David T Jones
Affiliation: Mayo Clinic
- Default mode network disruption secondary to a lesion in the anterior thalamusDavid T Jones
Department of Neurology, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
Arch Neurol 68:242-7. 2011..To describe the neuroanatomical correlations of an isolated lesion in the anterior thalamus using functional imaging in a 40-year-old man with multiple sclerosis...
- Cascading network failure across the Alzheimer's disease spectrumDavid T Jones
1 Department of Neurology, Mayo Clinic, Rochester, MN, 55905, USA 2 Department of Radiology, Mayo Clinic, Rochester, MN, 55905, USA
Brain 139:547-62. 2016..Possible interpretations include that the molecular-level events drive the network failure, a pathological interaction between the network-level and the molecular-level, or other upstream factors are driving both...
- Evolution of neurodegeneration-imaging biomarkers from clinically normal to dementia in the Alzheimer disease spectrumDavid S Knopman
Department of Neurology, Mayo Clinic and Foundation, Rochester, MN, USA Mayo Clinic Alzheimer s Disease Research Center, Mayo Clinic and Foundation, Rochester, MN, USA Electronic address
Neurobiol Aging 46:32-42. 2016..Expansion of regional involvement and faster rate of neurodegeneration characterizes progression in the AD pathway. ..
- Age and neurodegeneration imaging biomarkers in persons with Alzheimer disease dementiaDavid S Knopman
From the Departments of Neurology D S K, P V, M M Mielke, R O R, B F B, D T J, R C P and Radiology C R J, V J L, K K, J L G, M L S, D T J, Mayo Clinic Alzheimer s Disease Research Center D S K, C R J, B F B, D T J, R C P, Division of Biomedical Statistics and Informatics, Department of Health Sciences Research H J W, S D W, Division of Epidemiology, Department of Health Sciences Research M M Mielke, R O R, R C P, and Department of Psychiatry, Division of Psychology M M Machulda, Mayo Clinic and Foundation, Rochester, MN
Neurology 87:691-8. 2016..To examine neurodegenerative imaging biomarkers in Alzheimer disease (AD) dementia from middle to old age...
- Working memory and language network dysfunctions in logopenic aphasia: a task-free fMRI comparison with Alzheimer's dementiaJennifer L Whitwell
Department of Radiology, Mayo Clinic, Rochester, MN, USA Electronic address
Neurobiol Aging 36:1245-52. 2015..Patterns of network dysfunction differ across these 2 clinical variants of Alzheimer's disease, with lvPPA particularly associated with disruptions in the language and left working memory networks. ..
- Defining imaging biomarker cut points for brain aging and Alzheimer's diseaseClifford R Jack
Department of Radiology, Mayo Clinic, Rochester, MN, USA Electronic address
Alzheimers Dement . 2016..Our goal was to develop cut points for amyloid positron emission tomography (PET), tau PET, flouro-deoxyglucose (FDG) PET, and MRI cortical thickness...
- Predicting Survival in Dementia With Lewy Bodies With Hippocampal VolumetryJonathan Graff-Radford
Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA
Mov Disord 31:989-94. 2016..The clinical course of dementia with Lewy bodies patients is heterogeneous. The ability to more accurately prognosticate survival is important...
- Role of β-Amyloidosis and Neurodegeneration in Subsequent Imaging Changes in Mild Cognitive ImpairmentDavid S Knopman
Department of Neurology, Mayo Clinic and Foundation, Rochester, Minnesota2Mayo Clinic Alzheimer s Disease Research Center, Mayo Clinic and Foundation, Rochester, Minnesota
JAMA Neurol 72:1475-83. 2015..To understand how a model of Alzheimer disease pathophysiology based on β-amyloidosis and neurodegeneration predicts the regional anatomic expansion of hypometabolism and atrophy in persons with mild cognitive impairment (MCI)...
- Amyloid-first and neurodegeneration-first profiles characterize incident amyloid PET positivityClifford R Jack
From the Departments of Radiology C R J, V L, P V, D T J, M L S, J L G, B E G, Health Sciences Research H J W, S D W, M M M, V S P, and Neurology D S K, R C P, Mayo Clinic and Foundation, Rochester, MN
Neurology 81:1732-40. 2013..To estimate the incidence of and to characterize cognitive and imaging findings associated with incident amyloid PET positivity...
- Regional brain stiffness changes across the Alzheimer's disease spectrumMatthew C Murphy
Department of Radiology, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA
Neuroimage Clin 10:283-90. 2016....
- AV-1451 Tau and β-Amyloid PET Imaging in Dementia with Lewy BodiesKejal Kantarci
Department of Radiology, Mayo Clinic, Rochester, MN
Ann Neurol . 2016....
- Non-stationarity in the "resting brain's" modular architectureDavid T Jones
Department of Neurology, Mayo Clinic, Rochester, Minnesota, United States of America
PLoS ONE 7:e39731. 2012..DMN dwell time in specific modular configurations may also underlie the TF-fMRI findings that have been described in mild cognitive impairment and cognitively normal subjects who are at risk for Alzheimer's dementia...
