David B Herzog

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. ncbi request reprint Drug abuse in women with eating disorders
    David B Herzog
    Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Int J Eat Disord 39:364-8. 2006
  2. ncbi request reprint Secretory dynamics of leptin in adolescent girls with anorexia nervosa and healthy adolescents
    Madhusmita Misra
    Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Am J Physiol Endocrinol Metab 289:E373-81. 2005
  3. ncbi request reprint Relationships between serum adipokines, insulin levels, and bone density in girls with anorexia nervosa
    Madhusmita Misra
    Neuroendocrine Unit, Massachusetts General Hospital, Boston, MA 02114, USA
    J Clin Endocrinol Metab 92:2046-52. 2007
  4. pmc Percentage extremity fat, but not percentage trunk fat, is lower in adolescent boys with anorexia nervosa than in healthy adolescents
    Madhusmita Misra
    Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Am J Clin Nutr 88:1478-84. 2008
  5. ncbi request reprint Effects of anorexia nervosa on clinical, hematologic, biochemical, and bone density parameters in community-dwelling adolescent girls
    Madhusmita Misra
    Neuroendocrine Unit, and Harvard Medical School, Boston, Massachusetts 02114, USA
    Pediatrics 114:1574-83. 2004
  6. pmc Effects of recombinant human growth hormone in anorexia nervosa: a randomized, placebo-controlled study
    Pouneh K Fazeli
    Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 95:4889-97. 2010
  7. pmc Nutrient intake in community-dwelling adolescent girls with anorexia nervosa and in healthy adolescents
    Madhusmita Misra
    Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Am J Clin Nutr 84:698-706. 2006
  8. pmc Increased hypothalamic-pituitary-adrenal drive is associated with decreased appetite and hypoactivation of food-motivation neurocircuitry in anorexia nervosa
    Elizabeth A Lawson
    Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, Bulfinch 457 D, Boston, Massachusetts 02114, USA
    Eur J Endocrinol 169:639-47. 2013
  9. pmc Bone density characteristics and major depressive disorder in adolescents
    Pouneh K Fazeli
    Neuroendocrine Unit, Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, BUL 457, 55 Fruit St, Boston, MA 02114, USA
    Psychosom Med 75:117-23. 2013
  10. pmc Oxytocin secretion is associated with severity of disordered eating psychopathology and insular cortex hypoactivation in anorexia nervosa
    Elizabeth A Lawson
    Neuroendocrine Unit, Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 97:E1898-908. 2012

Research Grants

Collaborators

Detail Information

Publications78

  1. ncbi request reprint Drug abuse in women with eating disorders
    David B Herzog
    Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Int J Eat Disord 39:364-8. 2006
    ..Drug abuse in women with eating disorders has received relatively little attention. The frequency of drug use disorder (DUD) by specific drug type was examined in the current longitudinal study...
  2. ncbi request reprint Secretory dynamics of leptin in adolescent girls with anorexia nervosa and healthy adolescents
    Madhusmita Misra
    Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Am J Physiol Endocrinol Metab 289:E373-81. 2005
    ..Leptin predicts GH and cortisol parameters and with ghrelin predicts GH burst frequency. Low leptin and high ghrelin may be dual stimuli for high GH concentrations in undernutrition...
  3. ncbi request reprint Relationships between serum adipokines, insulin levels, and bone density in girls with anorexia nervosa
    Madhusmita Misra
    Neuroendocrine Unit, Massachusetts General Hospital, Boston, MA 02114, USA
    J Clin Endocrinol Metab 92:2046-52. 2007
    ..Adolescents with anorexia nervosa (AN) have low bone mineral density (BMD). Adipokines and insulin play an important role in bone metabolism in healthy individuals. However, their association with bone metabolism in AN is unknown...
  4. pmc Percentage extremity fat, but not percentage trunk fat, is lower in adolescent boys with anorexia nervosa than in healthy adolescents
    Madhusmita Misra
    Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Am J Clin Nutr 88:1478-84. 2008
    ..However, the effect of low testosterone and other hormonal alterations on body composition in boys with AN is not known...
