M Laposata

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. ncbi "Pre-pre" and "post-post" analytical error: high-incidence patient safety hazards involving the clinical laboratory
    Michael Laposata
    Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Clin Chem Lab Med 45:712-9. 2007
  2. ncbi Fatty acid ethyl esters: recent observations
    Michael Laposata
    Department of Pathology, Division of Laboratory Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Prostaglandins Leukot Essent Fatty Acids 67:193-6. 2002
  3. ncbi Physician survey of a laboratory medicine interpretive service and evaluation of the influence of interpretations on laboratory test ordering
    Martha E Laposata
    Massachusetts General Hospital, Boston, MA 02114, USA
    Arch Pathol Lab Med 128:1424-7. 2004
  4. pmc Rapid fatty acid ethyl ester synthesis by porcine myocardium upon ethanol infusion into the left anterior descending coronary artery
    Danita M Yoerger
    Division of Cardiology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Am J Pathol 168:1435-42. 2006
  5. ncbi Differences in the fatty acid composition of fatty acid ethyl esters in organs and their secretions
    M Laposata
    Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston 02114, USA
    Alcohol Clin Exp Res 24:1488-91. 2000
  6. ncbi Fatty acid ethyl esters: current facts and speculations
    M Laposata
    Division of Laboratory Medicine, Department of Pathology, Massachusetts General Hospital Harvard Medical School, Boston 02114, USA
    Prostaglandins Leukot Essent Fatty Acids 60:313-5. 1999
  7. ncbi Fatty acid ethyl esters in liver and adipose tissues as postmortem markers for ethanol intake
    R O Salem
    Division of Laboratory Medicine, Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Clin Chem 47:722-5. 2001
  8. ncbi Fatty acid ethyl esters: short-term and long-term serum markers of ethanol intake
    M Laposata
    Massachusetts General Hospital, Boston 02114, USA
    Clin Chem 43:1527-34. 1997
  9. ncbi Ethyl arachidonate is the predominant fatty acid ethyl ester in the brains of alcohol-intoxicated subjects at autopsy
    M A Refaai
    Division of Laboratory Medicine, Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Lipids 38:269-73. 2003
  10. ncbi The generation of narrative interpretations in laboratory medicine: a description of service-specific sign-out rounds
    A Kratz
    Department of Pathology, Massachusetts General Hospital, Boston 02114, USA
    Am J Clin Pathol 116:S133-40. 2001

Collaborators

Detail Information

Publications68

  1. ncbi "Pre-pre" and "post-post" analytical error: high-incidence patient safety hazards involving the clinical laboratory
    Michael Laposata
    Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Clin Chem Lab Med 45:712-9. 2007
    ....
  2. ncbi Fatty acid ethyl esters: recent observations
    Michael Laposata
    Department of Pathology, Division of Laboratory Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Prostaglandins Leukot Essent Fatty Acids 67:193-6. 2002
    ..The use of the serum ethyl oleate concentration may be helpful in differentiating binge drinkers from chronic alcoholics...
  3. ncbi Physician survey of a laboratory medicine interpretive service and evaluation of the influence of interpretations on laboratory test ordering
    Martha E Laposata
    Massachusetts General Hospital, Boston, MA 02114, USA
    Arch Pathol Lab Med 128:1424-7. 2004
    ..Complex coagulation test panels ordered by clinicians are typically reported to clinicians without a patient-specific interpretive paragraph...
  4. pmc Rapid fatty acid ethyl ester synthesis by porcine myocardium upon ethanol infusion into the left anterior descending coronary artery
    Danita M Yoerger
    Division of Cardiology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Am J Pathol 168:1435-42. 2006
    ..These data demonstrate that FAEEs may be mediators of ethanol-induced cardiotoxicity...
  5. ncbi Differences in the fatty acid composition of fatty acid ethyl esters in organs and their secretions
    M Laposata
    Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston 02114, USA
    Alcohol Clin Exp Res 24:1488-91. 2000
    ..This raised the possibility that there is some selectivity toward the fatty acid used for FAEE to be exported from the liver into the blood...
