Harald C Ott

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. doi request reprint Regeneration and orthotopic transplantation of a bioartificial lung
    Harald C Ott
    Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Nat Med 16:927-33. 2010
  2. ncbi request reprint Invited commentary
    Harald C Ott
    Department of Surgery, Massachusetts General Hospital, Harvard Medical School, 55 Fruit St, GRB425, Boston, MA 02114, USA
    Ann Thorac Surg 84:1727-8. 2007
  3. pmc Regeneration and experimental orthotopic transplantation of a bioengineered kidney
    Jeremy J Song
    Center for Regenerative Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA
    Nat Med 19:646-51. 2013
  4. doi request reprint Enhanced in vivo function of bioartificial lungs in rats
    Jeremy J Song
    Division of Thoracic Surgery, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Ann Thorac Surg 92:998-1005; discussion 1005-6. 2011
  5. pmc Regenerative potential of human airway stem cells in lung epithelial engineering
    Sarah E Gilpin
    Division of Thoracic Surgery, Department of Surgery, Massachusetts General Hospital, United States Harvard Medical School, United States Center for Regenerative Medicine, Massachusetts General Hospital, United States
    Biomaterials 108:111-9. 2016
  6. pmc Bioengineering Human Myocardium on Native Extracellular Matrix
    Jacques P Guyette
    From the Center for Regenerative Medicine J P G, J M C, B J J, P T M, S E G, T O, G G, H C O, Cardiovascular Research Center R W M, D J M, Division of Cardiology D J M, and Division of Thoracic Surgery, Department of Surgery H C O, Massachusetts General Hospital, Boston, MA Harvard Medical School, Boston, MA J P G, B J J, P T M, S E G, G G, H C O Department of Biomedical Engineering, Worcester Polytechnic Institute, Worcester, MA J R G, G R G and Harvard Stem Cell Institute, Cambridge, MA H C O
    Circ Res 118:56-72. 2016
  7. doi request reprint Bioengineering Human Lung Grafts on Porcine Matrix
    Haiyang Zhou
    Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA Harvard Medical School, Boston, MA Division of Thoracic Surgery, Department of Surgery, Massachusetts General Hospital, Boston, MA Harvard Stem Cell Institute, Boston, MA Department of Surgery, Changzheng Hospital, Shanghai, China Department of Biomedical Engineering, Tufts University, Medford, MA
    Ann Surg . 2017
  8. doi request reprint Engineering pulmonary vasculature in decellularized rat and human lungs
    Xi Ren
    Center for Regenerative Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA
    Nat Biotechnol 33:1097-102. 2015
  9. pmc Human lung cancer cells grown on acellular rat lung matrix create perfusable tumor nodules
    Dhruva K Mishra
    Department of Surgery, The Methodist Hospital Research Institute, Houston, Texas, USA
    Ann Thorac Surg 93:1075-81. 2012
  10. pmc Enhanced lung epithelial specification of human induced pluripotent stem cells on decellularized lung matrix
    Sarah E Gilpin
    Department of Surgery, Massachusetts General Hospital, and Harvard Medical School, Boston, Massachusetts
    Ann Thorac Surg 98:1721-9; discussion 1729. 2014