  5. ncbi request reprint Effects of anorexia nervosa on clinical, hematologic, biochemical, and bone density parameters in community-dwelling adolescent girls
    Madhusmita Misra
    Neuroendocrine Unit, and Harvard Medical School, Boston, Massachusetts 02114, USA
    Pediatrics 114:1574-83. 2004
    ..The prevalence of AN is increasing in adolescents, and it is the third most common chronic disease in adolescent girls. Therefore, it is important to determine the medical effects of this disorder in this young population...
  6. pmc Effects of recombinant human growth hormone in anorexia nervosa: a randomized, placebo-controlled study
    Pouneh K Fazeli
    Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 95:4889-97. 2010
    ..The effects of supraphysiological recombinant human GH (rhGH) on GH resistance in AN are not currently known...
  7. pmc Nutrient intake in community-dwelling adolescent girls with anorexia nervosa and in healthy adolescents
    Madhusmita Misra
    Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Am J Clin Nutr 84:698-706. 2006
    ..Adolescence is a common time for the onset of anorexia nervosa (AN), a condition associated with long-term medical and hormonal consequences...
  8. pmc Increased hypothalamic-pituitary-adrenal drive is associated with decreased appetite and hypoactivation of food-motivation neurocircuitry in anorexia nervosa
    Elizabeth A Lawson
    Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, Bulfinch 457 D, Boston, Massachusetts 02114, USA
    Eur J Endocrinol 169:639-47. 2013
    ..We investigated the relationship between HPA activity, appetite, and food-motivation neurocircuitry hypoactivation in AN...
  9. pmc Bone density characteristics and major depressive disorder in adolescents
    Pouneh K Fazeli
    Neuroendocrine Unit, Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, BUL 457, 55 Fruit St, Boston, MA 02114, USA
    Psychosom Med 75:117-23. 2013
    ..MDD has recently been associated with lower bone mineral density (BMD) in adults. Our objective was to determine whether MDD is associated with BMD, bone turnover markers, vitamin D, and gonadal steroids in adolescents...
  10. pmc Oxytocin secretion is associated with severity of disordered eating psychopathology and insular cortex hypoactivation in anorexia nervosa
    Elizabeth A Lawson
    Neuroendocrine Unit, Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 97:E1898-908. 2012
    ..The relationships between oxytocin, food-motivation neurocircuitry, and disordered eating psychopathology have not been investigated in humans...
  11. ncbi request reprint Ghrelin and bone metabolism in adolescent girls with anorexia nervosa and healthy adolescents
    Madhusmita Misra
    BUL 457, Neuroendocrine Unit, Massachusetts General Hospital, 55 Fruit Street, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 90:5082-7. 2005
    ..Anorexia nervosa (AN) in adolescents is associated with low bone mineral density (BMD) and increases in ghrelin secretion, an orexigenic GH secretagogue that stimulates osteoblast proliferation in vitro...
  12. pmc Weight gain and restoration of menses as predictors of bone mineral density change in adolescent girls with anorexia nervosa-1
    Madhusmita Misra
    Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 93:1231-7. 2008
    ..We hypothesized that menstrual recovery and weight gain (> or =10% increase in body mass index) would predict an increase in these measures of bone density...
  13. pmc Postprandial oxytocin secretion is associated with severity of anxiety and depressive symptoms in anorexia nervosa
    Elizabeth A Lawson
    Neuroendocrine Unit, Massachusetts General Hospital, Boston, MA 02114, USA
    J Clin Psychiatry 74:e451-7. 2013
    ..A meal may represent a significant source of stress in patients with disordered eating. We therefore investigated the association between postprandial oxytocin secretion and symptoms of anxiety and depression in anorexia nervosa...
  14. pmc Leptin levels are associated with decreased depressive symptoms in women across the weight spectrum, independent of body fat
    Elizabeth A Lawson
    Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Clin Endocrinol (Oxf) 76:520-5. 2012
    ..We investigated the relationship between leptin and ghrelin levels and symptoms of depression, anxiety and perceived stress in women across the weight spectrum...
