Keith A Johnson

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. pmc Pro: Can biomarkers be gold standards in Alzheimer's disease?
    Reisa Sperling
    Brigham and Women s Hospital, Massachusetts General Hospital, Harvard Medical School, Longwood Avenue Boston, MA 02115, USA
    Alzheimers Res Ther 2:17. 2010
  2. pmc Single photon emission computed tomography perfusion differences in mild cognitive impairment
    K A Johnson
    Department of Radiology, Massachusetts General Hospital, Fruit Street, Boston, MA 02114, USA
    J Neurol Neurosurg Psychiatry 78:240-7. 2007
  3. ncbi request reprint Amyloid imaging of Alzheimer's disease using Pittsburgh Compound B
    Keith A Johnson
    Department of Radiology, Tilton 201, Massachusetts General Hospital, Boston, MA 02114, USA
    Curr Neurol Neurosci Rep 6:496-503. 2006
  4. pmc Amyloid and APOE ε4 interact to influence short-term decline in preclinical Alzheimer disease
    Elizabeth C Mormino
    From the Departments of Neurology E C M, A P S, D M R, K A J, R A S, Radiology T H, A P S, K A J, R A S, and Psychiatry A P S, A W, and the Division of Nuclear Medicine and Molecular Imaging, Department of Radiology K A J, Massachusetts General Hospital, Harvard Medical School the Department of Biostatistics R A B, Harvard School of Public Health, Boston the Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology T H, Massachusetts General Hospital, Charleston and the Center for Alzheimer Research and Treatment, Department of Neurology A W, w h, D M R, K A J, R A S, Brigham and Women s Hospital, Harvard Medical School, Boston, MA
    Neurology 82:1760-7. 2014
  5. pmc Amyloid is linked to cognitive decline in patients with Parkinson disease without dementia
    STEPHEN N GOMPERTS
    Department of Neurology, Massachusetts General Hospital, Boston, USA
    Neurology 80:85-91. 2013
  6. pmc Instrumental activities of daily living impairment is associated with increased amyloid burden
    Gad A Marshall
    Center for Alzheimer Research and Treatment, Department of Neurology, Brigham and Women s Hospital, 221 Longwood Avenue, Boston, MA 02115, USA
    Dement Geriatr Cogn Disord 31:443-50. 2011
  7. pmc Cognition, reserve, and amyloid deposition in normal aging
    Dorene M Rentz
    Department of Neurology, Brigham and Women s Hospital, Harvard Medical School, 33 Fruit Street, Boston, MA 02114, USA
    Ann Neurol 67:353-64. 2010
  8. pmc The ups and downs of the posteromedial cortex: age- and amyloid-related functional alterations of the encoding/retrieval flip in cognitively normal older adults
    Patrizia Vannini
    Department of Psychiatry, Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    Cereb Cortex 23:1317-28. 2013
  9. doi request reprint Appropriate use criteria for amyloid PET: a report of the Amyloid Imaging Task Force, the Society of Nuclear Medicine and Molecular Imaging, and the Alzheimer's Association
    Keith A Johnson
    Department of Radiology and Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    J Nucl Med 54:476-90. 2013
  10. pmc Cognitive profile of amyloid burden and white matter hyperintensities in cognitively normal older adults
    Trey Hedden
    Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
    J Neurosci 32:16233-42. 2012

Detail Information

Publications79

  1. pmc Pro: Can biomarkers be gold standards in Alzheimer's disease?
    Reisa Sperling
    Brigham and Women s Hospital, Massachusetts General Hospital, Harvard Medical School, Longwood Avenue Boston, MA 02115, USA
    Alzheimers Res Ther 2:17. 2010
    ....
  2. pmc Single photon emission computed tomography perfusion differences in mild cognitive impairment
    K A Johnson
    Department of Radiology, Massachusetts General Hospital, Fruit Street, Boston, MA 02114, USA
    J Neurol Neurosurg Psychiatry 78:240-7. 2007
    ..To relate cerebral perfusion abnormalities to subsequent changes in clinical status among patients with mild cognitive impairment (MCI)...
  3. ncbi request reprint Amyloid imaging of Alzheimer's disease using Pittsburgh Compound B
    Keith A Johnson
    Department of Radiology, Tilton 201, Massachusetts General Hospital, Boston, MA 02114, USA
    Curr Neurol Neurosci Rep 6:496-503. 2006
    ....
