Jan L Shifren
Affiliation: Massachusetts General Hospital
- Testosterone patch for the treatment of hypoactive sexual desire disorder in naturally menopausal women: results from the INTIMATE NM1 StudyJan L Shifren
Department of Obstetrics and Gynecology, Massachusetts General Hospital, Boston, MA 02114, USA
Menopause 13:770-9. 2006..To evaluate the efficacy and safety of a testosterone patch for the treatment of women with hypoactive sexual desire disorder after natural menopause...
- Surgical menopause: effects on psychological well-being and sexualityJan L Shifren
Vincent OB GYN Service, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
Menopause 14:586-91. 2007..Women anticipating surgical menopause often have significant concerns regarding the effects of surgery on psychological well-being and sexuality...
- A randomized, open-label, crossover study comparing the effects of oral versus transdermal estrogen therapy on serum androgens, thyroid hormones, and adrenal hormones in naturally menopausal womenJan L Shifren
Vincent Obstetrics and Gynecology Service, Massachusetts General Hospital, Boston, MA 02114, USA
Menopause 14:985-94. 2007....
- A comparison of the short-term effects of oral conjugated equine estrogens versus transdermal estradiol on C-reactive protein, other serum markers of inflammation, and other hepatic proteins in naturally menopausal womenJan L Shifren
Section of Endocrinology, Diabetes and Nutrition, Boston University School of Medicine, 670 Albany Street, Boston, MA 02118, USA
J Clin Endocrinol Metab 93:1702-10. 2008....
- Sexual problems and distress in United States women: prevalence and correlatesJan L Shifren
Massachusetts General Hospital, Boston, Massachusetts 02114, USA
Obstet Gynecol 112:970-8. 2008..To estimate the prevalence of self-reported sexual problems (any, desire, arousal, and orgasm), the prevalence of problems accompanied by personal distress, and to describe related correlates...
- Help-seeking behavior of women with self-reported distressing sexual problemsJan L Shifren
Massachusetts General Hospital, Boston, Massachusetts 02114, USA
J Womens Health (Larchmt) 18:461-8. 2009..The objective was to describe the healthcare and information-seeking behavior of women with self-reported sexual problems and accompanying sexually related personal distress identified from a large, population-based U.S. survey...
- Role of hormone therapy in the management of menopauseJan L Shifren
Department of Obstetrics, Gynecology and Reproductive Biology, Harvard Medical School, and Vincent Obstetrics and Gynecology Service, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
Obstet Gynecol 115:839-55. 2010..Women must be informed of the potential benefits and risks of all therapeutic options, and care should be individualized, based on a woman's medical history, needs, and preferences...
- Short-term use of estradiol for depression in perimenopausal and postmenopausal women: a preliminary reportLee S Cohen
Perinatal and Reproductive Psychiatry Clinical Research Program and Vicent Memorail Obstetrics and Gynecology Service, Massachusetts General Hospital, Boston, MA 02114, USA
Am J Psychiatry 160:1519-22. 2003..The authors examined the effect of a 4-week course of estrogen therapy on depression in perimenopausal and postmenopausal women...
- The role of androgens in female sexual dysfunctionJan L Shifren
Menopause Program, Vincent Memorial Obstetrics and Gynecology Service, Massachusetts General Hospital and Harvard Medical School, Boston, Mass 02114, USA
Mayo Clin Proc 79:S19-24. 2004..Possible risks include hirsutism, acne, liver dysfunction, lowering of the voice, adverse lipid changes, virilization of a female fetus, and, as androgens are aromatized to estrogens, potentially the risks of estrogen therapy...
- Sexual function in nondepressed women using escitalopram for vasomotor symptoms: a randomized controlled trialSusan D Reed
Department of Obstetrics and Gynecology, University of Washington School of Medicine, Seattle, Washington 98104, USA
Obstet Gynecol 119:527-38. 2012..Information on sexual function in nondepressed midlife women using selective serotonin reuptake inhibitors for vasomotor symptoms is lacking; any treatments that might impair function are of concern...