  15. pmc Bone metabolism in adolescent boys with anorexia nervosa
    Madhusmita Misra
    BUL 457, Neuroendocrine Unit, Massachusetts General Hospital, 55 Fruit Street, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 93:3029-36. 2008
    ..Although primarily a disease in females, AN is increasingly being recognized in males. However, there are few or no data regarding BMD, bone turnover markers or their predictors in adolescent AN boys...
  16. ncbi request reprint Alterations in cortisol secretory dynamics in adolescent girls with anorexia nervosa and effects on bone metabolism
    Madhusmita Misra
    Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 89:4972-80. 2004
    ..Therefore, high cortisol values in AN may contribute to the low bone density observed in adolescents with this disorder by decreasing bone formation...
  17. pmc Hormonal and nutritional effects on cardiovascular risk markers in young women
    Elizabeth A Lawson
    Neuroendocrine Unit, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 92:3089-94. 2007
    ..Moreover, oral estrogens, known to increase hsCRP in other populations, are commonly prescribed in AN. To date, hsCRP levels and their physiological determinants have not been reported in women with AN...
  18. ncbi request reprint Personality pathology and substance abuse in eating disorders: a longitudinal study
    Heather Thompson-Brenner
    Center for Anxiety and Related Disorders, Boston University, Boston, Massachusetts 02215, USA
    Int J Eat Disord 41:203-8. 2008
    ..This study investigates longitudinal associations between personality and substance use...
  19. pmc Cortical microstructure and estimated bone strength in young amenorrheic athletes, eumenorrheic athletes and non-athletes
    Kathryn E Ackerman
    Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Bone 51:680-7. 2012
    ..Finite element analysis (FEA) is a unique tool to estimate bone strength in vivo, and the contribution of cortical microstructure to bone strength in young athletes is not well understood...
  20. ncbi request reprint Role of cortisol in menstrual recovery in adolescent girls with anorexia nervosa
    Madhusmita Misra
    Neuroendocrine Unit, Massachusetts General Hospital, Boston, MA 02114, USA
    Pediatr Res 59:598-603. 2006
    ..Baseline cortisol level strongly predicted increases in the percentage of body fat. We demonstrate that 1) high baseline cortisol level predicts increases in body fat and 2) increases in body fat predict menses recovery in AN...
  21. doi request reprint A personality classification system for eating disorders: a longitudinal study
    Heather Thompson-Brenner
    Massachusetts General Hospital, 2 Longfellow Place, Suite 200, Boston, MA 02114, USA
    Compr Psychiatry 49:551-60. 2008
    ..Longitudinal outcomes for personality subtypes have not been examined...
  22. pmc Peptide YY in adolescent athletes with amenorrhea, eumenorrheic athletes and non-athletic controls
    Melissa Russell
    Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Bone 45:104-9. 2009
    ..The role of other nutritionally regulated hormones such as peptide YY (PYY) and adiponectin in mediating gonadal status and bone metabolism remains to be determined...
  23. pmc Hypercortisolemia is associated with severity of bone loss and depression in hypothalamic amenorrhea and anorexia nervosa
    Elizabeth A Lawson
    Neuroendocrine Unit, Bulfinch 457B, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 94:4710-6. 2009
    ..Significant hypercortisolemia, as in Cushing's disease, causes bone loss. It is unknown whether anxiety and depression and/or cortisol dysregulation contribute to low bone density in AN or HA...
  24. pmc Cortisol secretory parameters in young exercisers in relation to LH secretion and bone parameters
    Kathryn E Ackerman
    Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Clin Endocrinol (Oxf) 78:114-9. 2013
    ..We hypothesized that higher cortisol secretion in young endurance weight-bearing AE compared with EE and nonexercisers predicts lower LH secretion, lower levels of a bone formation marker and higher levels of a bone resorption marker...
  25. pmc Higher ghrelin and lower leptin secretion are associated with lower LH secretion in young amenorrheic athletes compared with eumenorrheic athletes and controls
    Kathryn E Ackerman
    Neuroendocrine Unit, Massachusetts General Hospital, Boston, 02114, USA
    Am J Physiol Endocrinol Metab 302:E800-6. 2012
    ..We conclude that higher ghrelin and lower leptin secretion in AA related to lower fat mass may contribute to altered LH pulsatility and amenorrhea...
