EDWARD MARK SCOLNICK
Affiliation: Massachusetts Institute of Technology
- Schizophrenia: do the genetics and neurobiology of neuregulin provide a pathogenesis model?Edward M Scolnick
Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge 02139, USA
Harv Rev Psychiatry 14:64-77. 2006..The model outlines experimental approaches that may, in the future, shed more light on its validity...
- Program to improve cognitive functioning in patients with schizophrenia: reflectionsEdward Scolnick
Psychiatric Disease Initiative, Broad Institute, USA
Schizophr Res 72:75-7. 2004..Significant credit is due Dr. Steven Hyman and his colleagues for stimulating this bold initiative. Many problems remain to be solved to accomplish the goal. This article articulates a few such problems...
- Mechanisms of action of medicines for schizophrenia and bipolar illness: status and limitationsEdward M Scolnick
Psychiatric Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02139, USA
Biol Psychiatry 59:1039-45. 2006..An approach to identifying risk genes based upon association studies starting with very large sample sizes based upon currently available diagnoses of bipolar disorder and schizophrenia is advocated...
- Identifying relationships among genomic disease regions: predicting genes at pathogenic SNP associations and rare deletionsSoumya Raychaudhuri
Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America
PLoS Genet 5:e1000534. 2009..An online version of this method is available for public use (http://www.broad.mit.edu/mpg/grail/)...
- Analysis of high-resolution HapMap of DTNBP1 (Dysbindin) suggests no consistency between reported common variant associations and schizophreniaMousumi Mutsuddi
Psychiatric Disease Initiative, Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA, USA
Am J Hum Genet 79:903-9. 2006..Evidence of association is, at present, equivocal and unsatisfactory. The new dense map of the region may be valuable in more-comprehensive follow-up studies...