Emiko Mizoguchi

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. ncbi A unique seroepidemiological pattern of HBV, HCV and HTLV-I in Nenets and Komi in northwestern Russia
    Liliya K Dobrodeeva
    Department of Ecological Immunology, Institute of Adaptations of Physiology to Environment, the Ural Branch of the Russian Academy of Sciences, Arkhangelsk, Russia
    Asian Pac J Cancer Prev 6:342-5. 2005
  2. pmc Potential association between TLR4 and chitinase 3-like 1 (CHI3L1/YKL-40) signaling on colonic epithelial cells in inflammatory bowel disease and colitis-associated cancer
    A Kamba
    Gastrointestinal Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Curr Mol Med 13:1110-21. 2013
  3. doi TNF receptor type I-dependent activation of innate responses to reduce intestinal damage-associated mortality
    Emiko Mizoguchi
    Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Gastroenterology 134:470-80. 2008
  4. ncbi Colonic epithelial functional phenotype varies with type and phase of experimental colitis
    Emiko Mizoguchi
    Center for the Study of Inflammatory Bowel Diseases and Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, USA
    Gastroenterology 125:148-61. 2003
  5. pmc Lymphocyte-dependent and Th2 cytokine-associated colitis in mice deficient in Wiskott-Aldrich syndrome protein
    Deanna D Nguyen
    Gastrointestinal Unit, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Gastroenterology 133:1188-97. 2007
  6. pmc Dependence of intestinal granuloma formation on unique myeloid DC-like cells
    Atsushi Mizoguchi
    Department of Pathology Service, Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    J Clin Invest 117:605-15. 2007
  7. doi Regulatory role of B-1 B cells in chronic colitis
    Yasuyo Shimomura
    Experimental Pathology, Massachusetts General Hospital, Boston, MA 02114, USA
    Int Immunol 20:729-37. 2008
  8. pmc Chitin microparticles for the control of intestinal inflammation
    Katsuya Nagatani
    Gastrointestinal Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Inflamm Bowel Dis 18:1698-710. 2012
  9. pmc Inducible colitis-associated glycome capable of stimulating the proliferation of memory CD4+ T cells
    Atsushi Nishida
    Molecular Pathology Unit, Massachusetts General Hospital, Boston, MA 02114, USA
    J Exp Med 209:2383-94. 2012
  10. pmc A unique B2 B cell subset in the intestine
    Yasuyo Shimomura
    Experimental Pathology Unit, Massachusetts General Hospital, Boston, MA 02114, USA
    J Exp Med 205:1343-55. 2008

Research Grants

  1. TNF Receptors of Colonic Epithelial Cells in IBD
    Emiko Mizoguchi; Fiscal Year: 2007
  2. Regulatory Role of TNFR1 in Inflammatory Bowel Disease
    Emiko Mizoguchi; Fiscal Year: 2007

Detail Information

Publications58

  1. ncbi A unique seroepidemiological pattern of HBV, HCV and HTLV-I in Nenets and Komi in northwestern Russia
    Liliya K Dobrodeeva
    Department of Ecological Immunology, Institute of Adaptations of Physiology to Environment, the Ural Branch of the Russian Academy of Sciences, Arkhangelsk, Russia
    Asian Pac J Cancer Prev 6:342-5. 2005
    ..We conclude that HBV is prevalent with unique serological patterns among the Nenets, while HCV and HTLV-I infections are negligible...
  2. pmc Potential association between TLR4 and chitinase 3-like 1 (CHI3L1/YKL-40) signaling on colonic epithelial cells in inflammatory bowel disease and colitis-associated cancer
    A Kamba
    Gastrointestinal Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Curr Mol Med 13:1110-21. 2013
    ..In this review article, we have concisely summarized the cellular and molecular mechanisms underlining the development of IBD and colitis-associated cancer, with particular focus on the TLR4- and CHI3L1-signaling pathways in CECs. ..
  3. doi TNF receptor type I-dependent activation of innate responses to reduce intestinal damage-associated mortality
    Emiko Mizoguchi
    Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Gastroenterology 134:470-80. 2008
    ..However, it remains unclear which cell types activated through TNFR-associated signaling cascades are involved in the pathogenesis of colitis...
  4. ncbi Colonic epithelial functional phenotype varies with type and phase of experimental colitis
    Emiko Mizoguchi
    Center for the Study of Inflammatory Bowel Diseases and Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, USA
    Gastroenterology 125:148-61. 2003
    ..Colonic crypt elongation occurs during both chronic colitis and in the recovery phase of acute colitis. The impact of these alterations on epithelial cell functions is not fully defined...
