Darren P Casey

Summary

Affiliation: Mayo Clinic
Country: USA

Publications

  1. pmc Vasoconstrictor responsiveness during hyperbaric hyperoxia in contracting human muscle
    Darren P Casey
    Department of Anesthesiology, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Appl Physiol (1985) 114:217-24. 2013
  2. pmc α-Adrenergic Blockade Unmasks a Greater Compensatory Vasodilation in Hypoperfused Contracting Muscle
    Darren P Casey
    Human and Integrative Physiology Laboratory, Department of Anesthesiology, Mayo Clinic Rochester, MN, USA
    Front Physiol 3:271. 2012
  3. pmc Influence of α-adrenergic vasoconstriction on the blunted skeletal muscle contraction-induced rapid vasodilation with aging
    Darren P Casey
    Department of Anesthesiology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    J Appl Physiol (1985) 113:1201-12. 2012
  4. pmc The effects of acute beta-adrenergic blockade on aortic wave reflection in postmenopausal women
    Darren P Casey
    Department of Anesthesiology, Mayo Clinic, Rochester, MN, USA
    Am J Hypertens 26:503-10. 2013
  5. doi request reprint Role of nitric oxide and adenosine in the onset of vasodilation during dynamic forearm exercise
    Darren P Casey
    Department of Anesthesiology, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
    Eur J Appl Physiol 113:295-303. 2013
  6. pmc Compensatory vasodilatation during hypoxic exercise: mechanisms responsible for matching oxygen supply to demand
    Darren P Casey
    Department of Anesthesiology, Mayo Clinic, Rochester, MN 55905, USA
    J Physiol 590:6321-6. 2012
  7. pmc α-adrenergic vasoconstriction contributes to the age-related increase in conduit artery retrograde and oscillatory shear
    Darren P Casey
    Department of Anesthesiology, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
    Hypertension 60:1016-22. 2012
  8. ncbi request reprint Progressive resistance training without volume increases does not alter arterial stiffness and aortic wave reflection
    Darren P Casey
    The Center for Exercise Science, Department of Applied Physiology and Kinesiology, College of Health and Human Performance, University of Florida, Gainesville, Florida 32611, USA
    Exp Biol Med (Maywood) 232:1228-35. 2007
  9. pmc Acute β-adrenergic blockade increases aortic wave reflection in young men and women: differing mechanisms between sexes
    Darren P Casey
    Department of Anesthesiology, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
    Hypertension 59:145-50. 2012
  10. pmc Local control of skeletal muscle blood flow during exercise: influence of available oxygen
    Darren P Casey
    Dept of Anesthesiology, Mayo Clinic, Rochester, MN 55905, USA
    J Appl Physiol (1985) 111:1527-38. 2011

Detail Information

Publications46

  1. pmc Vasoconstrictor responsiveness during hyperbaric hyperoxia in contracting human muscle
    Darren P Casey
    Department of Anesthesiology, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Appl Physiol (1985) 114:217-24. 2013
    ....
  2. pmc α-Adrenergic Blockade Unmasks a Greater Compensatory Vasodilation in Hypoperfused Contracting Muscle
    Darren P Casey
    Human and Integrative Physiology Laboratory, Department of Anesthesiology, Mayo Clinic Rochester, MN, USA
    Front Physiol 3:271. 2012
    ....
  3. pmc Influence of α-adrenergic vasoconstriction on the blunted skeletal muscle contraction-induced rapid vasodilation with aging
    Darren P Casey
    Department of Anesthesiology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    J Appl Physiol (1985) 113:1201-12. 2012
    ..30-0.81 vs. control). Our data indicate that α-adrenergic vasoconstriction and/or blunted functional sympatholysis might contribute to the age-related decreases in skeletal muscle contraction-induced rapid vasodilation in humans...
  4. pmc The effects of acute beta-adrenergic blockade on aortic wave reflection in postmenopausal women
    Darren P Casey
    Department of Anesthesiology, Mayo Clinic, Rochester, MN, USA
    Am J Hypertens 26:503-10. 2013
    ..Taken together, our data suggest that the negative effects (i.e. increased aortic wave reflection) of nonselective beta-adrenergic blockade are less pronounced in postmenopausal than in young women...
