Robert L Owens

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. pmc Sitting and supine esophageal pressures in overweight and obese subjects
    Robert L Owens
    Sleep Disorders Research Program, Division of Sleep Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Obesity (Silver Spring) 20:2354-60. 2012
  2. doi request reprint Supplemental oxygen needs during sleep. Who benefits?
    Robert L Owens
    Division of Pulmonary and Critical Care Medicine, and the Division of Sleep Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Respir Care 58:32-47. 2013
  3. pmc Upper airway collapsibility and patterns of flow limitation at constant end-expiratory lung volume
    Robert L Owens
    Sleep Disorders Research Program, Division of Sleep Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Appl Physiol (1985) 113:691-9. 2012
  4. pmc Upper airway function in the pathogenesis of obstructive sleep apnea: a review of the current literature
    Robert L Owens
    Pulmonary and Critical Care Division, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Curr Opin Pulm Med 14:519-24. 2008
  5. pmc Is the way to man's heart (and lung) through the abdomen?
    Robert L Owens
    Sleep Disorders Research Program, Division of Sleep Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Crit Care 13:199. 2009
  6. pmc The influence of end-expiratory lung volume on measurements of pharyngeal collapsibility
    Robert L Owens
    Sleep Disorders Research Program, Div of Sleep Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Appl Physiol (1985) 108:445-51. 2010
  7. pmc Sleep-disordered breathing and COPD: the overlap syndrome
    Robert L Owens
    Sleep Disorders Research Program, Brigham and Women s Hospital, Boston, MA 02115, USA
    Respir Care 55:1333-44; discussion 1344-6. 2010
  8. pmc Acetazolamide improves loop gain but not the other physiological traits causing obstructive sleep apnoea
    Bradley A Edwards
    Sleep Disorders Research Program, Division of Sleep Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    J Physiol 590:1199-211. 2012
  9. pmc A method for measuring and modeling the physiological traits causing obstructive sleep apnea
    Andrew Wellman
    221 Longwood Ave, 036 BLI, Boston, MA 02115, USA
    J Appl Physiol (1985) 110:1627-37. 2011
  10. pmc A simplified method for determining phenotypic traits in patients with obstructive sleep apnea
    Andrew Wellman
    Division of Sleep Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    J Appl Physiol (1985) 114:911-22. 2013

Collaborators

Detail Information

Publications35

  1. pmc Sitting and supine esophageal pressures in overweight and obese subjects
    Robert L Owens
    Sleep Disorders Research Program, Division of Sleep Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Obesity (Silver Spring) 20:2354-60. 2012
    ..These data indicate that mediastinal weight and postural effects on P(Es) are within a clinically acceptable range, and suggest that esophageal manometry can be used to inform clinical decision making across wide range of body types...
  2. doi request reprint Supplemental oxygen needs during sleep. Who benefits?
    Robert L Owens
    Division of Pulmonary and Critical Care Medicine, and the Division of Sleep Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Respir Care 58:32-47. 2013
    ..Because of its prevalence, obstructive sleep apnea may commonly overlap with lung disease in many patients and have important consequences. Patients with overlap syndromes may be good candidates for noninvasive ventilation during sleep...
  3. pmc Upper airway collapsibility and patterns of flow limitation at constant end-expiratory lung volume
    Robert L Owens
    Sleep Disorders Research Program, Division of Sleep Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Appl Physiol (1985) 113:691-9. 2012
    ..These results also highlight the importance of inspiratory collapse in OSA pathogenesis. The cause of negative effort dependence within and across breaths is not known and requires further study...
  4. pmc Upper airway function in the pathogenesis of obstructive sleep apnea: a review of the current literature
    Robert L Owens
    Pulmonary and Critical Care Division, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Curr Opin Pulm Med 14:519-24. 2008
    ..However, recent work has focused on the function, rather than structure alone, of the upper airway...
  5. pmc Is the way to man's heart (and lung) through the abdomen?
    Robert L Owens
    Sleep Disorders Research Program, Division of Sleep Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Crit Care 13:199. 2009
    ..However, their work raises several questions for clinicians and researchers regarding the pathophysiology and management of IAP...
  6. pmc The influence of end-expiratory lung volume on measurements of pharyngeal collapsibility
    Robert L Owens
    Sleep Disorders Research Program, Div of Sleep Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Appl Physiol (1985) 108:445-51. 2010
    ..Changes in lung volume alter Pcrit substantially. This work supports a role for lung volume in the pathogenesis of OSA, and lung volume changes should be a consideration during assessment of pharyngeal mechanics...