  5. pmc Lymphocyte-dependent and Th2 cytokine-associated colitis in mice deficient in Wiskott-Aldrich syndrome protein
    Deanna D Nguyen
    Gastrointestinal Unit, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Gastroenterology 133:1188-97. 2007
    ..Wiskott-Aldrich syndrome protein (WASP) deficiency in mice results in similar clinical features. Herein, we characterized the colitis in WASP-deficient mice...
  6. pmc Dependence of intestinal granuloma formation on unique myeloid DC-like cells
    Atsushi Mizoguchi
    Department of Pathology Service, Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    J Clin Invest 117:605-15. 2007
    ....
  7. doi Regulatory role of B-1 B cells in chronic colitis
    Yasuyo Shimomura
    Experimental Pathology, Massachusetts General Hospital, Boston, MA 02114, USA
    Int Immunol 20:729-37. 2008
    ..We conclude that B-1 cells play a regulatory role in T(h)2-mediated colitis under non-hygienic conditions, possibly by generating natural antibodies in response to microbial flora...
  8. pmc Chitin microparticles for the control of intestinal inflammation
    Katsuya Nagatani
    Gastrointestinal Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Inflamm Bowel Dis 18:1698-710. 2012
    ..Chitin is a polymer of N-acetylglucosamine with the ability to regulate innate and adaptive immune responses. However, the detailed mechanisms of chitin-mediated regulation of intestinal inflammation are only partially known...
  9. pmc Inducible colitis-associated glycome capable of stimulating the proliferation of memory CD4+ T cells
    Atsushi Nishida
    Molecular Pathology Unit, Massachusetts General Hospital, Boston, MA 02114, USA
    J Exp Med 209:2383-94. 2012
    ..Therefore, the CAG may be an attractive therapeutic target to specifically suppress the expansion of effector memory CD4+ T cells in intestinal inflammation such as that seen in inflammatory bowel disease...
  10. pmc A unique B2 B cell subset in the intestine
    Yasuyo Shimomura
    Experimental Pathology Unit, Massachusetts General Hospital, Boston, MA 02114, USA
    J Exp Med 205:1343-55. 2008
    ..These results describe the existence of an alternative pathway of B cell maturation in the periphery that gives rise to a tissue-specific B cell subset...
  11. ncbi Colitis is associated with thymic destruction attenuating CD4+25+ regulatory T cells in the periphery
    William A Faubion
    Division of Immunology, Beth Israel Deaconess Medical Center, 330 Brookline Avenue RE 204, Boston, MA 02215, USA
    Gastroenterology 126:1759-70. 2004
    ..The aim of this study is to test the hypothesis that treatment of colitis restores thymic capability to generate regulatory T cells (CD4+25+ T(R) cells)...
  12. pmc The membrane-bound mucin Muc1 regulates T helper 17-cell responses and colitis in mice
    Atsushi Nishida
    Molecular Pathology Unit, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
    Gastroenterology 142:865-874.e2. 2012
    ..The gene MUC1 has been associated with susceptibility to inflammatory bowel disease; we investigated the role of Muc1 in development of colitis in mice...
  13. doi Chitinase 3-like-1 enhances bacterial adhesion to colonic epithelial cells through the interaction with bacterial chitin-binding protein
    Mayumi Kawada
    Gastrointestinal Unit, Department of Medicine, Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Lab Invest 88:883-95. 2008
    ..CBP21 and its homologs may be required for the CHI3L1-mediated enhancement of bacterial adhesion to CECs through the conserved amino-acid residues...
  14. ncbi Chronic intestinal inflammatory condition generates IL-10-producing regulatory B cell subset characterized by CD1d upregulation
    Atsushi Mizoguchi
    Immunopathology Unit, Department of Pathology, Massachusetts General Hospital, Boston, MA 02114, USA
    Immunity 16:219-30. 2002
    ..This study indicates that B cells, by producing cytokines such as IL-10, can act as regulatory cells in immunologically mediated inflammatory reactions...
  15. ncbi Induced reactivity of intestinal CD4(+) T cells with an epithelial cell lectin, galectin-4, contributes to exacerbation of intestinal inflammation
    Akira Hokama
    Department of Pathology, Massachussets General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Immunity 20:681-93. 2004
    ..These studies identify the presence of an immunogenic, endogenous lectin in the intestine and dissect the biological role of lectin/CD4(+) T cell interactions under inflammatory conditions...
