with human asthma and allergic diseases...
  7. pmc T-bet expression by dendritic cells is required for the repolarization of allergic airway inflammation
    Karin L Heckman
    Department of Immunology, College of Medicine, Mayo Clinic, Rochester, MN 55905, USA
    Eur J Immunol 38:2464-74. 2008
    ....
  8. pmc Increased risk of serious pneumococcal disease in patients with atopic conditions other than asthma
    Ji A Jung
    Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN 55905, USA
    J Allergy Clin Immunol 125:217-21. 2010
    ..We reported an increased risk of serious pneumococcal disease (SPD) among patients with asthma. It is not known whether this is true for patients with other atopic conditions...
  9. pmc IL-33-activated dendritic cells induce an atypical TH2-type response
    Matthew A Rank
    Department of Medicine, Division of Allergic Diseases, Mayo Clinic, Rochester, Minn, USA
    J Allergy Clin Immunol 123:1047-54. 2009
    ..IL-33, a recently discovered IL-1 family cytokine, is implicated in the development of T(H)2-type responses in vivo. However, the cellular targets for IL-33 are poorly understood...
  10. pmc IL-33-responsive lineage- CD25+ CD44(hi) lymphoid cells mediate innate type 2 immunity and allergic inflammation in the lungs
    Kathleen R Bartemes
    Division of Allergic Diseases, Department of Internal Medicine, Mayo Clinic, Rochester, MN 55905, USA
    J Immunol 188:1503-13. 2012
    ..These cells may provide a novel mechanism for type 2 immunity in the airways and induction of allergic airway diseases such as asthma...
  11. pmc The danger signal, extracellular ATP, is a sensor for an airborne allergen and triggers IL-33 release and innate Th2-type responses
    Hideaki Kouzaki
    Division of Allergic Diseases, Department of Internal Medicine, Mayo Clinic, Rochester, MN 55905, USA
    J Immunol 186:4375-87. 2011
    ....
  12. ncbi request reprint Intranasal exposure to staphylococcal enterotoxin B elicits an acute systemic inflammatory response
    Govindarajan Rajagopalan
    Department of Immunology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Shock 25:647-56. 2006
    ..Thus, we have shown, for the first time, that intranasal administration of SEB can cause systemic immune activation...
  13. ncbi request reprint Chronic rhinosinusitis: an enhanced immune response to ubiquitous airborne fungi
    Seung Heon Shin
    Department of Internal Medicine, Mayo Clinic Rochester, Rochester, MN 55905, USA
    J Allergy Clin Immunol 114:1369-75. 2004
    ..Chronic rhinosinusitis (CRS) is one of the most common long-term illnesses in the United States. The etiology of CRS is unknown, and no effective treatment has been established...
  14. pmc Recognition of fungal protease activities induces cellular activation and eosinophil-derived neurotoxin release in human eosinophils
    Yoshinori Matsuwaki
    Department of Medicine and Immunology, Mayo Clinic, Rochester, MN 55905, USA
    J Immunol 183:6708-16. 2009
    ..Thus, fungal aspartate protease and eosinophil PAR-2 appear critical for the eosinophils' innate immune response to certain fungi, suggesting a novel mechanism for pathologic inflammation in asthma and for host-pathogen interaction...
  15. ncbi request reprint Striking deposition of toxic eosinophil major basic protein in mucus: implications for chronic rhinosinusitis
    Jens U Ponikau
    Department of Otorhinolaryngology Head and Neck Surgery, Mayo Clinic Rochester, Rochester, MN 55905, USA
    J Allergy Clin Immunol 116:362-9. 2005
    ..The mechanisms by which eosinophilic inflammation damages the epithelium and contributes to recurrent acute exacerbations in chronic rhinosinusitis (CRS) have not been fully elucidated...
  16. pmc A proposed model to study immunologic changes during chronic rhinosinusitis exacerbations: data from a pilot study
    Matthew A Rank
    Division of Allergy, Asthma, and Immunology, Mayo Clinic, Scottsdale, Arizona, USA
    Am J Rhinol Allergy 27:98-101. 2013
    ..One way to gain insight into the pathophysiology of chronic rhinosinusitis (CRS) is to study the immunologic changes that occur with exacerbation. This study describes the immunologic changes during CRS exacerbation..
  17. pmc Pimecrolimus reduces eosinophil activation associated with calcium mobilization
    Douglas A Plager
    Allergic Diseases Research Laboratory, Department of Dermatology, Mayo Clinic, Guggenheim 4 94, 200 First Street Southwest, Rochester, MN 55905, USA
    Int Arch Allergy Immunol 149:119-26. 2009
    ..However, its effects on eosinophils, a cell type implicated in allergic disease pathology, are unknown. Therefore, we examined the effects of pimecrolimus on eosinophil superoxide anion production, degranulation and survival...
  18. ncbi request reprint Platelet-activating factor stimulates cytoplasmic alkalinization and granule acidification in human eosinophils
    Jennifer L Bankers-Fulbright
    Department of Medicine, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    J Cell Sci 117:5749-57. 2004
    ..We propose that granule acidification is an important step in solubilization of major basic protein crystals, which are stored within the granule core, in preparation for degranulation and release of these proteins...