  7. pmc Sleep-disordered breathing and COPD: the overlap syndrome
    Robert L Owens
    Sleep Disorders Research Program, Brigham and Women s Hospital, Boston, MA 02115, USA
    Respir Care 55:1333-44; discussion 1344-6. 2010
    ..Treatment currently consists of continuous positive airway pressure, and oxygen as needed. Noninvasive ventilation may be helpful in overlap syndrome patients, but this has not yet been well studied...
  8. pmc Acetazolamide improves loop gain but not the other physiological traits causing obstructive sleep apnoea
    Bradley A Edwards
    Sleep Disorders Research Program, Division of Sleep Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    J Physiol 590:1199-211. 2012
    ..Identification of patients who may benefit from reductions in LG alone or in combination with other therapies to alter the remaining traits may facilitate pharmacological resolution of OSA in the future...
  9. pmc A method for measuring and modeling the physiological traits causing obstructive sleep apnea
    Andrew Wellman
    221 Longwood Ave, 036 BLI, Boston, MA 02115, USA
    J Appl Physiol (1985) 110:1627-37. 2011
    ..This technique could conceivably be used clinically to define a patient's physiology and guide therapy based on the traits...
  10. pmc A simplified method for determining phenotypic traits in patients with obstructive sleep apnea
    Andrew Wellman
    Division of Sleep Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    J Appl Physiol (1985) 114:911-22. 2013
    ..This technique is a relatively simple way of defining mechanisms underlying OSA and could potentially be used in a clinical setting to individualize therapy...
  11. pmc An Integrative Model of Physiological Traits Can be Used to Predict Obstructive Sleep Apnea and Response to Non Positive Airway Pressure Therapy
    Robert L Owens
    Sleep Disorders Research Program, Division of Sleep Medicine, Brigham and Women s and Harvard Medical School, Boston, MA
    Sleep 38:961-70. 2015
    ..A valid model, and knowledge of the published effect sizes of trait manipulation, would also allow us to predict the number of patients with OSA who might be effectively treated without using positive airway pressure (PAP)...
  12. pmc Test of the Starling resistor model in the human upper airway during sleep
    Andrew Wellman
    Division of Sleep Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts
    J Appl Physiol (1985) 117:1478-85. 2014
    ..These findings support the idea that there is not a single model of pharyngeal collapse, but rather that different mechanisms may dominate in different patients. These differences could potentially be exploited for treatment selection...
  13. pmc Enhanced upper-airway muscle responsiveness is a distinct feature of overweight/obese individuals without sleep apnea
    Scott A Sands
    1 Division of Sleep Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts
    Am J Respir Crit Care Med 190:930-7. 2014
    ..Body habitus is a major determinant of obstructive sleep apnea (OSA). However, many individuals do not have OSA despite being overweight/obese (body mass index > 25 kg/m(2)) for reasons that are not fully elucidated...
  14. pmc Quantifying the ventilatory control contribution to sleep apnoea using polysomnography
    Philip I Terrill
    Division of Sleep Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA School of Information Technology and Electrical Engineering, The University of Queensland, Brisbane, Australia
    Eur Respir J 45:408-18. 2015
    ..We validated a means to quantify the ventilatory control contribution to OSA pathogenesis using clinical polysomnography, enabling identification of likely responders to therapies targeting ventilatory control...
  15. pmc Influence of pharyngeal muscle activity on inspiratory negative effort dependence in the human upper airway
    Pedro R Genta
    Division of Sleep and Circadian Disorders, Departments of Medicine and Neurology, Brigham and Women s Hospital, Harvard Medical School, 221 Longwood Avenue, Boston, MA 02115, USA Electronic address
    Respir Physiol Neurobiol 201:55-9. 2014
    ..6┬▒5.8% (p=0.056). In conclusion, phasic EMG(GG) had little effect on NED. This finding suggests that individual differences in phasic EMG(GG) activation do not likely explain the variability in NED found among OSA patients...
  16. pmc Tube Law of the Pharyngeal Airway in Sleeping Patients with Obstructive Sleep Apnea
    Pedro R Genta
    Division of Sleep and Circadian Disorders, Departments of Medicine and Neurology, Brigham and Women s Hospital, Boston, MA
    Sleep 39:337-43. 2016
    ..Therefore, we hypothesized that during inspiratory flow limitation, as opposed to static conditions, the pharynx becomes stiffer as luminal pressure decreases...
