David E Sosnovik

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. ncbi request reprint Non-invasive imaging of plaque vulnerability: an important tool for the assessment of agents to stabilise atherosclerotic plaques
    David E Sosnovik
    Division of Cardiology, CIMIT Massachusetts General Hospital, Boston, MA 02114, USA
    Expert Opin Investig Drugs 11:693-704. 2002
  2. pmc Fluorescence tomography of rapamycin-induced autophagy and cardioprotection in vivo
    Howard H Chen
    Martinos Center for Biomedical Imaging, Center for Molecular Imaging Research, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Circ Cardiovasc Imaging 6:441-7. 2013
  3. pmc Microstructural impact of ischemia and bone marrow-derived cell therapy revealed with diffusion tensor magnetic resonance imaging tractography of the heart in vivo
    David E Sosnovik
    From Martinos Center for Biomedical Imaging, Department of Radiology D E S, C M, S H, H H C, G D, R W, W J K, V J W, and Cardiovascular Research Center, Cardiology Division D E S, H H C, W J K, Massachusetts General Hospital, Harvard Medical School, Boston, MA Institute for Biomedical Engineering, University and ETH Zurich, Zurich, Switzerland C T S, S K Cardiac Muscle Research Laboratory, Divisions of Cardiology and Genetics, Brigham and Woman s Hospital, Harvard Medical School, Boston, MA S N, J G, R L and Department of Computer Science, Institute of Mathematics and Statistics, University of Sao Paulo, Sao Paulo, Brazil M P J
    Circulation 129:1731-41. 2014
  4. ncbi request reprint Dual channel optical tomographic imaging of leukocyte recruitment and protease activity in the healing myocardial infarct
    Matthias Nahrendorf
    Center for Molecular Imaging Research, Massachusetts General Hospital, Boston, USA
    Circ Res 100:1218-25. 2007
  5. pmc Fiber architecture in remodeled myocardium revealed with a quantitative diffusion CMR tractography framework and histological validation
    Choukri Mekkaoui
    Athinoula A, Martinos Center for Biomedical Imaging, Boston, MA, USA
    J Cardiovasc Magn Reson 14:70. 2012
  6. pmc Classification of coronary atherosclerotic plaques ex vivo with T1, T2, and ultrashort echo time CMR
    Mihály Károlyi
    Cardiac MR PET CT Program, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    JACC Cardiovasc Imaging 6:466-74. 2013
  7. pmc MR-optical imaging of cardiovascular molecular targets
    Matthias Nahrendorf
    Center for Molecular Imaging Research, Massachusetts General Hospital, Boston, MA, USA
    Basic Res Cardiol 103:87-94. 2008
  8. pmc Diffusion spectrum MRI tractography reveals the presence of a complex network of residual myofibers in infarcted myocardium
    David E Sosnovik
    Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Mass, USA
    Circ Cardiovasc Imaging 2:206-12. 2009
  9. pmc Molecular MRI detects low levels of cardiomyocyte apoptosis in a transgenic model of chronic heart failure
    David E Sosnovik
    Center for Molecular Imaging Research, The Cardiology Division, and Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Boston, Masss, USA
    Circ Cardiovasc Imaging 2:468-75. 2009
  10. ncbi request reprint Fluorescence tomography and magnetic resonance imaging of myocardial macrophage infiltration in infarcted myocardium in vivo
    David E Sosnovik
    Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Circulation 115:1384-91. 2007

Detail Information

Publications32

  1. ncbi request reprint Non-invasive imaging of plaque vulnerability: an important tool for the assessment of agents to stabilise atherosclerotic plaques
    David E Sosnovik
    Division of Cardiology, CIMIT Massachusetts General Hospital, Boston, MA 02114, USA
    Expert Opin Investig Drugs 11:693-704. 2002
    ..This knowledge will be extremely important for physicians and scientists involved in the clinical evaluation of novel agents to stabilise the vulnerable plaque...
  2. pmc Fluorescence tomography of rapamycin-induced autophagy and cardioprotection in vivo
    Howard H Chen
    Martinos Center for Biomedical Imaging, Center for Molecular Imaging Research, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Circ Cardiovasc Imaging 6:441-7. 2013
    ..The impact of autophagy in the heart, however, remains unclear in part because of the inability to noninvasively image this process in living animals...