  19. pmc Gene transcription changes in asthmatic chronic rhinosinusitis with nasal polyps and comparison to those in atopic dermatitis
    Douglas A Plager
    Allergic Diseases Research Laboratory, Mayo Clinic, Rochester, Minnesota, United States of America
    PLoS ONE 5:e11450. 2010
    ....
  20. ncbi request reprint Effects of the very late adhesion molecule 4 antagonist WAY103 on human peripheral blood eosinophil vascular cell adhesion molecule 1-dependent functions
    Julie B Sedgwick
    Allergy and Immunology Unit, Department of Medicine, University of Wisconsin, Madison, WI, USA
    J Allergy Clin Immunol 116:812-9. 2005
    ..Small-molecule VLA-4 antagonists have been proposed as a therapeutic mechanism to prevent eosinophil infiltration in asthma; however, they might affect other eosinophil functions...
  21. ncbi request reprint Treatment of chronic rhinosinusitis with intranasal amphotericin B: a randomized, placebo-controlled, double-blind pilot trial
    Jens U Ponikau
    Department of Otorhinolaryngology Head and Neck Surgery, Mayo Clinic, Rochester, MN 55905, USA
    J Allergy Clin Immunol 115:125-31. 2005
    ..Chronic rhinosinusitis (CRS) is one of the most common chronic diseases. Its etiology is unknown, and there is a paucity of effective medical treatments...
  22. pmc Proteases induce production of thymic stromal lymphopoietin by airway epithelial cells through protease-activated receptor-2
    Hideaki Kouzaki
    Division of Allergic Diseases, Department of Internal Medicine, Mayo Clinic, Rochester, MN 55905, USA
    J Immunol 183:1427-34. 2009
    ..By promoting TSLP production in the airways, proteases associated with airborne allergens may facilitate the development and/or exacerbation of Th2-type airway inflammation, particularly in allergic individuals...
  23. ncbi request reprint Severity of childhood asthma and human leukocyte antigens type
    Young J Juhn
    Department of Pediatric and Adolescent Medicine, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    J Asthma 44:163-8. 2007
    ..Because of limited statistical power, our study findings are subject to further investigation...
  24. doi request reprint Influence of asthma status on serotype-specific pneumococcal antibody levels
    Ji A Jung
    Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN 55905, USA
    Postgrad Med 122:116-24. 2010
    ..Asthma has been reported to be associated with an increased risk of invasive pneumococcal disease (IPD)...
  25. ncbi request reprint Dendritic cells activated by cross-linking B7-DC (PD-L2) block inflammatory airway disease
    Suresh Radhakrishnan
    Department of Immunology, Mayo Clinic College of Medicine, Mayo Clinic, Rochester, MN 55905, USA
    J Allergy Clin Immunol 116:668-74. 2005
    ..A novel human antibody that activates human and mouse dendritic cells (DCs) by cross-linking B7-DC has strong immunomodulatory properties and blocks antigen-induced inflammatory lung disease in mice...
  26. pmc Spontaneous myocarditis mimicking human disease occurs in the presence of an appropriate MHC and non-MHC background in transgenic mice
    Veena Taneja
    Department of Immunology, Mayo Clinic College of Medicine, 200 First Street S W, Rochester, MN 55905, USA
    J Mol Cell Cardiol 42:1054-64. 2007
    ..This model of myocarditis occurs predominantly in female mice and may provide insight into the pathogenesis of heart disease in women...
  27. pmc Alternaria fungus induces the production of GM-CSF, interleukin-6 and interleukin-8 and calcium signaling in human airway epithelium through protease-activated receptor 2
    Yoshinori Matsuwaki
    Department of Immunology and Medicine, Mayo Clinic, Rochester, Minn, USA
    Int Arch Allergy Immunol 158:19-29. 2012
    ..However, our current knowledge on the innate immune responses of epithelium to environmental fungi is very limited. We investigated the responses of epithelium to fungi and the mechanisms of these responses...
  28. pmc Marked deposition of eosinophil-derived neurotoxin in adult patients with eosinophilic esophagitis
    Gail M Kephart
    Allergic Diseases Research Laboratory, Mayo Clinic, Rochester, Minnesota 55905, USA
    Am J Gastroenterol 105:298-307. 2010
    ..The goal of this study was to evaluate the magnitude and distribution of EDN deposition in tissue specimens from the esophagus of EoE patients...
  29. pmc A novel IL-1 family cytokine, IL-33, potently activates human eosinophils
    W Brett Cherry
    Division of Allergic Diseases, Department of Internal Medicine, Mayo Clinic, Rochester, Minn, USA
    J Allergy Clin Immunol 121:1484-90. 2008
    ..Mice injected with IL-33 display profound mucosal eosinophilia with associated pathologic changes. Although mast cells and T(H)2 cells express the IL-33 receptor, ST2, the roles of IL-33 and ST2 in eosinophil biology are unknown...
  30. pmc Dynamic role of epithelium-derived cytokines in asthma
    Kathleen R Bartemes
    Division of Allergic Diseases, Department of Internal Medicine, Mayo Clinic, Rochester, MN 55905, USA
    Clin Immunol 143:222-35. 2012
    ..Thus, the airway epithelium can no longer be regarded as a mere structural barrier, but must be considered an active player in the pathogenesis of asthma and other allergic disorders...