  17. pmc Effects of hyperoxia and hypoxia on the physiological traits responsible for obstructive sleep apnoea
    Bradley A Edwards
    Division of Sleep Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    J Physiol 592:4523-35. 2014
    ..The effects of hypoxia described above may explain the disappearance of OSA and the emergence of central sleep apnoea in conditions such as high altitude. ..
  18. pmc The classical Starling resistor model often does not predict inspiratory airflow patterns in the human upper airway
    Robert L Owens
    Sleep Disorders Research Program, Division of Sleep Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts
    J Appl Physiol (1985) 116:1105-12. 2014
    ..In contrast to the classical Starling resistor model, the upper airway exhibits marked NED in some subjects. ..
  19. doi request reprint Effect of the chest wall on pressure-volume curve analysis of acute respiratory distress syndrome lungs
    Robert L Owens
    Departments of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Crit Care Med 36:2980-5. 2008
    ..We sought to quantify the effect of the chest wall by considering the chest wall and lung in series...
  20. pmc Quantifying unintended exposure to high tidal volumes from breath stacking dyssynchrony in ARDS: the BREATHE criteria
    Jeremy R Beitler
    Division of Pulmonary and Critical Care Medicine, University of California, San Diego, 200 West Arbor Drive, 8409, San Diego, CA, 92103, USA
    Intensive Care Med 42:1427-36. 2016
    ....
  21. pmc The Combination of Supplemental Oxygen and a Hypnotic Markedly Improves Obstructive Sleep Apnea in Patients with a Mild to Moderate Upper Airway Collapsibility
    Bradley A Edwards
    Division of Sleep and Circadian Disorders, Departments of Medicine and Neurology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA
    Sleep 39:1973-1983. 2016
    ..Therefore, our aim was to determine how the combination of oxygen and eszopiclone alters the phenotypic traits and OSA severity and to assess the baseline phenotypic characteristics of responders/nonresponders to combination therapy...
  22. pmc Clinical predictors of the respiratory arousal threshold in patients with obstructive sleep apnea
    Bradley A Edwards
    1 Division of Sleep and Circadian Disorders, Departments of Medicine and Neurology, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts
    Am J Respir Crit Care Med 190:1293-300. 2014
    ..A low respiratory arousal threshold (ArTH) is one of several traits involved in obstructive sleep apnea pathogenesis and may be a therapeutic target; however, there is no simple way to identify patients without invasive measurements...
  23. pmc Obstructive sleep apnea in older adults is a distinctly different physiological phenotype
    Bradley A Edwards
    Division of Sleep Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA
    Sleep 37:1227-36. 2014
    ..However, previous studies examining individual physiological traits known to contribute to OSA pathogenesis have been assessed in isolation, primarily in healthy individuals...
  24. pmc Obstructive airway disease and obstructive sleep apnea: effect of pulmonary function
    Bhavneesh Sharma
    Division of Sleep Medicine, Harvard Medical School Brigham and Women s Hospital, Boston, MA 02115, USA
    Lung 189:37-41. 2011
    ..However, the high prevalence of OSA in OAD patients appears to be due to obesity, and reduced pulmonary function is not an independent risk factor for OSA...
  25. pmc Upper-Airway Collapsibility and Loop Gain Predict the Response to Oral Appliance Therapy in Patients with Obstructive Sleep Apnea
    Bradley A Edwards
    1 Division of Sleep and Circadian Disorders, Departments of Medicine and Neurology, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts
    Am J Respir Crit Care Med 194:1413-1422. 2016
    ..Understanding this variability may lie with the recognition that OSA is a multifactorial disorder and that OAs may affect more than just upper-airway anatomy/collapsibility...
  26. pmc Evaluation of right ventricular remodeling using cardiac magnetic resonance imaging in co-existent chronic obstructive pulmonary disease and obstructive sleep apnea
    Bhavneesh Sharma
    Division of Sleep Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    COPD 10:4-10. 2013
    ..65, p = 0.03). Our pilot results suggest that untreated overlap syndrome may cause more extensive RV remodeling than COPD alone...