- The alien limb phenomenonJonathan Graff-Radford
Department of Neurology, Mayo Clinic, 200 1st Street SW, Rochester, MN 55905, USA
J Neurol 260:1880-8. 2013..004). These findings support the notion that the alien limb phenomenon is partially related to damage underlying the parietal cortex, especially right parietal, disconnecting it from other cortical areas...
- Effect of APOE ε4 status on intrinsic network connectivity in cognitively normal elderly subjectsMary M Machulda
Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MN 55905, USA
Arch Neurol 68:1131-6. 2011..To examine default mode and salience network functional connectivity as a function of APOE ε4 status in a group of cognitively normal age-, sex-, and education-matched older adults...
- Classification and clinicoradiologic features of primary progressive aphasia (PPA) and apraxia of speechHugo Botha
Department of Neurology Behavioural Neurology, Mayo Clinic, Rochester, MN, USA
Cortex 69:220-36. 2015..Our findings support consideration of an alternative way of identifying and categorizing subtypes of degenerative speech and language disorders. ..
- An autoradiographic evaluation of AV-1451 Tau PET in dementiaVal J Lowe
Department of Radiology, Mayo Clinic, Rochester, MN, USA
Acta Neuropathol Commun 4:58. 2016..We performed autoradiography in autopsy-confirmed Alzheimer disease and other neurodegenerative disorders to evaluate the specificity of AV-1451 binding for tau aggregates...
- Duration and Pathologic Correlates of Lewy Body DiseaseJonathan Graff-Radford
Department of Neurology, Mayo Clinic, Rochester, Minnesota
JAMA Neurol . 2017..Although patients with dementia with Lewy bodies (DLB) have shorter disease duration than patients with Alzheimer disease dementia, little is known about which factors influence disease duration among patients with DLB...
- Disrupted thalamocortical connectivity in PSP: a resting-state fMRI, DTI, and VBM studyJennifer L Whitwell
Department of Radiology, Mayo Clinic, 200 1st Street SW, Rochester, MN 55905, USA
Parkinsonism Relat Disord 17:599-605. 2011..PSP is therefore associated with disrupted thalamocortical connectivity that is associated with degeneration of the dentatorubrothalamic tract and the presence of cortical atrophy...
- Statistical SPECT processing in MRI-negative epilepsy surgeryVlastimil Sulc
From the Departments of Neurology V S, B H B, D T J, G D C, L C W K, J W B, E L S, G A W and Radiology M L S, B P M, R E W and Biomedical Imaging Resource S S, D P H, D R H, R A R, Mayo Clinic, Rochester, MN International Clinical Research Center V S, D H, St Anne s University Hospital, Brno and the Department of Neurology V S, 2nd Faculty of Medicine, Charles University in Prague and Motol University Hospital, Prague, Czech Republic
Neurology 82:932-9. 2014....
- Magnetic resonance elastography of frontotemporal dementiaJohn Huston
Department of Radiology, Mayo Clinic, Rochester, Minnesota, USA
J Magn Reson Imaging 43:474-8. 2016..Magnetic resonance elastography (MRE) is a noninvasive technique for evaluating the mechanical properties of brain tissue in vivo. MRE has demonstrated decreased brain stiffness in patients with Alzheimer's disease...
- The neuroanatomy of pure apraxia of speech in strokeJonathan Graff-Radford
Department of Neurology, Mayo Clinic, Rochester, MN, USA
Brain Lang 129:43-6. 2014..While both neurodegenerative AOS and stroke induced pure AOS involve the premotor cortex, further studies are needed to establish whether stroke-induced AOS and neurodegenerative AOS share a common anatomic substrate. ..
- On mind wandering, attention, brain networks, and meditationAmit Sood
Complementary and Integrative Medicine Program, Mayo Clinic, Rochester, MN, USA
Explore (NY) 9:136-41. 2013..This narrative review presents a mechanistic understanding of meditation in the context of recent advances in neurosciences about mind wandering, attention, and the brain networks...
- Resting state functional MRI in Alzheimer's DiseasePrashanthi Vemuri
Department of Radiology, Mayo Clinic and Foundation, 200 First Street SW, Rochester, MN 55905, USA
Alzheimers Res Ther 4:2. 2012..Then we present the current state of knowledge in this area by summarizing various AD resting-state fMRI studies presented in the first section and end with a discussion of future developments and open questions in the field...
- A neurological complication of a uterine fibroidJonathan Graff-Radford
Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA
Neurocrit Care 18:93-5. 2013..Uterine leiomyoma (or fibroid) can be associated with secondary polycythemia and venous thrombosis, but there has been no report of intracranial venous thrombosis associated with leiomyoma...
- Statistical parametric mapping demonstrates asymmetric uptake with Tc-99m ECD and Tc-99m HMPAO SPECT in normal brainBenjamin H Brinkmann
Mayo Systems Electrophysiology Laboratory, Mayo Clinic, Rochester, Minnesota 55905, USA
J Cereb Blood Flow Metab 32:190-8. 2012..The results have important implications for the use of normal control SPECT images in the evaluation of patients with neurologic disease...