Genomes and Genes
Nina P Paynter
Affiliation: Massachusetts General Hospital
- Cardiovascular disease risk prediction with and without knowledge of genetic variation at chromosome 9p21.3Nina P Paynter
Brigham and Women s Hospital, 900 Commonwealth Avenue East, Boston, MA 02215, USA
Ann Intern Med 150:65-72. 2009..Although genetic variation at chromosome 9p21.3 is associated with incident cardiovascular disease, it is unclear whether screening for this polymorphism improves risk prediction...
- Are Genetic Tests for Atherosclerosis Ready for Routine Clinical Use?Nina P Paynter
From the Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Boston, MA
Circ Res 118:607-19. 2016..The third area, pharmacogenetics, has utility for some therapies today. Future utility for pharmacogenetics will wax or wane depending on the nature of available drugs and therapeutic strategies. ..
- Comparison of lifestyle-based and traditional cardiovascular disease prediction in a multiethnic cohort of nonsmoking womenNina P Paynter
From Brigham and Women s Hospital and Harvard Medical School, Boston, MA N P P, J E M, P MR, N R C School of Public Health and Health Professions, State University of New York at Buffalo, Buffalo, NY M J L George Washington University School of Medicine, Washington, DC L W M Emory University School of Medicine, Atlanta, GA L S P and College of Public Health, University of Iowa, Iowa City J G R
Circulation 130:1466-73. 2014..Healthy levels of lifestyle factors can reduce the risk of cardiovascular disease. However, except for smoking status, often considered a traditional risk factor, their effect on cardiovascular risk prediction is unclear...
- A bias-corrected net reclassification improvement for clinical subgroupsNina P Paynter
Division of Preventive Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02215, USA
Med Decis Making 33:154-62. 2013..Comparing prediction models using reclassification within subgroups at intermediate risk is often of clinical interest...
- Effect of correcting for long-term variation in major coronary heart disease risk factors: relative hazard estimation and risk prediction in the Atherosclerosis Risk in Communities StudyNina P Paynter
Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, USA
Ann Epidemiol 22:191-7. 2012..To examine the effect of correcting coronary heart disease (CHD) risk factors for long-term within-person variation on CHD risk...
- Cardiovascular risk prediction in diabetic men and women using hemoglobin A1c vs diabetes as a high-risk equivalentNina P Paynter
Brigham and Women s Hospital, Division of Preventive Medicine, 900 Commonwealth Ave, Boston, MA 02215, USA
Arch Intern Med 171:1712-8. 2011....
- Lipoprotein subclass abnormalities and incident hypertension in initially healthy womenNina P Paynter
Divisions of Preventive Medicine, Brigham and Women s Hospital, Boston, Massachusetts, USA
Clin Chem 57:1178-87. 2011..Whether lipoprotein particle size or subclass concentrations play a role in the development of hypertension is unknown...
- Paired comparison of observed and expected coronary heart disease rates over 12 years from the Atherosclerosis Risk in Communities StudyNina P Paynter
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, USA
Ann Epidemiol 20:683-90. 2010..To quantify the relationship between coronary heart disease (CHD) risk factor levels and changes over time and population-wide CHD morbidity and mortality...
- Association between a literature-based genetic risk score and cardiovascular events in womenNina P Paynter
Center for Cardiovascular Disease Prevention and the Divisions of Preventive Medicine and Cardiovascular Diseases, Brigham and Women s Hospital, Boston, Massachusetts 02215, USA
JAMA 303:631-7. 2010..While multiple genetic markers associated with cardiovascular disease have been identified by genome-wide association studies, their aggregate effect on risk beyond traditional factors is uncertain, particularly among women...
- Prediction of incident hypertension risk in women with currently normal blood pressureNina P Paynter
The Center for Cardiovascular Disease Prevention and the Division of Preventive Medicine, Brigham and Women s Hospital, Boston, Mass 02215, USA
Am J Med 122:464-71. 2009..We examined whether a hypertension risk prediction model based on clinical characteristics and blood biomarkers might improve on risk prediction based on current blood pressure alone...
- C-reactive protein and parental history improve global cardiovascular risk prediction: the Reynolds Risk Score for menPaul M Ridker
Donald W Reynolds Center for Cardiovascular Research, Division of Preventive Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
Circulation 118:2243-51, 4p following 2251. 2008....
- Clinical utility of lipoprotein-associated phospholipase A₂ for cardiovascular disease prediction in a multiethnic cohort of womenNancy R Cook
Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
Clin Chem 58:1352-63. 2012..Findings regarding the association of lipoprotein-associated phospholipase A₂ (Lp-PLA2) activity and mass with incident cardiovascular disease (CVD) have been inconsistent, and their role in risk prediction is uncertain...