  26. pmc Prognostic indicators of changes in bone density measures in adolescent girls with anorexia nervosa-II
    Madhusmita Misra
    Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 93:1292-7. 2008
    ..We hypothesized that baseline levels of nutritionally regulated hormones and of bone turnover markers would predict DeltaBMD overall...
  27. ncbi request reprint Hormonal determinants of regional body composition in adolescent girls with anorexia nervosa and controls
    Madhusmita Misra
    Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, BUL 457, 55 Fruit Street, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 90:2580-7. 2005
    ..High cortisol levels in AN predict a redistribution of lean body mass such that extremity lean mass decreases. Further studies are necessary to better understand the implications of these data...
  28. pmc Diagnostic crossover in anorexia nervosa and bulimia nervosa: implications for DSM-V
    Kamryn T Eddy
    Department of Psychiatry, Massachusetts General Hospital, 2 Longfellow Place, Suite 200, Boston, MA 02214, USA
    Am J Psychiatry 165:245-50. 2008
    ..This study was designed to examine diagnostic crossover longitudinally in anorexia nervosa and bulimia nervosa to inform the validity of the DSM-IV-TR eating disorders classification system...
  29. pmc Decreased nocturnal oxytocin levels in anorexia nervosa are associated with low bone mineral density and fat mass
    Elizabeth A Lawson
    Neuroendocrine Unit, Bulfinch 457B, Massachusetts General Hospital, Boston, MA 02114, USA
    J Clin Psychiatry 72:1546-51. 2011
    ..Our objective was to investigate the relationship between oxytocin levels, bone mineral density, and body composition in women with anorexia nervosa...
  30. pmc Peptide YY (PYY) levels and bone mineral density (BMD) in women with anorexia nervosa
    Andrea L Utz
    Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Bone 43:135-9. 2008
    ..Y2 receptor knockout mice have increased bone mineral density (BMD) and thus PYY may play a role in regulating bone mass. We hypothesized that PYY levels would be inversely associated with BMD in women with AN...
  31. ncbi request reprint Androgen deficiency: association with increased anxiety and depression symptom severity in anorexia nervosa
    Karen K Miller
    Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    J Clin Psychiatry 68:959-65. 2007
    ..Because androgens are known to affect mood and behavior, we hypothesized that low endogenous androgen production in anorexia nervosa would predict anxiety and depression severity...
  32. ncbi request reprint Hormonal and body composition predictors of soluble leptin receptor, leptin, and free leptin index in adolescent girls with anorexia nervosa and controls and relation to insulin sensitivity
    Madhusmita Misra
    BUL 457B, Neuroendocrine Unit, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA
    J Clin Endocrinol Metab 89:3486-95. 2004
    ..Resumption of menses is associated with significant increases in the FLI, suggesting that free leptin may be an important determinant of menstrual recovery...
  33. pmc Diagnostic classification of eating disorders in children and adolescents: how does DSM-IV-TR compare to empirically-derived categories?
    Kamryn T Eddy
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    J Am Acad Child Adolesc Psychiatry 49:277-87; quiz 293. 2010
    ....
  34. ncbi request reprint Elevated peptide YY levels in adolescent girls with anorexia nervosa
    Madhusmita Misra
    BUL 457, Neuroendocrine Unit, Massachusetts General Hospital, 55 Fruit Street, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 91:1027-33. 2006
    ..In addition, known regulators of bone turnover, such as GH, cortisol, and estrogen, explain only a fraction of the variability in bone turnover marker levels...
  35. pmc A longitudinal investigation of mortality in anorexia nervosa and bulimia nervosa
    Debra L Franko
    Harris Center for Education and Advocacy in Eating Disorders and Department of Psychiatry, Massachusetts General Hospital, Boston, USA
    Am J Psychiatry 170:917-25. 2013
    ....