  31. pmc Lineage(-)Sca1+c-Kit(-)CD25+ cells are IL-33-responsive type 2 innate cells in the mouse bone marrow
    Adipong Brickshawana
    Department of Immunology, Mayo Clinic, Rochester, MN 55905, USA
    J Immunol 187:5795-804. 2011
    ..Thus, we identify the enigmatic bone marrow LSK(-)CD25(+) cells as IL-33 responsive, both in vitro and in vivo, with attributes similar to other type 2 innate cells described in peripheral tissues...
  32. ncbi request reprint Nonpathogenic, environmental fungi induce activation and degranulation of human eosinophils
    Yoshinari Inoue
    Department of Immunology, Mayo Clinic, Rochester, MN 55905, USA
    J Immunol 175:5439-47. 2005
    ..This innate response by eosinophils to certain environmental fungi may be important in host defense and in the exacerbation of inflammation in asthma and allergic diseases...
  33. pmc Cigarette smoke-induced oxidative stress suppresses generation of dendritic cell IL-12 and IL-23 through ERK-dependent pathways
    Paula R Kroening
    Department of Internal Medicine, Thoracic Diseases Research Unit, Division of Pulmonary Critical Care, Mayo Clinic and Foundation, Rochester, MN 55905, USA
    J Immunol 181:1536-47. 2008
    ..Some of the cigarette smoke-induced inhibitory effects on DC function may be mitigated by antioxidants...
  34. pmc Innate antifungal immunity of human eosinophils mediated by a beta 2 integrin, CD11b
    Juhan Yoon
    Department of Immunology, Division of Allergic Disease, Mayo Graduate School, Mayo Clinic, Rochester, MN 55905, USA
    J Immunol 181:2907-15. 2008
    ..This immune response by eosinophils may benefit the host, but, in turn, it may also play a role in the development and/or exacerbation of eosinophil-related allergic human diseases, such as asthma...
  35. pmc IL-33 and thymic stromal lymphopoietin mediate immune pathology in response to chronic airborne allergen exposure
    Koji Iijima
    Division of Allergic Diseases, Department of Internal Medicine, Mayo Clinic, Rochester, MN 55905
    J Immunol 193:1549-59. 2014
    ..Thus, chronic exposure to natural airborne allergens triggers a network of innate and adaptive type 2 immune responses and airway pathology, and IL-33 and thymic stromal lymphopoietin most likely play key roles in this process. ..
  36. doi request reprint Serum 25-hydroxyvitamin D concentrations and waning pneumococcal antibody titers among individuals with atopy
    Eell Ryoo
    Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN 55905, USA
    Allergy Asthma Proc 34:370-7. 2013
    ..Serum 25(OH)D concentrations are inversely associated with the waning of PATs over time, especially individuals with asthma and other atopy conditions. These study findings deserve further investigation. ..
  37. doi request reprint Swallowed fluticasone improves histologic but not symptomatic response of adults with eosinophilic esophagitis
    Jeffrey A Alexander
    Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Clin Gastroenterol Hepatol 10:742-749.e1. 2012
    ..We evaluated the effect of aerosolized fluticasone therapy on symptomatic dysphagia and histologic eosinophilia in adults with eosinophilic esophagitis (EoE)...
  38. ncbi request reprint CD66b regulates adhesion and activation of human eosinophils
    Juhan Yoon
    Department of Immunology, Mayo Graduate School, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    J Immunol 179:8454-62. 2007
    ..Binding of exogenous or endogenous carbohydrate ligands(s) to CD66b may be important in the release of proinflammatory mediators by human eosinophils...
  39. pmc Extensive fractionation and identification of proteins within nasal lavage fluids from allergic rhinitis and asthmatic chronic rhinosinusitis patients
    Linda M Benson
    Mayo Proteomics Research Center, Mayo Clinic, Rochester, MN, USA
    J Sep Sci 32:44-56. 2009
    ..This is the first extensive list of NLF proteins generated from CRS patients with coexisting asthma...
  40. ncbi request reprint Secretory IgA induces antigen-independent eosinophil survival and cytokine production without inducing effector functions
    Kathleen R Bartemes
    Division of Allergic Diseases, Department of Internal Medicine, Mayo Clinic Rochester, MN 55905, USA
    J Allergy Clin Immunol 116:827-35. 2005
    ..Secretory IgA (S-IgA) is the predominant antibody secreted by these tissues and likely plays a role in the innate immune response...
  41. doi request reprint Antigen-specific IgG and IgA, but not IgE, activate the effector functions of eosinophils in the presence of antigen
    Masato Muraki
    Division of Allergic Diseases and Department of Medicine, Mayo Clinic Rochester, Rochester, Minn, USA
    Int Arch Allergy Immunol 154:119-27. 2011
    ..Prior reports suggest that eosinophils have receptors recognizing IgA, IgG and IgE; however, little is known regarding the direct effects of antigens and antigen-specific immunoglobulins on the functions of eosinophils...
  42. pmc Antifungal therapy for chronic rhinosinusitis: the controversy persists
    Matthew A Rank
    Division of Allergic Diseases, Mayo Clinic, Rochester, Minnesota 55905, USA
    Curr Opin Allergy Clin Immunol 9:67-72. 2009
    ..Recent research examining the pathophysiological mechanisms and treatment options for chronic rhinosinusitis have yielded contradicting results, particularly in regard to the role of fungi and antifungal therapies...
