J N Hirschhorn
Affiliation: Massachusetts Institute of Technology
- Genomewide linkage analysis of stature in multiple populations reveals several regions with evidence of linkage to adult heightJ N Hirschhorn
Whitehead MIT Center for Genome Research, One Kendall Square, Cambridge, MA 02139, USA
Am J Hum Genet 69:106-16. 2001..These studies suggest that highly heritable complex traits such as stature may be genetically tractable and provide insight into the genetic architecture of complex traits...
- Large-scale discovery and genotyping of single-nucleotide polymorphisms in the mouseK Lindblad-Toh
Whitehead Institute MIT Center for Genome Research, Whitehead Institute for Biomedical Research, Cambridge, MA, USA
Nat Genet 24:381-6. 2000..We have also developed a multiplex genotyping procedure by which a genome scan can be performed with only six genotyping reactions per animal...
- The common PPARgamma Pro12Ala polymorphism is associated with decreased risk of type 2 diabetesD Altshuler
Whitehead Institute MIT Center for Genome Research, Cambridge, Massachusetts, USA
Nat Genet 26:76-80. 2000..Because the risk allele occurs at such high frequency, its modest effect translates into a large population attributable risk-influencing as much as 25% of type 2 diabetes in the general population...
- Association testing of common variants in the insulin receptor substrate-1 gene (IRS1) with type 2 diabetesJ C Florez
Simches Research Building CPZN 6820, Diabetes Unit Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA 02114, USA
Diabetologia 50:1209-17. 2007..However, other nearby variants might account for the putative association signal...