Steven M Stufflebeam

Summary

Affiliation: Massachusetts Institute of Technology
Country: USA

Publications

  1. doi request reprint Clinical applications of magnetoencephalography
    Steven M Stufflebeam
    Department of Radiology, Athinoula A Martinos Center for Biomedical Imaging, Harvard Medical School, Massachusetts General Hospital, 149 Thirteenth Street, Charlestown, MA 02129, USA
    Hum Brain Mapp 30:1813-23. 2009
  2. pmc Comparison of three methods for localizing interictal epileptiform discharges with magnetoencephalography
    Hideaki Shiraishi
    Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, USA
    J Clin Neurophysiol 28:431-40. 2011
  3. pmc Propagation of epileptic spikes reconstructed from spatiotemporal magnetoencephalographic and electroencephalographic source analysis
    Naoaki Tanaka
    Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA 02129, USA
    Neuroimage 50:217-22. 2010
  4. pmc Quantitative analysis and biophysically realistic neural modeling of the MEG mu rhythm: rhythmogenesis and modulation of sensory-evoked responses
    Stephanie R Jones
    Massachusetts General Hospital, Athinoula A Martinos Center for Biomedical Imaging, Charlestown, MA 02129, USA
    J Neurophysiol 102:3554-72. 2009
  5. ncbi request reprint Application of magnetoencephalography in epilepsy patients with widespread spike or slow-wave activity
    Hideaki Shiraishi
    MGH MIT HMS Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital Harvard Medical School, Charlestown, Massachusetts, USA
    Epilepsia 46:1264-72. 2005
  6. ncbi request reprint Assessing and improving the spatial accuracy in MEG source localization by depth-weighted minimum-norm estimates
    Fa Hsuan Lin
    MGH MIT HMS Athinoula A Martinos Center for Biomedical Imaging, Building 149 13th St Charlestown, MA 02129, USA
    Neuroimage 31:160-71. 2006
  7. pmc Diffuse cerebral language representation in tuberous sclerosis complex
    Anne Gallagher
    Athinoula A Martinos Center for Biomedical Imaging, 149 Thirteenth Street, Charlestown, MA 02129, USA
    Epilepsy Res 104:125-33. 2013
  8. pmc Magnetoencephalographic analysis in patients with vagus nerve stimulator
    Naoaki Tanaka
    Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA 02129, USA
    Pediatr Neurol 41:383-7. 2009
  9. pmc Current dipole orientation and distribution of epileptiform activity correlates with cortical thinning in left mesiotemporal epilepsy
    Claus Reinsberger
    Department of Radiology, Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA 02129, USA
    Neuroimage 52:1238-42. 2010
  10. pmc Mapping the signal-to-noise-ratios of cortical sources in magnetoencephalography and electroencephalography
    Daniel M Goldenholz
    Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, USA
    Hum Brain Mapp 30:1077-86. 2009