  43. pmc Intranasal exposure to bacterial superantigens induces airway inflammation in HLA class II transgenic mice
    Govindarajan Rajagopalan
    Department of Immunology, Mayo Clinic College of Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Infect Immun 74:1284-96. 2006
    ..In conclusion, repeated chronic intranasal exposure to bacterial superantigens causes airway inflammation and systemic immune activation...
  44. ncbi request reprint Features of airway remodeling and eosinophilic inflammation in chronic rhinosinusitis: is the histopathology similar to asthma?
    Jens U Ponikau
    Department of Otolaryngology Head and Neck Surgery, Mayo Clinic, Rochester, Minn 55905, USA
    J Allergy Clin Immunol 112:877-82. 2003
    ..Although epithelial damage and basement membrane thickening are well-known features of airway remodeling in asthma, they have not been described in CRS...
  45. ncbi request reprint Peripheral blood eosinophils from patients with allergic asthma contain increased intracellular eosinophil-derived neurotoxin
    Julie B Sedgwick
    Allergy and Immunology, Department of Medicine, University of Wisconsin, Madison, WI 53792, USA
    J Allergy Clin Immunol 114:568-74. 2004
    ....
  46. pmc Induction of malignant plasma cell proliferation by eosinophils
    Tina W Wong
    Department of Immunology, Mayo Clinic, Rochester, Minneapolis, USA
    PLoS ONE 8:e70554. 2013
    ..Taken together, our study demonstrates for the first time a role for Eos in the pathology of MM and suggests that therapeutic strategies targeting these cells may be beneficial. ..
  47. doi request reprint Increased numbers of eosinophils, rather than only etiology, predict histologic changes in patients with esophageal eosinophilia
    Srividya Sridhara
    Division of Allergy and Immunology, Mayo Clinic, Rochester, MN 55905, USA
    Clin Gastroenterol Hepatol 10:735-41. 2012
    ..We investigated differences in histologic and eosinophil patterns and numbers of mast cells between patients with these disorders...
  48. pmc Reduced immunoglobulin M is associated with sinus mucosal thickening, osteitis and sinus surgery in patients with common variable immunodeficiency
    John B Hagan
    Department of Medicine, Division of Allergic Diseases, Mayo Clinic and Foundation, Rochester, Minn, USA
    Int Arch Allergy Immunol 152:81-6. 2010
    ....
  49. pmc Nicotine and oxidative cigarette smoke constituents induce immune-modulatory and pro-inflammatory dendritic cell responses
    Robert Vassallo
    Thoracic Diseases Research Unit, Mayo Clinic and Foundation, Rochester, MN 55905, USA
    Mol Immunol 45:3321-9. 2008
    ..Certain pharmacologic strategies such as anti-oxidant therapy may be only partially effective in mitigating cigarette smoke-induced pro-inflammatory DC-mediated responses in smokers...
  50. ncbi request reprint Blockade of allergic airway inflammation following systemic treatment with a B7-dendritic cell (PD-L2) cross-linking human antibody
    Suresh Radhakrishnan
    Department of Immunology, and Division of Allergic Disease and Internal Medicine, Mayo Clinic College of Medicine, Mayo Clinic, Rochester, MN 55905, USA
    J Immunol 173:1360-5. 2004
    ..These studies demonstrate that the immune response of hypersensitized responders can be modulated using B7-DC cross-linking Abs, preventing allergic airway disease upon re-exposure to allergen...
  51. pmc Human eosinophils recognize endogenous danger signal crystalline uric acid and produce proinflammatory cytokines mediated by autocrine ATP
    Takehito Kobayashi
    Division of Allergic Diseases, Department of Medicine and Department of Immunology, Mayo Clinic, Rochester, MN 55905, USA
    J Immunol 184:6350-8. 2010
    ..These responses by eosinophils to tissue damage may explain the self-perpetuating nature of chronic inflammation in certain human diseases, such as asthma...
  52. ncbi request reprint The role of protease activation of inflammation in allergic respiratory diseases
    Charles E Reed
    Allergic Diseases Research Laboratory, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    J Allergy Clin Immunol 114:997-1008; quiz 1009. 2004
    ..Future research promises to promote our understanding of the pathogenesis of allergic respiratory diseases and point the way to new therapies...
  53. ncbi request reprint Allergen-specific in vitro cytokine production in adult patients with eosinophilic esophagitis
    Kiyoshi Yamazaki
    Division of Allergic Diseases, Department of Internal Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Dig Dis Sci 51:1934-41. 2006
    ..Thus, immune responses in EE are characterized by enhanced production of Th2-like cytokines against both food and environmental allergens...
  54. ncbi request reprint Intranasal antifungal treatment in 51 patients with chronic rhinosinusitis
    Jens U Ponikau
    Department of Otorhinolaryngology Head and Neck Surgery, Mayo Clinic Rochester, Rochester, MN 55905, USA
    J Allergy Clin Immunol 110:862-6. 2002
    ..Chronic rhinosinusitis (CRS) is the most common chronic disease that is frequently refractory to treatment...