  6. ncbi Fatty acid ethyl esters: current facts and speculations
    M Laposata
    Division of Laboratory Medicine, Department of Pathology, Massachusetts General Hospital Harvard Medical School, Boston 02114, USA
    Prostaglandins Leukot Essent Fatty Acids 60:313-5. 1999
    ..A list of major unanswered questions in each of these categories is also included...
  7. ncbi Fatty acid ethyl esters in liver and adipose tissues as postmortem markers for ethanol intake
    R O Salem
    Division of Laboratory Medicine, Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Clin Chem 47:722-5. 2001
    ..CONCLUSIONS: For at least 12 h after death, FAEEs in liver and adipose tissues are useful postmortem markers of premortem ethanol ingestion...
  8. ncbi Fatty acid ethyl esters: short-term and long-term serum markers of ethanol intake
    M Laposata
    Massachusetts General Hospital, Boston 02114, USA
    Clin Chem 43:1527-34. 1997
    ..With the markers described in the review, algorithms to assess recent ethanol intake, chronic ethanol intake, and end organ damage are included to provide a practical approach to the evaluation of the patient...
  9. ncbi Ethyl arachidonate is the predominant fatty acid ethyl ester in the brains of alcohol-intoxicated subjects at autopsy
    M A Refaai
    Division of Laboratory Medicine, Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Lipids 38:269-73. 2003
    ..Since arachidonate is derived from linoleate, which is depleted in FAEE while arachidonate is enriched, the synthesis of FAEE may be linked to the desaturation and elongation of linoleate to arachidonate...
  10. ncbi The generation of narrative interpretations in laboratory medicine: a description of service-specific sign-out rounds
    A Kratz
    Department of Pathology, Massachusetts General Hospital, Boston 02114, USA
    Am J Clin Pathol 116:S133-40. 2001
    ..The information in this report should provide sufficient detail to allow development of interpretive services with successful billing for the areas in laboratory medicine described...
  11. ncbi Laboratory evaluation of hypercoagulability with venous or arterial thrombosis
    Elizabeth M Van Cott
    Department of Pathology, Massachusetts General Hospital, Boston 02114, USA
    Arch Pathol Lab Med 126:1281-95. 2002
    ..To provide recommendations for hypercoagulation testing for patients with venous, arterial, or neurovascular thrombosis, as reflected in the medical literature and the consensus opinion of recognized experts in the field...
  12. ncbi Assessment of the stability of dalteparin sodium in prepared syringes for up to thirty days: an in vitro study
    Michael Laposata
    Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Clin Ther 25:1219-25. 2003
    ....
  13. doi A double-blind dose-finding pilot study of docosahexaenoic acid (DHA) for major depressive disorder
    David Mischoulon
    Depression Clinical and Research Program, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, United States
    Eur Neuropsychopharmacol 18:639-45. 2008
    ..05). For completers and intent-to-treat subjects, plasma DHA increased significantly (p<0.05), EPA had little change (p>0.05), and n-6/n-3 decreased significantly (p<0.05). DHA may be effective for depression at lower doses...
  14. ncbi Fatty acid ethyl esters, nonoxidative ethanol metabolites, synthesis, uptake, and hydrolysis by human platelets
    Raneem O Salem
    Massachusetts General Hospital, Room 235 Gray Building, 55 Fruit Street, Boston, MA 02114, USA
    Biochim Biophys Acta 1738:99-104. 2005
    ..These studies show that FAEEs, non-oxidative metabolite of ethanol, can be incorporated into, synthesized, and hydrolyzed by human platelets...
  15. ncbi Method to assess fatty acid ethyl ester binding to albumin
    Catherine A Best
    Department of Biomedical Sciences, Northeastern University, Boston, MA 02115, USA
    Alcohol Alcohol 41:240-6. 2006
    ..To develop a method to assess the relative binding of fatty acid ethyl esters (FAEE) and free fatty acids (FFA) to albumin, and to determine if binding affinity is related to fatty acid chain length and or degree of saturation...
