Michiro Susa

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. pmc Soft tissue mixed tumor of the hand
    Hiroshi Shimosawa
    Department of Orthopaedic Surgery, Eiju General Hospital, Tokyo, Japan
    Rare Tumors 1:e30. 2009
  2. ncbi Alendronate inhibits growth of high-grade chondrosarcoma cells
    Michiro Susa
    Department of Orthopaedic Surgery, Keio University School of Medicine, Tokyo, Japan
    Anticancer Res 29:1879-88. 2009
  3. pmc Doxorubicin loaded Polymeric Nanoparticulate Delivery System to overcome drug resistance in osteosarcoma
    Michiro Susa
    Department of Orthopaedic Surgery, Massachusetts General Hospital, Boston, MA 02114, USA
    BMC Cancer 9:399. 2009
  4. pmc Inhibition of ABCB1 (MDR1) expression by an siRNA nanoparticulate delivery system to overcome drug resistance in osteosarcoma
    Michiro Susa
    Department of Orthopaedic Surgery, Massachusetts General Hospital, Boston, Massachusetts, USA
    PLoS ONE 5:e10764. 2010
  5. pmc Oleanane triterpenoid CDDO-Me induces apoptosis in multidrug resistant osteosarcoma cells through inhibition of Stat3 pathway
    Keinosuke Ryu
    Department of Orthopaedic Surgery, Massachusetts General Hospital, Boston, MA 02114, USA
    BMC Cancer 10:187. 2010
  6. doi Activation of signal transducer and activator of transcription 3 (Stat3) pathway in osteosarcoma cells and overexpression of phosphorylated-Stat3 correlates with poor prognosis
    Keinosuke Ryu
    Department of Orthopedic Surgery, Massachusetts General Hospital, Center for Sarcoma and Connective Tissue Oncology, 55 Fruit St Jackson 1115, Boston, Massachusetts 02114, USA
    J Orthop Res 28:971-8. 2010
  7. doi Cyclin G-associated kinase is necessary for osteosarcoma cell proliferation and receptor trafficking
    Michiro Susa
    Department of Orthopaedic Surgery, and SarcomaBiology Laboratory, Center for Sarcoma and Connective Tissue Oncology, Massachusetts General Hospital, Boston, MA 02114, USA
    Mol Cancer Ther 9:3342-50. 2010
  8. pmc Fibrous Dysplasia with Massive Cartilaginous Differentiation (Fibrocartilaginous Dysplasia) in the Proximal Femur: A Case Report and Review of the Literature
    Hideo Morioka
    Department of Orthopaedic Surgery, Keio University School of Medicine, Tokyo, Japan
    Case Rep Oncol 9:126-33. 2016
  9. doi Nanoparticles: a promising modality in the treatment of sarcomas
    Michiro Susa
    Department of Orthopaedic Surgery, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Pharm Res 28:260-72. 2011
  10. pmc MicroRNA-199a-3p is downregulated in human osteosarcoma and regulates cell proliferation and migration
    Zhenfeng Duan
    Center for Sarcoma and Connective Tissue Oncology, Massachusetts General Hospital, Boston, MA 02114, USA
    Mol Cancer Ther 10:1337-45. 2011

Collaborators

Detail Information

Publications28

  1. pmc Soft tissue mixed tumor of the hand
    Hiroshi Shimosawa
    Department of Orthopaedic Surgery, Eiju General Hospital, Tokyo, Japan
    Rare Tumors 1:e30. 2009
    ..The occurrence of these tumors in the hand is especially limited. In this article we report the clinical, radiological, and histological features of a mixed tumor of the hypothenar region of the right hand...
  2. ncbi Alendronate inhibits growth of high-grade chondrosarcoma cells
    Michiro Susa
    Department of Orthopaedic Surgery, Keio University School of Medicine, Tokyo, Japan
    Anticancer Res 29:1879-88. 2009
    ..Bisphosphonates inhibit growth of various cell types, including cancer cells and perhaps chondrosarcoma...
