Scott B Snapper

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. ncbi request reprint WASP deficiency leads to global defects of directed leukocyte migration in vitro and in vivo
    Scott B Snapper
    Gastrointestinal Unit and the Center for Inflammatory Bowel Diseases, Massachusetts General Hospital, Boston, 02114, USA
    J Leukoc Biol 77:993-8. 2005
  2. pmc Lymphocyte-dependent and Th2 cytokine-associated colitis in mice deficient in Wiskott-Aldrich syndrome protein
    Deanna D Nguyen
    Gastrointestinal Unit, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Gastroenterology 133:1188-97. 2007
  3. pmc Wiskott Aldrich syndrome protein (WASP) and N-WASP are critical for T cell development
    Vinicius Cotta-de-Almeida
    Gastrointestinal Unit, Massachusetts General Hospital, Boston, MA 02114, USA
    Proc Natl Acad Sci U S A 104:15424-9. 2007
  4. pmc Wiskott-Aldrich syndrome protein deficiency in innate immune cells leads to mucosal immune dysregulation and colitis in mice
    Deanna D Nguyen
    Gastrointestinal Unit and Center for Study of Inflammatory Bowel Disease, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Gastroenterology 143:719-29.e1-2. 2012
  5. pmc Activating WASP mutations associated with X-linked neutropenia result in enhanced actin polymerization, altered cytoskeletal responses, and genomic instability in lymphocytes
    Lisa S Westerberg
    Gastrointestinal Unit, Center for the Study of Inflammatory Bowel Diseases, Massachusetts General Hospital, and Harvard Medical School, Boston, MA 02114, USA
    J Exp Med 207:1145-52. 2010
  6. pmc Wiskott-Aldrich syndrome protein (WASP) and N-WASP are critical for peripheral B-cell development and function
    Lisa S Westerberg
    Gastrointestinal Unit, Massachusetts General Hospital, Boston, MA 02115, USA
    Blood 119:3966-74. 2012
  7. pmc Toll-like receptor 4-mediated regulation of spontaneous Helicobacter-dependent colitis in IL-10-deficient mice
    Kabir S Matharu
    Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital, Boston, Massachusetts, USA
    Gastroenterology 137:1380-90.e1-3. 2009
  8. pmc Colitis and colon cancer in WASP-deficient mice require helicobacter species
    Deanna D Nguyen
    Gastrointestinal Unit and the Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital, Boston, MA 02139, USA
    Inflamm Bowel Dis 19:2041-50. 2013
  9. pmc Enteropathogenic Escherichia coli and vaccinia virus do not require the family of WASP-interacting proteins for pathogen-induced actin assembly
    John J Garber
    Gastrointestinal Unit and Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital, Boston, Massachusetts, USA
    Infect Immun 80:4071-7. 2012
  10. ncbi request reprint The NF2 tumor suppressor Merlin and the ERM proteins interact with N-WASP and regulate its actin polymerization function
    Nitasha Manchanda
    Molecular Neurogenetics Unit, Center for Human Genetic Research, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
    J Biol Chem 280:12517-22. 2005

Detail Information

Publications41

  1. ncbi request reprint WASP deficiency leads to global defects of directed leukocyte migration in vitro and in vivo
    Scott B Snapper
    Gastrointestinal Unit and the Center for Inflammatory Bowel Diseases, Massachusetts General Hospital, Boston, 02114, USA
    J Leukoc Biol 77:993-8. 2005
    ..These results further delineate immunological abnormalities in WASP-deficient mice, which will be useful to assess preclinical gene therapy studies...
  2. pmc Lymphocyte-dependent and Th2 cytokine-associated colitis in mice deficient in Wiskott-Aldrich syndrome protein
    Deanna D Nguyen
    Gastrointestinal Unit, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Gastroenterology 133:1188-97. 2007
    ..Wiskott-Aldrich syndrome protein (WASP) deficiency in mice results in similar clinical features. Herein, we characterized the colitis in WASP-deficient mice...
  3. pmc Wiskott Aldrich syndrome protein (WASP) and N-WASP are critical for T cell development
    Vinicius Cotta-de-Almeida
    Gastrointestinal Unit, Massachusetts General Hospital, Boston, MA 02114, USA
    Proc Natl Acad Sci U S A 104:15424-9. 2007
    ..In summary, this study suggests that, although WASP serves a unique role for peripheral T cell function, T cell development depends on the combined activity of WASP and N-WASP...