  16. ncbi Prevalence of heparin/platelet factor 4 antibodies before and after cardiac surgery
    Brendan M Everett
    Department of Medicine, Cardiology Division, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Ann Thorac Surg 83:592-7. 2007
    ..We prospectively investigated whether the presence of heparin/PF4 antibodies would predict clinical thrombosis in this population...
  17. doi Successful use of bivalirudin for combined carotid endarterectomy and coronary revascularization with the use of cardiopulmonary bypass in a patient with an elevated heparin-platelet factor 4 antibody titer
    Edwin G Avery
    Department of Anesthesia and Critical Care, Massachusetts General Hospital Heart Center, 55 Fruit St, Boston, MA 02114, USA
    Anesth Analg 108:1113-5. 2009
    ..The patient experienced procedural success for both the carotid and coronary surgeries. Increased blood and blood product transfusion was required postoperatively...
  18. ncbi Omega-3 fatty acid monotherapy for pediatric bipolar disorder: a prospective open-label trial
    Janet Wozniak
    Pediatric Psychopharmacology Research Unit, Massachusetts General Hospital, Boston, MA 02138, USA
    Eur Neuropsychopharmacol 17:440-7. 2007
    ..To test the effectiveness and safety of omega-3 fatty acids (Omegabrite(R) brand) in the treatment of pediatric bipolar disorder (BPD)...
  19. ncbi The synthesis and secretion of fatty acid ethyl esters from HepG2 cells are stimulated by lipoproteins and albumin
    A Hasaba
    Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston 02114, USA
    Alcohol Clin Exp Res 25:338-43. 2001
    ..CONCLUSION: These observations indicate that lipoproteins and albumin can extract ethyl esters from HepG2 cells and thereby may limit alcohol-induced liver damage...
  20. ncbi Assessment of ethanol intake. Current tests and new assays on the horizon
    M Laposata
    Department of Pathology, Massachusetts General Hospital, Boston 02114 2696, USA
    Am J Clin Pathol 112:443-50. 1999
    ..The ultimate configuration of a panel of tests for monitoring ethanol intake awaits the results of studies that identify the clinical usefulness of each marker...
  21. ncbi Linkage of oxidative and nonoxidative ethanol metabolism in the pancreas and toxicity of nonoxidative ethanol metabolites for pancreatic acinar cells
    J Werner
    Department of Surgery, Massachusetts General Hospital and Harvard Medical School, 55 Fruit St, Boston, MA 02114
    Surgery 129:736-44. 2001
    ....
  22. ncbi Predictors for the development of elevated anti-heparin/platelet factor 4 antibody titers in patients undergoing cardiac catheterization
    Robert W Yeh
    Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Am J Cardiol 98:419-21. 2006
    ..It is possible to identify patients at high risk for developing elevated titers of antiheparin/PF4 antibodies on the basis of their baseline clinical characteristics...
  23. ncbi Prevalence of heparin-induced thrombocytopenia in patients undergoing cardiac catheterization
    Shi Yin Foo
    Cardiology Division, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Am Heart J 152:290.e1-7. 2006
    ..The objective was to examine prospectively the prevalence of anti-platelet factor 4 (PF4)/heparin antibodies and heparin-induced thrombocytopenia in the population undergoing cardiac catheterization...
  24. ncbi Liver and adipose tissue fatty acid ethyl esters obtained at autopsy are postmortem markers for premortem ethanol intake
    Majed A Refaai
    Division of Laboratory Medicine, Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Clin Chem 48:77-83. 2002
    ..Because blood is not always available at autopsy, in this study we quantified FAEEs in human liver and adipose tissue as potential postmortem markers of premortem ethanol intake...
  25. ncbi Fatty acid ethyl esters in human mononuclear cells: Production by endogenous synthesis greatly exceeds the uptake of preformed ethyl esters
    Khaled Alhomsi
    Department of Pathology, Division of Laboratory Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Alcohol Clin Exp Res 30:560-6. 2006
    ..In addition, they serve as specific and sensitive biomarkers for ethanol intake. Following ethanol consumption, FAEE are found in circulating blood bound to albumin or/and lipoproteins...