- Comparison of the Framingham and Reynolds Risk scores for global cardiovascular risk prediction in the multiethnic Women's Health InitiativeNancy R Cook
Division of Preventive Medicine, Brigham and Women s Hospital, 900 Commonwealth Ave E, Boston, MA 02215, USA
Circulation 125:1748-56, S1-11. 2012..Framingham-based and Reynolds Risk scores for cardiovascular disease (CVD) prediction have not been directly compared in an independent validation cohort...
- Socioeconomic status and incident type 2 diabetes mellitus: data from the Women's Health StudyTimothy C Lee
Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts, United States of America
PLoS ONE 6:e27670. 2011..We prospectively examined whether socioeconomic status (SES) predicts incident type II diabetes (diabetes), a cardiovascular risk equivalent and burgeoning public health epidemic among women...
- Performance of reclassification statistics in comparing risk prediction modelsNancy R Cook
Division of Preventive Medicine, Brigham and Women s Hospital, Boston, MA, USA
Biom J 53:237-58. 2011..The relative power of the RC statistic, a test of calibration, and the NRI, a test of discrimination, varied depending on the model assumptions. These tools provide unique but complementary information...
- Cardiovascular disease risk prediction in women: is there a role for novel biomarkers?Nina P Paynter
Division of Preventive Medicine, Brigham and Women s Hospital, Boston, MA
Clin Chem 60:88-97. 2014..The incidence of CVD is lower in women than men, and the effects of a number of traditional biomarkers on CVD risk differ in women compared to men. Both of these factors influence the ability to accurately predict CVD risk...
- Novel locus including FGF21 is associated with dietary macronutrient intakeAudrey Y Chu
Division of Preventive Medicine, Brigham and Women s Hospital, Boston, MA, USA
Hum Mol Genet 22:1895-902. 2013..9 × 10(-9)). A cytokine involved in cellular metabolism, FGF21 is a potential susceptibility gene for obesity and type 2 diabetes. Our results highlight the potential of genetic variation for determining dietary macronutrient intake...
- Lifetime risk of cardiovascular disease among individuals with and without diabetes stratified by obesity status in the Framingham heart studyCaroline S Fox
National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, Massachusetts, USA
Diabetes Care 31:1582-4. 2008..We assessed the lifetime risk of cardiovascular disease (CVD) among individuals with and without obesity and diabetes...
- Prognostic factors in pediatric high-grade astrocytoma: the importance of accurate pathologic diagnosisRussell K Hales
Department of Radiation Oncology and Molecular Radiation Sciences, The Johns Hopkins University School of Medicine, 401 North Broadway, Suite 1440, Baltimore, MD 21231, USA
J Neurooncol 99:65-71. 2010..Pathologic misdiagnosis should be suspected in patients who are long term survivors of a pediatric high grade astrocytoma...
- Tests of calibration and goodness-of-fit in the survival settingOlga V Demler
Division of Preventive Medicine, Brigham and Women s Hospital Harvard Medical School, 900 Commonwealth Ave, East Boston, MA, 02215, U S A
Stat Med 34:1659-80. 2015..We also discuss the application to small cell sizes...
- High-density lipoprotein particle subclass heterogeneity and incident coronary heart diseaseAkintunde O Akinkuolie
Divisions of Preventive Medicine and Cardiovascular Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA
Circ Cardiovasc Qual Outcomes 7:55-63. 2014..We prospectively evaluated the association of HDL subclasses, defined by a recently proposed nomenclature, with incident coronary heart disease (CHD)...
- A double blind randomized placebo control trial of levetiracetam in Tourette syndromeConstance L Smith-Hicks
Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
Mov Disord 22:1764-70. 2007..There was no significant difference between treatments and no evidence of sequence or cross-over effects. In conclusion, Levetiracetam is not more beneficial than placebo in suppressing tics in children with TS...
- The effect of weight loss on C-reactive protein: a systematic reviewElizabeth Selvin
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, The Johns Hopkins University, Baltimore, MD 21287, USA
Arch Intern Med 167:31-9. 2007..Our objective was to test the hypothesis that weight loss is directly related to a decline in CRP level...
- Coffee and sweetened beverage consumption and the risk of type 2 diabetes mellitus: the atherosclerosis risk in communities studyNina P Paynter
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
Am J Epidemiol 164:1075-84. 2006..In summary, increased coffee consumption was significantly associated with a decreased risk of diagnosed type 2 diabetes mellitus in community-based US adults...