  4. pmc Wiskott-Aldrich syndrome protein deficiency in innate immune cells leads to mucosal immune dysregulation and colitis in mice
    Deanna D Nguyen
    Gastrointestinal Unit and Center for Study of Inflammatory Bowel Disease, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Gastroenterology 143:719-29.e1-2. 2012
    ..We investigated the interactions between innate and adaptive immune cells in mucosal regulation during development of T cell-mediated colitis in mice with WASP-deficient cells of the innate immune system...
  5. pmc Activating WASP mutations associated with X-linked neutropenia result in enhanced actin polymerization, altered cytoskeletal responses, and genomic instability in lymphocytes
    Lisa S Westerberg
    Gastrointestinal Unit, Center for the Study of Inflammatory Bowel Diseases, Massachusetts General Hospital, and Harvard Medical School, Boston, MA 02114, USA
    J Exp Med 207:1145-52. 2010
    ..These data indicate that there are unique requirements for the presence and activation status of WASP in B and T cells and that WASP-activating mutations interfere with lymphocyte cell survival and genomic stability...
  6. pmc Wiskott-Aldrich syndrome protein (WASP) and N-WASP are critical for peripheral B-cell development and function
    Lisa S Westerberg
    Gastrointestinal Unit, Massachusetts General Hospital, Boston, MA 02115, USA
    Blood 119:3966-74. 2012
    ..Our results reveal that the combined activity of WASP and N-WASP is required for peripheral B-cell development and function...
  7. pmc Toll-like receptor 4-mediated regulation of spontaneous Helicobacter-dependent colitis in IL-10-deficient mice
    Kabir S Matharu
    Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital, Boston, Massachusetts, USA
    Gastroenterology 137:1380-90.e1-3. 2009
    ..We investigated the role of the anti-inflammatory cytokine interleukin (IL)-10 in this signaling pathway using a mouse model of colitis...
  8. pmc Colitis and colon cancer in WASP-deficient mice require helicobacter species
    Deanna D Nguyen
    Gastrointestinal Unit and the Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital, Boston, MA 02139, USA
    Inflamm Bowel Dis 19:2041-50. 2013
    ..have been implicated in disease pathogenesis. We sought to determine the role of Helicobacter spp. in colitis development in Wiskott-Aldrich syndrome protein-deficient (WKO) mice...
  9. pmc Enteropathogenic Escherichia coli and vaccinia virus do not require the family of WASP-interacting proteins for pathogen-induced actin assembly
    John J Garber
    Gastrointestinal Unit and Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital, Boston, Massachusetts, USA
    Infect Immun 80:4071-7. 2012
    ..Overall, these data highlight similar pathogenic strategies shared by EPEC and vaccinia virus by demonstrating a requirement for both Nck and N-WASP, but not WIP or WIP family members in pathogen-induced actin assembly...
  10. ncbi request reprint The NF2 tumor suppressor Merlin and the ERM proteins interact with N-WASP and regulate its actin polymerization function
    Nitasha Manchanda
    Molecular Neurogenetics Unit, Center for Human Genetic Research, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
    J Biol Chem 280:12517-22. 2005
    ..This novel function of merlin and the ERMs illustrates a mechanism by which these proteins directly exert their effects on actin reorganization and also provides new insight into N-WASP regulation...
  11. pmc Interleukin-10 receptor signaling in innate immune cells regulates mucosal immune tolerance and anti-inflammatory macrophage function
    Dror S Shouval
    Division of Gastroenterology, Hepatology and Nutrition, Boston Children s Hospital, Boston, MA 02115, USA Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA interNational Early Onset Paediatric IBD Cohort Study NEOPICS
    Immunity 40:706-19. 2014
    ..Collectively, our studies define innate immune IL-10R signaling as a key factor regulating mucosal immune homeostasis in mice and humans...
  12. pmc The Wiskott-Aldrich syndrome protein is required for the function of CD4(+)CD25(+)Foxp3(+) regulatory T cells
    Michel H Maillard
    Gastrointestinal Unit, Massachusetts General Hospital, Boston, MA 02114, USA
    J Exp Med 204:381-91. 2007
    ..Overall, our data reveal a critical role for WASP in nTreg cell function and implicate nTreg cell dysfunction in the autoimmunity associated with WASP deficiency...
