Subra Suresh

Summary

Affiliation: Massachusetts Institute of Technology
Country: USA

Publications

  1. doi request reprint Nanomedicine: elastic clues in cancer detection
    Subra Suresh
    Nat Nanotechnol 2:748-9. 2007
  2. doi request reprint Reprint of: Connections between single-cell biomechanics and human disease states: gastrointestinal cancer and malaria
    S Suresh
    Department of Materials Science and Engineering, and Division of Bioengineering, Massachusetts Institute of Technology, Room 8 309, 77 Massachusetts Ave, Cambridge, MA 02139 4307, USA Division of Biological Engineering and Affiliated Faculty of the Harvard MIT Division of Health Sciences and Technology, Cambridge, MA 02139 4307, USA Electronic address
    Acta Biomater 23:S3-15. 2015
  3. ncbi request reprint Connections between single-cell biomechanics and human disease states: gastrointestinal cancer and malaria
    S Suresh
    Department of Materials Science and Engineering, and Division of Bioengineering, Massachusetts Institute of Technology, Cambridge, MA 02139 4307, USA
    Acta Biomater 1:15-30. 2005
  4. pmc Biomechanics and biophysics of cancer cells
    Subra Suresh
    Department of Materials Science and Engineering, Division of Biological Engineering, and Harvard MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139 4307, USA
    Acta Biomater 3:413-38. 2007
  5. pmc Lipid bilayer and cytoskeletal interactions in a red blood cell
    Zhangli Peng
    Department of Materials Science and Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 110:13356-61. 2013
  6. pmc Static and dynamic light scattering of healthy and malaria-parasite invaded red blood cells
    Yongkeun Park
    Massachusetts Institute of Technology, G R Harrison Spectroscopy Laboratory, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA
    J Biomed Opt 15:020506. 2010
  7. pmc Metabolic remodeling of the human red blood cell membrane
    Yongkeun Park
    G R Harrison Spectroscopy Laboratory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 107:1289-94. 2010
  8. pmc Electric impedance microflow cytometry for characterization of cell disease states
    E Du
    Department of Materials Science and Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
    Lab Chip 13:3903-9. 2013
  9. pmc Pf155/RESA protein influences the dynamic microcirculatory behavior of ring-stage Plasmodium falciparum infected red blood cells
    Monica Diez-Silva
    Department of Materials Science and Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Sci Rep 2:614. 2012
  10. pmc A microfabricated deformability-based flow cytometer with application to malaria
    Hansen Bow
    Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Room 36 841, Cambridge, MA 02139, USA
    Lab Chip 11:1065-73. 2011