  55. ncbi request reprint Localization of eosinophil-derived neurotoxin and eosinophil cationic protein in neutrophilic leukocytes
    S Sur
    Department of Immunology, Mayo Clinic and Mayo Foundation, and Mayo Medical School, Rochester, Minnesota 55905, USA
    J Leukoc Biol 63:715-22. 1998
    ..Thus, caution must be exercised in interpreting the presence of EDN and ECP as specific markers of eosinophil-associated inflammation in human disease...
  56. pmc B cells play key roles in th2-type airway immune responses in mice exposed to natural airborne allergens
    Li Yin Drake
    Department of Internal Medicine, Division of Allergic Diseases, Mayo Clinic, Rochester, Minnesota, United States of America
    PLoS ONE 10:e0121660. 2015
    ..The therapeutic targeting of B cells may be beneficial to treat asthma in certain patients...
  57. ncbi request reprint Human eosinophils are activated by cysteine proteases and release inflammatory mediators
    Satoshi Miike
    Department of Medicine Division of Allergic Diseases, Mayo Clinic Rochester, MN 55905, USA
    J Allergy Clin Immunol 111:704-13. 2003
    ..However, the functions of other proteases, such as cysteine proteases, are poorly understood and need elucidation...
  58. pmc Gene transcription abnormalities in canine atopic dermatitis and related human eosinophilic allergic diseases
    Douglas A Plager
    Allergic Diseases Research Laboratory, Mayo Clinic, Rochester, MN 55905, USA
    Vet Immunol Immunopathol 149:136-42. 2012
    ..Overall, numerous abnormally transcribed genes were observed only in canine AD; however, many others are common to related human eosinophilic allergic diseases and represent therapeutic targets testable in dogs with AD...
  59. doi request reprint Serum 25-hydroxyvitamin D is associated with enhanced pneumococcal antibody levels in individuals with asthma
    Jusuk Lee
    Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA
    Allergy Asthma Proc 32:445-52. 2011
    ..Atopic conditions may have an important effect modifier in the relationship between serum 25(OH)D concentrations and immune function...
  60. ncbi request reprint Treatment of asthma with nebulized lidocaine: a randomized, placebo-controlled study
    Loren W Hunt
    Department of Internal Medicine, Division of Allergic Diseases, Mayo Clinic and Foundation, Mayo Graduate School of Medicine, Rochester, MN 55905, USA
    J Allergy Clin Immunol 113:853-9. 2004
    ..In 2 prior uncontrolled studies, nebulized lidocaine reduced oral glucocorticoid use in patients with severe glucocorticoid-dependent asthma...
  61. pmc Increased risk of serious pneumococcal disease in patients with asthma
    Young J Juhn
    Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN 55905, USA
    J Allergy Clin Immunol 122:719-23. 2008
    ..Individuals with asthma have been reported to be at increased risk of invasive pneumococcal disease (IPD). These findings need to be confirmed in a different population-based study setting...
  62. ncbi request reprint Regulation of eosinophil membrane depolarization during NADPH oxidase activation
    Jennifer L Bankers-Fulbright
    Department of Medicine, Mayo Clinic Rochester, Rochester, MN 55905, USA
    J Cell Sci 116:3221-6. 2003
    ..Thus, the membrane depolarization that is associated with NADPH oxidase activation in eosinophils is sufficient to produce marked proton channel activation under physiological conditions...
  63. ncbi request reprint Innate immunomodulatory effects of cereal grains through induction of IL-10
    Kiyoshi Yamazaki
    Division of Allergic Diseases, Mayo Clinic College of Medicine, Rochester, MN, USA
    J Allergy Clin Immunol 121:172-178.e3. 2008
    ..Although immunomodulation by microbial factors has been studied extensively, little attention has been given to the potential immunomodulatory effects of ingested foods...
  64. ncbi request reprint Pathogenesis of chronic rhinosinusitis: role of airborne fungi and bacteria
    Laura J B Davis
    Division of Allergic Diseases, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Immunol Allergy Clin North Am 24:59-73. 2004
  65. ncbi request reprint Childhood asthma and human leukocyte antigen type
    Y J Juhn
    Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN 55905, USA
    Tissue Antigens 69:38-46. 2007
    ..However, the HLA class II gene does not explain the influences of family history of asthma or atopy on development of asthma. The mechanism underlying the association between asthma and HLA genes needs to be elucidated...
  66. ncbi request reprint Regulation of human eosinophil NADPH oxidase activity: a central role for PKCdelta
    J L Bankers-Fulbright
    Allergic Diseases Research Laboratory, Department of Immunology, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
    J Cell Physiol 189:306-15. 2001
    ..Our results indicate that the G-protein-coupled LTB4 receptor and the IL-5 cytokine receptor converge on a common signaling pathway involving PI 3-kinase and PKCdelta to regulate NADPH oxidase activity in human eosinophils...
  67. ncbi request reprint Ursodeoxycholic acid inhibits eosinophil degranulation in patients with primary biliary cirrhosis
    K Yamazaki
    Department of Immunology, Mayo Clinic and Mayo Foundation, Rochester, MN, USA
    Hepatology 30:71-8. 1999
    ..Our results suggest that eosinophils in patients with PBC are not only increased in number, but also release granule proteins, and that UDCA treatment inhibits this eosinophil activation/degranulation...