  4. pmc Amyloid and APOE ε4 interact to influence short-term decline in preclinical Alzheimer disease
    Elizabeth C Mormino
    From the Departments of Neurology E C M, A P S, D M R, K A J, R A S, Radiology T H, A P S, K A J, R A S, and Psychiatry A P S, A W, and the Division of Nuclear Medicine and Molecular Imaging, Department of Radiology K A J, Massachusetts General Hospital, Harvard Medical School the Department of Biostatistics R A B, Harvard School of Public Health, Boston the Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology T H, Massachusetts General Hospital, Charleston and the Center for Alzheimer Research and Treatment, Department of Neurology A W, w h, D M R, K A J, R A S, Brigham and Women s Hospital, Harvard Medical School, Boston, MA
    Neurology 82:1760-7. 2014
    ..To examine whether β-amyloid (Aβ) and APOE ε4 status independently contribute or interact to influence longitudinal cognitive decline in clinically normal older individuals (CN)...
  5. pmc Amyloid is linked to cognitive decline in patients with Parkinson disease without dementia
    STEPHEN N GOMPERTS
    Department of Neurology, Massachusetts General Hospital, Boston, USA
    Neurology 80:85-91. 2013
    ..A related aim is to determine whether amyloid burden predicts cognitive decline in a cohort of subjects with PD without dementia...
  6. pmc Instrumental activities of daily living impairment is associated with increased amyloid burden
    Gad A Marshall
    Center for Alzheimer Research and Treatment, Department of Neurology, Brigham and Women s Hospital, 221 Longwood Avenue, Boston, MA 02115, USA
    Dement Geriatr Cogn Disord 31:443-50. 2011
    ..We sought to determine whether IADL impairment is associated with increased cortical Pittsburgh Compound B (PiB) retention...
  7. pmc Cognition, reserve, and amyloid deposition in normal aging
    Dorene M Rentz
    Department of Neurology, Brigham and Women s Hospital, Harvard Medical School, 33 Fruit Street, Boston, MA 02114, USA
    Ann Neurol 67:353-64. 2010
    ..To determine whether amyloid deposition is associated with impaired neuropsychological (NP) performance and whether cognitive reserve (CR) modifies this association...
  8. pmc The ups and downs of the posteromedial cortex: age- and amyloid-related functional alterations of the encoding/retrieval flip in cognitively normal older adults
    Patrizia Vannini
    Department of Psychiatry, Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    Cereb Cortex 23:1317-28. 2013
    ..These findings support a specific link between amyloid pathology and neural dysfunction in PMC and elucidate the underpinnings of age-related memory dysfunction...
  9. doi request reprint Appropriate use criteria for amyloid PET: a report of the Amyloid Imaging Task Force, the Society of Nuclear Medicine and Molecular Imaging, and the Alzheimer's Association
    Keith A Johnson
    Department of Radiology and Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    J Nucl Med 54:476-90. 2013
    ..Because both dementia care and amyloid PET technology are in active development, these AUC will require periodic reassessment. Future research directions are also outlined, including diagnostic utility and patient-centered outcomes...
  10. pmc Cognitive profile of amyloid burden and white matter hyperintensities in cognitively normal older adults
    Trey Hedden
    Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
    J Neurosci 32:16233-42. 2012
    ..These findings suggest that even before clinical impairment, amyloid burden and WMH likely represent neuropathological cascades with distinct etiologies and dissociable influences on cognition...
  11. pmc Amyloid-β associated cortical thinning in clinically normal elderly
    J Alex Becker
    Department of Radiology, Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Ann Neurol 69:1032-42. 2011
    ....
  12. pmc Florbetapir (F18-AV-45) PET to assess amyloid burden in Alzheimer's disease dementia, mild cognitive impairment, and normal aging
    Keith A Johnson
    Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA Electronic address
    Alzheimers Dement 9:S72-83. 2013
    ..To evaluate the performance characteristics of florbetapir F18 positron emission tomography (PET) in patients with Alzheimer's disease (AD), mild cognitive impairment (MCI), and healthy control subjects (HCs)...
  13. pmc Amyloid deposition is linked to aberrant entorhinal activity among cognitively normal older adults
    Willem Huijbers
    Center for Alzheimer Research and Treatment, Department of Neurology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, Massachusetts 02129, Harvard Aging Brain Study, Department of Neurology, and Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114
    J Neurosci 34:5200-10. 2014
    ..Together these findings link neocortical amyloid-β deposition to neuronal dysfunction specifically in entorhinal cortex, while aging is associated with more widespread functional changes across the MTL. ..
  14. doi request reprint Update on appropriate use criteria for amyloid PET imaging: dementia experts, mild cognitive impairment, and education
    Keith A Johnson
    Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    J Nucl Med 54:1011-3. 2013
    ....
  15. pmc Face-name associative memory performance is related to amyloid burden in normal elderly
    Dorene M Rentz
    Center for Alzheimer Research and Treatment, Department of Neurology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Neuropsychologia 49:2776-83. 2011
    ..Associative memory for faces and names, a common complaint among older adults, may be a sensitive marker of early Aβ-related impairment...
