Caroline C O'Brien

Summary

Affiliation: Massachusetts Institute of Technology
Country: USA

Publications

  1. pmc Vascular Response to Experimental Stent Malapposition and Under-Expansion
    Caroline C O'Brien
    Institute of Medical Engineering and Science, Massachusetts Institute of Technology, 77 Massachusetts Avenue, E25 449, Cambridge, MA, 02139, USA
    Ann Biomed Eng 44:2251-60. 2016
  2. pmc Impact of flow pulsatility on arterial drug distribution in stent-based therapy
    Caroline C O'Brien
    Graduate School of Biomedical Engineering, University of New South Wales, Sydney, Australia
    J Control Release 168:115-24. 2013
  3. pmc Constraining OCT with Knowledge of Device Design Enables High Accuracy Hemodynamic Assessment of Endovascular Implants
    Caroline C O'Brien
    Institute of Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, United States of America
    PLoS ONE 11:e0149178. 2016
  4. doi request reprint Analysis of drug distribution from a simulated drug-eluting stent strut using an in vitro framework
    Caroline C O'Brien
    Graduate School of Biomedical Engineering, University of New South Wales, Sydney, NSW, Australia
    Ann Biomed Eng 40:2687-96. 2012
  5. pmc Enhancing physiologic simulations using supervised learning on coarse mesh solutions
    Kumaran Kolandaivelu
    Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA Cardiovascular Division, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
    J R Soc Interface 12:20141073. 2015
  6. pmc The Impact of Blood Rheology on Drug Transport in Stented Arteries: Steady Simulations
    Pujith R S Vijayaratnam
    School of Mechanical and Manufacturing Engineering, The University of New South Wales, Sydney, New South Wales, Australia
    PLoS ONE 10:e0128178. 2015
  7. ncbi request reprint Pulsatility and high shear stress deteriorate barrier phenotype in brain microvascular endothelium
    Fernando Garcia-Polite
    Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, USA IQS School of Engineering, Universitat Ramon Llull, Barcelona, Spain
    J Cereb Blood Flow Metab . 2016
  8. doi request reprint Development of an in vitro method for modeling drug release and subsequent tissue drug uptake and deposition in a pulsatile flow network
    Caroline C O'Brien
    Graduate School of Biomedical Engineering, The University of New South Wales, Sydney, UNSW, Australia 2052
    Conf Proc IEEE Eng Med Biol Soc 2011:3262-5. 2011

Collaborators

  • Vijaya B Kolachalama
  • Kumaran Kolandaivelu
  • Fernando Garcia-Polite
  • Elazer R Edelman
  • Pujith R S Vijayaratnam
  • Jordi Martorell
  • Angel Ois
  • Jaume Roquer
  • Pedro Melgar-Lesmes
  • Alessandro Principe
  • Paula Del Rey-Puech
  • Mercedes Balcells
  • John A Reizes
  • Tracie J Barber

Detail Information

Publications8

  1. pmc Vascular Response to Experimental Stent Malapposition and Under-Expansion
    Caroline C O'Brien
    Institute of Medical Engineering and Science, Massachusetts Institute of Technology, 77 Massachusetts Avenue, E25 449, Cambridge, MA, 02139, USA
    Ann Biomed Eng 44:2251-60. 2016
    ..Malapposition as a result of stent under-expansion is resolved acutely in healthy normal arteries, suggesting existing animal models are limited in replicating clinically observed persistent stent malapposition. ..
  2. pmc Impact of flow pulsatility on arterial drug distribution in stent-based therapy
    Caroline C O'Brien
    Graduate School of Biomedical Engineering, University of New South Wales, Sydney, Australia
    J Control Release 168:115-24. 2013
    ..Our results indicate that factors governing pulsatile luminal flow on arterial drug deposition should be carefully considered in conjunction with device deployment settings for better utilization of drug-eluting stent therapy...
  3. pmc Constraining OCT with Knowledge of Device Design Enables High Accuracy Hemodynamic Assessment of Endovascular Implants
    Caroline C O'Brien
    Institute of Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, United States of America
    PLoS ONE 11:e0149178. 2016
    ..In a porcine coronary stent model, we demonstrate enhanced OCT reconstruction with preservation of between-frame features through fusion with angiography and a priori knowledge of stent design...
  4. doi request reprint Analysis of drug distribution from a simulated drug-eluting stent strut using an in vitro framework
    Caroline C O'Brien
    Graduate School of Biomedical Engineering, University of New South Wales, Sydney, NSW, Australia
    Ann Biomed Eng 40:2687-96. 2012
    ..Results confirm the existence of inhomogeneous and asymmetric arterial drug distributions, with this distribution shown to be sensitive to the flow field surrounding the strut...
  5. pmc Enhancing physiologic simulations using supervised learning on coarse mesh solutions
    Kumaran Kolandaivelu
    Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA Cardiovascular Division, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
    J R Soc Interface 12:20141073. 2015
    ....
  6. pmc The Impact of Blood Rheology on Drug Transport in Stented Arteries: Steady Simulations
    Pujith R S Vijayaratnam
    School of Mechanical and Manufacturing Engineering, The University of New South Wales, Sydney, New South Wales, Australia
    PLoS ONE 10:e0128178. 2015
    ..The impact of these rheological models was elucidated through comparisons of haemodynamic flow details and drug transport behaviour at various blood flow rates...
  7. ncbi request reprint Pulsatility and high shear stress deteriorate barrier phenotype in brain microvascular endothelium
    Fernando Garcia-Polite
    Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, USA IQS School of Engineering, Universitat Ramon Llull, Barcelona, Spain
    J Cereb Blood Flow Metab . 2016
    ..This decrease was lost under high shear and pulsatile flow. In conclusion, abnormal shear stress inherent to systemic vascular disease leads to barrier impairment, which could be reverted by hemodynamic interventions...
  8. doi request reprint Development of an in vitro method for modeling drug release and subsequent tissue drug uptake and deposition in a pulsatile flow network
    Caroline C O'Brien
    Graduate School of Biomedical Engineering, The University of New South Wales, Sydney, UNSW, Australia 2052
    Conf Proc IEEE Eng Med Biol Soc 2011:3262-5. 2011
    ..Furthermore, these results showed that the novel method could be used to study the effects of luminal flow in the presence of single or multiple struts. The method could also be used to explore more complex drug release strategies...