  3. pmc Doxorubicin loaded Polymeric Nanoparticulate Delivery System to overcome drug resistance in osteosarcoma
    Michiro Susa
    Department of Orthopaedic Surgery, Massachusetts General Hospital, Boston, MA 02114, USA
    BMC Cancer 9:399. 2009
    ....
  4. pmc Inhibition of ABCB1 (MDR1) expression by an siRNA nanoparticulate delivery system to overcome drug resistance in osteosarcoma
    Michiro Susa
    Department of Orthopaedic Surgery, Massachusetts General Hospital, Boston, Massachusetts, USA
    PLoS ONE 5:e10764. 2010
    ..However, for patients who progress after chemotherapy, its effectiveness diminishes due to the emergence of multi-drug resistance (MDR) after prolonged therapy...
  5. pmc Oleanane triterpenoid CDDO-Me induces apoptosis in multidrug resistant osteosarcoma cells through inhibition of Stat3 pathway
    Keinosuke Ryu
    Department of Orthopaedic Surgery, Massachusetts General Hospital, Boston, MA 02114, USA
    BMC Cancer 10:187. 2010
    ....
  6. doi Activation of signal transducer and activator of transcription 3 (Stat3) pathway in osteosarcoma cells and overexpression of phosphorylated-Stat3 correlates with poor prognosis
    Keinosuke Ryu
    Department of Orthopedic Surgery, Massachusetts General Hospital, Center for Sarcoma and Connective Tissue Oncology, 55 Fruit St Jackson 1115, Boston, Massachusetts 02114, USA
    J Orthop Res 28:971-8. 2010
    ..Our results suggest that Stat3 may be a prognostic indicator and potential therapeutic target for osteosarcoma. Blocking the pathway of Stat3 may lead to develop new therapeutic strategies against osteosarcoma...
  7. doi Cyclin G-associated kinase is necessary for osteosarcoma cell proliferation and receptor trafficking
    Michiro Susa
    Department of Orthopaedic Surgery, and SarcomaBiology Laboratory, Center for Sarcoma and Connective Tissue Oncology, Massachusetts General Hospital, Boston, MA 02114, USA
    Mol Cancer Ther 9:3342-50. 2010
    ..In conclusion, our results suggest that osteosarcoma cell proliferation and survival are dependent on GAK. These findings may lead to the development of new therapeutic options for osteosarcoma...
  8. pmc Fibrous Dysplasia with Massive Cartilaginous Differentiation (Fibrocartilaginous Dysplasia) in the Proximal Femur: A Case Report and Review of the Literature
    Hideo Morioka
    Department of Orthopaedic Surgery, Keio University School of Medicine, Tokyo, Japan
    Case Rep Oncol 9:126-33. 2016
    ..Herein, we report on a case of FD of the proximal femur associated with intralesional extensive carti laginous differentiation in which a pathological fracture occurred during follow-up, with a review of the literature. ..
  9. doi Nanoparticles: a promising modality in the treatment of sarcomas
    Michiro Susa
    Department of Orthopaedic Surgery, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Pharm Res 28:260-72. 2011
    ..In this review, we will discuss the application of nanoparticles for improving the treatment of sarcoma patients...
  10. pmc MicroRNA-199a-3p is downregulated in human osteosarcoma and regulates cell proliferation and migration
    Zhenfeng Duan
    Center for Sarcoma and Connective Tissue Oncology, Massachusetts General Hospital, Boston, MA 02114, USA
    Mol Cancer Ther 10:1337-45. 2011
    ..Restoring miR-199a-3p's function may provide therapeutic benefits in osteosarcoma...
  11. pmc CT guided cryoablation for locally recurrent or metastatic bone and soft tissue tumor: initial experience
    Michiro Susa
    Department of Orthopaedic Surgery, Keio University School of Medicine, Shinjuku ku, Tokyo, 160 8582, Japan
    BMC Cancer 16:798. 2016
    ..In this study, we analyzed the clinical outcome of CT-guided cryoablation for malignant bone and soft tissue tumors to elucidate potential problems associated with this procedure...