  16. pmc Amyloid deposition is associated with impaired default network function in older persons without dementia
    Reisa A Sperling
    Center for Alzheimer Research and Treatment, Department of Neurology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Neuron 63:178-88. 2009
    ....
  17. pmc In vivo characterization of the early states of the amyloid-beta network
    Jorge Sepulcre
    Division of Nuclear Medicine and Molecular Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    Brain 136:2239-52. 2013
    ....
  18. pmc Age and amyloid-related alterations in default network habituation to stimulus repetition
    Patrizia Vannini
    Athinoula A Martinos Center for Biomedical Imaging, Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA
    Neurobiol Aging 33:1237-52. 2012
    ....
  19. pmc Detection of isolated cerebrovascular beta-amyloid with Pittsburgh compound B
    Steven M Greenberg
    Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Ann Neurol 64:587-91. 2008
    ..These results offer compelling evidence that Pittsburgh Compound B positron emission tomography can noninvasively detect isolated cerebral amyloid angiopathy before overt signs of tissue damage such as hemorrhage or white matter lesions...
  20. pmc Lower Late-Life Body-Mass Index is Associated with Higher Cortical Amyloid Burden in Clinically Normal Elderly
    David C Hsu
    Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    J Alzheimers Dis 53:1097-105. 2016
    ..Lower body-mass index (BMI) in late life has been associated with an increased risk of dementia, and weight loss has been associated with more rapid decline in Alzheimer's disease (AD) dementia...
  21. pmc Neuropsychiatric Symptoms and Functional Connectivity in Mild Cognitive Impairment
    Catherine E Munro
    Department of Neurology, Massachusetts General Hospital, Boston, MA, USA
    J Alzheimers Dis 46:727-35. 2015
    ..Prior studies have shown associations between affective NPS and neurodegeneration of medial frontal and inferior temporal regions in mild cognitive impairment (MCI) and AD dementia...
  22. pmc The Apathy Evaluation Scale: A Comparison of Subject, Informant, and Clinician Report in Cognitively Normal Elderly and Mild Cognitive Impairment
    Brendan J Guercio
    Harvard Medical School, Boston, MA, USA
    J Alzheimers Dis 47:421-32. 2015
    ..Detecting apathy accurately may facilitate earlier diagnosis of AD. The Apathy Evaluation Scale (AES) is a promising tool for measurement of apathy in prodromal and possibly preclinical AD...
  23. pmc Depressive Symptoms and Biomarkers of Alzheimer's Disease in Cognitively Normal Older Adults
    Nancy J Donovan
    Center for Alzheimer Research and Treatment, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    J Alzheimers Dis 46:63-73. 2015
    ..Amyloid was not a significant predictor in any model. In conclusion, very low-level dysphoria, apathy and anhedonia may point to neurodegeneration in AD-related regions but this association appears to be independent of amyloid burden...
  24. pmc Apathy is associated with lower inferior temporal cortical thickness in mild cognitive impairment and normal elderly individuals
    Brendan J Guercio
    From the Harvard Medical School BG, NJD, Rea, DMR, KAJ, RAS, GAM Center for Alzheimer Research and Treatment BG, NJD, NL, Rea, DMR, KAJ, RAS, GAM Dept of Neurology NJD, AW, NL, REA DMR, KAJ, RAS, GAM and Dept of Psychiatry NJD, Rea, DMR Brigham and Women s Hospital, Boston, MA Dept of Neurology AW, As, NL, Rea, DMR, KAJ, RAS, GAM and Dept of Radiology KAJ, Massachusetts General Hospital, Boston, MA
    J Neuropsychiatry Clin Neurosci 27:e22-7. 2015
    ..Lower inferior temporal cortical thickness was predictive of greater apathy. Greater anterior cingulate cortical thickness was also predictive of greater apathy, suggesting an underlying reactive process...
  25. pmc Cognitive activity relates to cognitive performance but not to Alzheimer disease biomarkers
    Christopher M Gidicsin
    From the Division of Nuclear Medicine and Molecular Imaging C M G, J E M, L C P, M P, J A B, K A J and Departments of Neurology J J L, A P S, R E A, G A M, D M R, R A S, K A J, Psychiatry A P Y, A P S, and Radiology T H, K A J, Massachusetts General Hospital, Harvard Medical School, Boston Athinoula A Martinos Center for Biomedical Imaging A P Y, A P S, T H, R A S, Department of Radiology, Massachusetts General Hospital, Charlestown and Center for Alzheimer Research and Treatment M D, R E A, G A M, D M R, R A S, K A J, Department of Neurology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA
    Neurology 85:48-55. 2015
    ..We aimed to determine whether there was a relationship between lifestyle factors and Alzheimer disease biomarkers...
