Joshua L Roffman

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. ncbi Neuroimaging and the functional neuroanatomy of psychotherapy
    Joshua L Roffman
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Psychol Med 35:1385-98. 2005
  2. ncbi Effects of the methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism on executive function in schizophrenia
    Joshua L Roffman
    Schizophrenia Research Program, Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, USA
    Schizophr Res 92:181-8. 2007
  3. pmc MTHFR 677C>T effects on anterior cingulate structure and function during response monitoring in schizophrenia: a preliminary study
    Joshua L Roffman
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Brain Imaging Behav 5:65-75. 2011
  4. doi Use of antipsychotic medication in chemotherapy-induced nausea and vomiting
    Joshua L Roffman
    The Massachusetts General Hospital Harvard Medical School, Massachusetts General Hospital, Department of Psychiatry, 55 Fruit Street, Boston, MA 02114, USA
    Expert Rev Neurother 3:77-84. 2003
  5. pmc Randomized multicenter investigation of folate plus vitamin B12 supplementation in schizophrenia
    Joshua L Roffman
    Department of Psychiatry, Massachusetts General Hospital, Charlestown, MA 02129, USA
    JAMA Psychiatry 70:481-9. 2013
  6. pmc Genetic variation throughout the folate metabolic pathway influences negative symptom severity in schizophrenia
    Joshua L Roffman
    Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Schizophr Bull 39:330-8. 2013
  7. pmc A hypomethylating variant of MTHFR, 677C>T, blunts the neural response to errors in patients with schizophrenia and healthy individuals
    Joshua L Roffman
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts, United States of America
    PLoS ONE 6:e25253. 2011
  8. pmc MTHFR 677C --> T genotype disrupts prefrontal function in schizophrenia through an interaction with COMT 158Val --> Met
    Joshua L Roffman
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA
    Proc Natl Acad Sci U S A 105:17573-8. 2008
  9. doi Eight ball
    Joshua L Roffman
    Psychiatric Neuroscience Research Program, Rm 2656, Bldg 149, Massachusetts General Hospital, 149 13th St, Charlestown, MA 02129, USA
    Am J Psychiatry 165:956-7. 2008
  10. doi Interactive effects of COMT Val108/158Met and MTHFR C677T on executive function in schizophrenia
    Joshua L Roffman
    Schizophrenia Program, Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Am J Med Genet B Neuropsychiatr Genet 147:990-5. 2008

Detail Information

Publications28

  1. ncbi Neuroimaging and the functional neuroanatomy of psychotherapy
    Joshua L Roffman
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Psychol Med 35:1385-98. 2005
    ..This review examines initial attempts to measure directly the effects of psychotherapy on brain function in patients with depression or anxiety disorders...
  2. ncbi Effects of the methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism on executive function in schizophrenia
    Joshua L Roffman
    Schizophrenia Research Program, Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, USA
    Schizophr Res 92:181-8. 2007
    ..This study examined whether schizophrenia patients homozygous for the risk allele (T/T) exhibit greater impairment in executive function, and determined the extent to which MTHFR's effects on negative symptoms underlie this relationship...
  3. pmc MTHFR 677C>T effects on anterior cingulate structure and function during response monitoring in schizophrenia: a preliminary study
    Joshua L Roffman
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Brain Imaging Behav 5:65-75. 2011
    ..These findings suggest that the MTHFR 677T allele blunts response monitoring in schizophrenia, presumably via effects on dopamine signaling and dACC white matter microstructural integrity...
  4. doi Use of antipsychotic medication in chemotherapy-induced nausea and vomiting
    Joshua L Roffman
    The Massachusetts General Hospital Harvard Medical School, Massachusetts General Hospital, Department of Psychiatry, 55 Fruit Street, Boston, MA 02114, USA
    Expert Rev Neurother 3:77-84. 2003
    ....
  5. pmc Randomized multicenter investigation of folate plus vitamin B12 supplementation in schizophrenia
    Joshua L Roffman
    Department of Psychiatry, Massachusetts General Hospital, Charlestown, MA 02129, USA
    JAMA Psychiatry 70:481-9. 2013
    ....
  6. pmc Genetic variation throughout the folate metabolic pathway influences negative symptom severity in schizophrenia
    Joshua L Roffman
    Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Schizophr Bull 39:330-8. 2013
    ..A relationship between folate level and negative symptom severity among patients with greater genetic vulnerability is biologically plausible and suggests the utility of folate supplementation in these patients...