  68. doi request reprint The FACT score in predicting pneumococcal antibody levels in asthmatics
    Jenna C Podjasek
    Division of Allergic Diseases, Mayo Clinic, Rochester, MN, USA
    J Asthma 52:370-5. 2015
    ..There is no measure currently available to identify asthmatics with potential immune incompetence...
  69. doi request reprint Accuracy, safety, and tolerability of tissue collection by Cytosponge vs endoscopy for evaluation of eosinophilic esophagitis
    David A Katzka
    Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota Electronic address
    Clin Gastroenterol Hepatol 13:77-83.e2. 2015
    ..We compared the accuracy, safety, and tolerability of sample collection via Cytosponge (an ingestible gelatin capsule comprising compressed mesh attached to a string) with those of endoscopy for assessment of EoE...
  70. doi request reprint Analysis of fluticasone propionate in induced sputum by mass spectrometry
    John B Hagan
    Division of Allergic Diseases, Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota, USA
    Allergy Asthma Proc 32:18-21. 2011
    ..Induced asthmatic sputum from one induction may be used to concomitantly assess sputum eosinophilia as well as recent administration of FP...
  71. ncbi request reprint Marked airway eosinophilia prevents development of airway hyper-responsiveness during an allergic response in IL-5 transgenic mice
    Takao Kobayashi
    Division of Allergic Diseases, Department of Internal Medicine, Mayo Clinic, Rochester, MN 55905, USA
    J Immunol 170:5756-63. 2003
    ..Overall, the roles of eosinophils in asthma and in animal models need to be addressed carefully for their potentially detrimental and beneficial effects...
  72. ncbi request reprint Detection of fungal organisms in eosinophilic mucin using a fluorescein-labeled chitin-specific binding protein
    Matthew J Taylor
    Division of Allergy and Infection Diseases, Mayo Clinic, Rochester, MN 55905, USA
    Otolaryngol Head Neck Surg 127:377-83. 2002
    ..The ability to identify fungal hyphae in patients with chronic rhinosinusitis (CRS) has been inconsistent. A new fluorescein-labeled staining method targets chitin found in fungal cell walls...
  73. doi request reprint Neuropeptide levels in nasal secretions from patients with and without chronic cough
    Kaiser G Lim
    Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, Minnesota, USA
    Ann Allergy Asthma Immunol 107:360-3. 2011
    ..The pathophysiology of upper airway cough syndrome is not well understood...
  74. pmc The Role of IL-17 in the Association between Pneumococcal Pneumonia and Allergic Sensitization
    Hongxia Zhao
    Division of Community Pediatric and Adolescent Medicine, Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN, USA
    Int J Microbiol 2011:709509. 2011
    ..1, 95%CI: 1.03-1.17 per increment of 1.0 pg/mL, P = 0.003) in determining the risk of pneumococcal pneumonia. IL-17 levels result in a much smaller impact on the risk for pneumococcal pneumonia, compared to IL-4 levels...
  75. ncbi request reprint Human eosinophils produce neurotrophins and secrete nerve growth factor on immunologic stimuli
    Hitoshi Kobayashi
    Department of Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Blood 99:2214-20. 2002
    ..Alternatively, eosinophils may play important roles in maintenance and restoration of homeostatic functions of mucosal tissues through the pleitropic activities of NGF...
  76. ncbi request reprint The chemotactic behavior of eosinophils in patients with chronic rhinosinusitis
    Julie L Wei
    Department of Otorhinolaryngology, Mayo Clinic, 200 First Street Southwest, Rochester, MN 55905, USA
    Laryngoscope 113:303-6. 2003
    ..To characterize peripheral eosinophil migration in patients with chronic rhinosinusitis in the presence of nasal mucin and nasal tissue extracts...
  77. ncbi request reprint Biological activities of ecalectin: a novel eosinophil-activating factor
    Ryoji Matsumoto
    Department of Immunology, Mayo Clinic and Mayo Foundation, Rochester, MN 55905, USA
    J Immunol 168:1961-7. 2002
    ..Therefore, we conclude that ecalectin is a novel eosinophil-activating factor. Presumably, these effects allow ecalectin to play a distinctive role in allergic inflammation...
  78. ncbi request reprint Removal of bronchoalveolar cells augments the late eosinophilic response to segmental allergen challenge
    L W Hunt
    Division of Allergic Diseases Department of Internal Medicine, Mayo Clinic and Foundation, Rochester, Minnesota, USA
    Clin Exp Allergy 32:210-6. 2002
    ..Through activation via their FcepsilonRII receptors or by acting as antigen-presenting cells, macrophages could, in theory, promote the late airway response to allergen...
  79. ncbi request reprint Bile acids induce eosinophil degranulation by two different mechanisms
    K Yamazaki
    Department of Immunology, Mayo Clinic and Mayo Foundation, Rochester, MN 55905, USA
    Hepatology 33:582-90. 2001
    ..In conclusion, we have shown that bile acids are capable of directly activating eosinophils...