  26. ncbi The total body mass of fatty acid ethyl esters in skeletal muscles following ethanol exposure greatly exceeds that found in the liver and the heart
    Raneem O Salem
    Massachusetts General Hospital and Harvard Medical School, Division of Laboratory Medicine, Boston, MA 02114, USA
    Alcohol Alcohol 41:598-603. 2006
    ..We hypothesized that accumulation of FAEE in skeletal muscle could contribute to the development of alcoholic myopathy...
  27. ncbi Increased plasma fatty acid ethyl ester levels following inhibition of oxidative metabolism of ethanol by 4-methylpyrazole treatment in human subjects
    Catherine A Best
    Department of Pathology, Division of Laboratory Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Alcohol Clin Exp Res 30:1126-31. 2006
    ..A direct association between pancreas-specific toxicity and increased levels of FAEE following inhibition of the oxidative metabolism of ethanol by 4-methylpyrazole (4-MP) has previously been shown in studies with rats...
  28. ncbi Stearic acid stimulates FA ethyl ester synthesis in HepG2 cells exposed to ethanol
    Ali Hasaba
    Division of Laboratory Medicine, Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Lipids 38:1051-5. 2003
    ..Ethyl palmitate, ethyl stearate, and ethyl oleate were the predominant FAEE species identified in all cases, independent of the specific supplemental FA added to the medium...
  29. ncbi Fatty acid ethyl esters. Ethanol metabolites that reflect ethanol intake
    Britt L Soderberg
    Division of Laboratory Medicine, Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, USA
    Am J Clin Pathol 119:S94-9. 2003
    ..Thus, FAEEs are markers of ethanol intake in blood and tissues and can be useful in distinguishing chronic alcoholics from binge drinkers...
  30. ncbi Fatty acid ethyl esters: toxic non-oxidative metabolites of ethanol and markers of ethanol intake
    Catherine A Best
    Division of Laboratory Medicine, Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Front Biosci 8:e202-17. 2003
    ..Also a summary of reports on the emerging clinical significance and diagnostic utility of FAEE as short and long-term markers of alcohol consumption, and the methodological aspects of FAEE assessment is included...
  31. ncbi Clinical significance of a borderline titer in a negative ELISA test for heparin-induced thrombocytopenia
    Majed A Refaai
    Division of Laboratory Medicine, Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, USA
    Am J Clin Pathol 119:61-5. 2003
    ....
  32. pmc Adenoviral gene transfer of Caenorhabditis elegans n--3 fatty acid desaturase optimizes fatty acid composition in mammalian cells
    Z B Kang
    Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Proc Natl Acad Sci U S A 98:4050-4. 2001
    ..This study demonstrates an effective approach to modifying fatty acid composition of mammalian cells and also provides a basis for potential applications of this gene transfer in experimental and clinical settings...
  33. ncbi Combination of D-dimer and amino-terminal pro-B-type natriuretic Peptide testing for the evaluation of dyspneic patients with and without acute pulmonary embolism
    Stacy E F Melanson
    Department of Pathology, Division of Clinical Laboratories, Brigham and Women s Hospital and Harvard Medical School, Boston, Mass, USA
    Arch Pathol Lab Med 130:1326-9. 2006
    ..However, clinicians frequently order unnecessary supplemental testing in patients with low concentrations of D-dimer. Elevations in natriuretic peptides have also been described in the setting of pulmonary embolism...
  34. ncbi Activation and impairment of platelet function in vitro by fatty acid ethyl ester, a nonoxidative ethanol metabolite: effect of fatty acid ethyl esters on human platelets
    Raneem O Salem
    Division of Laboratory Medicine, Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Alcohol Clin Exp Res 30:2079-88. 2006
    ..We hypothesized that FAEE increase the risk of bleeding by producing an alteration in platelet membrane structure or function...