  36. doi request reprint Interactions between eating disorders and drug abuse
    Debra L Franko
    Department of Psychiatry, Harris Center for Eating Disorders, Massachusetts General Hospital, Boston, MA 02114, USA
    J Nerv Ment Dis 196:556-61. 2008
    ..Drug abuse in women with eating disorders is an area of clinical concern and should be monitored routinely...
  37. pmc Bone metabolism in adolescent athletes with amenorrhea, athletes with eumenorrhea, and control subjects
    Karla Christo
    Massachusetts General Hospital, Neuroendocrine Unit, BUL 457, 55 Fruit St, Boston, MA 02114, USA
    Pediatrics 121:1127-36. 2008
    ....
  38. ncbi request reprint Secondary prevention for eating disorders: the impact of education, screening, and referral in a college-based screening program
    Anne E Becker
    Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Int J Eat Disord 36:157-62. 2004
    ..The current study assessed the impact of the NEDSP on participants...
  39. doi request reprint Eating disorder not otherwise specified in adolescents
    Kamryn T Eddy
    Massachusetts General Hospital, 2 Longfellow Place, Boston, MA 02114, USA
    J Am Acad Child Adolesc Psychiatry 47:156-64. 2008
    ..To examine the frequency, type, and clinical severity of eating disorder not otherwise specified (EDNOS) in adolescents seeking treatment through an outpatient eating disorders service...
  40. pmc Depression and eating disorders: treatment and course
    David Mischoulon
    Depression Clinical and Research Program, Massachusetts General Hospital, Boston, MA 02114, USA
    J Affect Disord 130:470-7. 2011
    ..We examined the course of major depressive disorder (MDD) and predictors of MDD recovery and relapse in a longitudinal sample of women with eating disorders (ED)...
  41. ncbi request reprint Cross-ethnic differences in eating disorder symptoms and related distress
    Debra L Franko
    Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Int J Eat Disord 40:156-64. 2007
    ..This study investigated ethnic differences in the frequency of eating disorder symptoms and related distress in a U.S. college-based eating disorders screening program...
  42. doi request reprint Determinants of height in adolescent girls with anorexia nervosa
    Rajani Prabhakaran
    BUL 457, MassGeneral Hospital, Neuroendocrine Unit, 55 Fruit St, Boston, MA 02114, USA
    Pediatrics 121:e1517-23. 2008
    ..In addition, growth hormone may have direct effects on the growth plate independent of insulin-like growth factor 1 to increase statural growth...
  43. ncbi request reprint How do eating disorders and alcohol use disorder influence each other?
    Debra L Franko
    Harvard Eating Disorders Center, Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Int J Eat Disord 38:200-7. 2005
    ..Although eating disorders and alcohol use disorder (AUD) are known to co-occur, the influence of one on the other has not been studied...
  44. pmc Weight suppression predicts weight change over 5 years in bulimia nervosa
    David B Herzog
    Harris Center, Department of Psychiatry, Massachusetts General Hospital, 2 Longfellow Place, Ste 200, Boston, MA 02114, USA
    Psychiatry Res 177:330-4. 2010
    ..Because weight gain could spur radical dieting that maintains BN, these results have important treatment implications...
  45. ncbi request reprint Secretory dynamics of ghrelin in adolescent girls with anorexia nervosa and healthy adolescents
    Madhusmita Misra
    Neuroendocrine Unit, Massachusetts General Hospital, 55 Fruit St, Boston, MA 02114, USA
    Am J Physiol Endocrinol Metab 289:E347-56. 2005
    ..The most important predictor of ghrelin concentration is insulin resistance, and ghrelin in turn predicts GH and cortisol burst frequency...
  46. ncbi request reprint Longitudinal comparison of anorexia nervosa subtypes
    Kamryn T Eddy
    Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Int J Eat Disord 31:191-201. 2002
    ..To compare patients with restricting anorexia nervosa (ANR) and binge/purge anorexia nervosa (ANBP) on measures of impulsivity, course, and outcome...