  16. ncbi Human neonatal Fc receptor mediates transport of IgG into luminal secretions for delivery of antigens to mucosal dendritic cells
    Masaru Yoshida
    Gastroenterology Division, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Immunity 20:769-83. 2004
    ..These results explain how IgG is secreted onto mucosal surfaces and scavenges luminal antigens for recognition by the immune system...
  17. ncbi Role of tumor necrosis factor receptor 2 (TNFR2) in colonic epithelial hyperplasia and chronic intestinal inflammation in mice
    Emiko Mizoguchi
    Center for the Study of Inflammatory Bowel Disease, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
    Gastroenterology 122:134-44. 2002
    ..Tumor necrosis factor (TNF) induces multiple effects including cell proliferation and death by ligation with TNF receptor type II (TNFR2). We studied the role of TNFR2 in chronic inflammation-induced colonic epithelial alteration...
  18. pmc Impaired IgA class switching in APRIL-deficient mice
    Emanuela Castigli
    Division of Immunology, Children s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 101:3903-8. 2004
    ..APRIL by itself induced IgA as well as IgG1 isotype switching in CD40-deficient IgM(+)IgD(+) sorted B cells. These results suggest that APRIL down-regulates T cell-dependent antibody responses and promotes IgA class switching...
  19. pmc Toll-like receptor 4-mediated regulation of spontaneous Helicobacter-dependent colitis in IL-10-deficient mice
    Kabir S Matharu
    Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital, Boston, Massachusetts, USA
    Gastroenterology 137:1380-90.e1-3. 2009
    ..We investigated the role of the anti-inflammatory cytokine interleukin (IL)-10 in this signaling pathway using a mouse model of colitis...
  20. pmc IL-22 ameliorates intestinal inflammation in a mouse model of ulcerative colitis
    Ken Sugimoto
    Experimental Pathology Unit, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Clin Invest 118:534-44. 2008
    ..These data demonstrate what we believe to be a novel function for IL-22 in the intestine and suggest the potency of a local IL-22 gene-delivery system for treating UC...
  21. pmc Chitin-binding domains of Escherichia coli ChiA mediate interactions with intestinal epithelial cells in mice with colitis
    Daren Low
    Department of Medicine, Harvard Medical School, Boston, MA, USA
    Gastroenterology 145:602-12.e9. 2013
    ..We performed a structure-function analysis of the chitin-binding domains encoded by the chiA gene, which mediates the pathogenic effects of adherent invasive Escherichia coli (AIEC)...
  22. pmc Bone marrow stromal cell transplants prevent experimental enterocolitis and require host CD11b+ splenocytes
    Biju Parekkadan
    Center for Engineering in Medicine and Surgical Services, Massachusetts General Hospital, Harvard Medical School, and Shriners Hospitals for Children, Boston, Massachusetts 02114, USA
    Gastroenterology 140:966-75. 2011
    ..We investigated the effects of MSCs in mice with chemically induced colitis and determined the effects of CD11b(+) cells based on the hypothesis that MSCs increase numbers of regulatory T cells...
  23. pmc Neonatal Fc receptor for IgG regulates mucosal immune responses to luminal bacteria
    Masaru Yoshida
    Department of Medicine, Brigham and Women s Hospital, and Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, MA 02115, USA
    J Clin Invest 116:2142-2151. 2006
    ....
  24. ncbi Is the sugar always sweet in intestinal inflammation?
    Emiko Mizoguchi
    Center for the Study of Inflammatory Bowel Disease, Gastrointestinal Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Immunol Res 37:47-60. 2007
    ..CHI3L1 enhances the host/microbial interaction that leads to the exacerbation of intestinal inflammation. In this review, we discuss a novel aspect of lectin/carbohydrate interactions in intestinal inflammation...
  25. pmc Chitinase 3-like-1 expression in colonic epithelial cells as a potentially novel marker for colitis-associated neoplasia
    Chun Chuan Chen
    Gastrointestinal Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Am J Pathol 179:1494-503. 2011
    ..In summary, CHI3L1 may contribute to the proliferation, migration, and neoplastic progression of CECs under inflammatory conditions and could be a useful biomarker for neoplastic changes in patients with IBD...
  26. pmc Insights from advances in research of chemically induced experimental models of human inflammatory bowel disease
    Mayumi Kawada
    Department of Medicine, Massachusetts General Hospital, Harvard Medical School, MA 02114, USA
    World J Gastroenterol 13:5581-93. 2007
    ..We also summarize some regulatory and pathogenic factors demonstrated by these models that can, hopefully, be exploited to develop future therapeutic strategies against IBD...