  80. ncbi request reprint Effects of (R)- and (S)-isomers of beta-adrenergic agonists on eosinophil response to interleukin-5
    G W Volcheck
    Department of Internal Medicine, Division of Allergic Diseases, The Allergic Diseases Research Laboratory, Mayo Clinic and Foundation, Mayo Graduate School of Medicine, Rochester, MN 55905, USA
    Clin Exp Allergy 35:1341-6. 2005
    ..Potential differences in the biological activities and clinical efficacies among racemic beta2-agonists and their isomers are controversial, and research into these possible differences is limited...
  81. doi request reprint Inhibition of MEK pathway in vestibular schwannoma cell culture
    Brian A Neff
    Department of Otolaryngology Head and Neck Surgery, Mayo Clinic School of Medicine, Rochester, Minnesota 55905, USA
    Laryngoscope 122:2269-78. 2012
    ..Mitogen-activated protein kinase kinase (MEK) inhibitor CI-1040 (PD184352) was utilized to evaluate the effect of specific MEK inhibition on benign schwannoma cell culture proliferation and apoptosis...
  82. doi request reprint Preoperative evaluation of patients with history of allergy to penicillin: comparison of 2 models of practice
    Evangelo Frigas
    Division of Allergic Diseases, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
    Mayo Clin Proc 83:651-62. 2008
    ..To study whether allergy consultation and penicillin allergy skin testing affects the selection of antibacterial prophylaxis perioperatively in surgical patients with history of allergy to penicillin (HOAP)...
  83. ncbi request reprint Eosinophilic-lymphocytic myocarditis after smallpox vaccination
    Joseph G Murphy
    Division of Cardiovascular Diseases, Mayo Clinic and Foundation, 200 First Street SW, Rochester, MN 55905, USA
    Lancet 362:1378-80. 2003
    ..A better understanding of the aberrant immune mechanism of myocyte injury after smallpox vaccination might improve the risk/benefit assessment for people considering smallpox vaccination and better smallpox vaccines in the future...
  84. ncbi request reprint Phase I trial of sirolimus combined with radiation and cisplatin in non-small cell lung cancer
    Jann N Sarkaria
    Department of Radiation Oncology, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Thorac Oncol 2:751-7. 2007
    ..The safety and tolerability of sirolimus combined with thoracic radiation and cisplatin was evaluated in patients with lung cancer. In parallel, the effects of sirolimus were studied in a murine model of radiation pneumonitis...
  85. ncbi request reprint Childhood asthma and measles vaccine response
    Young J Juhn
    Division of Pediatric and Adolescent Medicine, Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA
    Ann Allergy Asthma Immunol 97:469-76. 2006
    ..Asthmatic patients have a TH2-predominant milieu that is associated with humoral immunity. However, little is known about whether humoral immune responses to viral antigens differ between asthmatic and nonasthmatic children...
  86. ncbi request reprint Ligation of the beta2 integrin triggers activation and degranulation of human eosinophils
    M Kato
    Department of Immunology, Mayo Clinic and Mayo Foundation, Rochester, Minnesota, USA
    Am J Respir Cell Mol Biol 18:675-86. 1998
    ..Tyrosine phosphorylation of a 115 kD protein and Cbl may play important roles in adhesion-dependent cellular functions of eosinophils...
  87. ncbi request reprint Trypsin induces activation and inflammatory mediator release from human eosinophils through protease-activated receptor-2
    S Miike
    Department of Medicine, Division of Allergic Diseases, Mayo Clinic, Rochester, MN 55905, USA
    J Immunol 167:6615-22. 2001
    ..The expression and functional relevance of other PARs still need to be determined...
  88. ncbi request reprint A critical role for vesicle-associated membrane protein-7 in exocytosis from human eosinophils and neutrophils
    M R Logan
    Pulmonary Research Group, Department of Medicine, University of Alberta, Edmonton, AB, Canada, and Department of Medicine and Immunology, Mayo Clinic, Rochester, MN, USA
    Allergy 61:777-84. 2006
    ..Vesicle-associated membrane proteins-7 and -8 have been implicated in endosome/lysosome trafficking, however, their role in granulocyte exocytosis remains obscure...
  89. ncbi request reprint Eosinophil-active cytokine from mononuclear cells cultured with L-tryptophan products: an unexpected consequence of endotoxin contamination
    H Kita
    Department of Immunology, Mayo Clinic, Rochester, MN 55905, USA
    J Allergy Clin Immunol 95:1261-7. 1995
    ..Endotoxin contamination must be considered as a possible cause of eosinophil-active cytokine production by peripheral blood mononuclear cells...
  90. ncbi request reprint The role of ubiquitous airborne fungi in chronic rhinosinusitis
    Jens U Ponikau
    Department of Otorhinolaryngology, University at Buffalo, The State University of New York, Buffalo, NY, USA
    Clin Rev Allergy Immunol 30:187-94. 2006
    ..Overall, these recent discoveries provide a logical mechanism for the pathophysiology of CRS, and they also suggest promising avenues for treatment of CRS with antifungal agents...
  91. ncbi request reprint The synthetic chemoattractant peptide WKYMVm induces superoxide production by human eosinophils via the phosphoinositide 3-kinase-mediated activation of ERK1/2
    Myeong Heon Shin
    Department of Parasitology, Institute of Tropical Medicine and Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, Seoul, Korea
    Int Arch Allergy Immunol 137:21-6. 2005
    ..The synthetic peptide, Trp-Lys-Tyr-Met-Val-D-Met (WKYMVm), has been previously shown to activate eosinophils and thus to enhance respiratory burst through the formyl peptide receptors...
