Joshua N Goldstein

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. ncbi request reprint Timing of fresh frozen plasma administration and rapid correction of coagulopathy in warfarin-related intracerebral hemorrhage
    Joshua N Goldstein
    Department of Emergency Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Stroke 37:151-5. 2006
  2. ncbi request reprint Contrast extravasation on CT angiography predicts hematoma expansion in intracerebral hemorrhage
    J N Goldstein
    Department of Emergency Medicine, Massachusetts General Hospital, Boston, MA 02114, USA
    Neurology 68:889-94. 2007
  3. pmc CT angiography predicts use of tertiary interventional services in acute ischemic stroke patients
    Lisa E Thomas
    Department of Emergency Medicine, Massachusetts General Hospital, Boston, MA, USA
    Int J Emerg Med 4:62. 2011
  4. pmc Critical care management of acute intracerebral hemorrhage
    Joshua N Goldstein
    Massachusetts General Hospital, Department of Emergency Medicine, Zero Emerson Place, Suite 3B, Boston, MA, 02114, USA
    Curr Treat Options Neurol 13:204-16. 2011
  5. pmc Should anticoagulation be resumed after intracerebral hemorrhage?
    Joshua N Goldstein
    Department of Emergency Medicine, Massachusetts General Hospital, Zero Emerson Place, Suite 3B, Boston, MA 02114, USA
    Cleve Clin J Med 77:791-9. 2010
  6. pmc Risk of thromboembolism following acute intracerebral hemorrhage
    Joshua N Goldstein
    Department of Emergency Medicine, Massachusetts General Hospital, Zero Emerson Place, Suite 3B, Boston, MA 02114, USA
    Neurocrit Care 10:28-34. 2009
  7. pmc Management of thrombolysis-associated symptomatic intracerebral hemorrhage
    Joshua N Goldstein
    Department of Emergency Medicine, Massachusetts General Hospital, Zero Emerson Place, STE 3B, Boston, MA 02114, USA
    Arch Neurol 67:965-9. 2010
  8. doi request reprint Rapid focused neurological assessment in the emergency department and ICU
    Joshua N Goldstein
    Department of Emergency Medicine, Massachusetts General Hospital, Boston, MA 02114, USA
    Emerg Med Clin North Am 27:1-16, vii. 2009
  9. pmc Apolipoprotein E genotype is associated with CT angiography spot sign in lobar intracerebral hemorrhage
    H Bart Brouwers
    Center for Human Genetic Research Rosand Lab, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Stroke 43:2120-5. 2012
  10. pmc Heritability estimates identify a substantial genetic contribution to risk and outcome of intracerebral hemorrhage
    William J Devan
    Center for Human Genetic Research, Massachusetts General Hospital, 185 Cambridge St, CPZN 6818, Boston, MA 02114, USA
    Stroke 44:1578-83. 2013

Detail Information

Publications56

  1. ncbi request reprint Timing of fresh frozen plasma administration and rapid correction of coagulopathy in warfarin-related intracerebral hemorrhage
    Joshua N Goldstein
    Department of Emergency Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Stroke 37:151-5. 2006
    ..We sought to determine whether particular emergency department (ED) interventions are effective in reversing coagulopathy and improving outcome...
  2. ncbi request reprint Contrast extravasation on CT angiography predicts hematoma expansion in intracerebral hemorrhage
    J N Goldstein
    Department of Emergency Medicine, Massachusetts General Hospital, Boston, MA 02114, USA
    Neurology 68:889-94. 2007
    ..However, only a minority arrive within this time frame. Therefore, alternative markers for expansion risk are needed...
  3. pmc CT angiography predicts use of tertiary interventional services in acute ischemic stroke patients
    Lisa E Thomas
    Department of Emergency Medicine, Massachusetts General Hospital, Boston, MA, USA
    Int J Emerg Med 4:62. 2011
    ..We hypothesized that the presence of a proximal cerebral artery occlusion on CT angiography (CTA) is an independent predictor of the use of these services...