  5. doi request reprint Role of nitric oxide and adenosine in the onset of vasodilation during dynamic forearm exercise
    Darren P Casey
    Department of Anesthesiology, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
    Eur J Appl Physiol 113:295-303. 2013
    ..0 ± 2.2 vs. 14.7 ± 2.0 FVC units/duty cycle; P = 0.67 vs. control). Our data indicate that NO and adenosine (in the absence of NO) contribute to the onset of vasodilation during dynamic forearm exercise...
  6. pmc Compensatory vasodilatation during hypoxic exercise: mechanisms responsible for matching oxygen supply to demand
    Darren P Casey
    Department of Anesthesiology, Mayo Clinic, Rochester, MN 55905, USA
    J Physiol 590:6321-6. 2012
    ..Along these lines, this review will highlight the interactions between various local metabolic and endothelial derived substances that influence vascular tone during hypoxic exercise...
  7. pmc α-adrenergic vasoconstriction contributes to the age-related increase in conduit artery retrograde and oscillatory shear
    Darren P Casey
    Department of Anesthesiology, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
    Hypertension 60:1016-22. 2012
    ..05) and markedly reduced, yet still persistent, in older adults (P<0.01). Our data indicate that α-adrenergic vasoconstriction is a major contributor to age-related discrepancies in conduit artery shear-rate patterns at rest...
  8. ncbi request reprint Progressive resistance training without volume increases does not alter arterial stiffness and aortic wave reflection
    Darren P Casey
    The Center for Exercise Science, Department of Applied Physiology and Kinesiology, College of Health and Human Performance, University of Florida, Gainesville, Florida 32611, USA
    Exp Biol Med (Maywood) 232:1228-35. 2007
    ....
  9. pmc Acute β-adrenergic blockade increases aortic wave reflection in young men and women: differing mechanisms between sexes
    Darren P Casey
    Department of Anesthesiology, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
    Hypertension 59:145-50. 2012
    ....
  10. pmc Local control of skeletal muscle blood flow during exercise: influence of available oxygen
    Darren P Casey
    Dept of Anesthesiology, Mayo Clinic, Rochester, MN 55905, USA
    J Appl Physiol (1985) 111:1527-38. 2011
    ..This is important from a basic biological perspective and also has pathophysiological implications for diseases associated with either hypoxia or hypoperfusion...
  11. pmc Prostaglandins do not contribute to the nitric oxide-mediated compensatory vasodilation in hypoperfused exercising muscle
    Darren P Casey
    Dept of Anesthesiology, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
    Am J Physiol Heart Circ Physiol 301:H261-8. 2011
    ..01) but not attenuated further during combined NOS-COX inhibition (62 ± 10%, P = 0.74 vs. l-NMMA alone). Our data indicate that PGs are not obligatory to the compensatory dilation observed during forearm exercise with hypoperfusion...
  12. pmc Hyperbaric hyperoxia reduces exercising forearm blood flow in humans
    Darren P Casey
    Dept of Anesthesiology, Mayo Clinic, 200 First St SW, Rochester, MN 55905
    Am J Physiol Heart Circ Physiol 300:H1892-7. 2011
    ..01). Our data suggest that exercise hyperemia in skeletal muscle is highly dependent on oxygen availability during hyperoxia...
  13. pmc Contribution of adenosine to compensatory dilation in hypoperfused contracting human muscles is independent of nitric oxide
    Darren P Casey
    Department of Anesthesiology, Mayo Clinic Rochester, MN 55905, USA
    J Appl Physiol (1985) 110:1181-9. 2011
    ..05 vs. aminophylline). Our data indicate that adenosine contributes to compensatory vasodilation in an NO-independent manner during exercise with acute hypoperfusion...
  14. pmc Ageing reduces the compensatory vasodilatation during hypoxic exercise: the role of nitric oxide
    Darren P Casey
    Department of Anesthesiology, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
    J Physiol 589:1477-88. 2011
    ..L-NMMA during hypoxic exercise only blunted the compensatory vasodilator response in the young group (P <0.05). Our data suggest that ageing reduces the compensatory vasodilator response to hypoxic exercise via blunted NO signalling...
  15. pmc Relationship between muscle sympathetic nerve activity and aortic wave reflection characteristics in young men and women
    Darren P Casey
    Department of Anesthesiology, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
    Hypertension 57:421-7. 2011
    ..59), and wasted left ventricular energy (r = -0.58; P<0.01 for all). Our results suggest another possible mechanism by which young women are protected against the development of cardiovascular disease...