  92. pmc Degranulation of human eosinophils induced by Paragonimus westermani-secreted protease
    Myeong Heon Shin
    Department of Parasitology, Institute of Tropical Medicine, and Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, Seoul 120 752, Korea
    Korean J Parasitol 43:33-7. 2005
    ..These findings suggest that human eosinophils become degranulated in response to P. westermani-secreted proteases, which may contribute to in vivo tissue inflammation around the worms...
  93. ncbi request reprint The role of ubiquitous airborne fungi in chronic rhinosinusitis
    Jens U Ponikau
    Department of Otorhinolaryngology, University at Buffalo, State University of New York, Buffalo, New York, USA
    Clin Allergy Immunol 20:177-84. 2007
  94. ncbi request reprint CD38-deficient mice have reduced airway hyperresponsiveness following IL-13 challenge
    Alonso G P Guedes
    Department of Veterinary Clinicial Sciences, University of Minnesota, St Paul, MN 55108, USA
    Am J Physiol Lung Cell Mol Physiol 291:L1286-93. 2006
    ..The results indicate that CD38 contributes to airway hyperresponsiveness in lungs exposed to IL-13 at least partly by increasing airway smooth muscle reactivity to contractile agonists...
  95. ncbi request reprint Role of CD38 in TNF-alpha-induced airway hyperresponsiveness
    Alonso G P Guedes
    Department of Veterinary and Biomedical Sciences, College of Veterinary Medicine, University of Minnesota, 1971 Commonwealth Avenue, St Paul, MN 55108, USA
    Am J Physiol Lung Cell Mol Physiol 294:L290-9. 2008
    ..The mechanisms involved in this remission remain to be determined...
  96. ncbi request reprint The role of ubiquitous airborne fungi in chronic rhinosinusitis
    Jens U Ponikau
    Department of Otorhinolaryngology, University at Buffalo, The State University of New York, 3C41 Millard Fillmore Hospital, 3 Gates Circle, Buffalo, NY 14209, USA
    Curr Allergy Asthma Rep 5:472-6. 2005
    ..Overall, these recent discoveries provide a logical mechanism for the pathophysiology of CRS, and they also suggest promising avenues for treatment of CRS with antifungal agents...
  97. pmc Blood and sputum eosinophil levels in asthma and their relationship to sinus computed tomographic findings
    Vinay Mehta
    Center for Allergy, Asthma and Immunology, Creighton University, Omaha, NE, USA
    Mayo Clin Proc 83:671-8. 2008
    ..To investigate the relationship among blood and sputum eosinophil levels, sinus mucosal thickening, and osteitis in patients with asthma...
  98. pmc A 27 kDa cysteine protease secreted by newly excysted Paragonimus westermani metacercariae induces superoxide anion production and degranulation of human eosinophils
    Young Bae Chung
    Department of Parasitology, Cheju National University College of Medicine, Jeju 690 756, Korea
    Korean J Parasitol 46:95-9. 2008
    ....
  99. ncbi request reprint Platelet-activating factor activates two distinct effector pathways in human eosinophils
    Masahiko Kato
    Department of Pediatrics, Gunma University School of Medicine, Japan
    J Immunol 169:5252-9. 2002
    ..These two activation pathways may explain the eosinophils' strong and diverse biological responses to PAF...
  100. pmc Studies on regulation of IGF (insulin-like growth factor)-binding protein (IGFBP) 4 proteolysis by pregnancy-associated plasma protein-A (PAPP-A) in cells treated with phorbol ester
    Arun S Sivanandam
    Musculoskeletal Disease Center, J L Pettis Memorial Veterans Medical Center, 11201 Benton Street, Loma Linda, CA 92357, USA
    Biochem J 379:57-64. 2004
    ..These data suggest that a novel mechanism, namely conversion of PAPP-A470 to the less-active PAPP-A400, could account for the TPA-induced suppression of PAPP-A activity...
  101. ncbi request reprint School examinations enhance airway inflammation to antigen challenge
    Lin Ying Liu
    Allergy and Immunology and Pulmonary and Critical Care Sections of the Department of Medicine, University of Wisconsin, Madison, Wisconsin, USA
    Am J Respir Crit Care Med 165:1062-7. 2002
    ..Our findings suggest that stress associated with final examinations can act as a cofactor to increase eosinophilic airway inflammation to antigen challenge and thus may enhance asthma severity...

Research Grants3

  1. Mechanisms of Eosinophilic Inflammation in Human Asthma
    Hirohito Kita; Fiscal Year: 2005
    ..abstract_text> ..
  2. Planning a Multicenter Oral Itraconazole Trial in Chronic Rhinosinusitis Patients
    Hirohito Kita; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  3. MECHANISMS OF EOSINOPHIL DEGRANULATION IN HUMAN DISEASE
    Hirohito Kita; Fiscal Year: 2010
    ..Relevance: Patients with asthma have persistent respiratory problems. This research will investigate how the interaction of immune cells and our environment cause and worsen the disease. ..