  7. pmc A hypomethylating variant of MTHFR, 677C>T, blunts the neural response to errors in patients with schizophrenia and healthy individuals
    Joshua L Roffman
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts, United States of America
    PLoS ONE 6:e25253. 2011
    ..MTHFR is a key regulator of the intracellular one-carbon milieu, including DNA methylation, and each copy of the 677T allele reduces MTHFR activity by 35%...
  8. pmc MTHFR 677C --> T genotype disrupts prefrontal function in schizophrenia through an interaction with COMT 158Val --> Met
    Joshua L Roffman
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA
    Proc Natl Acad Sci U S A 105:17573-8. 2008
    ..The findings also suggest the importance of weighing COMT effects on prefrontal function within the context of MTHFR genotype...
  9. doi Eight ball
    Joshua L Roffman
    Psychiatric Neuroscience Research Program, Rm 2656, Bldg 149, Massachusetts General Hospital, 149 13th St, Charlestown, MA 02129, USA
    Am J Psychiatry 165:956-7. 2008
  10. doi Interactive effects of COMT Val108/158Met and MTHFR C677T on executive function in schizophrenia
    Joshua L Roffman
    Schizophrenia Program, Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Am J Med Genet B Neuropsychiatr Genet 147:990-5. 2008
    ..It is plausible that cumulative effects of the MTHFR T and COMT Val alleles on intracellular methylation profiles and prefrontal dopamine transmission underlie their interactive effect on perseverative errors...
  11. ncbi Contribution of methylenetetrahydrofolate reductase (MTHFR) polymorphisms to negative symptoms in schizophrenia
    Joshua L Roffman
    Schizophrenia Research Program, Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Biol Psychiatry 63:42-8. 2008
    ..We examined whether the methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C functional polymorphisms contribute to negative symptoms...
  12. ncbi Neuroscience in psychiatry training: how much do residents need to know?
    Joshua L Roffman
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    Am J Psychiatry 163:919-26. 2006
    ..The authors sought to determine how this dilemma is currently being played out in residency training programs, in which training directors must decide how best to integrate neuroscience teaching in a rapidly changing clinical landscape...
  13. ncbi Neuroimaging-genetic paradigms: a new approach to investigate the pathophysiology and treatment of cognitive deficits in schizophrenia
    Joshua L Roffman
    Harvard Medical School and Department of Psychiatry, Massachusetts General Hospital, Boston, MA 02129, USA
    Harv Rev Psychiatry 14:78-91. 2006
    ..The potential of this approach for improving patient care will depend on its ability to predict outcomes with greater accuracy and sensitivity than current clinical measures...
  14. doi Folate supplementation in schizophrenia: a possible role for MTHFR genotype
    Michele Hill
    Schizophrenia Program, Massachusetts General Hospital, Harvard Medical School, United States
    Schizophr Res 127:41-5. 2011
    ..This study examined the effect of folate supplementation on negative symptoms overall and in relation to MTHFR 677C>T genotype...
  15. pmc DISC1 is associated with cortical thickness and neural efficiency
    Stefan Brauns
    MGH MIT HMS Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA 02129 2000, USA
    Neuroimage 57:1591-600. 2011
    ..Here, we investigated the effects of variation in DISC1 on cortical thickness. In a subsequent analysis we tested whether the identified DISC1 risk variant is also associated with neural activity during working memory functioning...
  16. pmc Disrupted Working Memory Circuitry in Schizophrenia: Disentangling fMRI Markers of Core Pathology vs Other Aspects of Impaired Performance
    Hamdi Eryilmaz
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, USA
    Neuropsychopharmacology 41:2411-20. 2016
    ..Our findings suggest that altered FPCN activation in patients reflects performance difference, and that limbic and thalamic dysfunction is critically involved in WM deficits in schizophrenia. ..
  17. pmc Multidimensional heritability analysis of neuroanatomical shape
    Tian Ge
    Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Nat Commun 7:13291. 2016
    ..Our results demonstrate that neuroanatomical shape can be significantly heritable, above and beyond volume, and can serve as a complementary phenotype to study the genetic determinants and clinical relevance of brain structure...