- Sexual function in women on estradiol or venlafaxine for hot flushes: a randomized controlled trialSusan D Reed
Departments of Obstetrics and Gynecology and Epidemiology, University of Washington School of Medicine, The Group Health Research Institute, and the Data Coordinating Center, Fred Hutchinson Cancer Research Center, Seattle, Washington the Departments of Psychiatry and Medicine, Brigham and Women s Hospital, the Departments of Psychiatry and Obstetrics and Gynecology, Massachusetts General Hospital, and Harvard Medical School, Boston, Massachusetts and the Departments of Obstetrics and Gynecology and Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania
Obstet Gynecol 124:233-41. 2014..To evaluate sexual function in midlife women taking low-dose oral estradiol or venlafaxine for hot flushes...
- Efficacy of citalopram as a monotherapy or as an adjunctive treatment to estrogen therapy for perimenopausal and postmenopausal women with depression and vasomotor symptomsClaudio N Soares
Perinatal and Reproductive Psychiatry Clinical Research Program, Massachusetts General Hospital and the Department of Psychiatry, Harvard Medical School, Boston, 02114, USA
J Clin Psychiatry 64:473-9. 2003..It is still unclear whether the use of antidepressants alone may alleviate menopause-related mood and vasomotor symptoms or enhance the response observed with short-term use of estrogen therapy...
- Androgen deficiency in the oophorectomized womanJan L Shifren
Massachusetts General Hospital, Vincent Obstetrics and Gynecology Service, Boston, Massachusetts 02114, USA
Fertil Steril 77:S60-2. 2002..Studies of both the consequences of oophorectomy and the effects of testosterone replacement are consistent with an important role for androgens in female sexual function and psychological well-being...
- Self-reported sleep in postmenopausal womenQuentin R Regestein
Brigham and Women s Hospital and Massachusetts General Hospital, Boston, MA, USA
Menopause 11:198-207. 2004..A secondary aim was to find if self-reported sleep showed expected correlations with hyperarousal (Hyperarousal Scale)...
- Absence of polycystic ovary syndrome features in human immunodeficiency virus-infected women despite significant hyperinsulinemia and truncal adiposityStine Johnsen
Program in Nutritional Metabolism, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
J Clin Endocrinol Metab 90:5596-604. 2005..It is unknown whether insulin resistance and truncal adiposity are associated with features of the polycystic ovary syndrome in this population...
- Is testosterone or estradiol the hormone of desire? A novel study of the effects of testosterone treatment and aromatase inhibition in postmenopausal womenJan L Shifren
Menopause 13:8-9. 2006
- Safety and efficacy of a testosterone patch for the treatment of hypoactive sexual desire disorder in surgically menopausal women: a randomized, placebo-controlled trialGlenn D Braunstein
Department of Medicine, Cedars Sinai Medical Center, Los Angeles, Calif, 90048, USA
Arch Intern Med 165:1582-9. 2005..Oophorectomy reduces serum testosterone levels. We studied the efficacy and safety of transdermal testosterone in treating hypoactive sexual desire disorder in surgically menopausal women...
- Influence of raloxifene on the efficacy of an estradiol-releasing ring for treating vaginal atrophy in postmenopausal womenJoann V Pinkerton
University of Virginia Health System, Charlottesville, VA, USA
Menopause 10:45-52. 2003..To determine the potential interaction of oral raloxifene 60 mg/day on the efficacy of a low-dose, estradiol-releasing vaginal ring used to treat signs and symptoms of vaginal atrophy in postmenopausal women...
- Transdermal testosterone for women: a new physiological approach for androgen therapyNorman A Mazer
Department of Medical Affairs, Watson Laboratories, Inc, 417 Wakara Way, Suite 100, Salt Lake City, UT 84108, USA
Obstet Gynecol Surv 58:489-500. 2003..Although still in development, transdermal testosterone therapy appears to be a promising new approach for providing physiologically based androgen therapy to women...
- Is there a role for testosterone therapy in premenopausal women?Jan L Shifren
Menopause 10:383-4. 2003
- Safety profile of transdermal testosterone therapy in womenJan L Shifren
Am J Obstet Gynecol 189:898-9; author reply 899. 2003
- Experts offer advice on testosterone testing and whether to discontinue hormone therapy before surgeryLeon Speroff
Oregon Health and Science University, Portland, USA
Geriatrics 63:2 p following 31. 2008
- Endocrine aspects of female sexual dysfunctionSusan R Davis
NHMRC Centre of Clinical Research Excellence, The Jean Hailes Foundation and Monash University, Clayton, Vic, Australia
J Sex Med 1:82-6. 2004..Various endogenous hormones, including estrogen, testosterone, progesterone and prolactin, may influence female sexual function...