Nilufer Ertekin-Taner

Summary

Affiliation: Mayo Clinic
Country: USA

Publications

  1. pmc Development of monoclonal antibodies and quantitative ELISAs targeting insulin-degrading enzyme
    Anthony DelleDonne
    Department of Neuroscience, Mayo Clinic, 4500 San Pablo Road S, Jacksonville, FL 32224, USA
    Mol Neurodegener 4:39. 2009
  2. pmc Genetics of Alzheimer's disease: a centennial review
    Nilufer Ertekin-Taner
    Department of Neurology, Mayo Clinic Rochester, Rochester, MN 55905, USA
    Neurol Clin 25:611-67, v. 2007
  3. pmc Genetics of Alzheimer disease in the pre- and post-GWAS era
    Nilufer Ertekin-Taner
    Mayo Clinic Florida, Departments of Neurology and Neuroscience, 4500 San Pablo Road, Birdsall 210, Jacksonville, FL 32224 USA
    Alzheimers Res Ther 2:3. 2010
  4. pmc Gene expression endophenotypes: a novel approach for gene discovery in Alzheimer's disease
    Nilufer Ertekin-Taner
    Mayo Clinic Florida, Departments of Neurology and Neuroscience, 4500 San Pablo Road, Birdsall 210, Jacksonville, Florida 32224 USA
    Mol Neurodegener 6:31. 2011
  5. pmc Novel late-onset Alzheimer disease loci variants associate with brain gene expression
    Mariet Allen
    Department of Neuroscience, Biostatistics Unit, Mayo Clinic Florida, Jacksonville, FL, USA
    Neurology 79:221-8. 2012
  6. pmc Concordant association of insulin degrading enzyme gene (IDE) variants with IDE mRNA, Abeta, and Alzheimer's disease
    Minerva M Carrasquillo
    Department of Neuroscience, Mayo Clinic College of Medicine, Jacksonville, Florida, United States of America
    PLoS ONE 5:e8764. 2010
  7. pmc Glutathione S-transferase omega genes in Alzheimer and Parkinson disease risk, age-at-diagnosis and brain gene expression: an association study with mechanistic implications
    Mariet Allen
    Mayo Clinic Florida, Department of Neuroscience, Jacksonville, FL, USA
    Mol Neurodegener 7:13. 2012
  8. ncbi request reprint Genetic variants in a haplotype block spanning IDE are significantly associated with plasma Abeta42 levels and risk for Alzheimer disease
    Nilufer Ertekin-Taner
    Mayo Clinic Jacksonville, Department of Neuroscience, Jacksonville, FL, USA
    Hum Mutat 23:334-42. 2004
  9. pmc Late-onset Alzheimer's risk variants in memory decline, incident mild cognitive impairment, and Alzheimer's disease
    Minerva M Carrasquillo
    Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA
    Neurobiol Aging 36:60-7. 2015
  10. pmc Human whole genome genotype and transcriptome data for Alzheimer's and other neurodegenerative diseases
    Mariet Allen
    Mayo Clinic, Department of Neuroscience, 4500 San Pablo Road, Jacksonville, Florida 32224, USA
    Sci Data 3:160089. 2016