Collaborators

Detail Information

Publications24

  1. doi request reprint Regeneration and orthotopic transplantation of a bioartificial lung
    Harald C Ott
    Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Nat Med 16:927-33. 2010
    ..After transplantation, constructs were perfused by the recipient's circulation and ventilated by means of the recipient's airway and respiratory muscles, and they provided gas exchange in vivo for up to 6 h after extubation...
  2. ncbi request reprint Invited commentary
    Harald C Ott
    Department of Surgery, Massachusetts General Hospital, Harvard Medical School, 55 Fruit St, GRB425, Boston, MA 02114, USA
    Ann Thorac Surg 84:1727-8. 2007
  3. pmc Regeneration and experimental orthotopic transplantation of a bioengineered kidney
    Jeremy J Song
    Center for Regenerative Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA
    Nat Med 19:646-51. 2013
    ..When transplanted in an orthotopic position in rat, the grafts were perfused by the recipient's circulation and produced urine through the ureteral conduit in vivo...
  4. doi request reprint Enhanced in vivo function of bioartificial lungs in rats
    Jeremy J Song
    Division of Thoracic Surgery, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Ann Thorac Surg 92:998-1005; discussion 1005-6. 2011
    ....
  5. pmc Regenerative potential of human airway stem cells in lung epithelial engineering
    Sarah E Gilpin
    Division of Thoracic Surgery, Department of Surgery, Massachusetts General Hospital, United States Harvard Medical School, United States Center for Regenerative Medicine, Massachusetts General Hospital, United States
    Biomaterials 108:111-9. 2016
    ..We anticipate these advances to have clinically relevant implications for whole lung bioengineering and ex vivo organ repair. ..
  6. pmc Bioengineering Human Myocardium on Native Extracellular Matrix
    Jacques P Guyette
    From the Center for Regenerative Medicine J P G, J M C, B J J, P T M, S E G, T O, G G, H C O, Cardiovascular Research Center R W M, D J M, Division of Cardiology D J M, and Division of Thoracic Surgery, Department of Surgery H C O, Massachusetts General Hospital, Boston, MA Harvard Medical School, Boston, MA J P G, B J J, P T M, S E G, G G, H C O Department of Biomedical Engineering, Worcester Polytechnic Institute, Worcester, MA J R G, G R G and Harvard Stem Cell Institute, Cambridge, MA H C O
    Circ Res 118:56-72. 2016
    ..As a theoretical alternative to allotransplantation, patient-derived bioartificial myocardium could provide functional support and ultimately impact the treatment of heart failure...
  7. doi request reprint Bioengineering Human Lung Grafts on Porcine Matrix
    Haiyang Zhou
    Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA Harvard Medical School, Boston, MA Division of Thoracic Surgery, Department of Surgery, Massachusetts General Hospital, Boston, MA Harvard Stem Cell Institute, Boston, MA Department of Surgery, Changzheng Hospital, Shanghai, China Department of Biomedical Engineering, Tufts University, Medford, MA
    Ann Surg . 2017
    ..Bioengineering of viable, functional, and implantable human lung grafts on porcine matrix...
  8. doi request reprint Engineering pulmonary vasculature in decellularized rat and human lungs
    Xi Ren
    Center for Regenerative Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA
    Nat Biotechnol 33:1097-102. 2015
    ..Finally, we scaled our approach to the human lung lobe and achieved efficient cell delivery, maintenance of cell viability and establishment of perfusable vascular lumens. ..
  9. pmc Human lung cancer cells grown on acellular rat lung matrix create perfusable tumor nodules
    Dhruva K Mishra
    Department of Surgery, The Methodist Hospital Research Institute, Houston, Texas, USA
    Ann Thorac Surg 93:1075-81. 2012
    ..Whether human lung cancer cells grown in a decellularized rat lung matrix would create perfusable human lung cancer nodules was tested...
  10. pmc Enhanced lung epithelial specification of human induced pluripotent stem cells on decellularized lung matrix
    Sarah E Gilpin
    Department of Surgery, Massachusetts General Hospital, and Harvard Medical School, Boston, Massachusetts
    Ann Thorac Surg 98:1721-9; discussion 1729. 2014
    ..This study evaluated the capacity of acellular lung scaffolds to support recellularization with lung progenitors derived from human induced pluripotent stem cells (iPSCs)...
  11. doi request reprint Organ engineering based on decellularized matrix scaffolds
    Jeremy J Song
    Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Trends Mol Med 17:424-32. 2011
    ..This review summarizes achievements to date and discusses the role of native ECM scaffolds in organ regeneration...
  12. pmc Design and validation of a clinical-scale bioreactor for long-term isolated lung culture
    Jonathan M Charest
    Thoracic Surgery, Massachusetts General Hospital, USA
    Biomaterials 52:79-87. 2015
    ..Creation of this stable, biomimetic long-term culture environment will enable advanced interventions in both donor lungs and engineered grafts of human scale...