  27. ncbi Chitinase 3-like-1 exacerbates intestinal inflammation by enhancing bacterial adhesion and invasion in colonic epithelial cells
    Emiko Mizoguchi
    Center for the Study of Inflammatory Bowel Disease, Gastroenterology Division, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, 02114, USA
    Gastroenterology 130:398-411. 2006
    ..However, molecular events leading to the dysregulation have not yet been defined fully. Studies were designed to characterize a key molecule that is involved in the dysregulation...
  28. pmc Glucocorticoid-induced TNF receptor family-related protein ligand regulates the migration of monocytes to the inflamed intestine
    Gongxian Liao
    1Division of Immunology, Beth Israel Deaconess Medical Center, Harvard Medical School, 3 Blackfan Circle, CLS 928, Boston, MA 02115, USA G L
    FASEB J 28:474-84. 2014
    ..We conclude that GITR-L regulates the number of proinflammatory macrophages in sites of inflammation by controlling the egress of monocytes from the splenic reservoir...
  29. ncbi C4b-binding protein (C4BP) activates B cells through the CD40 receptor
    Scott R Brodeur
    Division of Immunology, Children s Hospital and Department of Pediatrics, Harvard Medical School, Boston, MA, USA
    Immunity 18:837-48. 2003
    ..Furthermore, C4BP colocalized with B cells in the germinal centers of human tonsils. These observations suggest that C4BP is an activating ligand for CD40 and establish a novel interface between complement and B cell activation...
  30. ncbi Blocking inducible co-stimulator in the absence of CD28 impairs Th1 and CD25+ regulatory T cells in murine colitis
    Ype P De Jong
    Division of Immunology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Int Immunol 16:205-13. 2004
    ....
  31. pmc p40phox expression regulates neutrophil recruitment and function during the resolution phase of intestinal inflammation
    Kara L Conway
    Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    J Immunol 189:3631-40. 2012
    ..We propose that p40(phox) deficiency enhances intestinal inflammation through the dysregulation of these two pathways in neutrophils...
  32. ncbi Epicutaneous sensitization with superantigen induces allergic skin inflammation
    Dhafer Laouini
    Division of Immunology, Children s Hospital, Harvard Medical School, Boston, Mass 02115, USA
    J Allergy Clin Immunol 112:981-7. 2003
    ..The skin of patients with AD is frequently colonized with enterotoxin-secreting strains of Staphylococcus aureus. Staphylococcal enterotoxins have been implicated in the exacerbations of the inflammatory skin lesions in patients with AD...
  33. ncbi Role of mammalian chitinases in inflammatory conditions
    Mayumi Kawada
    Gatrointestinal Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Keio J Med 56:21-7. 2007
    ....
  34. ncbi Role of the CD5 molecule on TCR gammadelta T cell-mediated immune functions: development of germinal centers and chronic intestinal inflammation
    Atsushi Mizoguchi
    Department of Pathology and Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital, Boston, MA 02114, USA
    Int Immunol 15:97-108. 2003
    ..The CD4(+) TCRgammadelta T cells possess immune functions similar to CD4(+) TCRalphabeta T cells...
  35. pmc Carbohydrate-binding motif in chitinase 3-like 1 (CHI3L1/YKL-40) specifically activates Akt signaling pathway in colonic epithelial cells
    Chun Chuan Chen
    Gastrointestinal Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Clin Immunol 140:268-75. 2011
    ..In conclusion, CBM region of CHI3L1 is critical in activating Akt signaling in CECs, and the activation may be associated with the development of chronic colitis...
  36. pmc MyD88-dependent TLR1/2 signals educate dendritic cells with gut-specific imprinting properties
    Sen Wang
    Gastrointestinal Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    J Immunol 187:141-50. 2011
    ..Thus, MyD88-dependent TLR2 signals are necessary and sufficient to educate DC with gut-specific imprinting properties and contribute in vivo to the generation of gut-tropic T cells...
  37. ncbi Immune networks in animal models of inflammatory bowel disease
    Atsushi Mizoguchi
    Department of Pathology, Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, U S A
    Inflamm Bowel Dis 9:246-59. 2003
    ..The study of these complicated immune networks provides the rationale for the development of new therapeutic interventions in inflammatory bowel disease...
