Piyush B Gupta

Summary

Affiliation: Massachusetts Institute of Technology
Country: USA

Publications

  1. pmc Cancer cells exhibit clonal diversity in phenotypic plasticity.
    Robert Austin Mathis
    Open Biol 7:. 2017
  2. pmc Cell-state transitions regulated by SLUG are critical for tissue regeneration and tumor initiation
    Sarah Phillips
    Department of Developmental, Molecular and Chemical Biology, Sackler School of Graduate Biomedical Sciences, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA 02111, USA Molecular Oncology Research Institute, Tufts Medical Center, 800 Washington Street, Boston, MA 02111, USA
    Stem Cell Reports 2:633-47. 2014
  3. doi request reprint Stochastic state transitions give rise to phenotypic equilibrium in populations of cancer cells
    Piyush B Gupta
    Broad Institute, Cambridge, MA 02142, USA
    Cell 146:633-44. 2011
  4. pmc Identification of selective inhibitors of cancer stem cells by high-throughput screening
    Piyush B Gupta
    Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Cell 138:645-59. 2009
  5. doi request reprint Cinnamides as selective small-molecule inhibitors of a cellular model of breast cancer stem cells
    Andrew R Germain
    Chemical Biology Platform and Probe Development Center, Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, MA 02142, USA
    Bioorg Med Chem Lett 23:1834-8. 2013
  6. pmc Growth of human breast tissues from patient cells in 3D hydrogel scaffolds
    Ethan S Sokol
    Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA, 02142, USA
    Breast Cancer Res 18:19. 2016
  7. doi request reprint Loss of E-cadherin promotes metastasis via multiple downstream transcriptional pathways
    Tamer T Onder
    Whitehead Institute for Biomedical Research, Cambridge, Massachusetts, USA
    Cancer Res 68:3645-54. 2008
  8. ncbi request reprint Systemic stromal effects of estrogen promote the growth of estrogen receptor-negative cancers
    Piyush B Gupta
    Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA
    Cancer Res 67:2062-71. 2007
  9. doi request reprint Cancer stem cells: mirage or reality?
    Piyush B Gupta
    Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, Massachusetts, USA
    Nat Med 15:1010-2. 2009
  10. pmc A physical and regulatory map of host-influenza interactions reveals pathways in H1N1 infection
    Sagi D Shapira
    Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, MA 02142, USA
    Cell 139:1255-67. 2009

Collaborators

  • Sendurai A Mani
  • Charlotte Kuperwasser
  • Ethan S Sokol
  • Kai Tao
  • David E Hill
  • Aviv Regev
  • Jing Yang
  • David E Root
  • Christine M Fillmore
  • Irit Gat-Viks
  • Christine L Chaffer
  • Andrew R Germain
  • Eric S Lander
  • Robert Austin Mathis
  • Eric J Solís
  • Sarah Phillips
  • Benito Munoz
  • Partha P Nag
  • Michelle Palmer
  • Lynn VerPlank
  • Sivaraman Dandapani
  • Yuxiong Feng
  • Jose R Perez
  • Cristina Fernandez
  • Leigh C Carmody
  • Stuart L Schreiber
  • Barbara Morgan
  • Sagi D Shapira
  • Tamer T Onder
  • Edoardo M Airoldi
  • Vladimir Denic
  • Dexter X Jin
  • Jai P Pandey
  • David Pincus
  • Xu Zheng
  • Charles M Perou
  • Adam Skibinski
  • Theresa Proia
  • Aleix Prat
  • Maja Sedic
  • Sohini Mazumdar
  • Stephanie H Shirley
  • Ania Wronski
  • Grace Gill
  • Etienne Donckele
  • Timothy A Lewis
  • Erin Forbeck
  • Amal Ting
  • Serena J Silver
  • Tong Hao
  • Marciela M de Grace
  • Bennett O V Shum
  • Liguo Wu
  • Nir Hacohen
  • Amelie Dricot
  • Robert A Weinberg