Collaborators

Detail Information

Publications31

  1. doi request reprint Clinical applications of magnetoencephalography
    Steven M Stufflebeam
    Department of Radiology, Athinoula A Martinos Center for Biomedical Imaging, Harvard Medical School, Massachusetts General Hospital, 149 Thirteenth Street, Charlestown, MA 02129, USA
    Hum Brain Mapp 30:1813-23. 2009
    ..We also describe the most common clinical MEG applications that affect the management of patients, and discuss some applications that are close to having a clinical impact on patients...
  2. pmc Comparison of three methods for localizing interictal epileptiform discharges with magnetoencephalography
    Hideaki Shiraishi
    Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, USA
    J Clin Neurophysiol 28:431-40. 2011
    ....
  3. pmc Propagation of epileptic spikes reconstructed from spatiotemporal magnetoencephalographic and electroencephalographic source analysis
    Naoaki Tanaka
    Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA 02129, USA
    Neuroimage 50:217-22. 2010
    ..Spatiotemporal source analysis may be useful for planning epilepsy surgery, by predicting the pattern of IEEG spikes...
  4. pmc Quantitative analysis and biophysically realistic neural modeling of the MEG mu rhythm: rhythmogenesis and modulation of sensory-evoked responses
    Stephanie R Jones
    Massachusetts General Hospital, Athinoula A Martinos Center for Biomedical Imaging, Charlestown, MA 02129, USA
    J Neurophysiol 102:3554-72. 2009
    ..These data provide new information on the dynamics of the mu rhythm in humans and the model provides a novel mechanistic interpretation of this rhythm and its functional significance...
  5. ncbi request reprint Application of magnetoencephalography in epilepsy patients with widespread spike or slow-wave activity
    Hideaki Shiraishi
    MGH MIT HMS Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital Harvard Medical School, Charlestown, Massachusetts, USA
    Epilepsia 46:1264-72. 2005
    ....
  6. ncbi request reprint Assessing and improving the spatial accuracy in MEG source localization by depth-weighted minimum-norm estimates
    Fa Hsuan Lin
    MGH MIT HMS Athinoula A Martinos Center for Biomedical Imaging, Building 149 13th St Charlestown, MA 02129, USA
    Neuroimage 31:160-71. 2006
    ..The application of depth weighting to auditory and somatosensory experimental data illustrated the beneficial effect of depth weighting on the accuracy of spatiotemporal mapping of neuronal sources...
  7. pmc Diffuse cerebral language representation in tuberous sclerosis complex
    Anne Gallagher
    Athinoula A Martinos Center for Biomedical Imaging, 149 Thirteenth Street, Charlestown, MA 02129, USA
    Epilepsy Res 104:125-33. 2013
    ..In the present study, we used magnetoencephalography (MEG) to investigate spatiotemporal cerebral language processing in subjects with TSC and epilepsy during a reading semantic decision task, compared to healthy control participants...
  8. pmc Magnetoencephalographic analysis in patients with vagus nerve stimulator
    Naoaki Tanaka
    Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA 02129, USA
    Pediatr Neurol 41:383-7. 2009
    ..These findings supported the diagnosis of symptomatic generalized epilepsy in this patient. Magnetoencephalography may thus be a useful option for evaluating patients with intractable epilepsy who have a vagus nerve stimulator...
  9. pmc Current dipole orientation and distribution of epileptiform activity correlates with cortical thinning in left mesiotemporal epilepsy
    Claus Reinsberger
    Department of Radiology, Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA 02129, USA
    Neuroimage 52:1238-42. 2010
    ..This finding may, in part, explain the unfavorable outcome in some MTLE patients after epilepsy surgery...
  10. pmc Mapping the signal-to-noise-ratios of cortical sources in magnetoencephalography and electroencephalography
    Daniel M Goldenholz
    Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, USA
    Hum Brain Mapp 30:1077-86. 2009
    ..Clinically, SNR maps in a patient explained differential sensitivity of MEG and EEG in detecting epileptic activity. Our results emphasize the benefits of recording MEG and EEG simultaneously...
  11. pmc Task-free presurgical mapping using functional magnetic resonance imaging intrinsic activity
    Hesheng Liu
    Massachusetts General Hospital Massachusetts Institute of Technology Harvard Medical School Athinoula A Martinos Center for Biomedical Imaging, Charlestown, Massachusetts 02129, USA
    J Neurosurg 111:746-54. 2009
    ..The ability to use such methods in individual patients may provide a powerful tool for presurgical planning. The authors explore the feasibility of presurgical motor function mapping in which a task-free paradigm is used...