  13. pmc Targeted deletion of integrin-linked kinase reveals a role in T-cell chemotaxis and survival
    Emerson Liu
    Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Charlestown, 02129, USA
    Mol Cell Biol 25:11145-55. 2005
    ..These data extend the role of ILK to immune-cell trafficking and survival via modulation of Akt- and Rac-dependent substrates, and have implications for cell recruitment in both homeostatic and pathological processes...
  14. pmc Interleukin 10 receptor signaling: master regulator of intestinal mucosal homeostasis in mice and humans
    Dror S Shouval
    Division of Gastroenterology, Hepatology and Nutrition, Boston Children s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Adv Immunol 122:177-210. 2014
    ..In addition, we discuss the impact of IL10 and IL10R signaling defects in humans and their relationship to very early-onset IBD (VEO-IBD). ..
  15. pmc MyD88-dependent TLR1/2 signals educate dendritic cells with gut-specific imprinting properties
    Sen Wang
    Gastrointestinal Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    J Immunol 187:141-50. 2011
    ..Thus, MyD88-dependent TLR2 signals are necessary and sufficient to educate DC with gut-specific imprinting properties and contribute in vivo to the generation of gut-tropic T cells...
  16. pmc WASP confers selective advantage for specific hematopoietic cell populations and serves a unique role in marginal zone B-cell homeostasis and function
    Lisa S Westerberg
    Gastrointestinal Unit and the Center for the Study of Inflammatory Bowel Diseases, Massachusetts General Hospital, Boston, USA
    Blood 112:4139-47. 2008
    ..Our findings reveal that WASP regulates both development and function of hematopoietic cells. We demonstrate that WASP deficiency leads to an aberrant MZ that may affect responses to blood-borne pathogens and peripheral B-cell tolerance...
  17. pmc Neural Wiskott-Aldrich syndrome protein modulates Wnt signaling and is required for hair follicle cycling in mice
    Anna Lyubimova
    Gastrointestinal Unit and Center for Inflammatory Bowel Disease, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Clin Invest 120:446-56. 2010
    ..We therefore propose that N-WASP acts as a positive regulator of beta-catenin-dependent transcription, modulating differentiation of HF progenitor cells...
  18. ncbi request reprint Impaired signaling via the high-affinity IgE receptor in Wiskott-Aldrich syndrome protein-deficient mast cells
    Vadim I Pivniouk
    Division of Immunology, Children s Hospital, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02115, USA
    Int Immunol 15:1431-40. 2003
    ..We conclude that WASP regulates FcepsilonRI-mediated granule exocytosis, cytokine production and cytoskeletal changes in mast cells...
  19. ncbi request reprint Cortactin regulates cell migration through activation of N-WASP
    Jennifer R Kowalski
    Biological and Biomedical Sciences Program, Harvard Medical School, Boston, MA 02215, USA
    J Cell Sci 118:79-87. 2005
    ..Thus, our results suggest that cortactin has multiple mechanisms by which it can recruit and modulate the actin machinery and ultimately regulate cell migration...
  20. pmc Gut-tropic T cells that express integrin α4β7 and CCR9 are required for induction of oral immune tolerance in mice
    Barbara Cassani
    Gastrointestinal Unit, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Gastroenterology 141:2109-18. 2011
    ..We investigated whether gut-tropic T cells that express the integrin α4β7 and the chemokine receptor CCR9 are required for OT...
  21. pmc WAVE2 deficiency reveals distinct roles in embryogenesis and Rac-mediated actin-based motility
    Catherine Yan
    Center for Blood Research, 200 Longwood Avenue, Boston, MA 02115, USA
    EMBO J 22:3602-12. 2003
    ..These results imply a non-redundant role for WAVE2 in murine embryogenesis and a critical role for WAVE2 in actin-based processes downstream of Rac that are essential for cell movement...
  22. pmc AHR Activation Is Protective against Colitis Driven by T Cells in Humanized Mice
    Jeremy A Goettel
    Division of Gastroenterology, Hepatology and Nutrition, Boston Children s Hospital, Boston, MA 02115, USA Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA
    Cell Rep 17:1318-1329. 2016
    ..These results develop an experimental model to investigate human CD4+ T responses in vivo and identify the non-toxic AHR agonist ITE as a potential therapy for promoting immune tolerance in the intestine...