  4. pmc Critical care management of acute intracerebral hemorrhage
    Joshua N Goldstein
    Massachusetts General Hospital, Department of Emergency Medicine, Zero Emerson Place, Suite 3B, Boston, MA, 02114, USA
    Curr Treat Options Neurol 13:204-16. 2011
    ..After the hemorrhage has stabilized, efforts to minimize complications include thromboembolism prophylaxis, physical therapy, and acute rehabilitation...
  5. pmc Should anticoagulation be resumed after intracerebral hemorrhage?
    Joshua N Goldstein
    Department of Emergency Medicine, Massachusetts General Hospital, Zero Emerson Place, Suite 3B, Boston, MA 02114, USA
    Cleve Clin J Med 77:791-9. 2010
    ..After such an event, clinicians wonder whether their patients should resume anticoagulant therapy. The authors review the management of anticoagulation during and after anticoagulation-associated ICH...
  6. pmc Risk of thromboembolism following acute intracerebral hemorrhage
    Joshua N Goldstein
    Department of Emergency Medicine, Massachusetts General Hospital, Zero Emerson Place, Suite 3B, Boston, MA 02114, USA
    Neurocrit Care 10:28-34. 2009
    ..We hypothesized that TEs are relatively common following ICH, and that anticoagulated patients are at higher risk for these complications...
  7. pmc Management of thrombolysis-associated symptomatic intracerebral hemorrhage
    Joshua N Goldstein
    Department of Emergency Medicine, Massachusetts General Hospital, Zero Emerson Place, STE 3B, Boston, MA 02114, USA
    Arch Neurol 67:965-9. 2010
    ..It is not clear whether patients with sICH continue to bleed after diagnosis, nor has the most appropriate treatment been determined...
  8. doi request reprint Rapid focused neurological assessment in the emergency department and ICU
    Joshua N Goldstein
    Department of Emergency Medicine, Massachusetts General Hospital, Boston, MA 02114, USA
    Emerg Med Clin North Am 27:1-16, vii. 2009
    ....
  9. pmc Apolipoprotein E genotype is associated with CT angiography spot sign in lobar intracerebral hemorrhage
    H Bart Brouwers
    Center for Human Genetic Research Rosand Lab, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Stroke 43:2120-5. 2012
    ..The biological underpinnings of the spot sign remain poorly understood; it may be that the underlying vasculopathy influences its presence. Therefore, we conducted a study to identify genetic predictors of the spot sign...
  10. pmc Heritability estimates identify a substantial genetic contribution to risk and outcome of intracerebral hemorrhage
    William J Devan
    Center for Human Genetic Research, Massachusetts General Hospital, 185 Cambridge St, CPZN 6818, Boston, MA 02114, USA
    Stroke 44:1578-83. 2013
    ..However, a novel analytic tool based on genome-wide data allows heritability estimation from unrelated subjects. We sought to apply this method to provide heritability estimates for ICH risk, severity, and outcome...
  11. pmc Burden of blood pressure-related alleles is associated with larger hematoma volume and worse outcome in intracerebral hemorrhage
    Guido J Falcone
    Center for Human Genetic Research, Massachusetts General Hospital, 185 Cambridge St, CPZN 6818, Boston, MA 02114, USA
    Stroke 44:321-6. 2013
    ..As the burden of high blood pressure-related alleles is associated with both hypertension-related end-organ damage and risk of ICH, we sought to determine whether this burden influences ICH baseline hematoma volume...
  12. pmc Predictors of hematoma volume in deep and lobar supratentorial intracerebral hemorrhage
    Guido J Falcone
    Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    JAMA Neurol 70:988-94. 2013
    ..Despite known differences in the underlying biology between deep and lobar ICHs, limited data are available on location specificity of factors reported to affect hematoma volume...
  13. pmc Apolipoprotein E genotype predicts hematoma expansion in lobar intracerebral hemorrhage
    H Bart Brouwers
    Center for Human Genetic Research Rosand Lab, Massachusetts General Hospital, Harvard Medical School, 185 Cambridge Street, CPZN 6818, Boston, MA 02114, USA
    Stroke 43:1490-5. 2012
    ..Among patients with lobar ICH, the apolipoprotein E (APOE) ε2 allele predicts larger hematoma volumes at presentation. We investigated whether the ε2 allele also identifies individuals at increased risk of hematoma expansion...