  16. pmc Nitric oxide-mediated vasodilation becomes independent of beta-adrenergic receptor activation with increased intensity of hypoxic exercise
    Darren P Casey
    Dept of Anesthesiology, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
    J Appl Physiol (1985) 110:687-94. 2011
    ..However, the source of the NO becomes less dependent on β-adrenergic mechanisms as exercise intensity increases...
  17. pmc Effect of enhanced external counterpulsation on inflammatory cytokines and adhesion molecules in patients with angina pectoris and angiographic coronary artery disease
    Darren P Casey
    Center for Exercise Science, Department of Applied Physiology and Kinesiology, College of Health and Human Performance, University of Florida, Gainesville, Florida, USA
    Am J Cardiol 101:300-2. 2008
    ..Changes in soluble vascular cell adhesion molecule-1 were not observed in either group. In conclusion, 35 sessions of EECP decreased circulating levels of proinflammatory biomarkers in patients with symptomatic coronary artery disease...
  18. doi request reprint Impact of aging on central pressure wave reflection characteristics during exercise
    Darren P Casey
    Center for Exercise Science, Department of Applied Physiology and Kinesiology, College of Health and Human Performance, University of Florida, Gainesville, Florida, USA
    Am J Hypertens 21:419-24. 2008
    ..We examined the impact of aging on the central blood pressure (BP) waveform and wave reflection responses during exercise...
  19. pmc Nitric oxide contributes to the augmented vasodilatation during hypoxic exercise
    Darren P Casey
    Department of Anesthesiology, Mayo Clinic, Rochester, MN 55905, USA
    J Physiol 588:373-85. 2010
    ..7 vs. -21.4 +/- 5.2%; P = 0.28) and 20% (-13.4 +/- 3.5 vs. -18.8 +/- 4.5%; P = 0.18) hypoxic exercise. These findings suggest that NO contributes to the augmented vasodilatation observed during hypoxic exercise independent of adenosine...
  20. doi request reprint Changes in central artery blood pressure and wave reflection during a cold pressor test in young adults
    Darren P Casey
    Department of Applied Physiology and Kinesiology, College of Health and Human Performance, University of Florida, Gainesville, FL, USA
    Eur J Appl Physiol 103:539-43. 2008
    ....
  21. pmc NOS inhibition blunts and delays the compensatory dilation in hypoperfused contracting human muscles
    Darren P Casey
    Department of Anesthesiology, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Appl Physiol (1985) 107:1685-92. 2009
    ..These observations suggest that NO is released by contracting muscles or that a portion of the dilation caused by ischemic metabolites is NO dependent...
  22. pmc Measuring muscle blood flow: a key link between systemic and regional metabolism
    Darren P Casey
    Department of Anesthesiology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Curr Opin Clin Nutr Metab Care 11:580-6. 2008
    ..To provide a brief overview of the main techniques to measure muscle blood flow in humans and highlight some of the strengths and weaknesses associated with each technique...
  23. pmc Adenosine receptor antagonist and augmented vasodilation during hypoxic exercise
    Darren P Casey
    Department of Anesthesiology, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
    J Appl Physiol (1985) 107:1128-37. 2009
    ..05 for both). These observations suggest that adenosine receptor activation is not obligatory for the augmented hyperemia during hypoxic exercise in humans...
  24. pmc Skeletal muscle blood flow responses to hypoperfusion at rest and during rhythmic exercise in humans
    Darren P Casey
    Department of Anesthesiology, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
    J Appl Physiol (1985) 107:429-37. 2009
    ....
  25. doi request reprint Relationship between endogenous concentrations of vasoactive substances and measures of peripheral vasodilator function in patients with coronary artery disease
    Darren P Casey
    Department of Applied Physiology and Kinesiology, College of Health and Human Performance, University of Florida, Center for Exercise Science, Gainesville, Florida, USA
    Clin Exp Pharmacol Physiol 37:24-8. 2010
    ..Therefore, measurement of plasma NO(x) may serve as a reliable marker for peripheral vasodilator dysfunction in patients with CAD...
  26. pmc Enhanced external counterpulsation improves peripheral artery flow-mediated dilation in patients with chronic angina: a randomized sham-controlled study
    Randy W Braith
    Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL 32611, USA
    Circulation 122:1612-20. 2010
    ..This was the first randomized sham-controlled study to investigate the extracardiac effects of EECP on peripheral artery flow-mediated dilation...
