- Immobilization of the thrombin inhibitor r-hirudin conserving its biological activityJ Lahann
Department of Macromolecular and Textile Chemistry, RWTH Aachen, Veltmanplatz 8, 52062 Aachen, Germany
J Mater Sci Mater Med 12:807-10. 2001..Based on these results we developed an immobilization method via an epsilon-amino group of r-hirudin preserving full biological activity of the r-hirudin coated surface...
- Bioactive immobilization of r-hirudin on CVD-coated metallic implant devicesJ Lahann
Department of Macromolecular and Textile Chemistry, RWTH Aachen, Germany
Biomaterials 22:817-26. 2001..In vitro results indicate that the bioactively coated stents are less thrombogenic than virgin metallic stents. Surface-bound r-hirudin decreases platelet adhesion drastically due to interactions between platelets and r-hirudin...