David T Jones
Affiliation: Mayo Clinic
- Default mode network disruption secondary to a lesion in the anterior thalamusDavid T Jones
Department of Neurology, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
Arch Neurol 68:242-7. 2011..To describe the neuroanatomical correlations of an isolated lesion in the anterior thalamus using functional imaging in a 40-year-old man with multiple sclerosis...
- Cascading network failure across the Alzheimer's disease spectrumDavid T Jones
1 Department of Neurology, Mayo Clinic, Rochester, MN, 55905, USA 2 Department of Radiology, Mayo Clinic, Rochester, MN, 55905, USA
Brain 139:547-62. 2016..Possible interpretations include that the molecular-level events drive the network failure, a pathological interaction between the network-level and the molecular-level, or other upstream factors are driving both. ..
- Working memory and language network dysfunctions in logopenic aphasia: a task-free fMRI comparison with Alzheimer's dementiaJennifer L Whitwell
Department of Radiology, Mayo Clinic, Rochester, MN, USA Electronic address
Neurobiol Aging 36:1245-52. 2015..Patterns of network dysfunction differ across these 2 clinical variants of Alzheimer's disease, with lvPPA particularly associated with disruptions in the language and left working memory networks. ..
- Role of β-Amyloidosis and Neurodegeneration in Subsequent Imaging Changes in Mild Cognitive ImpairmentDavid S Knopman
Department of Neurology, Mayo Clinic and Foundation, Rochester, Minnesota2Mayo Clinic Alzheimer s Disease Research Center, Mayo Clinic and Foundation, Rochester, Minnesota
JAMA Neurol 72:1475-83. 2015..To understand how a model of Alzheimer disease pathophysiology based on β-amyloidosis and neurodegeneration predicts the regional anatomic expansion of hypometabolism and atrophy in persons with mild cognitive impairment (MCI)...
- Amyloid-first and neurodegeneration-first profiles characterize incident amyloid PET positivityClifford R Jack
From the Departments of Radiology C R J, V L, P V, D T J, M L S, J L G, B E G, Health Sciences Research H J W, S D W, M M M, V S P, and Neurology D S K, R C P, Mayo Clinic and Foundation, Rochester, MN
Neurology 81:1732-40. 2013..To estimate the incidence of and to characterize cognitive and imaging findings associated with incident amyloid PET positivity...
- Regional brain stiffness changes across the Alzheimer's disease spectrumMatthew C Murphy
Department of Radiology, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA
Neuroimage Clin 10:283-90. 2016....
- Non-stationarity in the "resting brain's" modular architectureDavid T Jones
Department of Neurology, Mayo Clinic, Rochester, Minnesota, United States of America
PLoS ONE 7:e39731. 2012..DMN dwell time in specific modular configurations may also underlie the TF-fMRI findings that have been described in mild cognitive impairment and cognitively normal subjects who are at risk for Alzheimer's dementia...
- The alien limb phenomenonJonathan Graff-Radford
Department of Neurology, Mayo Clinic, 200 1st Street SW, Rochester, MN 55905, USA
J Neurol 260:1880-8. 2013..004). These findings support the notion that the alien limb phenomenon is partially related to damage underlying the parietal cortex, especially right parietal, disconnecting it from other cortical areas...
- Effect of APOE ε4 status on intrinsic network connectivity in cognitively normal elderly subjectsMary M Machulda
Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MN 55905, USA
Arch Neurol 68:1131-6. 2011..To examine default mode and salience network functional connectivity as a function of APOE ε4 status in a group of cognitively normal age-, sex-, and education-matched older adults...
- Classification and clinicoradiologic features of primary progressive aphasia (PPA) and apraxia of speechHugo Botha
Department of Neurology Behavioural Neurology, Mayo Clinic, Rochester, MN, USA
Cortex 69:220-36. 2015..Our findings support consideration of an alternative way of identifying and categorizing subtypes of degenerative speech and language disorders. ..
- Disrupted thalamocortical connectivity in PSP: a resting-state fMRI, DTI, and VBM studyJennifer L Whitwell
Department of Radiology, Mayo Clinic, 200 1st Street SW, Rochester, MN 55905, USA
Parkinsonism Relat Disord 17:599-605. 2011..PSP is therefore associated with disrupted thalamocortical connectivity that is associated with degeneration of the dentatorubrothalamic tract and the presence of cortical atrophy...
- Statistical SPECT processing in MRI-negative epilepsy surgeryVlastimil Sulc
From the Departments of Neurology V S, B H B, D T J, G D C, L C W K, J W B, E L S, G A W and Radiology M L S, B P M, R E W and Biomedical Imaging Resource S S, D P H, D R H, R A R, Mayo Clinic, Rochester, MN International Clinical Research Center V S, D H, St Anne s University Hospital, Brno and the Department of Neurology V S, 2nd Faculty of Medicine, Charles University in Prague and Motol University Hospital, Prague, Czech Republic
Neurology 82:932-9. 2014....
- Magnetic resonance elastography of frontotemporal dementiaJohn Huston
Department of Radiology, Mayo Clinic, Rochester, Minnesota, USA
J Magn Reson Imaging 43:474-8. 2016..Magnetic resonance elastography (MRE) is a noninvasive technique for evaluating the mechanical properties of brain tissue in vivo. MRE has demonstrated decreased brain stiffness in patients with Alzheimer's disease...
- The neuroanatomy of pure apraxia of speech in strokeJonathan Graff-Radford
Department of Neurology, Mayo Clinic, Rochester, MN, USA
Brain Lang 129:43-6. 2014..While both neurodegenerative AOS and stroke induced pure AOS involve the premotor cortex, further studies are needed to establish whether stroke-induced AOS and neurodegenerative AOS share a common anatomic substrate. ..
- On mind wandering, attention, brain networks, and meditationAmit Sood
Complementary and Integrative Medicine Program, Mayo Clinic, Rochester, MN, USA
Explore (NY) 9:136-41. 2013..This narrative review presents a mechanistic understanding of meditation in the context of recent advances in neurosciences about mind wandering, attention, and the brain networks...
- Resting state functional MRI in Alzheimer's DiseasePrashanthi Vemuri
Department of Radiology, Mayo Clinic and Foundation, 200 First Street SW, Rochester, MN 55905, USA
Alzheimers Res Ther 4:2. 2012..Then we present the current state of knowledge in this area by summarizing various AD resting-state fMRI studies presented in the first section and end with a discussion of future developments and open questions in the field...
- A neurological complication of a uterine fibroidJonathan Graff-Radford
Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA
Neurocrit Care 18:93-5. 2013..Uterine leiomyoma (or fibroid) can be associated with secondary polycythemia and venous thrombosis, but there has been no report of intracranial venous thrombosis associated with leiomyoma...
- Statistical parametric mapping demonstrates asymmetric uptake with Tc-99m ECD and Tc-99m HMPAO SPECT in normal brainBenjamin H Brinkmann
Mayo Systems Electrophysiology Laboratory, Mayo Clinic, Rochester, Minnesota 55905, USA
J Cereb Blood Flow Metab 32:190-8. 2012..The results have important implications for the use of normal control SPECT images in the evaluation of patients with neurologic disease...