  27. doi request reprint Roles of nitric oxide and prostaglandins in the hyperemic response to a maximal metabolic stimulus: redundancy prevails
    Marcos G Lopez
    Department of Anesthesiology, Vanderbilt University School of Medicine, 1161 21st Avenue, Nashville, TN 37232, USA
    Eur J Appl Physiol 113:1449-56. 2013
    ..5 ± 5.3 ml 100 ml(-1) 100 mmHg(-1) for saline, ketorolac, and ketorolac + L-NMMA trials, (P = 0.69). These results suggest that NO and PGs are not obligatory for the hyperemic response to IE, and other vasodilator mechanisms predominate...
  28. doi request reprint Effects of exercise training on forearm and calf vasodilation and proinflammatory markers in recent heart transplant recipients: a pilot study
    Gary L Pierce
    Department of Applied Physiology and Kinesiology, College of Health and Human Performance, University of Florida, Gainesville, Florida, USA
    Eur J Cardiovasc Prev Rehabil 15:10-8. 2008
    ..It is, however, currently unknown whether aerobic exercise has a similar effect in heart transplant recipients (HTR)...
  29. pmc Relationship between sympathetic nerve activity and aortic wave reflection characteristics in postmenopausal women
    Emma C Hart
    Department of Anesthesiology, Mayo Clinic, Rochester, MN, USA
    Menopause 20:967-72. 2013
    ..In young women, there is an inverse relationship. We investigated whether this inverse relationship persisted in postmenopausal women...
  30. doi request reprint Ischemic exercise hyperemia in the human forearm: reproducibility and roles of adenosine and nitric oxide
    Marcos G Lopez
    Department of Anesthesiology, Mayo Clinic, 200 1st Street Southwest, Rochester, MN 55905, USA
    Eur J Appl Physiol 112:2065-72. 2012
    ..Our data suggest that (1) the hyperemic response to IE is reproducible and (2) inhibition of ADO alone or combined ADO and NO does not blunt the hyperemic response following IE...
  31. pmc Effects of enhanced external counterpulsation on arterial stiffness and myocardial oxygen demand in patients with chronic angina pectoris
    Darren P Casey
    Department of Anesthesiology, Mayo Clinic, Rochester, Minnesota, USA
    Am J Cardiol 107:1466-72. 2011
    ..In conclusion, EECP therapy decreases central and peripheral arterial stiffness, which may explain improvements in myocardial oxygen demand in patients with chronic angina pectoris after treatment...
  32. pmc The catecholamines strike back. What NO does not do
    Michael J Joyner
    Department of Anesthesiology, Mayo Clinic, Rochester, MN 55905, USA
    Circ J 73:1783-92. 2009
    ..Thus the role of NO in two of the most extreme dilator responses seen in nature is limited and in muscle the sympathetic nerves can restrain the dilation to defend arterial blood pressure...
  33. ncbi request reprint Effect of resistance training on arterial wave reflection and brachial artery reactivity in normotensive postmenopausal women
    Darren P Casey
    Center for Exercise Science, Department of Applied Physiology and Kinesiology, College of Health and Human Performance, University of Florida, PO Box 118206, Gainesville, FL 32611, USA
    Eur J Appl Physiol 100:403-8. 2007
    ..This prospective, randomized study demonstrated that moderate intensity whole body RT in previously sedentary, normotensive postmenopausal women does not alter central aortic pressure wave reflection...
  34. pmc Exercise training reduces peripheral arterial stiffness and myocardial oxygen demand in young prehypertensive subjects
    Darren T Beck
    Malcom Randall VA Medical Center, Geriatric Research Education and Clinical Center, Gainesville, Florida
    Am J Hypertens 26:1093-102. 2013
    ..Large artery stiffness is a major risk factor for the development of hypertension and cardiovascular disease. Persistent prehypertension accelerates the progression of arterial stiffness...
  35. doi request reprint Association of age with timing and amplitude of reflected pressure waves during exercise in men
    Jeffrey S Martin
    Department of Applied Physiology and Kinesiology, Center for Exercise Science, College of Health and Human Performance, University of Florida, Gainesville, FL, USA
    Am J Hypertens 24:415-20. 2011
    ..The effects of aging on central hemodynamics during exercise have not been well characterized. This study sought to investigate changes in central hemodynamics during cycle exercise in young, middle-aged, and older men...
  36. ncbi request reprint Systemic plasma levels of nitrite/nitrate (NOx) reflect brachial flow-mediated dilation responses in young men and women
    Darren P Casey
    Center for Exercise Science, Department of Applied Physiology and Kinesiology, College of Health and Human Performance, University of Florida, Gainesville, FL 32611, USA
    Clin Exp Pharmacol Physiol 34:1291-3. 2007
    ..This relationship suggests that brachial FMD and/or plasma NO(x) may be used as markers of peripheral endothelial function...