Research Grants

  1. Mapping Novel Genes for Late-Onset Alzheimer's Disease
    Nilufer Ertekin Taner; Fiscal Year: 2008

Detail Information

Publications33

  1. pmc Development of monoclonal antibodies and quantitative ELISAs targeting insulin-degrading enzyme
    Anthony DelleDonne
    Department of Neuroscience, Mayo Clinic, 4500 San Pablo Road S, Jacksonville, FL 32224, USA
    Mol Neurodegener 4:39. 2009
    ..To address this important need, we generated and characterized new mouse monoclonal antibodies (mAbs) targeting natively folded human and rodent IDE...
  2. pmc Genetics of Alzheimer's disease: a centennial review
    Nilufer Ertekin-Taner
    Department of Neurology, Mayo Clinic Rochester, Rochester, MN 55905, USA
    Neurol Clin 25:611-67, v. 2007
    ..The future directions for genetic research in AD as a common and complex condition are also discussed...
  3. pmc Genetics of Alzheimer disease in the pre- and post-GWAS era
    Nilufer Ertekin-Taner
    Mayo Clinic Florida, Departments of Neurology and Neuroscience, 4500 San Pablo Road, Birdsall 210, Jacksonville, FL 32224 USA
    Alzheimers Res Ther 2:3. 2010
    ..Potential approaches that could provide further insight into the genetics of AD in the post-GWAS era are also discussed...
  4. pmc Gene expression endophenotypes: a novel approach for gene discovery in Alzheimer's disease
    Nilufer Ertekin-Taner
    Mayo Clinic Florida, Departments of Neurology and Neuroscience, 4500 San Pablo Road, Birdsall 210, Jacksonville, Florida 32224 USA
    Mol Neurodegener 6:31. 2011
    ....
  5. pmc Novel late-onset Alzheimer disease loci variants associate with brain gene expression
    Mariet Allen
    Department of Neuroscience, Biostatistics Unit, Mayo Clinic Florida, Jacksonville, FL, USA
    Neurology 79:221-8. 2012
    ..Single nucleotide polymorphisms that influence gene expression (eSNPs) constitute an important class of functional variants. We therefore investigated the influence of the novel LOAD risk loci on human brain gene expression...
  6. pmc Concordant association of insulin degrading enzyme gene (IDE) variants with IDE mRNA, Abeta, and Alzheimer's disease
    Minerva M Carrasquillo
    Department of Neuroscience, Mayo Clinic College of Medicine, Jacksonville, Florida, United States of America
    PLoS ONE 5:e8764. 2010
    ..The insulin-degrading enzyme gene (IDE) is a strong functional and positional candidate for late onset Alzheimer's disease (LOAD)...
  7. pmc Glutathione S-transferase omega genes in Alzheimer and Parkinson disease risk, age-at-diagnosis and brain gene expression: an association study with mechanistic implications
    Mariet Allen
    Mayo Clinic Florida, Department of Neuroscience, Jacksonville, FL, USA
    Mol Neurodegener 7:13. 2012
    ..4,617 controls) and PD (678 PDs vs. 712 controls) for association with disease risk (case-controls), age-at-diagnosis (cases) and brain gene expression levels (autopsied subjects)...
  8. ncbi request reprint Genetic variants in a haplotype block spanning IDE are significantly associated with plasma Abeta42 levels and risk for Alzheimer disease
    Nilufer Ertekin-Taner
    Mayo Clinic Jacksonville, Department of Neuroscience, Jacksonville, FL, USA
    Hum Mutat 23:334-42. 2004
    ..007) in our family series. These results provide strong evidence for pathogenic variant(s) in the 276-kb region harboring IDE that influence intermediate AD phenotypes and risk for AD...
  9. pmc Late-onset Alzheimer's risk variants in memory decline, incident mild cognitive impairment, and Alzheimer's disease
    Minerva M Carrasquillo
    Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA
    Neurobiol Aging 36:60-7. 2015
    ..Discovery of biologically functional variants at these loci may uncover stronger effects on memory and incident disease. ..
  10. pmc Human whole genome genotype and transcriptome data for Alzheimer's and other neurodegenerative diseases
    Mariet Allen
    Mayo Clinic, Department of Neuroscience, 4500 San Pablo Road, Jacksonville, Florida 32224, USA
    Sci Data 3:160089. 2016
    ..We expect that these datasets, which are available to all qualified researchers, will enable investigators to explore and identify transcriptional mechanisms contributing to neurodegenerative diseases...
  11. pmc Evaluating pathogenic dementia variants in posterior cortical atrophy
    Minerva M Carrasquillo
    Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA
    Neurobiol Aging 37:38-44. 2016
    ..In this first systematic variant screen of a PCA cohort, we report 2 rare mutations in TREM2 and PSEN2, validate our previously reported APOE ε4 association, and demonstrate the utility of NeuroX...
  12. pmc ABCA7 loss-of-function variants, expression, and neurologic disease risk