  18. pmc The COMT Val108/158Met polymorphism and medial temporal lobe volumetry in patients with schizophrenia and healthy adults
    Stefan Ehrlich
    MGH MIT HMS Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA 02129 2000, USA
    Neuroimage 53:992-1000. 2010
    ..Taken together with previous work, our data support a model in which lower COMT activity, and a resulting elevation in extracellular dopamine levels, stimulates growth of medial temporal lobe structures...
  19. pmc Distinguishing familiarity-based from source-based memory performance in patients with schizophrenia
    Anthony P Weiss
    Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA
    Schizophr Res 99:208-17. 2008
    ..Yet the exact nature of these deficits remains a matter of some debate. This study sought to examine performance on two distinct aspects of memory performance: familiarity-based and source-based memory processes...
  20. pmc Aberrant frontoparietal function during recognition memory in schizophrenia: a multimodal neuroimaging investigation
    Anthony P Weiss
    Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Neurosci 29:11347-59. 2009
    ..Inefficient utilization of prefrontal-parietal networks, with compensatory activation in temporal regions, may thus contribute to deficient old-new item recognition in schizophrenia...
  21. pmc Individual Differences in Cognitive Control Circuit Anatomy Link Sensation Seeking, Impulsivity, and Substance Use
    Avram J Holmes
    Department of Psychology, Yale University, New Haven, Connecticut 06520, Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Boston, Charlestown, Massachusetts 02129
    J Neurosci 36:4038-49. 2016
    ..Our findings suggest that, in healthy populations, covariation across these complex multidimensional behaviors may in part originate from a common underlying biology...
  22. doi Auditory stimulus repetition effects on cortical hemoglobin oxygenation: a near-infrared spectroscopy investigation
    Anthony P Weiss
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02129, USA
    Neuroreport 19:161-5. 2008
    ..These findings provide preliminary support for a relationship between the perceptual characteristics of auditory stimuli and modulation of cortical oxygenation as measured via an emerging neuromonitoring technique...
  23. pmc Dopamine D1 signaling organizes network dynamics underlying working memory
    Joshua L Roffman
    Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Boston, MA 02114, USA Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, 149 13th Street, Charlestown, MA 02129, USA
    Sci Adv 2:e1501672. 2016
    ..These findings specifically link cortical dopamine signaling to network crosstalk that redirects cognitive resources to working memory, echoing neuromodulatory effects of D1 signaling on the level of cortical microcircuits. ..
  24. pmc Dissociable genetic contributions to error processing: a multimodal neuroimaging study
    Yigal Agam
    Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America Athinoula A Martinos Center for Biomedical Imaging, Harvard Medical School, Charlestown, Massachusetts, United States of America
    PLoS ONE 9:e101784. 2014
    ..Here, we tested the hypothesis that these two error markers also have different genetic mediation...
  25. pmc Massively expedited genome-wide heritability analysis (MEGHA)
    Tian Ge
    Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital Harvard Medical School, Charlestown, MA 02129 Psychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA 02114 Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02138
    Proc Natl Acad Sci U S A 112:2479-84. 2015
    ..Our analyses demonstrate the unique capability of MEGHA for large-scale heritability-based screening and high-dimensional heritability profile construction. ..
  26. pmc Brain Genomics Superstruct Project initial data release with structural, functional, and behavioral measures
    Avram J Holmes
    Center for Brain Science, Harvard University, Cambridge, MA 02138, USA Department of Psychology, Harvard University, Cambridge, MA 02138, USA Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA Athinoula A Martinos Center for Biomedical Research, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA
    Sci Data 2:150031. 2015
    ..Analyses of data quality, structure, function, personality, and cognition are presented to demonstrate the dataset's utility. ..
  27. pmc The human ortholog of acid-sensing ion channel gene ASIC1a is associated with panic disorder and amygdala structure and function
    Jordan W Smoller
    Psychiatric and Neurodevelopmental Genetics Unit, Massachusetts General Hospital, Boston, Massachusetts Harvard School of Public Health, Boston, Massachusetts Electronic address
    Biol Psychiatry 76:902-10. 2014
    ..We examined whether the human ortholog of the ASIC1a gene, ACCN2, is associated with the presence of PD and with amygdala structure and function...
  28. doi Neural predictors of successful brief psychodynamic psychotherapy for persistent depression
    Joshua L Roffman
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, Mass, USA
    Psychother Psychosom 83:364-70. 2014
    ..Psychodynamic psychotherapy has been used to treat depression for more than a century. However, not all patients respond equally well, and there are few reliable predictors of treatment outcome...