  38. pmc Signaling lymphocyte activation molecule regulates development of colitis in mice
    Boaz van Driel
    Division of Immunology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
    Gastroenterology 143:1544-1554.e7. 2012
    ..Slamf1 regulates microbicidal mechanisms in macrophages, therefore we investigated whether the receptor affects development of colitis in mice...
  39. ncbi The binding site for TRAF2 and TRAF3 but not for TRAF6 is essential for CD40-mediated immunoglobulin class switching
    Haifa Jabara
    Division of Immunology, Children s Hospital and Department of Pediatrics, Harvard Medical School, Boston, MA, USA
    Immunity 17:265-76. 2002
    ..These results suggest that binding to TRAF2 and/or TRAF3 but not TRAF6 is essential for CD40 isotype switching and activation in B cells...
  40. pmc Chitinase 3-like 1 synergistically activates IL6-mediated STAT3 phosphorylation in intestinal epithelial cells in murine models of infectious colitis
    Hoa T Tran
    Gastrointestinal Unit and Center for the Study of Inflammatory Bowel Disease, Department of Medicine, Molecular Pathology Unit, Department of Pathology, and Division of Mucosal Immunology, Department of Pediatrics, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts and Section of Pulmonary and Critical Care Medicine, Department of Medicine, Yale University School of Medicine, New Haven, Connecticut
    Inflamm Bowel Dis 20:835-46. 2014
    ..Chitinase 3-like 1 (CHI3L1) is an inducible molecule on intestinal epithelial cells during the development of inflammatory bowel disease...
  41. pmc DNA methylation in inflammatory bowel disease and beyond
    Daren Low
    Gastrointestinal Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, United States
    World J Gastroenterol 19:5238-49. 2013
    ..In this review, we will discuss the recent advancement in understanding how DNA methylation alterations can contribute to the development of IBD...
  42. pmc Atg16l1 is required for autophagy in intestinal epithelial cells and protection of mice from Salmonella infection
    Kara L Conway
    Gastrointestinal Unit and Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts Center for Computational and Integrative Biology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts
    Gastroenterology 145:1347-57. 2013
    ..We investigated the role of autophagy in the response of intestinal epithelial and antigen-presenting cells to Salmonella infection in mice...
  43. pmc Intestinal alkaline phosphatase has beneficial effects in mouse models of chronic colitis
    Sundaram Ramasamy
    Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Inflamm Bowel Dis 17:532-42. 2011
    ....
  44. pmc Oral caffeine administration ameliorates acute colitis by suppressing chitinase 3-like 1 expression in intestinal epithelial cells
    In Ah Lee
    Gastrointestinal Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, GRJ 825D, 55 Fruit Street, Boston, MA, 02114, USA
    J Gastroenterol 49:1206-16. 2014
    ..Therefore, we test the hypothesis of inhibiting CHI3L1 using the pan-chitinase inhibitor caffeine to reduce the likelihood of early colitis onset...
  45. doi Inflammatory bowel disease, past, present and future: lessons from animal models
    Atsushi Mizoguchi
    Department of Pathology, Experimental Pathology, Simches 8234, Massachusetts General Hospital, 185 Cambridge Street, Boston, MA 02114, USA
    J Gastroenterol 43:1-17. 2008
    ....
  46. pmc Intestinal heat shock protein 110 regulates expression of CD1d on intestinal epithelial cells
    Sean P Colgan
    Center for Experimental Therapeutics, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Clin Invest 112:745-54. 2003
    ..These data support the presence of a novel autocrine pathway of CD1d regulation by Hsp110...
  47. pmc Current Understanding of Dysbiosis in Disease in Human and Animal Models
    Arianna K DeGruttola
    Gastrointestinal Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts Department of Immunology, Kurume University School of Medicine, Kurume, Fukuoka, Japan and Gastrointestinal Unit, Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts
    Inflamm Bowel Dis 22:1137-50. 2016
    ....
  48. doi Regulatory B cells in mouse models of intestinal inflammation
    Atsushi Nishida
    Molecular Pathology Unit, Massachusetts General Hospital, 149 CNY 6024, 13th Street, Charlestown, MA, 02114, USA
    Methods Mol Biol 1190:227-41. 2014
    ..Since some unique techniques are required to closely study the Breg in gut-associated lymphoid tissues (GALT), we herein describe how to induce colitis in mice and how to analyze the phenotype and function of GALT-specific Breg...