  3. pmc Microstructural impact of ischemia and bone marrow-derived cell therapy revealed with diffusion tensor magnetic resonance imaging tractography of the heart in vivo
    David E Sosnovik
    From Martinos Center for Biomedical Imaging, Department of Radiology D E S, C M, S H, H H C, G D, R W, W J K, V J W, and Cardiovascular Research Center, Cardiology Division D E S, H H C, W J K, Massachusetts General Hospital, Harvard Medical School, Boston, MA Institute for Biomedical Engineering, University and ETH Zurich, Zurich, Switzerland C T S, S K Cardiac Muscle Research Laboratory, Divisions of Cardiology and Genetics, Brigham and Woman s Hospital, Harvard Medical School, Boston, MA S N, J G, R L and Department of Computer Science, Institute of Mathematics and Statistics, University of Sao Paulo, Sao Paulo, Brazil M P J
    Circulation 129:1731-41. 2014
    ..A novel approach to characterize the microstructural response of the myocardium to ischemia and cell therapy, with the use of serial diffusion tensor magnetic resonance imaging tractography of the heart in vivo, is presented...
  4. ncbi request reprint Dual channel optical tomographic imaging of leukocyte recruitment and protease activity in the healing myocardial infarct
    Matthias Nahrendorf
    Center for Molecular Imaging Research, Massachusetts General Hospital, Boston, USA
    Circ Res 100:1218-25. 2007
    ..Spectrally resolved imaging agents allow for simultaneous assesment of key processes of in vivo cellular functions. Specifically, we show that in vivo FMT detects impaired healing in FXIII-/- mice...
  5. pmc Fiber architecture in remodeled myocardium revealed with a quantitative diffusion CMR tractography framework and histological validation
    Choukri Mekkaoui
    Athinoula A, Martinos Center for Biomedical Imaging, Boston, MA, USA
    J Cardiovasc Magn Reson 14:70. 2012
    ..The aim of this study was therefore to develop a technique for quantitative 3D diffusion CMR tractography of the heart, and to apply this method to quantify fiber architecture in the remote zone of remodeled hearts...
  6. pmc Classification of coronary atherosclerotic plaques ex vivo with T1, T2, and ultrashort echo time CMR
    Mihály Károlyi
    Cardiac MR PET CT Program, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    JACC Cardiovasc Imaging 6:466-74. 2013
    ....
  7. pmc MR-optical imaging of cardiovascular molecular targets
    Matthias Nahrendorf
    Center for Molecular Imaging Research, Massachusetts General Hospital, Boston, MA, USA
    Basic Res Cardiol 103:87-94. 2008
    ..We discuss strengths and limitations of respective imaging technologies, and comment on the potential of multi-modality imaging approaches...
  8. pmc Diffusion spectrum MRI tractography reveals the presence of a complex network of residual myofibers in infarcted myocardium
    David E Sosnovik
    Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Mass, USA
    Circ Cardiovasc Imaging 2:206-12. 2009
    ..Unlike diffusion tensor imaging, DSI tractography resolves multiple myofiber populations per voxel, thus generating accurate 3D tractograms, which we present in the myocardium for the first time...
  9. pmc Molecular MRI detects low levels of cardiomyocyte apoptosis in a transgenic model of chronic heart failure
    David E Sosnovik
    Center for Molecular Imaging Research, The Cardiology Division, and Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Boston, Masss, USA
    Circ Cardiovasc Imaging 2:468-75. 2009
    ..The myocardium in heart failure, however, is characterized by very low levels of CM apoptosis and normal vascular permeability, factors thought to preclude the use of molecular MRI...
  10. ncbi request reprint Fluorescence tomography and magnetic resonance imaging of myocardial macrophage infiltration in infarcted myocardium in vivo
    David E Sosnovik
    Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Circulation 115:1384-91. 2007
    ....
  11. pmc Cytoprotective nanoparticles by conjugation of a polyhis tagged annexin V to a nanoparticle drug
    Howard H Chen
    Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Boston, MA 02129, USA
    Nanoscale 7:2255-9. 2015
    ..Annexin-nanoparticles provide an approach to the design of nanomaterials which antagonize the plasma membrane permeability characteristic of necrosis and which may have applications as cytoprotective agents. ..