  14. pmc Risk factors for computed tomography angiography spot sign in deep and lobar intracerebral hemorrhage are shared
    Farid Radmanesh
    From the Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA F R, G J F, C D A, T W K B, J R, H B B Division of Neurocritical Care and Emergency Neurology, Department of Neurology, Massachusetts General Hospital, Boston, MA F R, G J F, C D A, T W K B, J R, H B B J Philip Kistler Stroke Research Center, Massachusetts General Hospital, Boston, MA F R, G J F, C D A, T W K B, A M A, A Vashkevich, K A M, K S, A Viswanathan, S M G, J R, H B B Departments of Radiology J M R and Emergency Medicine J N G, Massachusetts General Hospital, Boston, MA and Department of Neurosurgery, University Medical Center Utrecht, Utrecht University, Bethesda
    Stroke 45:1833-5. 2014
    ....
  15. pmc CTA spot sign predicts hematoma expansion in patients with delayed presentation after intracerebral hemorrhage
    H Bart Brouwers
    Center for Human Genetic Research Rosand Lab, Massachusetts General Hospital, Harvard Medical School, 185 Cambridge Street, CPZN 6818, Boston, MA 02114, USA
    Neurocrit Care 17:421-8. 2012
    ..We investigated the prevalence of hematoma expansion in these patients and assessed the accuracy of the CT angiography (CTA) spot sign for identifying risk of hematoma expansion...
  16. pmc CT angiography for intracerebral hemorrhage does not increase risk of acute nephropathy
    Alexandra Oleinik
    Department of Neurology, Massachusetts General Hospital, Boston, MA 02114, USA
    Stroke 40:2393-7. 2009
    ..Its use is limited by the concern for contrast induced nephropathy (CIN); however, the magnitude of this risk is not known...
  17. pmc Computed tomography angiography spot sign does not predict case fatality in aneurysmal subarachnoid hemorrhage with intraparenchymal extension
    H Bart Brouwers
    Center for Human Genetic Research Rosand Lab, Massachusetts General Hospital, Harvard Medical School, 185 Cambridge St, CPZN 6818, Boston, MA 02114, USA
    Stroke 44:1590-4. 2013
    ..We conducted a 2-center prospective cohort study to evaluate whether CTA spot sign predicts case fatality in aneurysmal subarachnoid hemorrhage with intraparenchymal extension...
  18. pmc Confounding by indication in retrospective studies of intracerebral hemorrhage: antiepileptic treatment and mortality
    Thomas W K Battey
    Hemorrhagic Stroke Research Group, Massachusetts General Hospital, Boston, MA, USA
    Neurocrit Care 17:361-6. 2012
    ..Published studies on AED treatment in ICH have provided conflicting results. We investigated the effect of AED treatment on 90-day mortality after ICH in a large prospectively ascertained cohort...
  19. pmc Prolonged emergency department length of stay is not associated with worse outcomes in patients with intracerebral hemorrhage
    Jonathan Elmer
    Department of Emergency Medicine, Massachusetts General Hospital, Boston, MA, USA
    Neurocrit Care 17:334-42. 2012
    ..We performed this study to explore the hypothesis that longer EDLOS would be associated with worse outcomes in a large cohort of patients presenting with spontaneous intracerebral hemorrhage (ICH)...
  20. doi request reprint Prediction of functional outcome in patients with primary intracerebral hemorrhage: the FUNC score
    Natalia S Rost
    Massachusetts General Hospital, Center for Human Genetic Research, Boston, MA 02114, USA
    Stroke 39:2304-9. 2008
    ..We developed an acute clinical score to predict likelihood of functional independence...
  21. pmc Association of subdural hematoma with increased mortality in lobar intracerebral hemorrhage
    Pratik V Patel
    Hemorrhagic Stroke Research Program, Department of Neurology, Massachusetts General Hospital, 175 Cambridge St, Ste 300, Boston, MA 02114, USA
    Arch Neurol 66:79-84. 2009
    ..To determine the prevalence of subdural hematoma (SDH) in patients presenting with primary nontraumatic lobar intracerebral hemorrhage (ICH) and characteristics associated with the presence of SDH...