  26. pmc Subjective cognitive concerns and neuropsychiatric predictors of progression to the early clinical stages of Alzheimer disease
    Nancy J Donovan
    Center for Alzheimer Research and Treatment and Department of Neurology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA Department of Psychiatry, Brigham and Women s Hospital, Harvard Medical School, Boston, MA Electronic address
    Am J Geriatr Psychiatry 22:1642-51. 2014
    ..To examine neuropsychiatric and neuropsychological predictors of progression from normal to early clinical stages of Alzheimer disease (AD)...
  27. pmc Cerebral amyloid angiopathy burden associated with leukoaraiosis: a positron emission tomography/magnetic resonance imaging study
    M Edip Gurol
    Hemorrhagic Stroke Research Center, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA Department of Biostatistics, Harvard School of Public Health, Boston, MA
    Ann Neurol 73:529-36. 2013
    ....
  28. pmc Mild to moderate Alzheimer dementia with insufficient neuropathological changes
    Alberto Serrano-Pozo
    Massachusetts Alzheimer Disease Research Center, Charlestown, MA Department of Neurology, Massachusetts General Hospital, Boston, MA Department of Neurology, University of Iowa Hospitals and Clinics, Iowa City, IA
    Ann Neurol 75:597-601. 2014
    ..More than half of these "Aβ-negative" subjects have low neurofibrillary tangle Braak stages. These findings support the implementation of a positive amyloid biomarker as an inclusion criterion in future anti-Aβ drug trials...
  29. doi request reprint Update on appropriate use criteria for amyloid PET imaging: dementia experts, mild cognitive impairment, and education. Amyloid Imaging Task Force of the Alzheimer’s Association and Society for Nuclear Medicine and Molecular Imaging
    Keith A Johnson
    Departments of Radiology and Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Alzheimers Dement 9:e106-9. 2013
    ....
  30. pmc Subjective cognitive complaints and amyloid burden in cognitively normal older individuals
    Rebecca E Amariglio
    Department of Neurology, Division of Cognitive and Behavioral Neurology, Brigham and Women s Hospital, 221 Longwood Avenue, Boston, MA 02115, United States
    Neuropsychologia 50:2880-6. 2012
    ..Our study suggests that SCC may be an early indicator of AD pathology detectable prior to significant objective impairment...
  31. pmc Functional alterations in memory networks in early Alzheimer's disease
    Reisa A Sperling
    Department of Neurology, Center for Alzheimer s Research and Treatment, Brigham and Women s Hospital, 221 Longwood Avenue, Boston, MA 02115, USA
    Neuromolecular Med 12:27-43. 2010
    ..Research is ongoing to determine if these early network alterations will serve as sensitive predictors of clinical decline, and eventually, as markers of pharmacological response to potential disease-modifying treatments for AD...
  32. pmc Spatial relation between microbleeds and amyloid deposits in amyloid angiopathy
    Gregory A Dierksen
    Hemorrhagic Stroke Research Program, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Ann Neurol 68:545-8. 2010
    ..0001). These findings indicate that microbleeds occur preferentially in local regions of concentrated amyloid and support therapeutic strategies aimed at reducing vascular amyloid deposition...
  33. pmc Association of Higher Cortical Amyloid Burden With Loneliness in Cognitively Normal Older Adults
    Nancy J Donovan
    Center for Alzheimer Research and Treatment, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts2Department of Neurology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts3Department of Psychiatry, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts4Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston
    JAMA Psychiatry 73:1230-1237. 2016
    ..We hypothesized that loneliness might occur in association with elevated cortical amyloid burden, an in vivo research biomarker of AD...
  34. pmc Maternal dementia age at onset in relation to amyloid burden in non-demented elderly offspring
    Jacqueline E Maye
    Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA Department of Clinical and Health Psychology, University of Florida, Gainesville, FL, USA
    Neurobiol Aging 40:61-7. 2016
    ..Overall, results suggest that not only is amyloid-beta burden greater in individuals with maternal FH, but also that the burden is greater in association with younger maternal AO...
  35. pmc Functional Activities Questionnaire Items that Best Discriminate and Predict Progression from Clinically Normal to Mild Cognitive Impairment
    Gad A Marshall
    Center for Alzheimer Research and Treatment, Brigham and Women s Hospital, 221 Longwood Avenue, BL 104H, Boston, MA 02115, USA
    Curr Alzheimer Res 12:493-502. 2015
    ..Some IADL scales are sensitive to early deficits in MCI, but none have been validated for detecting subtle functional changes in clinically normal (CN) elderly at risk for AD...