Detail Information

Publications14

  1. pmc Cancer cells exhibit clonal diversity in phenotypic plasticity.
    Robert Austin Mathis
    Open Biol 7:. 2017
    ..These findings establish new insights into phenotypic plasticity in cancer, and suggest design principles for optimizing the effectiveness of combination therapies for phenotypically heterogeneous tumours...
  2. pmc Cell-state transitions regulated by SLUG are critical for tissue regeneration and tumor initiation
    Sarah Phillips
    Department of Developmental, Molecular and Chemical Biology, Sackler School of Graduate Biomedical Sciences, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA 02111, USA Molecular Oncology Research Institute, Tufts Medical Center, 800 Washington Street, Boston, MA 02111, USA
    Stem Cell Reports 2:633-47. 2014
    ..Together, these results demonstrate that SLUG plays a dual role in repressing luminal epithelial differentiation while unlocking stem cell transitions necessary for tumorigenesis. ..
  3. doi request reprint Stochastic state transitions give rise to phenotypic equilibrium in populations of cancer cells
    Piyush B Gupta
    Broad Institute, Cambridge, MA 02142, USA
    Cell 146:633-44. 2011
    ..These findings contribute to our understanding of cancer heterogeneity and reveal how stochasticity in single-cell behaviors promotes phenotypic equilibrium in populations of cancer cells...
  4. pmc Identification of selective inhibitors of cancer stem cells by high-throughput screening
    Piyush B Gupta
    Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Cell 138:645-59. 2009
    ..This study demonstrates the ability to identify agents with specific toxicity for epithelial CSCs...
  5. doi request reprint Cinnamides as selective small-molecule inhibitors of a cellular model of breast cancer stem cells
    Andrew R Germain
    Chemical Biology Platform and Probe Development Center, Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, MA 02142, USA
    Bioorg Med Chem Lett 23:1834-8. 2013
    ..Herein, we report structure-activity relationships of this class of cinnamides for selective lethality towards CSC-enriched populations...
  6. pmc Growth of human breast tissues from patient cells in 3D hydrogel scaffolds
    Ethan S Sokol
    Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA, 02142, USA
    Breast Cancer Res 18:19. 2016
    ..Here we describe a 3D culture system with both of these properties that stimulates the outgrowth of morphologically complex and hormone-responsive mammary tissues from primary human breast epithelial cells...
  7. doi request reprint Loss of E-cadherin promotes metastasis via multiple downstream transcriptional pathways
    Tamer T Onder
    Whitehead Institute for Biomedical Research, Cambridge, Massachusetts, USA
    Cancer Res 68:3645-54. 2008
    ..These findings indicate that E-cadherin loss in tumors contributes to metastatic dissemination by inducing wide-ranging transcriptional and functional changes...
  8. ncbi request reprint Systemic stromal effects of estrogen promote the growth of estrogen receptor-negative cancers
    Piyush B Gupta
    Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA
    Cancer Res 67:2062-71. 2007
    ..Furthermore, bone marrow cells from estrogen-treated mice were sufficient to promote tumor growth. These results reveal a novel mechanism by which estrogens promote the growth of ER-negative cancers...
  9. doi request reprint Cancer stem cells: mirage or reality?
    Piyush B Gupta
    Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, Massachusetts, USA
    Nat Med 15:1010-2. 2009
    ..If present, such plasticity would have major implications for the CSC model and for future therapeutic approaches...
  10. pmc A physical and regulatory map of host-influenza interactions reveals pathways in H1N1 infection
    Sagi D Shapira
    Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, MA 02142, USA
    Cell 139:1255-67. 2009
    ..This multilayered approach provides a comprehensive and unbiased physical and regulatory model of influenza-host interactions and demonstrates a general strategy for uncovering complex host-pathogen relationships...
  11. pmc Perturbation-expression analysis identifies RUNX1 as a regulator of human mammary stem cell differentiation
    Ethan S Sokol
    Whitehead Institute for Biomedical Research, Cambridge, Massachusetts, United States of America Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America
    PLoS Comput Biol 11:e1004161. 2015
    ..Collectively, our findings show that RUNX1 is required for mammary stem cells to exit a bipotent state, and provide a new method for discovering cell-state regulators when markers are not available. ..
  12. pmc Defining the Essential Function of Yeast Hsf1 Reveals a Compact Transcriptional Program for Maintaining Eukaryotic Proteostasis
    Eric J Solís
    Department of Molecular and Cellular Biology, Northwest Labs, Harvard University, Cambridge, MA 02138, USA Systems Biology PhD Program, Harvard University, Cambridge, MA 02138, USA
    Mol Cell 63:60-71. 2016
    ..Our work reveals that yeast chaperone gene expression is an essential housekeeping mechanism and provides a roadmap for defining the function of HSF1 as a driver of oncogenesis. ..
  13. doi request reprint Identification of a selective small molecule inhibitor of breast cancer stem cells
    Andrew R Germain
    Chemical Biology Platform and Probe Development Center, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA
    Bioorg Med Chem Lett 22:3571-4. 2012
    ....
  14. ncbi request reprint Contributions of estrogen to ER-negative breast tumor growth
    Piyush B Gupta
    Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, MA 02142, USA
    J Steroid Biochem Mol Biol 102:71-8. 2006
    ..Taken together, these data suggest that estrogen may promote the growth of ER-negative cancers by acting on cells distinct from the cancer cells to stimulate angiogenesis...