  47. doi request reprint Recovery From Anorexia Nervosa and Bulimia Nervosa at 22-Year Follow-Up
    Kamryn T Eddy
    Eating Disorders Clinical and Research Program, Massachusetts General Hospital, 2 Longfellow Pl, Ste 200, Boston, MA 02114
    J Clin Psychiatry . 2016
    ..This study investigates early and long-term recovery in the Massachusetts General Hospital Longitudinal Study of Anorexia and Bulimia Nervosa...
  48. pmc Teriparatide increases bone formation and bone mineral density in adult women with anorexia nervosa
    Pouneh K Fazeli
    Neuroendocrine Unit P K F, I S W, K K M, M M, A K, Biostatistics Center H L, and Endocrine Unit J S F, Massachusetts General Hospital, Boston, Massachusetts 02114 Center for Advanced Orthopaedic Studies M L B, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215 and Harvard Medical School P K F, K K M, D B H, M M, H L, J S F, M L B, A K, Boston, Massachusetts 02115
    J Clin Endocrinol Metab 99:1322-9. 2014
    ..Increased clinical fractures are common, and most women have low bone mineral density (BMD). Previously investigated treatments have led to no or modest increases in BMD in AN...
  49. pmc Physiologic estrogen replacement increases bone density in adolescent girls with anorexia nervosa
    Madhusmita Misra
    Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    J Bone Miner Res 26:2430-8. 2011
    ..It is concluded that physiologic estradiol replacement increases spine and hip BMD in girls with AN...
  50. ncbi request reprint Effects of risedronate on bone density in anorexia nervosa
    Karen K Miller
    Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 89:3903-6. 2004
    ..S. for premenopausal women other than those receiving glucocorticoids. Further studies are needed to establish the efficacy and safety of bisphosphonate therapy in this population...
  51. ncbi request reprint Growth hormone and ghrelin responses to an oral glucose load in adolescent girls with anorexia nervosa and controls
    Madhusmita Misra
    Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 89:1605-12. 2004
    ..Further studies are needed to define GH suppression in an adolescent population...
  52. ncbi request reprint Uncoupling of cardiovascular risk markers in adolescent girls with anorexia nervosa
    Madhusmita Misra
    Neuroendocrine Unit, and the Eating Disorders Unit, Child Psychiatry Service, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    J Pediatr 149:763-769. 2006
    ..We hypothesized that in AN, growth hormone (GH) resistance and hypercortisolemia would increase CV risk through effects on pro-inflammatory cytokines and lipid status despite low weight...
  53. ncbi request reprint Disclosure patterns of eating and weight concerns to clinicians, educational professionals, family, and peers
    Anne E Becker
    Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Int J Eat Disord 38:18-23. 2005
    ..The current study investigated disclosure of eating and weight concerns to professionals, peers, and family...
  54. ncbi request reprint Should bulimia nervosa be subtyped by history of anorexia nervosa? A longitudinal validation
    Kamryn T Eddy
    Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts, USA
    Int J Eat Disord 40:S67-71. 2007
    ..To determine whether a past diagnosis of anorexia nervosa (AN) predicts longitudinal course and outcome among women with bulimia nervosa (BN)...
  55. ncbi request reprint Alterations in growth hormone secretory dynamics in adolescent girls with anorexia nervosa and effects on bone metabolism
    Madhusmita Misra
    Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 88:5615-23. 2003
    ..Acquired GH resistance may play a role in the osteopenia and decreased peak bone mass frequently associated with AN...
  56. ncbi request reprint Effects of estrogen and recombinant human insulin-like growth factor-I on ghrelin secretion in severe undernutrition
    Steven Grinspoon
    Neuroendocrine Unit, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 89:3988-93. 2004
    ..The mechanisms of these effects are unknown and may relate to direct effects on ghrelin or changes in GH. Further studies are needed to determine the mechanisms by which rhIGF-I and E increase ghrelin in human physiology...
  57. ncbi request reprint Regional cerebral brain metabolism correlates of neuroticism and extraversion
    Thilo Deckersbach
    Department of Psychiatry, Massachusetts General Hospital, Boston, USA
    Depress Anxiety 23:133-8. 2006
    ..No significant correlations were found involving anterior cingulate, amygdala, or ventral striatum. Neuroticism and Extraversion are associated with activity in insular cortex and orbitofrontal cortex, respectively...