  12. ncbi request reprint Aids to telemetry in the presurgical evaluation of epilepsy patients: MRI, MEG and other non-invasive imaging techniques
    Susanne Knake
    Athinoula A Martinos Center for Biomedical Imaging, Charlestown, MA 02129, USA
    Suppl Clin Neurophysiol 57:494-502. 2004
  13. pmc Localization of focal epileptic discharges using functional connectivity magnetic resonance imaging
    Steven M Stufflebeam
    Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, Massachusetts, USA
    J Neurosurg 114:1693-7. 2011
    ..The object of this study was to investigate whether the degree of coupling of spontaneous brain activity as measured with functional connectivity MR imaging (fcMR imaging) can accurately identify and localize epileptic discharges...
  14. pmc Altered structural connectome in temporal lobe epilepsy
    Matthew N DeSalvo
    From the Athinoula A Martinos Center for Biomedical Imaging, 149 Thirteenth St, Suite 2301, Charlestown, MA 02129 M N D, L D, N T, C R, S M S Department of Radiology, Massachusetts General Hospital, Charlestown, Mass M N D, L D, N T, S M S and Department of Neurology, Brigham and Women s Hospital, Boston, Mass C R
    Radiology 270:842-8. 2014
    ..To study differences in the whole-brain structural connectomes of patients with left temporal lobe epilepsy (TLE) and healthy control subjects...
  15. pmc Decreased language laterality in tuberous sclerosis complex: a relationship between language dominance and tuber location as well as history of epilepsy
    Anne Gallagher
    Athinoula A Martinos Center for Biomedical Imaging, Charlestown, MA, USA
    Epilepsy Behav 25:36-41. 2012
    ..Eleven patients (73.3%) had left-hemisphere language dominance, whereas four patients (26.7%) showed a bilateral language pattern, which was associated with a history of epilepsy and presence of tubers in language-related areas...
  16. pmc Dynamic statistical parametric mapping for analyzing ictal magnetoencephalographic spikes in patients with intractable frontal lobe epilepsy
    Naoaki Tanaka
    Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA 02129, USA
    Epilepsy Res 85:279-86. 2009
    ..Analyzing ictal MEG spikes by using dSPMs may provide useful information in presurgical evaluation of epilepsy...
  17. pmc Clinical magnetoencephalography for neurosurgery
    Steven M Stufflebeam
    Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA 02129, USA
    Neurosurg Clin N Am 22:153-67, vii-viii. 2011
    ..This article reviews the history of clinical MEG, introduces the basic concepts about the biophysics of MEG, and outlines the basic neurosurgical applications of MEG...
  18. doi request reprint Altered anterior-posterior connectivity through the arcuate fasciculus in temporal lobe epilepsy
    Shigetoshi Takaya
    MGH HST Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, Massachusetts
    Hum Brain Mapp 37:4425-4438. 2016
    ..Hum Brain Mapp 37:4425-4438, 2016. © 2016 Wiley Periodicals, Inc...
  19. pmc Clinical value of magnetoencephalographic spike propagation represented by spatiotemporal source analysis: correlation with surgical outcome
    Naoaki Tanaka
    Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, 149 Thirteenth Street, Suite 2301, Charlestown, MA 02129, USA Electronic address
    Epilepsy Res 108:280-8. 2014
    ..To investigate the correlation between spike propagation represented by spatiotemporal source analysis of magnetoencephalographic (MEG) spikes and surgical outcome in patients with temporal lobe epilepsy...
  20. pmc Neural correlates of tactile detection: a combined magnetoencephalography and biophysically based computational modeling study
    Stephanie R Jones
    Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
    J Neurosci 27:10751-64. 2007
    ..Furthermore, our model provides a biophysically realistic solution to the MEG signal and can predict the electrophysiological correlates of human perception...
  21. doi request reprint State-dependent variability of dynamic functional connectivity between frontoparietal and default networks relates to cognitive flexibility
    Linda Douw
    Department of Radiology, Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, 149 13th Street, Charlestown, MA 02129, USA Department of Anatomy and Neurosciences, VU University Medical Center, Van der Boechorststraat 7, 1081 BT Amsterdam, The Netherlands Electronic address
    Neuroscience 339:12-21. 2016
    ..In conclusion, our results suggest that not only the dynamics of connectivity between these networks is seminal for optimal functioning, but also that the contrast between dynamics across states reflects cognitive performance...
  22. pmc Resting-State Functional MR Imaging for Determining Language Laterality in Intractable Epilepsy
    Matthew N DeSalvo