  27. pmc Eszopiclone increases the respiratory arousal threshold and lowers the apnoea/hypopnoea index in obstructive sleep apnoea patients with a low arousal threshold
    Danny J Eckert
    Sleep Disorders Program, Division of Sleep Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Clin Sci (Lond) 120:505-14. 2011
    ..However, additional treatment strategies are probably required to achieve elimination of apnoea...
  28. pmc Influencing the decline of lung function in COPD: use of pharmacotherapy
    Ekaterina S Gladysheva
    Harvard Combined Pulmonary and Critical Care Fellowship, Harvard Medical School, Boston, MA, USA
    Int J Chron Obstruct Pulmon Dis 5:153-64. 2010
    ..A variety of newer classes of medications may help target other pathophysiologically important pathways, and could be used in the future to prevent lung function decline in COPD...
  29. pmc What is central sleep apnea?
    Atul Malhotra
    Division of Sleep, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Respir Care 55:1168-78. 2010
    ..A paucity of research exists in this area, emphasizing the opportunities for young investigators who are interested in this field...
  30. pmc T1 measurements for detection of expansion of the myocardial extracellular volume in chronic obstructive pulmonary disease
    Tomas G Neilan
    Division of Cardiology, Department of Medicine, Massachusetts General Hospital Cardiac MR PET CT Program, Division of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Can J Cardiol 30:1668-75. 2014
    ..We aimed to assess whether chronic obstructive pulmonary disease (COPD) is associated with expansion of the myocardial extracellular volume (ECV) using T1 measurements...
  31. pmc New Approaches to Diagnosing Sleep-Disordered Breathing
    Scott A Sands
    Division of Sleep and Circadian Disorders, Departments of Medicine and Neurology, Brigham and Women s Hospital and Harvard Medical School, 221 Longwood Avenue, Boston, MA 02115, USA Department of Allergy, Immunology and Respiratory Medicine and Central Clinical School, The Alfred and Monash University, 55 Commercial Road, Prahran, Victoria 3181, Australia Electronic address
    Sleep Med Clin 11:143-52. 2016
    ....
  32. pmc Volume Delivered During Recruitment Maneuver Predicts Lung Stress in Acute Respiratory Distress Syndrome
    Jeremy R Beitler
    1Division of Pulmonary and Critical Care Medicine, University of California, San Diego, San Diego, CA 2School of Medicine, University of California, San Diego, San Diego, CA 3Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, MN 4Division of Pulmonary and Critical Care Medicine, Massachusetts General Hospital, Boston, MA 5Department of Anesthesia, Critical Care, and Pain Medicine, Beth Israel Deaconess Medical Center, Boston, MA
    Crit Care Med 44:91-9. 2016
    ..We aimed to determine whether the volume delivered during a recruitment maneuver (V(RM)) is inversely associated with lung stress and mortality in acute respiratory distress syndrome...
  33. doi request reprint Do newer monitors of exhaled gases, mechanics, and esophageal pressure add value?
    Robert L Owens
    Department of Medicine, Pulmonary and Critical Care Unit, Cox 2, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA
    Clin Chest Med 29:297-312, vi-vii. 2008
    ..The authors explore the concepts, benefits, difficulties, and relevant clinical trials of each...
  34. doi request reprint Congestive Heart Failure and Central Sleep Apnea
    Scott A Sands
    Division of Sleep Medicine, Brigham and Women s Hospital and Harvard Medical School, 221 Longwood Avenue, Boston, MA 02115, USA Department of Allergy, Immunology and Respiratory Medicine and Central Clinical School, Alfred Hospital and Monash University, 55 Commercial Rd, Melbourne, VIC 3004, Australia
    Sleep Med Clin 11:127-42. 2016
    ..Few data are available to determine prevalence of CSR in the ICU, or how CSR might affect clinical management and weaning from mechanical ventilation. ..
  35. pmc Congestive heart failure and central sleep apnea
    Scott A Sands
    Division of Sleep Medicine, Brigham and Women s Hospital and Harvard Medical School, 221 Longwood Avenue, Boston, MA 02115, USA Department of Allergy, Immunology and Respiratory Medicine and Central Clinical School, Alfred Hospital and Monash University, 55 Commercial Rd, Melbourne, VIC 3004, Australia
    Crit Care Clin 31:473-95. 2015
    ..Few data are available to determine prevalence of CSR in the ICU, or how CSR might affect clinical management and weaning from mechanical ventilation. ..