  35. ncbi Ethanol administration to cystic fibrosis knockout mice results in increased fatty acid ethyl ester production
    Paola G Blanco
    Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
    Alcohol Clin Exp Res 29:2039-45. 2005
    ....
  36. ncbi Fatty acid alterations and n-3 fatty acid supplementation in cystic fibrosis
    M Rabie Al-Turkmani
    Department of Pathology, Harvard Medical School, Massachusetts General Hospital, GRB 235, 55 Fruit Street, Boston, MA 02114, USA
    Prostaglandins Leukot Essent Fatty Acids 77:309-18. 2007
    ..It is recommended that future trials include a larger population of CF patients and measure multiple clinical outcomes...
  37. ncbi Effects of physiological leptin administration on markers of inflammation, platelet activation, and platelet aggregation during caloric deprivation
    Bridget Canavan
    Program in Nutritional Metabolism, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 90:5779-85. 2005
    ..However, the effects of leptin administration on markers of inflammation and platelet aggregation in a human model of undernutrition have not previously been studied...
  38. ncbi Fatty acid ethyl ester effects on interleukin-2 production, cyclic AMP synthesis, and calcium influx in human mononuclear cells
    Khaled Alhomsi
    Division of Laboratory Medicine, Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Alcohol Clin Exp Res 30:1121-5. 2006
    ..Our previous studies have shown that there is significant synthesis of FAEE by human mononuclear cells within seconds of exposure to physiologic doses of ethanol...
  39. ncbi The timing of a positive test result for heparin-induced thrombocytopenia relative to the platelet count and anticoagulant therapy in 43 consecutive cases
    Majed A Refaai
    Division of Laboratory Medicine, Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, USA
    Am J Clin Pathol 119:497-504. 2003
    ..In study part 2, 1 platelet count value at the time of the HIT test did not provide useful information...
  40. ncbi Enhanced clinical consulting--moving toward the core competencies of laboratory professionals
    Alexander Kratz
    Clinical Laboratories, Division of Laboratory Medicine, Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114 2698, USA
    Clin Chim Acta 319:117-25. 2002
    ..This leads to a new role for laboratory professionals, in which their expertise in the selection and interpretation of laboratory tests is fully utilized...
  41. ncbi Red blood cell fatty acid ethyl esters: a significant component of fatty acid ethyl esters in the blood
    Catherine A Best
    Division of Laboratory Medicine, Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    J Lipid Res 44:612-20. 2003
    ..These data indicate that a significant percentage of FAEEs in the blood is associated with RBCs and that the metabolism of RBC FAEEs and that of plasma FAEEs (bound to albumin or lipoproteins) are largely independent...
  42. ncbi Association of cystic fibrosis with abnormalities in fatty acid metabolism
    Steven D Freedman
    Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    N Engl J Med 350:560-9. 2004
    ..In this study we determined whether humans with mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene have a similar fatty acid defect in tissues expressing CFTR...
  43. pmc A membrane lipid imbalance plays a role in the phenotypic expression of cystic fibrosis in cftr(-/-) mice
    S D Freedman
    Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 96:13995-4000. 1999
    ..These results strongly suggest that certain phenotypic manifestations of CF may result from remediable alterations in phospholipid-bound arachidonic acid and DHA levels...
  44. ncbi Regulations regarding reflexive testing and narrative interpretations in laboratory medicine
    D H MacMillan
    Department of Pathology, Massachusetts General Hospital, Boston 02114, USA
    Am J Clin Pathol 116:S129-32. 2001
    ..The codes used for narrative interpretations in laboratory medicine are also presented, as well as the use of those codes to obtain payment for the interpretation provided...
  45. ncbi Effects of fasting and glucose infusion on basal and overnight leptin concentrations in normal-weight women
    S K Grinspoon
    Department of Pathology, Massachusetts General Hospital, Boston, USA
    Am J Clin Nutr 66:1352-6. 1997
    ..05). These data show the sensitivity of plasma leptin concentrations to small changes in energy supply and suggest a basic role of substrate metabolism in the short-term regulation of leptin...
