Genomes and Genes
Avital A Rodal
Affiliation: Massachusetts Institute of Technology
- Conformational changes in the Arp2/3 complex leading to actin nucleationAvital A Rodal
Department of Biology, Rosenstiel Basic Medical Sciences Research Center, Brandeis University, Waltham, Massachusetts 02454, USA
Nat Struct Mol Biol 12:26-31. 2005..We conclude that WASp stabilizes p35-dependent closure of the complex, holding Arp2 and Arp3 closer together to nucleate an actin filament...
- Nervous wreck and Cdc42 cooperate to regulate endocytic actin assembly during synaptic growthAvital A Rodal
The Picower Institute for Learning and Memory, Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
J Neurosci 28:8316-25. 2008..Together, our results suggest that synaptic growth activated by growth factor signaling is controlled at an endosomal compartment via coordinated Nwk and Cdc42-dependent actin assembly...
- Actin and septin ultrastructures at the budding yeast cell cortexAvital A Rodal
Department of Biology, Rosenstiel Basic Medical Science Research Center, Brandeis University, Waltham, MA 02454, USA
Mol Biol Cell 16:372-84. 2005..These images provide the first high-resolution views of septin organization in cells...
- Structural and functional dissection of the Abp1 ADFH actin-binding domain reveals versatile in vivo adapter functionsOmar Quintero-Monzon
Department of Biology and Rosenstiel Basic Medical Science Research Center, Brandeis University, Waltham, MA 02454, USA
Mol Biol Cell 16:3128-39. 2005..Together, our data provide the first structural and functional view of the Abp1-actin interaction and show that Abp1 has distinct cellular roles as an adapter, linking different sets of ligands for each function...
- A presynaptic endosomal trafficking pathway controls synaptic growth signalingAvital A Rodal
Department of Biology, The Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
J Cell Biol 193:201-17. 2011..Our results define a presynaptic trafficking pathway mediated by SNX16, NWK, and the ESCRT complex that functions to control synaptic growth signaling at the interface between endosomal compartments...
- Formation of membrane ridges and scallops by the F-BAR protein Nervous WreckAgata N Becalska
Rosenstiel Basic Medical Sciences Research Center, Department of Biology, Brandeis University, Waltham, MA 02454, USA
Mol Biol Cell 24:2406-18. 2013..These findings expand the repertoire of F-BAR domain mediated membrane deformation and suggest that unique modes of higher-order assembly can define how these proteins sculpt the membrane. ..
- Synaptic endocytosis: illuminating the role of clathrin assemblyAvital A Rodal
Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
Curr Biol 18:R259-61. 2008....
- Membrane Charge Directs the Outcome of F-BAR Domain Lipid Binding and AutoregulationCharlotte F Kelley
Rosenstiel Basic Medical Sciences Research Center, Department of Biology, Brandeis University, Waltham, MA 02453, USA
Cell Rep 13:2597-609. 2015..Our findings uncover an unexpected mechanism by which lipid composition directs membrane remodeling. ..
- New approaches for studying synaptic development, function, and plasticity using Drosophila as a model systemC Andrew Frank
Department of Anatomy and Cell Biology, University of Iowa Carver College of Medicine, Iowa City, Iowa 52242, Stanford Institute for Neuro innovation and Translational Neurosciences and Department of Neurosurgery, Stanford University School of Medicine, Palo Alto, California 94305, Department of Molecular Cellular and Developmental Biology, University of Michigan, Ann Arbor, Michigan 48109, Department of Biology, Brandeis University, Waltham, Massachusetts 02453, National Institute of Neurological Disorders and Stroke, National Institute of Health, Bethesda, Maryland 20892, VIB, Center for the Biology of Disease and KU Leuven, Department for Human Genetics, 3000 Leuven, Belgium, and Department of Biology, University of Southern California, Los Angeles, California 90089
J Neurosci 33:17560-8. 2013..We will review some of the fresh insights into synaptic development, function, and plasticity that have recently emerged in Drosophila with an emphasis on the unique advantages of this model system. ..
- Coordinated regulation of actin filament turnover by a high-molecular-weight Srv2/CAP complex, cofilin, profilin, and Aip1Heath I Balcer
Department of Biology and Rosenstiel Basic Medical Sciences Research Center, Brandeis University, Waltham, MA 02454, USA
Curr Biol 13:2159-69. 2003..Xenopus Aip1 forms a cofilin-dependent cap at filament barbed ends. It has been unclear how these diverse activities are coordinated in vivo...
- Beyond the SNARE: Munc18-1 chaperones α-synucleinMugdha Deshpande
Department of Biology, Brandeis University, Waltham, MA 02453
J Cell Biol 214:641-3. 2016..In this issue, Chai et al. (2016. J. Cell Biol http://dx.doi.org/10.1083/jcb.201512016) find that Munc18-1 is a molecular chaperone for α-synuclein and that aggregated Munc18-1 EIEE-causing mutants promote α-synuclein aggregation. ..
- The EHD protein Past1 controls postsynaptic membrane elaboration and synaptic functionKate Koles
Rosenstiel Basic Medical Sciences Research Center, Department of Biology, Brandeis University, Waltham, MA 02453
Mol Biol Cell 26:3275-88. 2015..Our results suggest a mechanism by which the coordinated actions of multiple lipid-binding proteins lead to the elaboration of increasing layers of the SSR and uncover new roles for an EHD protein at synapses. ..
- Role of BMP receptor traffic in synaptic growth defects in an ALS modelMugdha Deshpande
Department of Biology, Brandeis University, Waltham, MA 02453
Mol Biol Cell 27:2898-910. 2016..Our results indicate that defects in receptor traffic lead to neuronal dysfunction downstream of TDP-43 misregulation and that rerouting receptor traffic may be a viable strategy for rescuing neurological impairment. ..
- Negative regulation of yeast WASp by two SH3 domain-containing proteinsAvital A Rodal
Department of Molecular and Cell Biology, University of California, Berkeley, 94720, USA
Curr Biol 13:1000-8. 2003..Some WASp family members are autoinhibited until bound by activating ligands; however, regulation of the budding yeast WASp homolog (Las17/Bee1) has not yet been explored...
- An actin nucleation mechanism mediated by Bni1 and profilinIsabelle Sagot
Department of Pediatric Oncology, The Dana Farber Cancer Institute Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA
Nat Cell Biol 4:626-31. 2002..Thus, formin and profilin mediate actin nucleation by an Arp2/3-independent mechanism. These findings suggest that distinct actin nucleation mechanisms may underlie the assembly of different actin cytoskeletal structures...