  12. pmc Diffusion MRI tractography of the developing human fetal heart
    Choukri Mekkaoui
    Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    PLoS ONE 8:e72795. 2013
    ..We aimed here to use diffusion tensor MRI (DTI) tractography to characterize the evolution of fiber architecture in the developing human fetal heart...
  13. pmc High-resolution imaging of murine myocardial infarction with delayed-enhancement cine micro-CT
    Matthias Nahrendorf
    Center for Molecular Imaging Research, Massachusetts General Hospital, Boston, MA, USA
    Am J Physiol Heart Circ Physiol 292:H3172-8. 2007
    ..This efficient imaging tool is a valuable addition to the current phenotyping armamentarium and will allow rapid testing of novel drugs and cell-based interventions in murine models...
  14. ncbi request reprint Value of fat suppression in the MRI evaluation of suspected arrhythmogenic right ventricular dysplasia
    Suhny Abbara
    Department of Radiology, Massachusetts General Hospital, Harvard Medical School, 100 Charles River Plaza, Ste 400, Boston, MA 02114, USA
    AJR Am J Roentgenol 182:587-91. 2004
    ..We investigated the value of fat suppression for enhancing the interpretation of intramyocardial fatty infiltration...
  15. ncbi request reprint Molecular imaging of myocardial infarction
    Farouc A Jaffer
    Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02129, USA
    J Mol Cell Cardiol 41:921-33. 2006
    ....
  16. pmc Functional and anatomical characterization of brown adipose tissue in heart failure with blood oxygen level dependent magnetic resonance
    Marcello Panagia
    Cardiology Section, Boston Medical Center, Boston, MA, USA
    NMR Biomed 29:978-84. 2016
    ..This may have important implications for substrate utilization and overall metabolic homeostasis in heart failure. Copyright © 2016 John Wiley & Sons, Ltd. ..
  17. pmc Molecular MRI of acute necrosis with a novel DNA-binding gadolinium chelate: kinetics of cell death and clearance in infarcted myocardium
    Shuning Huang
    Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Circ Cardiovasc Imaging 4:729-37. 2011
    ..Current techniques to image cell death in the myocardium are largely nonspecific. We report the use of a novel DNA-binding gadolinium chelate (Gd-TO) to specifically detect the exposed DNA in acutely necrotic (ruptured) cells in vivo...
  18. pmc Off-resonance angiography: a new method to depict vessels--phantom and rabbit studies
    Grigorios Korosoglou
    Russell H Morgan Department of Radiology and Radiological Science, Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Radiology 249:501-9. 2008
    ....
  19. pmc From molecules to myofibers: multiscale imaging of the myocardium
    Craig J Goergen
    Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    J Cardiovasc Transl Res 4:493-503. 2011
    ..This multiscale approach has the potential to be of significant value not only in preclinical research but, ultimately, in the clinical arena as well...
  20. ncbi request reprint Measurement of radial artery contrast intensity to assess cardiac microbubble behavior
    David E Sosnovik
    Cardiac Ultrasound Laboratory, Massachusetts Genral Hospital, Harvard Medical School, Boston, 02114, USA
    J Am Soc Echocardiogr 16:1267-73. 2003
    ..We sought to determine whether analysis of the contrast signal from the radial artery is better able to reflect changes in left ventricular (LV) microbubble dynamics than the signal from the LV itself...
  21. doi request reprint Imaging Lymphoid Cell Death In Vivo During Polymicrobial Sepsis
    Lin Zou
    1Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 2Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 3Department of Pathology and Laboratory Medicine, Children s Hospital Los Angeles, Los Angeles, CA
    Crit Care Med 43:2303-12. 2015
    ..An early and noninvasive detection of lymphoid cell death could thus have significant clinical implications. Here, we tested in vivo imaging of lymphoid cell death using a near-infrared annexin V (AV-750)...
  22. ncbi request reprint Feasibility and optimization of aortic valve planimetry with MDCT
    Suhny Abbara
    Department of Radiology, Massachusetts General Hospital, 165 Cambridge St, Ste 400, Boston, MA 02114, USA
    AJR Am J Roentgenol 188:356-60. 2007
    ..The aortic valve can be assessed using MDCT; however, measurements of the aortic opening area vary with the cardiac cycle. In this study, we sought to assess the optimal timing for measuring the area of the aortic opening with MDCT...