  36. pmc Regional cortical thinning predicts worsening apathy and hallucinations across the Alzheimer disease spectrum
    Nancy J Donovan
    Center for Alzheimer Research and Treatment, Brigham and Women s Hospital, Harvard Medical School, Boston, MA Department of Neurology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA Department of Psychiatry, Brigham and Women s Hospital, Harvard Medical School, Boston, MA Electronic address
    Am J Geriatr Psychiatry 22:1168-79. 2014
    ....
  37. pmc Amyloid-β deposition in mild cognitive impairment is associated with increased hippocampal activity, atrophy and clinical progression
    Willem Huijbers
    1 Centre for Alzheimer Research and Treatment, Department of Neurology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA 2 Athinoula A Martinos Centre for Biomedical Imaging, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA
    Brain 138:1023-35. 2015
    ..Increased hippocampal activity is discussed in relation to neuronal compensation and/or amyloid-β induced excitoxicity...
  38. pmc Synergistic effect of β-amyloid and neurodegeneration on cognitive decline in clinically normal individuals
    Elizabeth C Mormino
    Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston
    JAMA Neurol 71:1379-85. 2014
    ..Assessing the ability of Alzheimer disease neuroimaging markers to predict short-term cognitive decline among clinically normal (CN) individuals is critical for upcoming secondary prevention trials using cognitive outcomes...
  39. pmc Executive function and instrumental activities of daily living in mild cognitive impairment and Alzheimer's disease
    Gad A Marshall
    Center for Alzheimer Research and Treatment, Department of Neurology, Brigham and Women s Hospital Harvard Medical School, Boston, MA, USA
    Alzheimers Dement 7:300-8. 2011
    ....
  40. pmc Amyloid deposition detected with florbetapir F 18 ((18)F-AV-45) is related to lower episodic memory performance in clinically normal older individuals
    Reisa A Sperling
    Center for Alzheimer Research and Treatment, Departments of Neurology, Brigham and Women s Hospital and Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Neurobiol Aging 34:822-31. 2013
    ..Longitudinal follow-up is ongoing to determine whether (18)F-AV-45 may also predict subsequent cognitive decline...
  41. pmc Neuropsychiatric symptoms and global functional impairment along the Alzheimer's continuum
    Lauren P Wadsworth
    Center for Alzheimer Research and Treatment, Department of Neurology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Dement Geriatr Cogn Disord 34:96-111. 2012
    ..We sought to determine whether neuropsychiatric symptoms were related to global functional impairment at baseline and over a 3-year period in older normal control (NC), mild cognitive impairment (MCI) and mild AD dementia subjects...
  42. pmc Brain amyloid and cognition in Lewy body diseases
    STEPHEN N GOMPERTS
    Massachusetts General Hospital, 15 Parkman Street, Boston, MA 02114, USA
    Mov Disord 27:965-73. 2012
    ..Early amyloid deposits in DLB relative to PDD may account for their difference in the timing of dementia and parkinsonism...
  43. pmc Stepwise connectivity of the modal cortex reveals the multimodal organization of the human brain
    Jorge Sepulcre
    Division of Nuclear Medicine and Molecular Imaging, Department of Radiology, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Neurosci 32:10649-61. 2012
    ..We identify the large-scale multimodal integration network and essential connectivity axes for perceptual integration in the human brain...
  44. pmc Harvard Aging Brain Study: Dataset and accessibility
    Alexander Dagley
    Harvard Aging Brain Study, Department of Neurology, Massachusetts General Hospital, Boston, MA 02114, USA Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA 02129, USA Electronic address
    Neuroimage . 2015
    ..A cloud-based system enables access to interested researchers with blinded data available contingent upon completion of a data usage agreement and administrative approval. Data collection is ongoing and currently in its fifth year...
  45. pmc Episodic memory of odors stratifies Alzheimer biomarkers in normal elderly
    Alefiya Dhilla Albers
    Department of Neurology, Massachusetts General Hospital, Boston, MA
    Ann Neurol . 2016
    ..The objective of this study was to relate a novel test of identifying and recalling odor percepts to biomarkers of Alzheimer's disease (AD) in well-characterized elderly individuals, ranging from cognitively normal to demented...
  46. pmc Multiple Brain Markers are Linked to Age-Related Variation in Cognition
    Trey Hedden
    Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA, USA Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Cereb Cortex 26:1388-400. 2016
    ....
  47. pmc Vascular disease and risk factors are associated with cognitive decline in the alzheimer disease spectrum
    Natacha Lorius
    Department of Neurology, Center for Alzheimer Research and Treatment, Brigham and Women s Hospital Departments of Neurology Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA
    Alzheimer Dis Assoc Disord 29:18-25. 2015
    ..These results suggest a significant association of increased vascular disease and risk factors with cognitive impairment at baseline and over time in the AD spectrum in a sample that was selected to have low vascular burden at baseline. ..