  12. doi Desmoplastic fibroma arising in the distal phalanx of the great toe: a case report
    Takeshi Koba
    Department of Orthopaedic Surgery, Keio University School of Medicine, Shinjuku ku, Tokyo, Japan
    J Foot Ankle Surg 53:71-4. 2014
    ..The occurrence of these tumors in the foot is especially limited. We report the clinical, radiographic, and histologic features of DF arising in the distal phalanx of the great toe and a review of the published data. ..
  13. doi Detection of HEY1-NCOA2 fusion by fluorescence in-situ hybridization in formalin-fixed paraffin-embedded tissues as a possible diagnostic tool for mesenchymal chondrosarcoma
    Robert Nakayama
    Department of Orthopaedic Surgery, Keio University School of Medicine, Tokyo, Japan
    Pathol Int 62:823-6. 2012
    ..The current study adds further support for the use of HEY1-NCOA2 fusion as a valid diagnostic marker for MC...
  14. doi Lentiviral shRNA screen of human kinases identifies PLK1 as a potential therapeutic target for osteosarcoma
    Zhenfeng Duan
    Center for Sarcoma and Connective Tissue Oncology, Massachusetts General Hospital, Boston, MA 02114, USA
    Cancer Lett 293:220-9. 2010
    ..The development of more potent inhibitors that target PLK1 may open doors to a new range of anti-cancer strategies in osteosarcoma...
  15. pmc Hibernoma Showing High Uniform Accumulation on an 18F-Fluorodeoxyglucose Positron Emission Tomography Scan: A Case Report
    Yasuhiro Kamata
    Department of Orthopedic Surgery, Keio University School of Medicine, Tokyo, Japan
    Case Rep Oncol 9:427-431. 2016
    ..However, fewer studies have investigated the typical features of hibernoma on PET scans. We present the case of a hibernoma that was incidentally detected on 18F-FDG-PET...
  16. pmc Adamantinoma of the distal femur diagnosed 5 years after initial surgery: a case report
    Kai Cao
    Department of Orthopedic Surgery, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo, 160 8582, Japan
    J Med Case Rep 10:185. 2016
    ..Adamantinoma arising in the femur is extremely rare. We report a case of an adamantinoma occurring in the right medial femoral condyle that was diagnosed 5 years after the primary surgery...
  17. doi Anaplastic transformation of follicular thyroid carcinoma in a metastatic skeletal lesion presenting with paraneoplastic leukocytosis
    Robert Nakayama
    Department of Orthopedic Surgery, Keio University, Shinjuku ku, Tokyo, Japan
    Thyroid 22:200-4. 2012
    ..Anaplastic transformation of differentiated thyroid carcinoma (DTC) is a rare event with a poor clinical outcome. It usually occurs in the primary site or in regional lymph nodes, but rarely in distant metastatic lesions...
  18. pmc Diagnosis of extraskeletal myxoid chondrosarcoma in the thigh using EWSR1-NR4A3 gene fusion: a case report
    Hiroki Kobayashi
    Department of Orthopaedic Surgery, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, 160 8582, Tokyo, Japan
    J Med Case Rep 10:321. 2016
    ..Nevertheless, extraskeletal myxoid chondrosarcoma has a rare gene fusion (EWSR1-NR4A3) that is useful for making a differential diagnosis...
  19. doi Effects of siltuximab on the IL-6-induced signaling pathway in ovarian cancer
    Yuqi Guo
    Sarcoma Biology Laboratory, Center for Sarcoma and Connective Tissue Oncology, Massachusetts General Hospital, Boston, MA 02114, USA
    Clin Cancer Res 16:5759-69. 2010
    ..We then looked for enhancing paclitaxel sensitivity in multidrug-resistant ovarian cancer cell lines...
