Bradley D Olsen

Summary

Affiliation: Massachusetts Institute of Technology
Country: USA

Publications

  1. doi request reprint Complex coacervation of supercharged proteins with polyelectrolytes
    Allie C Obermeyer
    Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, USA
    Soft Matter 12:3570-81. 2016
  2. pmc Enhanced activity and stability of organophosphorus hydrolase via interaction with an amphiphilic polymer
    Minkyu Kim
    Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Chem Commun (Camb) 50:5345-8. 2014
  3. doi request reprint Coil fraction-dependent phase behaviour of a model globular protein-polymer diblock copolymer
    Carla S Thomas
    Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Soft Matter 10:3093-102. 2014
  4. doi request reprint Effect of small molecule osmolytes on the self-assembly and functionality of globular protein-polymer diblock copolymers
    Carla S Thomas
    Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States
    Biomacromolecules 14:3064-72. 2013
  5. doi request reprint Effect of ELP Sequence and Fusion Protein Design on Concentrated Solution Self-Assembly
    Guokui Qin
    Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States
    Biomacromolecules 17:928-34. 2016
  6. pmc Site-specific conjugation of RAFT polymers to proteins via expressed protein ligation
    Yan Xia
    Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA
    Chem Commun (Camb) 49:2566-8. 2013
  7. pmc Toughening of Thermoresponsive Arrested Networks of Elastin-Like Polypeptides To Engineer Cytocompatible Tissue Scaffolds
    Matthew J Glassman
    Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States
    Biomacromolecules 17:415-26. 2016
  8. pmc Thermoresponsive and Mechanical Properties of Poly(L-proline) Gels
    Manos Gkikas
    Department of Chemical Engineering and Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States
    Biomacromolecules 17:399-406. 2016
  9. doi request reprint The nature of protein interactions governing globular protein-polymer block copolymer self-assembly
    Christopher N Lam
    Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States
    Biomacromolecules 15:1248-58. 2014
  10. doi request reprint Kinetic Effects on Self-Assembly and Function of Protein-Polymer Bioconjugates in Thin Films Prepared by Flow Coating
    Dongsook Chang
    Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Ave, Cambridge, MA, 02142, USA
    Macromol Rapid Commun 38:. 2017

Collaborators

  • Ali Khademhosseini
  • Yan Xia
  • Carla S Thomas
  • Aaron Huang
  • Carolyn E Mills
  • Reginald K Avery
  • Christopher N Lam
  • Xue Hui Dong
  • Allie C Obermeyer
  • Dongsook Chang
  • Guokui Qin
  • Manos Gkikas
  • Muzhou Wang
  • Shengchang Tang
  • Minkyu Kim
  • Zheng Jun Li
  • Matthew J Glassman
  • Yin Fan
  • Liza Xu
  • Hassan Albadawi
  • Weichao Shi
  • Jeremy Walker
  • Rahmi Oklu
  • Paola M Perez
  • Yu Shrike Zhang
  • Romeo J Flores
  • Gregory Stephanopoulos
  • Helen Yao
  • Michael J Duggan
  • Haoran Zhang
  • Xuehui Dong
  • Kangjian Qiao
  • Allie Obermeyer
  • Mohsen Akbari
  • Dushyant V Sahani
  • Brian Pereira
  • Alexei E Likhtman
  • Chimdimma U Okwara
  • Nisaraporn Suthiwangcharoen
  • Gabriel E Sanoja
  • Edwin L Thomas
  • Jeon Woong Kang
  • Ramanathan Nagarajan