Collaborators

Detail Information

Publications25

  1. doi request reprint Nanomedicine: elastic clues in cancer detection
    Subra Suresh
    Nat Nanotechnol 2:748-9. 2007
  2. doi request reprint Reprint of: Connections between single-cell biomechanics and human disease states: gastrointestinal cancer and malaria
    S Suresh
    Department of Materials Science and Engineering, and Division of Bioengineering, Massachusetts Institute of Technology, Room 8 309, 77 Massachusetts Ave, Cambridge, MA 02139 4307, USA Division of Biological Engineering and Affiliated Faculty of the Harvard MIT Division of Health Sciences and Technology, Cambridge, MA 02139 4307, USA Electronic address
    Acta Biomater 23:S3-15. 2015
    ..Some general perspectives on connections among structure, single-cell mechanical properties and biological responses associated with pathogenic processes are also provided in the context of the two diseases considered in this work. ..
  3. ncbi request reprint Connections between single-cell biomechanics and human disease states: gastrointestinal cancer and malaria
    S Suresh
    Department of Materials Science and Engineering, and Division of Bioengineering, Massachusetts Institute of Technology, Cambridge, MA 02139 4307, USA
    Acta Biomater 1:15-30. 2005
    ..Some general perspectives on connections among structure, single-cell mechanical properties and biological responses associated with pathogenic processes are also provided in the context of the two diseases considered in this work...
  4. pmc Biomechanics and biophysics of cancer cells
    Subra Suresh
    Department of Materials Science and Engineering, Division of Biological Engineering, and Harvard MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139 4307, USA
    Acta Biomater 3:413-38. 2007
    ....
  5. pmc Lipid bilayer and cytoskeletal interactions in a red blood cell
    Zhangli Peng
    Department of Materials Science and Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 110:13356-61. 2013
    ....
  6. pmc Static and dynamic light scattering of healthy and malaria-parasite invaded red blood cells
    Yongkeun Park
    Massachusetts Institute of Technology, G R Harrison Spectroscopy Laboratory, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA
    J Biomed Opt 15:020506. 2010
    ..Progressive changes to the biophysical properties of the Pf-RBC membrane are captured from dynamic light scattering...
  7. pmc Metabolic remodeling of the human red blood cell membrane
    Yongkeun Park
    G R Harrison Spectroscopy Laboratory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 107:1289-94. 2010
    ....
  8. pmc Electric impedance microflow cytometry for characterization of cell disease states
    E Du
    Department of Materials Science and Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
    Lab Chip 13:3903-9. 2013
    ..The representative results provided here also point to the potential of the proposed experimental and analysis platform as a valuable tool for non-invasive diagnostics of a wide variety of disease states and for cell separation. ..
  9. pmc Pf155/RESA protein influences the dynamic microcirculatory behavior of ring-stage Plasmodium falciparum infected red blood cells
    Monica Diez-Silva
    Department of Materials Science and Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Sci Rep 2:614. 2012
    ....
  10. pmc A microfabricated deformability-based flow cytometer with application to malaria
    Hansen Bow
    Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Room 36 841, Cambridge, MA 02139, USA
    Lab Chip 11:1065-73. 2011
    ..These methods collectively provide a systematic approach to characterize the biomechanical properties of cells in a high-throughput manner...
  11. pmc Cellular normoxic biophysical markers of hydroxyurea treatment in sickle cell disease
    Poorya Hosseini
    Laser Biomedical Research Center, Massachusetts Institute of Technology, Cambridge, MA 02139 Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139 Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139
    Proc Natl Acad Sci U S A 113:9527-32. 2016
    ....
  12. pmc Biomechanics of single cortical neurons
    Kristin B Bernick
    Department of Biological Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139 4307, USA
    Acta Biomater 7:1210-9. 2011
    ..The simulated cell response was calibrated to the experimental measurements under the selected test conditions, providing a novel single cell model that could form the basis for further refinements...
  13. pmc Combined simulation and experimental study of large deformation of red blood cells in microfluidic systems
    David J Quinn
    Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA
    Ann Biomed Eng 39:1041-50. 2011
    ..In particular, we identify a cross-sectional area threshold below which the RBC membrane properties begin to dominate its flow behavior at room temperature; at physiological temperatures this effect is less profound...
  14. pmc Refractive index maps and membrane dynamics of human red blood cells parasitized by Plasmodium falciparum
    Yongkeun Park
    G R Harrison Spectroscopy Laboratory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 105:13730-5. 2008
    ..These findings offer potential, and sufficiently general, avenues for identifying, through cell membrane dynamics, pathological states that cause or accompany human diseases...
  15. pmc Protection mechanisms of the iron-plated armor of a deep-sea hydrothermal vent gastropod
    Haimin Yao
    Department of Materials Science and Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 107:987-92. 2010
    ..The structure-property-performance relationships described are expected to be of technological interest for a variety of civilian and defense applications...
  16. ncbi request reprint Nanoscale heterogeneity promotes energy dissipation in bone
    Kuangshin Tai
    Department of Materials Science and Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
    Nat Mater 6:454-62. 2007
    ..The fundamental concepts discovered here are applicable to a broad class of biological materials and may serve as a design consideration for biologically inspired materials technologies...
  17. pmc Kinetics of sickle cell biorheology and implications for painful vasoocclusive crisis
    E Du
    Department of Materials Science and Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139
    Proc Natl Acad Sci U S A 112:1422-7. 2015
    ..Such insights may also lead to a better understanding of the pathogenic basis and mechanism of drug response in SCD. ..
  18. doi request reprint Dynamic mechanical response of brain tissue in indentation in vivo, in situ and in vitro
    Thibault P Prevost
    Department of Materials Science and Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Acta Biomater 7:4090-101. 2011
    ....
  19. pmc Measuring single-cell density
    William H Grover
    Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 108:10992-6. 2011
    ..These demonstrations suggest that the ability to measure single-cell density will provide valuable insights into cell state for a wide range of biological processes...
  20. doi request reprint Biomechanics of brain tissue
    Thibault P Prevost
    Department of Materials Science and Engineering, Massachusetts Institute of Technology, Cambridge, 02139, USA
    Acta Biomater 7:83-95. 2011
    ..01-3000 s⁻¹), thereby providing a valuable tool for simulations of dynamic transients (impact, blast/shock wave propagation) leading to traumatic brain injury...
  21. pmc Cytoskeletal dynamics of human erythrocyte
    Ju Li
    Department of Materials Science and Engineering, Ohio State University, Columbus, OH 43210, USA
    Proc Natl Acad Sci U S A 104:4937-42. 2007
    ..These phenomena may have implication for RBC membrane loss and shape change in the context of hereditary hemolytic disorders such as spherocytosis and elliptocytosis...
  22. pmc Effect of plasmodial RESA protein on deformability of human red blood cells harboring Plasmodium falciparum
    J P Mills
    Department of Materials Science and Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 104:9213-7. 2007
    ..We also show that the effect of RESA on deformability is more pronounced at febrile temperature, which ring-stage parasite-harboring RBCs can be exposed to during a malaria attack, than at normal body temperature...
  23. pmc Spectrin-level modeling of the cytoskeleton and optical tweezers stretching of the erythrocyte
    J Li
    Department of Materials Science and Engineering, Ohio State University, Columbus, Ohio, USA
    Biophys J 88:3707-19. 2005
    ..We have devised and implemented a liquefied network structure evolution algorithm that relaxes shear stress everywhere in the network and generates cytoskeleton structures that mimic experimental observations...
  24. ncbi request reprint Viscoelasticity of the human red blood cell
    Marina Puig-de-Morales-Marinkovic
    Program in Molecular and Integrative Physiological Sciences MIPS Dept of Environmental Health, Harvard School of Public Health, Boston, MA 02115, USA
    Am J Physiol Cell Physiol 293:C597-605. 2007
    ....
  25. ncbi request reprint Crystal deformation: colloid model for atoms
    Subra Suresh
    Nat Mater 5:253-4. 2006