Affiliation: Massachusetts Institute of Technology
- A general SNP-based molecular barcode for Plasmodium falciparum identification and trackingRachel Daniels
Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA
Malar J 7:223. 2008....
- Genome-wide SNP genotyping highlights the role of natural selection in Plasmodium falciparum population divergenceDaniel E Neafsey
Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, MA 02142, USA
Genome Biol 9:R171. 2008..To that end, we have developed a high throughput single nucleotide polymorphism (SNP) genotyping platform for P. falciparum...
- Genome-wide detection and characterization of positive selection in human populationsPardis C Sabeti
Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02139, USA
Nature 449:913-8. 2007....
- The case for selection at CCR5-Delta32Pardis C Sabeti
Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America
PLoS Biol 3:e378. 2005..More broadly, the results have general implications for the design of future studies to detect the signs of positive selection in the human genome...
- Searching for signals of evolutionary selection in 168 genes related to immune functionEmily C Walsh
Novartis Institutes for BioMedical Research, 250 Mass Ave, Cambridge, MA 02139, USA
Hum Genet 119:92-102. 2006....
- Genome-wide comparison of African-ancestry populations from CARe and other cohorts reveals signals of natural selectionGaurav Bhatia
Harvard Massachusetts Institute of Technology MIT Division of Health, Science and Technology, Cambridge, USA
Am J Hum Genet 89:368-81. 2011..The most significantly differentiated marker in our analysis, rs2920283, is highly differentiated in both Africa and East Asia and has prior genome-wide significant associations to bladder and gastric cancers...
- Transforming Clinical Data into Actionable Prognosis Models: Machine-Learning Framework and Field-Deployable App to Predict Outcome of Ebola PatientsAndres Colubri
Center for Systems Biology, Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, Massachusetts, United States of America
PLoS Negl Trop Dis 10:e0004549. 2016..The pipeline was trained on a public EVD clinical dataset, from 106 patients in Sierra Leone...
- A second generation human haplotype map of over 3.1 million SNPsKelly A Frazer
The Scripps Research Institute, 10550 North Torrey Pines Road MEM275, La Jolla, California 92037, USA
Nature 449:851-61. 2007..Finally, we demonstrate increased differentiation at non-synonymous, compared to synonymous, SNPs, resulting from systematic differences in the strength or efficacy of natural selection between populations...
- Signatures of strong population differentiation shape extended haplotypes across the human CD28, CTLA4, and ICOS costimulatory genesVincent Butty
Section on Immunology and Immunogenetics, Joslin Diabetes Center, MA 02215, USA
Proc Natl Acad Sci U S A 104:570-5. 2007....
- A malaria fingerprint in the human genome?Johanna P Daily
N Engl J Med 358:1855-6. 2008
- Pardis Sabeti profile. Picking up evolution's beatMichael Balter
Science 320:442-3. 2008
- Spread of an inactive form of caspase-12 in humans is due to recent positive selectionYali Xue
The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambs CB10 1SA, United Kingdom
Am J Hum Genet 78:659-70. 2006..We further propose that its selective advantage was sepsis resistance in populations that experienced more infectious diseases as population sizes and densities increased...
- Is G6PD A- deficiency associated with recurrent stillbirths in The Gambia?Giorgio Sirugo
Am J Med Genet A 128:104-5. 2004