Detail Information

Publications21

  1. doi request reprint Complex coacervation of supercharged proteins with polyelectrolytes
    Allie C Obermeyer
    Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, USA
    Soft Matter 12:3570-81. 2016
    ..The stability of the coacervate phase in both the bulk and micelles improved to increased ionic strength as the net charge on the protein increased. The micelles were also stable to dehydration and elevated temperatures. ..
  2. pmc Enhanced activity and stability of organophosphorus hydrolase via interaction with an amphiphilic polymer
    Minkyu Kim
    Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Chem Commun (Camb) 50:5345-8. 2014
    ..This strategy provides an efficient route to new formulations for decontaminating organophosphate neurotoxins. ..
  3. doi request reprint Coil fraction-dependent phase behaviour of a model globular protein-polymer diblock copolymer
    Carla S Thomas
    Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Soft Matter 10:3093-102. 2014
    ....
  4. doi request reprint Effect of small molecule osmolytes on the self-assembly and functionality of globular protein-polymer diblock copolymers
    Carla S Thomas
    Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States
    Biomacromolecules 14:3064-72. 2013
    ..In contrast, trehalose is observed to macrophase separate from the block copolymer, which results in nanodomains becoming more disordered without changing significantly in size. ..
  5. doi request reprint Effect of ELP Sequence and Fusion Protein Design on Concentrated Solution Self-Assembly
    Guokui Qin
    Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States
    Biomacromolecules 17:928-34. 2016
    ..These results indicate that for a sufficiently hydrophobic and high molar mass ELP block, there is a great deal of design latitude in the construction of fusion protein block copolymers for self-assembling nanomaterials. ..
  6. pmc Site-specific conjugation of RAFT polymers to proteins via expressed protein ligation
    Yan Xia
    Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA
    Chem Commun (Camb) 49:2566-8. 2013
    ..Site-specific protein conjugates with RAFT polymers were synthesized using expressed protein ligation. Stable micelles were formed from both linear block copolymer and Y-shaped conjugates...
  7. pmc Toughening of Thermoresponsive Arrested Networks of Elastin-Like Polypeptides To Engineer Cytocompatible Tissue Scaffolds
    Matthew J Glassman
    Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States
    Biomacromolecules 17:415-26. 2016
    ....
  8. pmc Thermoresponsive and Mechanical Properties of Poly(L-proline) Gels
    Manos Gkikas
    Department of Chemical Engineering and Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States
    Biomacromolecules 17:399-406. 2016
    ....
  9. doi request reprint The nature of protein interactions governing globular protein-polymer block copolymer self-assembly
    Christopher N Lam
    Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States
    Biomacromolecules 15:1248-58. 2014
    ....
  10. doi request reprint Kinetic Effects on Self-Assembly and Function of Protein-Polymer Bioconjugates in Thin Films Prepared by Flow Coating
    Dongsook Chang
    Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Ave, Cambridge, MA, 02142, USA
    Macromol Rapid Commun 38:. 2017
    ..Fluorescence emission spectra of mCherry in films prepared at <25% relative humidity shows a small shift suggesting that proteins are more perturbed at low humidity than high humidity or the solution state...
  11. ncbi request reprint An injectable shear-thinning biomaterial for endovascular embolization
    Reginald K Avery
    Biomaterials Innovation Research Center, Department of Medicine, Division of Engineering in Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02139, USA
    Sci Transl Med 8:365ra156. 2016
    ....
  12. doi request reprint Three-Dimensional Ordered Antibody Arrays Through Self-Assembly of Antibody-Polymer Conjugates
    Xue Hui Dong
    Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA
    Angew Chem Int Ed Engl 56:1273-1277. 2017
    ..The nanostructure not only improves the packing density and the proper orientation of the IgG, but also provides nanochannels to facilitate substrate transport...
  13. doi request reprint Responsive block copolymer photonics triggered by protein-polyelectrolyte coacervation
    Yin Fan
    Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States
    ACS Nano 8:11467-73. 2014
    ..The results demonstrate that the BCP gels and their photonic effect provide a robust and visually interpretable method to differentiate different proteins. ..
  14. pmc Kinetically controlled nanostructure formation in self-assembled globular protein-polymer diblock copolymers
    Carla S Thomas
    Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA
    Biomacromolecules 13:2781-92. 2012
    ....
  15. doi request reprint Self-Assembly of Differently Shaped Protein-Polymer Conjugates through Modification of the Bioconjugation Site
    Aaron Huang
    Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, MA, 02139, USA
    Macromol Rapid Commun 37:1268-74. 2016
    ..Differences in domain spacing also suggest changes in protein orientation within the lamellae. ..
  16. doi request reprint The Effect of Protein Electrostatic Interactions on Globular Protein-Polymer Block Copolymer Self-Assembly
    Christopher N Lam
    Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States
    Biomacromolecules 17:2820-9. 2016
    ..Therefore, varying protein charge and electrostatics is demonstrated as a method of tuning the magnitude and directionality of protein-protein interactions to control self-assembly. ..
  17. ncbi request reprint Complex Coacervate Core Micelles for the Dispersion and Stabilization of Organophosphate Hydrolase in Organic Solvents
    Carolyn E Mills
    Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts02139, United States
    Langmuir 32:13367-13376. 2016
    ..While OPH alone retained less than 5% of its activity after this incubation in both solvents, OPH in C3Ms retained 35 ± 3% of its activity in DMMP and 26 ± 1% of its activity in ethanol...
  18. doi request reprint Crossover between activated reptation and arm retraction mechanisms in entangled rod-coil block copolymers
    Muzhou Wang
    Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    J Chem Phys 143:184904. 2015
    ....
  19. doi request reprint Anomalous self-diffusion and sticky Rouse dynamics in associative protein hydrogels
    Shengchang Tang
    Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States
    J Am Chem Soc 137:3946-57. 2015
    ....
  20. doi request reprint Biosynthesis of poly(glycolate-co-lactate-co-3-hydroxybutyrate) from glucose by metabolically engineered Escherichia coli
    Zheng Jun Li
    Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, United States Beijing Key Laboratory of Bioprocess, College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China
    Metab Eng 35:1-8. 2016
    ..This is the first study reporting efficient microbial production of poly(glycolate-co-lactate-co-3-hydroxybutyrate) from glucose. ..
  21. doi request reprint Highly Active Biocatalytic Coatings from Protein-Polymer Diblock Copolymers
    Aaron Huang
    Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States
    ACS Appl Mater Interfaces 7:14660-9. 2015
    ....