    From the Athinoula A Martinos Center for Biomedical Imaging, 149 Thirteenth St, Suite 2301, Charlestown, MA 02129 M N D, N T, L D, D N G, S M S and Departments of Neurology C L L and Radiology B R B, S M S, Massachusetts General Hospital, Boston, Mass
    Radiology 281:264-9. 2016
    ..Conclusion Resting-state functional MR imaging can be used to measure language laterality in patients with medically intractable focal epilepsy. (©) RSNA, 2016 Online supplemental material is available for this article. ..
  23. pmc Evidence from intrinsic activity that asymmetry of the human brain is controlled by multiple factors
    Hesheng Liu
    Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA 02129, USA
    Proc Natl Acad Sci U S A 106:20499-503. 2009
    ..These findings show the feasibility of measuring brain asymmetry using intrinsic activity fluctuations and suggest that multiple genetic or environmental mechanisms control cerebral lateralization...
  24. pmc Loss of resting-state posterior cingulate flexibility is associated with memory disturbance in left temporal lobe epilepsy
    Linda Douw
    Department of Radiology, Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, United States of America Department of Radiology, Harvard Medical School, Boston, MA, United States of America Department of Anatomy and Neurosciences, VU University Medical Center, Amsterdam, The Netherlands
    PLoS ONE 10:e0131209. 2015
    ..This study indicates that the dynamics of resting-state connectivity are associated with cognitive status of LTLE patients, rather than stationary connectivity. ..
  25. ncbi request reprint Dynamic statistical parametric mapping for analyzing the magnetoencephalographic epileptiform activity in patients with epilepsy
    Hideaki Shiraishi
    MGH MIT HMS Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital Harvard Medical School, Charlestown, MA, USA
    J Child Neurol 20:363-9. 2005
    ....
  26. pmc A non-invasive method to relate the timing of neural activity to white matter microstructural integrity
    Steven M Stufflebeam
    Department of Radiology at the Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA
    Neuroimage 42:710-6. 2008
    ..This preliminary report demonstrates a non-invasive, unbiased method to relate the timing information from evoked-response experiments to the biophysical properties of white matter measured with DTI...
  27. ncbi request reprint The interactive electrode localization utility: software for automatic sorting and labeling of intracranial subdural electrodes
    Roan A LaPlante
    Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    Int J Comput Assist Radiol Surg . 2016
    ..Existing methods for sorting, labeling, registering, and across-subject localization of electrodes in intracranial encephalography (iEEG) may involve laborious work requiring manual inspection of radiological images...
  28. pmc Functional MRI using regularized parallel imaging acquisition
    Fa Hsuan Lin
    Massachusetts General Hospital, Department of Radiology, MGH HMS MIT, Athinoula A Martinos Center for Biomedical Imaging, Charlestown, Massachusetts 02129, USA
    Magn Reson Med 54:343-53. 2005
    ..Human motor and visual fMRI data acquired at different field strengths and array coils also demonstrate that regularized SENSE improves the detection of functionally active brain regions...
  29. pmc Presurgical Mapping of the Language Network Using Resting-state Functional Connectivity
    Naoaki Tanaka
    Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown Institute for Medical Engineering and Science, Harvard MIT Division of Health Sciences, Technology Massachusetts Institute of Technology, Cambridge, MA
    Top Magn Reson Imaging 25:19-24. 2016
    ..In this article, we review the techniques and presurgical applications of resting-state fMRI analysis for language evaluation, and discuss the use in the clinical setting, focusing on planning for neurosurgery...
  30. pmc The Connectome Visualization Utility: software for visualization of human brain networks
    Roan A LaPlante
    Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, Massachusetts, United States of America
    PLoS ONE 9:e113838. 2014
    ..CVU offers a graphical user interface, interactive scripting, and represents data uses transparent neuroimaging and matrix-based file types rather than opaque application-specific file formats. ..
  31. pmc Mapping cognitive function
    Steven M Stufflebeam
    Harvard Medical School, Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Building 149, 13th Street, Charlestown, MA 02129, USA
    Neuroimaging Clin N Am 17:469-84, viii-ix. 2007
    ..A unifying theme of this article is the concept that a more complete understanding of cognition only comes through integration of multimodal structural and functional imaging technologies...