  13. doi request reprint Assessment of Proliferation and Cytotoxicity in a Biomimetic Three-Dimensional Model of Lung Cancer
    Luis F Tapias
    Division of Thoracic Surgery, Massachusetts General Hospital, Boston, Massachusetts Center for Regenerative Medicine, Massachusetts General Hospital, Boston, Massachusetts Harvard Medical School, Boston, Massachusetts
    Ann Thorac Surg 100:414-21. 2015
    ..However, there are no reproducible assays capable of directly monitoring processes involved in cancer progression within such scaffolds...
  14. doi request reprint Bioengineering Lungs for Transplantation
    Sarah E Gilpin
    Department of Surgery, Massachusetts General Hospital, Boston, MA 02114, USA Harvard Medical School, Boston, MA 02115, USA
    Thorac Surg Clin 26:163-71. 2016
    ..Repopulating the native lung matrix with sufficient cell numbers in appropriate anatomic locations is required to enable organ function. ..
  15. doi request reprint Idiopathic Subglottic Stenosis: Factors Affecting Outcome After Single-Stage Repair
    Haifeng Wang
    Massachusetts General Hospital, Boston, Massachusetts Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China
    Ann Thorac Surg 100:1804-11. 2015
    ..We have treated 263 patients (only 2 were male) with this condition. The purpose of this study is to determine factors affecting outcome and predisposing to complications...
  16. doi request reprint Perfusion-decellularized matrix: using nature's platform to engineer a bioartificial heart
    Harald C Ott
    Department of Surgery, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Boston, Massachusetts 02114, USA
    Nat Med 14:213-21. 2008
    ..By day 8, under physiological load and electrical stimulation, constructs could generate pump function (equivalent to about 2% of adult or 25% of 16-week fetal heart function) in a modified working heart preparation...
  17. doi request reprint Perfusion decellularization of whole organs
    Jacques P Guyette
    1 Center for Regenerative Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA 2 Harvard Medical School, Boston, Massachusetts, USA 3
    Nat Protoc 9:1451-68. 2014
    ....
  18. pmc Decellularized scaffolds as a platform for bioengineered organs
    Luis F Tapias
    aDivision of Thoracic Surgery, Department of Surgery, Massachusetts General Hospital bHarvard Medical School cCenter for Regenerative Medicine, Massachusetts General Hospital dHarvard Stem Cell Institute, Boston, Massachusetts, USA
    Curr Opin Organ Transplant 19:145-52. 2014
    ..Recent progress in the field of organ bioengineering based on decellularized organ scaffolds and patient-derived cells holds great promise to address these issues...
  19. doi request reprint Complications Following Carinal Resections and Sleeve Resections
    Luis F Tapias
    Division of Thoracic Surgery, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Blake 15, Boston, MA 02114, USA
    Thorac Surg Clin 25:435-47. 2015
    ..In this article, we focus on the technical details of the procedures, how to avoid complications and most importantly how to manage complications when they occur. ..
  20. pmc Engineered composite tissue as a bioartificial limb graft
    Bernhard J Jank
    Center for Regenerative Medicine, Massachusetts General Hospital, USA Harvard Medical School, Boston, MA, USA
    Biomaterials 61:246-56. 2015
    ..After confirmation of composite tissue formation, we transplanted the resulting bio-composite grafts to confirm perfusion in vivo. ..
  21. doi request reprint Using nature's platform to engineer bio-artificial lungs
    Sarah E Gilpin
    1 Division of Thoracic Surgery, Department of Surgery, Massachusetts General Hospital
    Ann Am Thorac Soc 12:S45-9. 2015
    ..Although substantial progress has been made, we are only beginning to grasp the complexity of this exciting new technology. ..
  22. pmc A quality improvement study on avoidable stressors and countermeasures affecting surgical motor performance and learning
    Claudius Conrad
    Harvard Medical School, Massachusetts General Hospital, Department of Surgery, Boston, MA 02114, USA
    Ann Surg 255:1190-4. 2012
    ..To explore how the 2 most important components of surgical performance--speed and accuracy-are influenced by different forms of stress and what the impact of music is on these factors...
  23. doi request reprint Pulmonary resection of metastatic sarcoma: prognostic factors associated with improved outcomes
    Samuel Kim
    Division of Thoracic Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Ann Thorac Surg 92:1780-6; discussion 1786-7. 2011
    ..There are few data to predict the benefit of pulmonary metastasectomy in patients with extrathoracic sarcoma. This study analyzes prognostic factors associated with improved outcomes...
  24. doi request reprint Multipotent mesenchymal stem cells acquire a lymphendothelial phenotype and enhance lymphatic regeneration in vivo
    Claudius Conrad
    Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Circulation 119:281-9. 2009
    ..We evaluated the potential of human and murine mesenchymal stem cells (MSCs) to acquire a lymphatic phenotype in vitro and to enhance lymphatic regeneration in vivo...