  37. pmc Cyclooxygenase inhibition augments central blood pressure and aortic wave reflection in aging humans
    Jill N Barnes
    Department of Anesthesiology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Am J Physiol Heart Circ Physiol 302:H2629-34. 2012
    ..Our results suggest that aging individuals have a limited ability to compensate for the acute hemodynamic changes caused by systemic COX inhibition...
  38. pmc Central, peripheral and resistance arterial reactivity: fluctuates during the phases of the menstrual cycle
    Eric J Adkisson
    Department of Applied Physiology and Kinesiology, Center for Exercise Science, College of Health and Human Performance, University of Florida, Gainesville, FL 32611, USA
    Exp Biol Med (Maywood) 235:111-8. 2010
    ..05). Young premenopausal women experienced an overwhelming pattern of reduced BP and increased systemic vascular reactivity during the LF phase prior to ovulation...
  39. pmc Exercise training improves endothelial function in young prehypertensives
    Darren T Beck
    Malcom Randall VA Medical Center, GRECC, Gainesville, FL 32601, USA
    Exp Biol Med (Maywood) 238:433-41. 2013
    ..This study provides novel evidence that resistance and endurance exercise separately have beneficial effects on resting peripheral blood pressure, brachial artery FMD and endothelial-derived vasoactive agents in young prehypertensives...
  40. pmc Enhanced external counterpulsation for ischemic heart disease: a look behind the curtain
    Randy W Braith
    Department of Applied Physiology and Kinesiology, College of Health and Human Performance, University of Florida, Gainesville, FL 32611, USA
    Exerc Sport Sci Rev 40:145-52. 2012
    ..The popular concept is that EECP may promote collateral development and improve myocardial perfusion. We hypothesize that improvements in peripheral arterial function are responsible for the clinical benefits of EECP...
  41. doi request reprint Exercise training attenuates progressive decline in brachial artery reactivity in heart transplant recipients
    Randy W Braith
    Center for Exercise Science, Department of Applied Physiology and Kinesiology, College of Health and Human Performance, University of Florida, Gainesville, Florida 32611, USA
    J Heart Lung Transplant 27:52-9. 2008
    ..Heart transplantation normalizes central hemodynamics, but endothelial dysfunction persists after transplantation...
  42. pmc Effect of vitamin C on hyperoxia-induced vasoconstriction in exercising skeletal muscle
    Sushant M Ranadive
    Department of Anesthesiology, Mayo Clinic, Rochester, Minnesota and
    J Appl Physiol (1985) 117:1207-11. 2014
    ..8 ± 6.1%, respectively. However, vitamin C had no effect in the other two subgroups. This analysis is consistent with the idea that ROS generation blunts the FBF responses to exercise in the subjects most affected by hyperoxia. ..
  43. doi request reprint Enhanced external counterpulsation improves peripheral resistance artery blood flow in patients with coronary artery disease
    Joseph C Avery
    a Department of Applied Physiology and Kinesiology, College of Health and Human Performance, University of Florida, Gainesville, FL 32611, USA
    Appl Physiol Nutr Metab 39:405-8. 2014
    ....
  44. pmc Acute effects of a mixed meal on arterial stiffness and central hemodynamics in healthy adults
    Jennifer L Taylor
    Department of Anesthesiology, Mayo Clinic, Rochester, Minnesota
    Am J Hypertens 27:331-7. 2014
    ..However, the acute effects of a meal on aortic wave reflection and stiffness are unknown. Therefore, we tested the hypothesis that aortic wave reflection and stiffness would increase after a meal...
  45. pmc Regulation of increased blood flow (hyperemia) to muscles during exercise: a hierarchy of competing physiological needs
    Michael J Joyner
    Department of Anesthesiology, Mayo Clinic, Rochester, Minnesota and Department of Physical Therapy and Rehabilitation Science, University of Iowa, Iowa City, Iowa
    Physiol Rev 95:549-601. 2015
    ....
  46. pmc Muscle blood flow, hypoxia, and hypoperfusion
    Michael J Joyner
    Department of Anesthesiology, Mayo Clinic, Rochester, Minnesota
    J Appl Physiol (1985) 116:852-7. 2014
    ..Together our findings emphasize both the tight linkage of oxygen demand and supply during exercise and the redundant nature of the vasomotor responses to contraction. ..