  48. pmc Everyday cognition scale items that best discriminate between and predict progression from clinically normal to mild cognitive impairment
    Gad A Marshall
    Center for Alzheimer Research and Treatment, Brigham and Women s Hospital, 221 Longwood Avenue, BL 104H, Boston, MA 02115, USA
    Curr Alzheimer Res 11:853-61. 2014
    ..The objective of this study was to determine which of the IADL-related Everyday Cognition (ECog) scale items are most sensitive for detection of early functional changes...
  49. ncbi request reprint Intelligence quotient-adjusted memory impairment is associated with abnormal single photon emission computed tomography perfusion
    Dorene M Rentz
    Department of Neurology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Int Neuropsychol Soc 13:821-31. 2007
    ..IQ-adjusted memory impairment in individuals with high cognitive reserve is associated with baseline SPECT abnormality in a pattern consistent with prodromal AD and predicts subsequent cognitive and functional decline...
  50. pmc Neuronal dysfunction and disconnection of cortical hubs in non-demented subjects with elevated amyloid burden
    Alexander Drzezga
    Department of Radiology, Massachusetts General Hospital and Harvard University Medical School, Boston, MA 02114, USA
    Brain 134:1635-46. 2011
    ....
  51. pmc Subjective cognitive concerns, amyloid-β, and neurodegeneration in clinically normal elderly
    Rebecca E Amariglio
    From the Center for Alzheimer Research and Treatment, Department of Neurology, Brigham and Women s Hospital R E A, A C P, G A M, P V, K A J, R A S, D M R, and the Departments of Neurology R E A, E C M, G A M, P V, K A J, R A S, D M R and Radiology K A J, Massachusetts General Hospital, Harvard Medical School, Boston, MA
    Neurology 85:56-62. 2015
    ..To determine whether neuroimaging biomarkers of amyloid-β (Aβ) and neurodegeneration (ND) are associated with greater self-reported subjective cognitive concerns (SCC) in clinically normal older individuals...
  52. pmc Odor identification and Alzheimer disease biomarkers in clinically normal elderly
    Matthew E Growdon
    From Harvard Medical School M E G, R E A, T H, D M R, K A J, R A S, M W A, G A M and Harvard T H Chan School of Public Health M E G, Boston, MA Athinoula A Martinos Center for Biomedical Imaging A P S, A S D, T H, R A S, M W A, Massachusetts General Hospital, Charlestown Departments of Neurology A P S, A S D, R E A, D M R, R A S, M W A, G A M, Psychiatry A P S, A S D, and Radiology T H, K A J, MassGeneral Institute of Neurodegenerative Disease M W A, Massachusetts General Hospital, Boston and Center for Alzheimer Research and Treatment R E A, D M R, K A J, R A S, G A M and Department of Neurology R E A
    Neurology 84:2153-60. 2015
    ....
  53. pmc Regional fluorodeoxyglucose metabolism and instrumental activities of daily living across the Alzheimer's disease spectrum
    Kamolika Roy
    Center for Alzheimer Research and Treatment, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA Department of Neurology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    J Alzheimers Dis 42:291-300. 2014
    ..IADL impairment in AD dementia has been associated with inferior parietal, inferior temporal, and superior occipital hypometabolism using 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET)...
  54. pmc Regional cortical thinning and cerebrospinal biomarkers predict worsening daily functioning across the Alzheimer's disease spectrum
    Gad A Marshall
    Center for Alzheimer Research and Treatment, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA Department of Neurology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA Massachusetts Alzheimer s Disease Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    J Alzheimers Dis 41:719-28. 2014
    ..Impairment in instrumental activities of daily living (IADL) heralds the transition from mild cognitive impairment (MCI) to dementia and is a major source of burden for both the patient and caregiver...
  55. pmc Brain imaging in Alzheimer disease
    Keith A Johnson
    Departments of Radiology and Neurology, Massachusetts General Hospital, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Cold Spring Harb Perspect Med 2:a006213. 2012
    ..The challenge for the future will be to combine imaging biomarkers to most efficiently facilitate diagnosis, disease staging, and, most importantly, development of effective disease-modifying therapies...
  56. pmc Predicting sites of new hemorrhage with amyloid imaging in cerebral amyloid angiopathy
    M Edip Gurol
    Departmentsof Neurology, Massachusetts General Hospital, Boston, USA
    Neurology 79:320-6. 2012
    ..We aimed to determine whether amyloid imaging can help predict the location and number of future hemorrhages in cerebral amyloid angiopathy (CAA)...