  49. pmc Novel methylxanthine derivative-mediated anti-inflammatory effects in inflammatory bowel disease
    In Ah Lee
    In Ah Lee, Alan Kamba, Daren Low, Emiko Mizoguchi, Gastrointestinal Unit, Department of Medicine, Harvard Medical School, Boston, MA 02114, United States
    World J Gastroenterol 20:1127-38. 2014
    ..We hope that this study will provide a rationale for the development of methylxanthine derivatives, in particular caffeine, -based anti-inflammatory therapeutics in the field of IBD and IBD-associated carcinogenesis...
  50. ncbi Essential role for Vav1 in activation, but not development, of gammadelta T cells
    Wojciech Swat
    The Center for Blood Research, Department of Pediatrics, The Children s Hospital, Boston, MA 02115, USA
    Int Immunol 15:215-21. 2003
    ..We propose that Vav1 has a unique and non-redundant role in the initiation of signaling downstream of the gammadelta TCR in lymphocytes...
  51. pmc Animal models of IBD: linkage to human disease
    Atsushi Mizoguchi
    Molecular Pathology Unit, Massachusetts General Hospital, Boston, MA, USA
    Curr Opin Pharmacol 10:578-87. 2010
    ..This review summarizes current information related to the function of IBD-associated genes as derived from genetically engineered mouse models...
  52. pmc Mechanistic roles of epithelial and immune cell signaling during the development of colitis-associated cancer
    Renuka Subramaniam
    Gastrointestinal Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    Cancer Res Front 2:1-21. 2016
    ..In depth understanding of these factors is necessary to develop novel anti-inflammatory and anti-cancer therapies for CAC in the near future...
  53. pmc Chitinase 3-like 1 induces survival and proliferation of intestinal epithelial cells during chronic inflammation and colitis-associated cancer by regulating S100A9
    Daren Low
    Gastrointestinal Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    Oncotarget 6:36535-50. 2015
    ....
  54. pmc Recent advancement in understanding colitis-associated tumorigenesis
    Daren Low
    Gastrointestinal Unit, Department of Medicine, Department of Pathology, and Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts
    Inflamm Bowel Dis 20:2115-23. 2014
    ....
  55. pmc Animal models of ulcerative colitis and their application in drug research
    Daren Low
    Gastrointestinal Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    Drug Des Devel Ther 7:1341-57. 2013
    ..Recent reports of the latest compounds, therapeutic strategies, and approaches tested on UC animal models are also discussed. ..
  56. pmc Cadherin-11 provides specific cellular adhesion between fibroblast-like synoviocytes
    Xavier Valencia
    Dept of Medicine, Div of Rheumatology, Immunology, and Allergy, Brigham and Women s Hospital, Smith Bldg, Rm 552, One Jimmy Fund Way, Boston, MA 02115, USA
    J Exp Med 200:1673-9. 2004
    ..These findings support a key role for cadherin-11 in the specific adhesion of FLS and in synovial tissue organization and behavior in health and RA...
  57. pmc Animal models of colitis-associated carcinogenesis
    Manasa Kanneganti
    Gastrointestinal Unit, Department of Medicine, Harvard Medical School, Massachusetts General Hospital GRJ702, 55 Fruit Street, Boston, MA 02114, USA
    J Biomed Biotechnol 2011:342637. 2011
    ..It may provide us some clues in developing a new class of therapeutic agents for the treatment of IBD and CAC in the near future...
  58. ncbi Mast cells regulate IFN-gamma expression in the skin and circulating IgE levels in allergen-induced skin inflammation
    Harri Alenius
    Division of Immunology, Children s Hospital, Harvard Medical School, Massachusetts General Hospital, 02115, USA
    J Allergy Clin Immunol 109:106-13. 2002
    ..Mast cells are important effector cells in IgE-mediated allergic reactions. They are present in normal skin and increased in skin lesions of patients with atopic dermatitis (AD)...

Research Grants2

  1. TNF Receptors of Colonic Epithelial Cells in IBD
    Emiko Mizoguchi; Fiscal Year: 2007
    ..Daniel K. Podolsky from the Division of Gastroenterology and by Dr. Atul K. Bhan from the Immunopathology Unit, both at Massachusetts General Hospital and Harvard Medical School. ..
  2. Regulatory Role of TNFR1 in Inflammatory Bowel Disease
    Emiko Mizoguchi; Fiscal Year: 2007
    ..We believe the data obtained from this study would provide an important rationale to develop new TNF related therapeutic approaches for human IBD. [unreadable] [unreadable] [unreadable]..