  23. pmc Interleukin 1β Mediates Intestinal Inflammation in Mice and Patients With Interleukin 10 Receptor Deficiency
    Dror S Shouval
    Division of Gastroenterology, Hepatology and Nutrition, Boston Children s Hospital, Boston, Massachusetts Harvard Medical School, Boston, Massachusetts Division of Pediatric Gastroenterology and Nutrition, Edmond and Lily Safra Children s Hospital, Sheba Medical Center, Tel Hashomer, Israel Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    Gastroenterology 151:1100-1104. 2016
    ..Agents that block IL1 signaling might be used to treat patients with inflammatory bowel disease resulting from IL10R deficiency...
  24. ncbi request reprint Gene therapy for Wiskott-Aldrich syndrome: rescue of T-cell signaling and amelioration of colitis upon transplantation of retrovirally transduced hematopoietic stem cells in mice
    Christoph Klein
    Division of Molecular Medicine and Pediatric Hematology Oncology, Howard Hughes Medical Institute, The Children s Hospital, Boston, MA, USA
    Blood 101:2159-66. 2003
    ..Our results provide proof of principle that the WAS-associated T-cell signaling defects can be improved upon transplantation of retrovirally transduced HSCs without overt toxicity and may encourage clinical gene therapy trials...
  25. pmc Intestinal alkaline phosphatase has beneficial effects in mouse models of chronic colitis
    Sundaram Ramasamy
    Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Inflamm Bowel Dis 17:532-42. 2011
    ....
  26. pmc Breakdown of T cell tolerance and autoimmunity in primary immunodeficiency--lessons learned from monogenic disorders in mice and men
    Lisa S Westerberg
    Gastrointestinal Unit and the Center for the Study of Inflammatory Bowel Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Curr Opin Immunol 20:646-54. 2008
    ..Finally, findings from PID have broadened our understanding of how homeostatic proliferation and increased load or decreased clearance of apoptotic cells and non-self pathogens can lead to breakdown of peripheral tolerance...
  27. ncbi request reprint Shigella interactions with the actin cytoskeleton in the absence of Ena/VASP family proteins
    Shabeen Ally
    Infectious Disease Division, Massachusetts General Hospital, Cambridge, MA 02139, USA
    Cell Microbiol 6:355-66. 2004
    ..Thus, although VASP is recruited to the surface of intracellular Shigella, it is not essential for Shigella actin-based motility...
  28. doi request reprint Very early-onset inflammatory bowel disease: gaining insight through focused discovery
    Christopher J Moran
    Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, MassGeneral Hospital for Children, Boston, Massachusetts Department of Pediatrics, Harvard Medical School, Boston, Massachusetts Dr von Hauner Children s Hospital, Ludwig Maximilians University, Munich, Germany Division of Gastroenterology, Hepatology, and Nutrition, Department of Paediatrics, University of Toronto, Hospital for Sick Children, Toronto, ON, Canada SickKids Inflammatory Bowel Disease Center and Cell Biology Program, Research Institute, Hospital for Sick Children, Toronto, ON, Canada Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Department of Medicine, Children s Hospital Boston, Boston, Massachusetts Division of Gastroenterology and Hepatology, Brigham and Women s Hospital, Boston, Massachusetts and Department of Medicine, Harvard Medical School, Boston, Massachusetts
    Inflamm Bowel Dis 21:1166-75. 2015
    ..This review describes what is known about the genetic causes of very early-onset IBD and genetic strategies that may unravel more of the genetic causes of IBD. ..
  29. ncbi request reprint A family of WASPs
    Scott B Snapper
    Massachusetts General Hospital, Boston, MA 02114, USA
    N Engl J Med 348:350-1. 2003
  30. pmc IL-10R polymorphisms are associated with very-early-onset ulcerative colitis
    Christopher J Moran
    Division of Pediatric Gastroenterology, Department of Pediatrics, MassGeneral Hospital for Children, Boston, Massachusetts, USA
    Inflamm Bowel Dis 19:115-23. 2013
    ..Our objective was to determine if IL-10R polymorphisms were associated with early-onset IBD (EO-IBD) and very-early-onset IBD (VEO-IBD)...