  20. doi Clinical outcome after bone metastasis (BM) surgery in patients with differentiated thyroid carcinoma (DTC): a retrospective study of 40 cases
    Robert Nakayama
    Department of Orthopaedic Surgery, School of Medicine, Keio University, Tokyo, Japan
    Jpn J Clin Oncol 44:918-25. 2014
    ....
  21. pmc Metastatic patterns of myxoid/round cell liposarcoma: a review of a 25-year experience
    Naofumi Asano
    Department of Orthopaedic Surgery, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Sarcoma 2012:345161. 2012
    ..027). 3 cases with pulmonary metastatic lesions were all diagnosed as high grade. In conclusion, large size and low histological grade were significantly associated with extrapulmonary metastasis...
  22. doi Multidrug resistance reversal agent, NSC77037, identified with a cell-based screening assay
    Michiro Susa
    Sarcoma Biology Laboratory, Center for Sarcoma and Connective Tissue Oncology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Biomol Screen 15:287-96. 2010
    ..The use of NSC77037 to restore sensitivity to chemotherapy or to prevent resistance could be a potential treatment strategy for cancer patients...
  23. pmc Osteoid osteoma of the acetabulum successfully treated with computed tomography-guided resection and ablation using a standard electrosurgical generator: a case report
    Kazutaka Kikuta
    Department of Orthopaedic Surgery, Keio University School of Medicine, 35 Shinanomachi, Shinjyuku ku, 160 8582, Tokyo, Japan
    J Med Case Rep 10:348. 2016
    ..Here, we report for the first time a rare case of osteoid osteoma in the acetabulum that was successfully treated via resection of the nidus and ablation using a standard electrosurgical generator under computed tomographic guidance...
  24. pmc Novel MR imaging method--MAVRIC--for metal artifact suppression after joint replacement in musculoskeletal tumor patients
    Michiro Susa
    Department of Orthopaedic Surgery, National Defense Medical College, 3 2 Namiki, Tokorozawa, Saitama, 359 8513, Japan
    BMC Musculoskelet Disord 16:377. 2015
    ..In this study, we tried to elucidate the effectiveness of metal artifact suppression using novel sequence, multiacquisition variable-resonance image combination (MAVRIC), after musculoskeletal tumor surgeries...
  25. pmc Prognostic Value of Relevant Clinicopathologic Variables in Epithelioid Sarcoma: A Multi-Institutional Retrospective Study of 44 Patients
    Naofumi Asano
    Department of Musculoskeletal Oncology, National Cancer Center Hospital, Tokyo, Japan
    Ann Surg Oncol 22:2624-32. 2015
    ..We investigated the clinicopathological features of patients with ES to identify the prognostic factors that influence survival...
  26. doi Reconstruction modality based on the spare part concept for massive soft tissue defects following oncological hemipelvectomy
    Takeshi Morii
    Department of Orthopedic Surgery, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo, 160 8582, Japan
    J Orthop Sci 14:192-7. 2009
    ..Recent innovations in plastic surgery have resulted in the development of novel reconstruction modalities based on "the spare part concept," applying tissues from amputated limbs...
  27. pmc Results of sub-analysis of a phase 2 study on trabectedin treatment for extraskeletal myxoid chondrosarcoma and mesenchymal chondrosarcoma
    Hideo Morioka
    Department of Orthopaedic Surgery, Keio University School of Medicine, 35 Shinanomachi Shinjuku ku, Tokyo, 160 8582, Japan
    BMC Cancer 16:479. 2016
    ..The aim of the present analysis was to clarify the efficacy of trabectedin for EMCS and MCS subjects in the randomized phase 2 study...
  28. doi Experimental assessment of a novel intramedullary nail for callus distraction by the segmental bone transport method
    Kenji Yamaguchi
    Department of Orthopedic Surgery School of Medicine, Keio University, 35 Shinanomachi, Shinjuku ku, Tokyo, 160 8582, Japan
    J Orthop Sci 19:323-31. 2014
    ..We also considered the possibilities and limitations of the IM in regard to clinical application...