  57. pmc Failure to modulate attentional control in advanced aging linked to white matter pathology
    Trey Hedden
    Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA 02129, USA
    Cereb Cortex 22:1038-51. 2012
    ..These results suggest failure to modulate frontal and parietal activity reflects a disruptive process in advanced aging associated with specific neuropathologic processes...
  58. pmc Cortical atrophy in patients with cerebral amyloid angiopathy: a case-control study
    Panagiotis Fotiadis
    Hemorrhagic Stroke Research Group, Massachusetts General Hospital, Boston, MA, USA
    Lancet Neurol 15:811-9. 2016
    ....
  59. pmc The Harvard Automated Phone Task: new performance-based activities of daily living tests for early Alzheimer's disease
    Gad A Marshall
    Center for Alzheimer Research and Treatment, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA Department of Neurology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA Massachusetts Alzheimer s Disease Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    J Prev Alzheimers Dis 2:242-253. 2015
    ....
  60. ncbi request reprint The influence of demographic factors on subjective cognitive concerns and beta-amyloid
    Sarah L Aghjayan
    Department of Neurology, Brigham and Women s Hospital, Center for Alzheimer Research and Treatment, Boston, MA, USA
    Int Psychogeriatr . 2016
    ..However, the sensitivity of SCC reports in early AD may be biased by demographic factors. Here, we sought to investigate whether age, education, and sex influence the relationship between SCC and amyloid (Aβ) burden...
  61. pmc Florbetapir-PET to diagnose cerebral amyloid angiopathy: A prospective study
    M Edip Gurol
    From the Hemorrhagic Stroke Research Center, Department of Neurology M E G, P F, G R, K S, S M G, and Division of Nuclear Medicine and Molecular Imaging J A B, K A J, Massachusetts General Hospital, Harvard Medical School, Boston
    Neurology 87:2043-2049. 2016
    ..We hypothesized that florbetapir, a Food and Drug Administration-approved PET tracer, could distinguish cerebral amyloid angiopathy (CAA)-related intracerebral hemorrhage (ICH) from hypertensive ICH (HTN-ICH)...
  62. pmc Accelerated decline in white matter integrity in clinically normal individuals at risk for Alzheimer's disease
    Anna Rieckmann
    Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA, USA Department of Radiation Sciences, Diagnostic Radiology, Umea University, Umea, Sweden
    Neurobiol Aging 42:177-88. 2016
    ..The results suggest that accumulation of cortical amyloid and white matter changes in parahippocampal cingulum are not independent processes in individuals at increased risk for AD. ..
  63. pmc SIST-M-IR activities of daily living items that best discriminate clinically normal elderly from those with mild cognitive impairment
    Amy S Zoller
    Center for Alzheimer Research and Treatment, Brigham and Women s Hospital, 221 Longwood Avenue, BL 104H, Boston, MA 02115, USA
    Curr Alzheimer Res 11:785-91. 2014
    ..Of the 60 SIST-M-IR items, 41 address IADL; we aimed to determine which of these best discriminate individuals with MCI from clinically normal (CN) elderly...
  64. doi request reprint Does hippocampal FDG-PET asymmetry predict verbal memory dysfunction after left temporal lobectomy?
    Beth A Leeman
    Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Epilepsy Behav 16:274-80. 2009
    ..Although hippocampal FDG-PET asymmetries did not significantly predict changes in VM, the predictive value of neocortical AIs should be further explored. Automated ROI parcellation provides a feasible tool for use in such investigations...
  65. pmc Preclinical Alzheimer disease-the challenges ahead
    Reisa A Sperling
    Center for Alzheimer Research and Treatment, Departments of Neurology, Brigham and Women s Hospital and Massachusetts General Hospital, Harvard Medical School, 221 Longwood Avenue Boston, MA 02115, USA
    Nat Rev Neurol 9:54-8. 2013
    ..A number of challenges remain to be overcome before this concept can be validated and translated into clinical practice...
  66. ncbi request reprint Quantitative SPECT leads to improved performance in discrimination tasks related to prodromal Alzheimer's disease
    Georges El Fakhri
    Department of Radiology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Nucl Med 45:2026-31. 2004
    ....
  67. pmc Dopamine transporter availability in clinically normal aging is associated with individual differences in white matter integrity
    Anna Rieckmann
    Department of Radiology, Massachusetts General Hospital, Athinoula A Martinos Center for Biomedical Imaging, Charlestown, Massachusetts
    Hum Brain Mapp 37:621-31. 2016
    ..Hum Brain Mapp 37:621-631, 2016. © 2015 Wiley Periodicals, Inc. ..