  23. ncbi request reprint Magnetic resonance imaging of cardiomyocyte apoptosis with a novel magneto-optical nanoparticle
    David E Sosnovik
    Center for Molecular Imaging Research, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Magn Reson Med 54:718-24. 2005
    ..1 versus 1.1, P<0.01). This study thus demonstrates the feasibility of obtaining high-resolution MR images of cardiomyocyte apoptosis in vivo with the novel nanoparticle, AnxCLIO-Cy5.5...
  24. pmc Molecular imaging in cardiovascular magnetic resonance imaging: current perspective and future potential
    David E Sosnovik
    Department of Cardiology, Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02129, USA
    Top Magn Reson Imaging 19:59-68. 2008
    ..The application of molecular MRI in diseases of the vasculature and myocardium is then reviewed. The clinical experience to date, as well as the promise and potential impact of molecular MRI, is extensively discussed...
  25. ncbi request reprint Noninvasive vascular cell adhesion molecule-1 imaging identifies inflammatory activation of cells in atherosclerosis
    Matthias Nahrendorf
    Center for Molecular Imaging Research, Massachusetts General Hospital, Boston, USA
    Circulation 114:1504-11. 2006
    ....
  26. ncbi request reprint Emerging concepts in molecular MRI
    David E Sosnovik
    Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Curr Opin Biotechnol 18:4-10. 2007
    ..These and other advances in molecular MRI offer great promise for the future and have significant potential for clinical translation...
  27. doi request reprint Transglutaminase activity in acute infarcts predicts healing outcome and left ventricular remodelling: implications for FXIII therapy and antithrombin use in myocardial infarction
    Matthias Nahrendorf
    Center for Molecular Imaging Research, Massachusetts General Hospital and Harvard Medical School, Building 149, 13th Street, Room 5406, Charlestown, MA 02129, USA
    Eur Heart J 29:445-54. 2008
    ..Here we assess the impact of transglutaminase-modulating therapies on healing and evolution of heart failure using a novel, non-invasive molecular imaging technique...
  28. pmc Impact of field strength and iron oxide nanoparticle concentration on the linearity and diagnostic accuracy of off-resonance imaging
    Christian T Farrar
    Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    NMR Biomed 21:453-63. 2008
    ..The optimal performance of ORI will thus likely be seen at low fields, with moderate MION concentrations and with sequences containing very short TEs...
  29. ncbi request reprint Cardiac MRI in mice at 9.4 Tesla with a transmit-receive surface coil and a cardiac-tailored intensity-correction algorithm
    David E Sosnovik
    Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
    J Magn Reson Imaging 26:279-87. 2007
    ..To evaluate the use of a transmit-receive surface (TRS) coil and a cardiac-tailored intensity-correction algorithm for cardiac MRI in mice at 9.4 Tesla (9.4T)...
  30. ncbi request reprint Effects of region-of-interest length on estimates of myocardial ultrasonic attenuation and backscatter
    Steven L Baldwin
    Washington University, St Louis, Missouri 63130, USA
    Med Phys 32:418-26. 2005
    ..Statistically significant differences were observed for measurements utilizing the ROI lengths as short as 0.4 cm with corresponding progressively increasing areas under the ROC curves for increasing ROI lengths. [NIH R37 HL40302]..
  31. pmc Noninvasive detection of macrophage-rich atherosclerotic plaque in hyperlipidemic rabbits using "positive contrast" magnetic resonance imaging
    Grigorios Korosoglou
    Department of Cardiology, University of Heidelberg, Heidelberg, Germany
    J Am Coll Cardiol 52:483-91. 2008
    ....
  32. pmc A 128-channel receive-only cardiac coil for highly accelerated cardiac MRI at 3 Tesla
    Melanie Schmitt
    Department of Radiology, A A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
    Magn Reson Med 59:1431-9. 2008
    ..The ability of the 128-channel coil to facilitate highly accelerated cardiac imaging was demonstrated in four volunteers using acceleration factors up to seven-fold (R=7) in a single spatial dimension...