  31. pmc Activating mutations of N-WASP alter Shigella pathogenesis
    David A Adamovich
    Gastrointestinal Unit, Massachusetts General Hospital, Boston, MA 02114, USA
    Biochem Biophys Res Commun 384:284-9. 2009
    ..However, plaque numbers were increased in cells expressing N-WASP L229P and L232P. These data demonstrate that N-WASP structural conformation is an important regulator of Shigella pathogenesis in distinct segments of its lifecycle...
  32. pmc Fatal autoimmunity in mice reconstituted with human hematopoietic stem cells encoding defective FOXP3
    Jeremy A Goettel
    Department of Pediatrics, Division of Gastroenterology, Hepatology and Nutrition, Boston Children s Hospital, Boston, MA Department of Medicine, Harvard Medical School, Boston, MA
    Blood 125:3886-95. 2015
    ....
  33. pmc Dysfunction of the intestinal microbiome in inflammatory bowel disease and treatment
    Xochitl C Morgan
    Department of Biostatistics, Harvard School of Public Health, Boston, MA 02115, USA
    Genome Biol 13:R79. 2012
    ..Gene and pathway composition were assessed, based on 16S data from phylogenetically-related reference genomes, and associated using sparse multivariate linear modeling with medications, environmental factors, and IBD status...
  34. pmc A new method for rapidly generating gene-targeting vectors by engineering BACs through homologous recombination in bacteria
    Vinicius Cotta-de-Almeida
    Gastrointestinal Unit and the Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Genome Res 13:2190-4. 2003
    ..This procedure avoids the need to construct or screen genomic libraries and permits the generation of most standard, conditional, or knock-in targeting vectors, often within two weeks...
  35. ncbi request reprint Regulatory T cells in inflammatory bowel disease
    Elisa K Boden
    Gastrointestinal Unit and the Center for the Study of Inflammatory Bowel Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Curr Opin Gastroenterol 24:733-41. 2008
    ..This review explores recent data that elucidate the role of regulatory T cells (Tregs) in the pathogenesis of IBD in mice and humans...
  36. ncbi request reprint Induced reactivity of intestinal CD4(+) T cells with an epithelial cell lectin, galectin-4, contributes to exacerbation of intestinal inflammation
    Akira Hokama
    Department of Pathology, Massachussets General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Immunity 20:681-93. 2004
    ..These studies identify the presence of an immunogenic, endogenous lectin in the intestine and dissect the biological role of lectin/CD4(+) T cell interactions under inflammatory conditions...
  37. pmc CellMapper: rapid and accurate inference of gene expression in difficult-to-isolate cell types
    Bradlee D Nelms
    Division of Gastroenterology, Children s Hospital and Harvard Medical School, Boston, MA, 02115, USA
    Genome Biol 17:201. 2016
    ..We demonstrate a clinically relevant application to prioritize candidate genes in disease susceptibility loci identified by GWAS...
  38. pmc Update on biologic pathways in inflammatory bowel disease and their therapeutic relevance
    Matthew J Hamilton
    Division of Gastroenterology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    J Gastroenterol 47:1-8. 2012
    ..In this review, the exciting recent advances in these biologic pathways of IBD are discussed, particularly in light of their therapeutic relevance...
  39. pmc Innate immune response to encephalomyocarditis virus infection mediated by CD1d
    Mark A Exley
    Cancer Biology Program, Hematology Oncology Division, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    Immunology 110:519-26. 2003
    ..We propose that CD1d-reactive T cells respond to early immune signals and function in the innate immune response to a physiological viral infection by rapidly augmenting APC IL-12 production and activating NK cells...
  40. ncbi request reprint A defect in hematopoietic stem cell migration explains the nonrandom X-chromosome inactivation in carriers of Wiskott-Aldrich syndrome
    Catherine Lacout
    U362 Institut National de la Santé et de la Recherche Médicale INSERM, Institut Gustave Roussy, Villejuif, France
    Blood 102:1282-9. 2003
    ..Therefore, the mechanism of the skewed X-chromosomal inactivation observed in WAS carriers may be related to a migration defect of WASP-deficient HSCs...
  41. ncbi request reprint A crucial role for macrophages in the pathology of K/B x N serum-induced arthritis
    Samuel Solomon
    Immunology, Department of Biology, Faculty of Sciences, University of Konstanz, Konstanz, Germany
    Eur J Immunol 35:3064-73. 2005
    ....