  68. pmc Structural network alterations and neurological dysfunction in cerebral amyloid angiopathy
    Yael D Reijmer
    1 Stroke Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Brain 138:179-88. 2015
    ....
  69. pmc Estimating Total Cerebral Microinfarct Burden From Diffusion-Weighted Imaging
    Eitan Auriel
    From the Department of Neurology, J Philip Kistler Stroke Research Center E A, M B W, M T B, Y R, S M R, J N, E V E, P F, K S, A Vashkevich, G B, M E G, A Viswanathan, S M G and Department of Pathology, Neuropathology Service, C S Kubik Laboratory for Neuropathology M P F, Massachusetts General Hospital, Harvard Medical School, Boston Department of Radiology, Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown A P Y, K A J, R A S, T H and Department of Neurology, Center for Alzheimer Research and Treatment, Brigham and Women s Hospital, Harvard Medical School, Boston, MA R A S
    Stroke 46:2129-35. 2015
    ..We aim to describe a mathematical method for estimating total number of CMI based on the presence of incidental DWI lesions...
  70. ncbi request reprint Imaging of amyloid burden and distribution in cerebral amyloid angiopathy
    Keith A Johnson
    Department of Radiology, Massachusetts General Hospital, Boston, MA 02114, USA
    Ann Neurol 62:229-34. 2007
    ....
  71. pmc Identifying cognitively healthy elderly individuals with subsequent memory decline by using automated MR temporoparietal volumes
    Gloria C Chiang
    Department of Radiology, University of California, San Francisco, 505 Parnassus Ave, Room M391, San Francisco, CA, 94143, USA
    Radiology 259:844-51. 2011
    ..To determine whether automated temporoparietal brain volumes can be used to accurately predict future memory decline among a multicenter cohort of cognitively healthy elderly individuals...
  72. ncbi request reprint Molecular imaging with Pittsburgh Compound B confirmed at autopsy: a case report
    Brian J Bacskai
    MassGeneral Institute for Neurodegenerative Diseases, Department of Neurology, Charlestown, MA 02129, USA
    Arch Neurol 64:431-4. 2007
    ..Imaging revealed marked region specific binding of PiB and abnormal fluorodeoxyglucose uptake. Intervention Autopsy was performed 3 months after the PiB scan...
  73. pmc Disruption of functional connectivity in clinically normal older adults harboring amyloid burden
    Trey Hedden
    Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA 02129, USA
    J Neurosci 29:12686-94. 2009
    ....
  74. pmc The A4 study: stopping AD before symptoms begin?
    Reisa A Sperling
    Center for Alzheimer Research and Treatment, Department of Neurology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Sci Transl Med 6:228fs13. 2014
    ..A new secondary prevention trial in older people with amyloid accumulation at high risk for Alzheimer's disease dementia should provide insights into whether anti-amyloid therapy can delay cognitive decline. ..
  75. pmc Network assemblies in the functional brain
    Jorge Sepulcre
    Division of Nuclear Medicine and Molecular Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Curr Opin Neurol 25:384-91. 2012
    ..This review focuses on recent advances in functional connectivity MRI and renewed interest in studying the large-scale functional network assemblies in the brain. We also consider some methodological aspects of graph theoretical analysis...
  76. pmc The Centiloid Project: standardizing quantitative amyloid plaque estimation by PET
    William E Klunk
    Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA Department of Neurology, University of Pittsburgh, Pittsburgh PA, USA Electronic address
    Alzheimers Dement 11:1-15.e1-4. 2015
    ..Basically, we describe a "standard" method of analyzing PiB PET data and then a method for scaling any "nonstandard" method of PiB PET analysis (or any other tracer) to the Centiloid scale...
  77. ncbi request reprint MRI-guided SPECT perfusion measures and volumetric MRI in prodromal Alzheimer disease
    Georges El Fakhri
    Department of Radiology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Arch Neurol 60:1066-72. 2003
    ....
  78. pmc Appropriate use criteria for amyloid PET: a report of the Amyloid Imaging Task Force, the Society of Nuclear Medicine and Molecular Imaging, and the Alzheimer's Association
    Keith A Johnson
    Departments of Radiology and Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Alzheimers Dement 9:e-1-16. 2013
    ..Because both dementia care and amyloid PET technology are in active development, these AUC will require periodic reassessment. Future research directions are also outlined, including diagnostic utility and patient-centered outcomes...
  79. pmc Amyloid deposition begins in the striatum of presenilin-1 mutation carriers from two unrelated pedigrees
    William E Klunk
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    J Neurosci 27:6174-84. 2007
    ..The early, focal striatal amyloid deposition observed in these PS1 mutation carriers is often is not associated with clinical symptoms...