  58. ncbi request reprint Strategic memory in adults with anorexia nervosa: are there similarities to obsessive compulsive spectrum disorders?
    Bonnie J Sherman
    Center for Excellence in Women s Health, Boston University Medical Center, and Department of Psychiatry, Massachusetts General Hospital, Boston, MA 02114, USA
    Int J Eat Disord 39:468-76. 2006
    ..This study evaluated nonverbal strategic memory in AN outpatients using an approach previously applied to OC spectrum disorders...
  59. doi request reprint Re-examining premature mortality in anorexia nervosa: a meta-analysis redux
    Aparna Keshaviah
    Eating Disorders Clinical and Research Program, Massachusetts General Hospital, Boston, MA, USA
    Compr Psychiatry 55:1773-84. 2014
    ..Risk of premature mortality was highest in studies with older participants, although confounding by treatment was present. Gender, ascertainment, and diagnostic criteria also impacted risk...
  60. doi request reprint Clinician reactions to patients with eating disorders: a review of the literature
    Heather Thompson-Brenner
    Center for Anxiety and Related Disorders, Department of Psychology, Boston University, 648 Beacon St, Boston, MA 02215, USA
    Psychiatr Serv 63:73-8. 2012
    ....
  61. ncbi request reprint Predictors of treatment utilization among women with anorexia and bulimia nervosa
    Pamela K Keel
    Department of Psychiatry, Massachusetts General Hospital, Boston, USA
    Am J Psychiatry 159:140-2. 2002
    ..The authors sought predictors of treatment utilization among women with eating disorders...
  62. ncbi request reprint Eating disorder pathology among overweight treatment-seeking youth: clinical correlates and cross-sectional risk modeling
    Kamryn T Eddy
    Center for Anxiety and Related Disorders, Boston University, 648 Beacon Street, 6th Floor, Boston, MA 02215, USA
    Behav Res Ther 45:2360-71. 2007
    ....
  63. ncbi request reprint Ethnicity and differential access to care for eating disorder symptoms
    Anne E Becker
    Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Int J Eat Disord 33:205-12. 2003
    ..The impact of ethnicity on access to health care for eating disorder symptoms among participants in the 1996 National Eating Disorders Screening Program (NEDSP) was examined in two studies...
  64. ncbi request reprint Testosterone administration attenuates regional brain hypometabolism in women with anorexia nervosa
    Karen K Miller
    Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, BUL 457B, Boston, MA 02114, USA
    Psychiatry Res 132:197-207. 2004
    ..Further study is warranted to replicate these findings, as well as to determine their physiological and clinical significance...
  65. ncbi request reprint Interpretation and use of weight information in the evaluation of eating disorders: counselor response to weight information in a National Eating Disorders Educational and Screening Program
    Anne E Becker
    Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Int J Eat Disord 37:38-43. 2005
    ..The current study investigated whether weight data were used appropriately in making recommendations for further care in the first National Eating Disorders Screening Program (NEDSP)...
  66. ncbi request reprint Report of the National Institutes of Health workshop on overcoming barriers to treatment research in anorexia nervosa
    W Stewart Agras
    Department of Psychiatry, Stanford University School of Medicine, Stanford, California, USA
    Int J Eat Disord 35:509-21. 2004
    ..The goals of this workshop were to discuss the stages of illness and illness severity, pharmacologic interventions, psychological interventions, and methodologic considerations...
  67. ncbi request reprint Eating behaviours and attitudes following prolonged exposure to television among ethnic Fijian adolescent girls
    Anne E Becker
    Department of Social Medicine, Harvard Medical School, Boston, MA, USA
    Br J Psychiatry 180:509-14. 2002
    ..There are no published studies evaluating the impact of introduction of television on disordered eating in media-naïve populations...