    Mariet Allen
    Form the Department of Neuroscience M A, S J L, M C, J O W, M M C, J S R, J D B, T N, K M, D W D, N E T, Department of Neurology N R G R, N E T, Mayo Clinic, Jacksonville, FL and Department of Neurology R C P, Mayo Clinic, Rochester, MN
    Neurol Genet 3:e126. 2017
    ..To investigate and characterize putative "loss-of-function" (LOF) adenosine triphosphate-binding cassette, subfamily A member 7 (ABCA7) mutations reported to associate with Alzheimer disease (AD) risk...
  13. pmc Gene expression, methylation and neuropathology correlations at progressive supranuclear palsy risk loci
    Mariet Allen
    Department of Neuroscience, Mayo Clinic, Jacksonville, FL, 32224, USA
    Acta Neuropathol 132:197-211. 2016
    ..MOBP, LRRC37A4, ARL17A and ARL17B warrant further assessment as candidate PSP risk genes. Our findings have implications for the mechanism of action of variants at some of the top PSP risk loci. ..
  14. pmc Late-onset Alzheimer disease genetic variants in posterior cortical atrophy and posterior AD
    Minerva M Carrasquillo
    From the Departments of Neuroscience M M C, M E M, S K, T N, L M, G B, S G Y, D W D, N E T and Neurology Q u A K, N R G R, N E T, Mayo Clinic Florida, Jacksonville and Departments of Biostatistics J A, V S P and Neurology R C P, B F B, Mayo Clinic Minnesota, Rochester
    Neurology 82:1455-62. 2014
    ....
  15. doi request reprint RAB39B gene mutations are not a common cause of Parkinson's disease or dementia with Lewy bodies
    Kyndall Hodges
    Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA Department of Biology, University of North Florida, Jacksonville, FL, USA
    Neurobiol Aging 45:107-8. 2016
    ..A cohort of 884 PD, 399 DLB, and 379 pLBD patients were screened for RAB39B mutations, but no coding variants were found, suggesting RAB39B mutations are not a common cause of PD, DLB, or pLBD in Caucasian population. ..
  16. doi request reprint A candidate regulatory variant at the TREM gene cluster associates with decreased Alzheimer's disease risk and increased TREML1 and TREM2 brain gene expression
    Minerva M Carrasquillo
    Department of Neuroscience, Mayo Clinic Florida, Jacksonville, FL, USA
    Alzheimers Dement . 2016
    ..We hypothesized that common Alzheimer's disease (AD)-associated variants within the triggering receptor expressed on myeloid (TREM) gene cluster influence disease through gene expression...
  17. pmc Evaluation of memory endophenotypes for association with CLU, CR1, and PICALM variants in black and white subjects
    Otto Pedraza
    Mayo Clinic Florida, Department of Psychiatry and Psychology, Jacksonville, FL, USA
    Alzheimers Dement 10:205-13. 2014
    ..In this study, our aim was to determine whether the LOAD risk variants at these three loci influence memory endophenotypes in black and white subjects...
  18. pmc Genetic variation in PCDH11X is associated with susceptibility to late-onset Alzheimer's disease
    Minerva M Carrasquillo
    Department of Neuroscience, Mayo Clinic College of Medicine, Jacksonville, Florida 32224, USA
    Nat Genet 41:192-8. 2009
    ..0 x 10(-7)) and 1.26 (95% CI = 1.05-1.51) for female heterozygotes (P = 0.01) compared to female noncarriers. For male hemizygotes (P = 0.07) compared to male noncarriers, the odds ratio was 1.18 (95% CI = 0.99-1.41)...
  19. pmc Expression and processing analyses of wild type and p.R47H TREM2 variant in Alzheimer's disease brains
    Li Ma
    Department of Neuroscience, Mayo Clinic, Jacksonville, 32224, FL, USA
    Mol Neurodegener 11:72. 2016
    ..The question of whether the p.R47H mutation affects expression or function of the receptor remains unanswered. To address this question we quantified mRNA and analyzed protein profiles of WT and p.R47H TREM2 in human brains...
  20. pmc LRRTM3 interacts with APP and BACE1 and has variants associating with late-onset Alzheimer's disease (LOAD)
    Sarah Lincoln
    Mayo Clinic Florida, Department of Neuroscience, Jacksonville, Florida, USA
    PLoS ONE 8:e64164. 2013
    ....
  21. doi request reprint Comprehensive Screening for Disease Risk Variants in Early-Onset Alzheimer's Disease Genes in African Americans Identifies Novel PSEN Variants
    Aurelie N'Songo
    Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA
    J Alzheimers Dis . 2017
    ..T331C:p.Phe111Leu and PSEN1-minilin rs777923890 variants were again not observed, indicating that these novel rare variants, may contribute to AD risk in this population...
  22. pmc TREM2 in neurodegeneration: evidence for association of the p.R47H variant with frontotemporal dementia and Parkinson's disease
    Sruti Rayaprolu
    Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA
    Mol Neurodegener 8:19. 2013
    ..With this in mind we set out to assess the genetic association of the Alzheimer's disease-related risk variant in TREM2 (rs75932628, p.R47H) with other related neurodegenerative disorders...
  23. pmc DNMT1 mutation hot spot causes varied phenotypes of HSAN1 with dementia and hearing loss
    Christopher J Klein
    Department of Neurology, Division of Peripheral Nerve Diseases, Mayo Clinic, Rochester, MN, USA
    Neurology 80:824-8. 2013
    ..The chromosomal location of the DNMT1 gene at 19p13.2 has been linked to familial late-onset Alzheimer disease...
  24. pmc MAPT haplotype H1G is associated with increased risk of dementia with Lewy bodies
    Catherine Labbe
    Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA
    Alzheimers Dement 12:1297-1304. 2016
    ..The MAPT H1 haplotype has been associated with several neurodegenerative diseases. We were interested in exploring the role of MAPT haplotypic variation in risk of dementia with Lewy bodies (DLB)...
  25. pmc Genome-wide association study of corticobasal degeneration identifies risk variants shared with progressive supranuclear palsy
    Naomi Kouri
    Department of Neuroscience, Mayo Clinic College of Medicine, Jacksonville, Florida 32224, USA
    Nat Commun 6:7247. 2015
    ..We identify new CBD susceptibility loci and show that CBD and PSP share a genetic risk factor other than MAPT at 3p22 MOBP (myelin-associated oligodendrocyte basic protein). ..
  26. pmc ApoE variant p.V236E is associated with markedly reduced risk of Alzheimer's disease
    Christopher W Medway
    Department of Neuroscience, Mayo Clinic College of Medicine, Jacksonville, FL 32224, USA
    Mol Neurodegener 9:11. 2014
    ....
  27. pmc Association and heterogeneity at the GAPDH locus in Alzheimer's disease
    Mariet Allen
    Department of Neuroscience, Mayo Clinic College of Medicine, Jacksonville, FL 32224, USA
    Neurobiol Aging 33:203.e25-33. 2012
    ..The most promising rs3741916 variant is unlikely to be functional given opposing effects in different series. Identification of functional variant(s) in this region likely awaits deep sequencing...
  28. pmc Brain expression genome-wide association study (eGWAS) identifies human disease-associated variants
    Fanggeng Zou
    Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, USA
    PLoS Genet 8:e1002707. 2012
    ..Our findings have implications for the design and interpretation of eGWAS in general and the use of brain expression quantitative trait loci in the study of human disease genetics...
  29. pmc Fine mapping of the alpha-T catenin gene to a quantitative trait locus on chromosome 10 in late-onset Alzheimer's disease pedigrees
    Nilufer Ertekin-Taner
    Department of Neuroscience, Mayo Clinic Jacksonville, Jacksonville, FL 32224, USA
    Hum Mol Genet 12:3133-43. 2003
    ..These findings indicate that VR22 has variant(s) which influence Abeta42 and contribute to the previously reported linkage for plasma Abeta42 in LOAD families...
  30. pmc Association of common KIBRA variants with episodic memory and AD risk
    Jeremy D Burgess
    Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA
    Neurobiol Aging 32:557.e1-9. 2011
    ..06) but not cerebellum. These results suggest a modest role for KIBRA as a cognition and AD risk gene, and also highlight the multifactorial complexity of its genetic associations...
  31. ncbi request reprint Elevated amyloid beta protein (Abeta42) and late onset Alzheimer's disease are associated with single nucleotide polymorphisms in the urokinase-type plasminogen activator gene
    Nilufer Ertekin-Taner
    Department of Neuroscience, Mayo Clinic Jacksonville, 4500 San Pablo Road, Jacksonville, FL 32224, USA
    Hum Mol Genet 14:447-60. 2005
    ..PLAU_1 is a plausible pathogenic mutation that could act by increasing Abeta42, but additional biological experiments are required to show this definitively...
  32. pmc Gene expression levels as endophenotypes in genome-wide association studies of Alzheimer disease
    F Zou
    Department of Neuroscience, Mayo Clinic College of Medicine, Jacksonville, FL 32224, USA
    Neurology 74:480-6. 2010
    ..Late-onset Alzheimer disease (LOAD) is a common disorder with a substantial genetic component. We postulate that many disease susceptibility variants act by altering gene expression levels...

Research Grants1

  1. Mapping Novel Genes for Late-Onset Alzheimer's Disease
    Nilufer Ertekin Taner; Fiscal Year: 2008
    ..These studies could potentially provide new insights to the pathogenesis of AD, lead to the discovery of novel therapeutic targets and allow for the identificationof "at risk" people by using plasma A6 as a biomarker. ..