  46. ncbi Potential utility of plasma fatty acid analysis in the diagnosis of cystic fibrosis
    Ibrahim Batal
    Division of Laboratory Medicine, Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Clin Chem 53:78-84. 2007
    ..An altered distribution of fatty acids in cells and tissues is found in patients with cystic fibrosis (CF). In this study, we assessed the potential role of plasma fatty acid analysis in the diagnosis of CF...
  47. ncbi Activated protein C resistance, the factor V Leiden mutation, and a laboratory testing algorithm
    Elizabeth M Van Cott
    Division of Laboratory Medicine, Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston 02114, USA
    Arch Pathol Lab Med 126:577-82. 2002
    ..To present the current understanding of factor V Leiden and activated protein C resistance, and to propose a laboratory testing algorithm...
  48. doi Induction of apoptosis and necrosis in human peripheral blood mononuclear cells by fatty acid ethyl esters
    Khaled Alhomsi
    Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Alcohol Clin Exp Res 32:534-43. 2008
    ..FAEE also caused a rapid increase in the intracellular cAMP. The mechanism by which alcohol suppresses the immune system remains undetermined...
  49. ncbi Laboratory diagnosis of dysfibrinogenemia
    Mark T Cunningham
    Department of Pathology, University of Kansas Medical Center, Kansas City, 66160, USA
    Arch Pathol Lab Med 126:499-505. 2002
    ..This article reviews the laboratory testing of dysfibrinogenemia and presents an algorithm for sequential test selection that can be used for diagnosis...
  50. ncbi Oral docosahexaenoic acid given to pregnant mice increases the amount of surfactant in lung and amniotic fluid in preterm fetuses
    Paola G Blanco
    Departments of Medicine and Obstetrics and Gynecology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Am J Obstet Gynecol 190:1369-74. 2004
    ..Our purpose was to determine whether docosahexaenoic acid increased surfactant production, as reflected by increased dipalmitoyl phosphatidylcholine, in mouse fetal lung and amniotic fluid...
  51. ncbi Case records of the Massachusetts General Hospital. Case 1-2007. A 40-year-old woman with epistaxis, hematemesis, and altered mental status
    Michael Laposata
    Department of Pathology, Massachusetts General Hospital, USA
    N Engl J Med 356:174-82. 2007
  52. ncbi Alcoholic pancreatitis in rats: injury from nonoxidative metabolites of ethanol
    Jens Werner
    Department of Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Am J Physiol Gastrointest Liver Physiol 283:G65-73. 2002
    ....
  53. ncbi Hypercoagulability test strategies in the protein C and protein S pathway
    Elizabeth M Van Cott
    Division of Laboratory Medicine, Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Room 235 Gray Building, 55 Fruit Street, Boston, MA 02114, USA
    Clin Lab Med 22:391-403. 2002
    ..This article describes the testing strategies associated with the diagnosis of activated protein C resistance, protein C deficiency, and protein S deficiency...
  54. ncbi Making the laboratory a partner in patient safety
    Anand S Dighe
    Massachussetts General Hospital, Boston, MA 02114, USA
    Clin Leadersh Manag Rev 18:356-60. 2004
  55. pmc Decreased inflammation and improved survival with recombinant human activated protein C treatment in experimental acute pancreatitis
    Guido Alsfasser
    Department of Surgery and Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Arch Surg 141:670-6; discussion 676-7. 2006
    ..Drotrecogin alfa (activated), the pharmacologic form of activated protein C and the first Food and Drug Administration-approved drug for treatment of severe sepsis, is beneficial in experimental acute pancreatitis (AP)...
  56. ncbi Effects of alcohol on hemostasis
    Raneem O Salem
    Division of Laboratory Medicine, Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Am J Clin Pathol 123:S96-105. 2005
    ..The effect of ethanol on platelets, coagulation factors, and the fibrinolytic system is likely to contribute to protection against CVD...