  68. ncbi request reprint Primary prevention of risk factors for eating disorders in adolescent girls: learning from practice
    Catherine Steiner-Adair
    Harvard Eating Disorders Center, Massachusetts General Hospital, Boston, Massachusetts 02115, USA
    Int J Eat Disord 32:401-11. 2002
    ..This study evaluates the effectiveness and feasibility of a primary prevention program for risk factors for eating disorders in adolescent girls...
  69. ncbi request reprint Serum osteoprotegerin in adolescent girls with anorexia nervosa
    Madhusmita Misra
    Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 88:3816-22. 2003
    ..OPG values correlate negatively with markers of nutritional status and lumbar bone density z-scores and may be a compensatory response to the bone loss seen in this population...
  70. doi request reprint Stereotypes, prejudice and discrimination of women with anorexia nervosa
    Maria Christina Stewart
    Department of Psychology, University of Hawai i, HI 96822, USA
    Eur Eat Disord Rev 16:311-8. 2008
    ..Findings support the existence of stigma toward individuals with AN. Future research should examine means of reducing stigma...
  71. ncbi request reprint Predictors of mortality in eating disorders
    Pamela K Keel
    Department of Psychology, Harvard University, 1320 William James Hall, 33 Kirkland St, Cambridge, MA 02138, USA
    Arch Gen Psychiatry 60:179-83. 2003
    ..However, potential predictors of mortality, such as comorbid psychiatric illnesses, remain unclear. We sought to determine mortality ratios and predictors of fatal outcome in women diagnosed as having anorexia or bulimia nervosa...
  72. ncbi request reprint Postremission predictors of relapse in women with eating disorders
    Pamela K Keel
    Department of Psychology, E11 Seashore Hall, University of Iowa, Iowa City, Iowa 52242, USA
    Am J Psychiatry 162:2263-8. 2005
    ..The authors sought to evaluate patterns and predictors of relapse among women with eating disorders...
  73. doi request reprint Sexual assault and disordered eating in Asian women
    Lareina N La Flair
    Department of Mental Health, Johns Hopkins University Bloomberg School of Public Health, USA
    Harv Rev Psychiatry 16:248-57. 2008
    ....
  74. doi request reprint Case records of the Massachusetts General Hospital. Case 29-2008. A 19-year-old man with weight loss and abdominal pain
    Mark A Goldstein
    Department of Pediatrics, Massachusetts General Hospital and Harvard Medical School, USA
    N Engl J Med 359:1272-83. 2008
  75. ncbi request reprint Residential treatment for eating disorders
    Maria J Frisch
    University of Minnesota, Minneapolis, Minnesota 55454, USA
    Int J Eat Disord 39:434-42. 2006
    ..The current study describes residential treatment for eating disorders in the United States...
  76. ncbi request reprint Arts-based therapies in the treatment of eating disorders
    Maria J Frisch
    University of Minnesota, Minneapolis, Minnesota, USA
    Eat Disord 14:131-42. 2006
    ....
  77. ncbi request reprint Federal advocacy for anorexia nervosa: an American model
    Jeanine C Cogan
    Eating Disorders Coalition, Washington, DC 20003, USA
    Int J Eat Disord 37:S101-2. 2005
    ..Federal advocacy in the United States is spearheaded by the Eating Disorders Coalition for Research, Policy, and Action (EDC) whose mission is to advance the federal recognition of eating disorders as a public health priority...
  78. ncbi request reprint Deaths by suicide among individuals with anorexia as arbiters between competing explanations of the anorexia-suicide link
    Jill M Holm-Denoma
    University of Vermont, Burlington, Vermont, USA
    J Affect Disord 107:231-6. 2008
    ..Suicide is a leading cause of death among individuals with anorexia nervosa (AN). In this paper, we examined competing explanations of the high rate of death by suicide among individuals with anorexia nervosa (AN)...

Research Grants2

  1. Substance Use Disorders In Women with Anorexia/Bulimia
    David Herzog; Fiscal Year: 2004
    ..abstract_text> ..
  2. Alcoholism In Women with Anorexia and Bulimia Nervosa
    David Herzog; Fiscal Year: 2004
    ....