  57. ncbi Aspirin resistance: moving forward with multiple definitions, different assays, and a clinical imperative
    Stewart M Knoepp
    Division of Laboratory Medicine, Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Am J Clin Pathol 123:S125-32. 2005
    ....
  58. ncbi Effects of adenoviral gene transfer of C. elegans n-3 fatty acid desaturase on the lipid profile and growth of human breast cancer cells
    Yinlin Ge
    Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Anticancer Res 22:537-43. 2002
    ..Human cells usually have a very high n-6/n-3 fatty acid ratio because they cannot convert n-6 PUFAs to n-3 PUFAs due to lack of an n-3 desaturase found in C. elegans...
  59. ncbi Elevated concentrations of free fatty acids are associated with increased insulin response to standard glucose challenge in human immunodeficiency virus-infected subjects with fat redistribution
    Gary Meininger
    Department of Pathology, Massachusetts General Hospital and Children s Hospital, Boston, MA 02114, USA
    Metabolism 51:260-6. 2002
    ..Further studies are necessary to determine the mechanism of increased fatty acid concentrations and the role played by increased FFA in mediating insulin resistance in this population...
  60. pmc A mechanism accounting for the low cellular level of linoleic acid in cystic fibrosis and its reversal by DHA
    M Rabie Al-Turkmani
    Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    J Lipid Res 49:1946-54. 2008
    ..In conclusion, the evidence suggests that low LA level in cultured CF cells is due to its increased metabolism, and this increased LA metabolism is corrected by DHA supplementation...
  61. pmc Cell culture models demonstrate that CFTR dysfunction leads to defective fatty acid composition and metabolism
    Charlotte Andersson
    Division of Gastroenterology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    J Lipid Res 49:1692-700. 2008
    ..In conclusion, these data demonstrate that CFTR dysfunction is associated with altered fatty acid metabolism in cultured airway epithelial cells...
  62. ncbi Comparison of serum fatty acid ethyl esters and urinary 5-hydroxytryptophol as biochemical markers of recent ethanol consumption
    Adam Bisaga
    Division on Substance Abuse, NYS Psychiatric Institute and Columbia University, New York, NY, USA
    Alcohol Alcohol 40:214-8. 2005
    ..To examine the effects of an acute dose of ethanol on serum fatty acid ethyl esters (FAEEs) concentration and urinary 5-hydroxytryptophol (5-HTOL)/5-hydroxyindole-3-acetic acid (5-HIAA) ratio...
  63. ncbi Diagnostic studies for thrombophilia in women on hormonal therapy and during pregnancy, and in children
    Benjamin R Brenner
    Hematology Institute, Rambam Medical Center, Haifa, Israel
    Arch Pathol Lab Med 126:1296-303. 2002
    ....
  64. ncbi Fatty acid methyl esters are detectable in the plasma and their presence correlates with liver dysfunction
    Samir Lutf Aleryani
    Department of Clinical Biochemistry, School of Medicine and Health Sciences, Sana a University, Sana a, Yemen
    Clin Chim Acta 359:141-9. 2005
    ..We tested the hypothesis that FAMEs appear in the blood after ethanol intake...
  65. ncbi Cysteine and venous thrombosis: a case report
    ElizabethM Van Cott
    Am J Clin Pathol 117:168. 2002
  66. ncbi Pathogenesis of alcoholic liver disease--recent advances
    Amin A Nanji
    Department of Pathology and Center for the Study of Liver Diseases, The University of Hong Kong and Queen Mary Hospital
    Alcohol Clin Exp Res 26:731-6. 2002
    ..French...
  67. ncbi Platelet activation in cystic fibrosis
    Brian P O'Sullivan
    Department of Pediatrics, UMass Memorial Health Care and University of Massachusetts Medical School, Worcester, MA 01655, USA
    Blood 105:4635-41. 2005
    ..Our findings may account, at least in part, for the beneficial effects of ibuprofen in CF...
  68. ncbi Translational research involving new biomarkers of disease: a leading role for pathologists
    Mario Plebani
    Am J Clin Pathol 126:169-71. 2006