  22. pmc Predicting hematoma expansion after primary intracerebral hemorrhage
    H Bart Brouwers
    Center for Human Genetic Research, Massachusetts General Hospital, Harvard Medical School, Boston2Division of Neurocritical Care and Emergency Neurology, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston3Hemorrhagic S
    JAMA Neurol 71:158-64. 2014
    ..Many clinical trials focus on restricting hematoma expansion following acute intracerebral hemorrhage (ICH), but selecting those patients at highest risk of hematoma expansion is challenging...
  23. pmc Common variants within oxidative phosphorylation genes influence risk of ischemic stroke and intracerebral hemorrhage
    Christopher D Anderson
    Massachusetts General Hospital, Boston, MA 02114, USA
    Stroke 44:612-9. 2013
    ....
  24. pmc Spot sign score predicts rapid bleeding in spontaneous intracerebral hemorrhage
    Javier M Romero
    Division of Neuroradiology, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Gray B, Office 279, Boston, MA 01778, USA
    Emerg Radiol 19:195-202. 2012
    ..Spot sign score on presentation correlates with rate of expansion, supporting the hypothesis that high spot sign scores likely reflect active bleeding in acute ICH...
  25. pmc Burden of risk alleles for hypertension increases risk of intracerebral hemorrhage
    Guido J Falcone
    Center for Human Genetic Research, Department of Neurology, Massachusetts General Hospital, and Department of Epidemiology, Harvard School of Public Health, 185 Cambridge Street CPZN 6818, Boston, MA 02114, USA
    Stroke 43:2877-83. 2012
    ..We sought to determine whether the cumulative burden of blood pressure-related SNPs is associated with risk of ICH and pre-ICH diagnosis of HTN...
  26. pmc Systematic characterization of the computed tomography angiography spot sign in primary intracerebral hemorrhage identifies patients at highest risk for hematoma expansion: the spot sign score
    Josser E Delgado Almandoz
    Division of Neuroradiology, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Stroke 40:2994-3000. 2009
    ..We aim to systematically characterize the spot sign to identify features that are most predictive of hematoma expansion and construct a spot sign scoring system...
  27. pmc Noncontrast Computed Tomography Hypodensities Predict Poor Outcome in Intracerebral Hemorrhage Patients
    Gregoire Boulouis
    From the Hemorrhagic Stroke Research Program, Department of Neurology, Massachusetts General Hospital Stroke Research Center, Harvard Medical School, Boston G B, A M, H B B, A C, M J J, E A, O P N, A A, A Vashkevich, K M S, J R, A Viswanathan, M E G, S M G, J N G Department of Neurosurgery, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht University, The Netherlands H B B Stroke Service, Department of Neuroscience and Behavioral Sciences, Ribeirao Pre to School of Medicine, University of Sao Paulo O P N Division of Neurocritical Care and Emergency Neurology, Massachusetts General Hospital, Harvard Medical School, Boston J R, J N G Department of Emergency Medicine, Massachusetts General Hospital, Boston J N G
    Stroke 47:2511-6. 2016
    ..We evaluated whether baseline noncontrast CT hypodensities are associated with poor clinical outcome...
  28. pmc Warfarin and statins are associated with hematoma volume in primary infratentorial intracerebral hemorrhage
    Guido J Falcone
    Center for Human Genetic Research, Massachusetts General Hospital, 185 Cambridge Street, CPZN 6818, Boston, MA, 02114, USA
    Neurocrit Care 21:192-9. 2014
    ..We therefore aimed to identify predictors of infratentorial ICH volume and to evaluate whether location specificity exists when comparing cerebellar to brainstem ICH...
  29. pmc Anatomic pattern of intracerebral hemorrhage expansion: relation to CT angiography spot sign and hematoma center
    Gregoire Boulouis
    From the Hemorrhagic Stroke Research Program, Department of Neurology G B, A D, H B B, P F, A Vashkevich, A A, K S, A Viswanathan, M E G, S M G, Division of Neuroradiology, Department of Radiology J M R, Department of Emergency Medicine J N G, and Division of Neurocritical Care and Emergency Neurology J R, Massachusetts General Hospital, Harvard Medical School, Boston, MA Department of Biostatistics, Harvard School of Public Health, Boston, MA R A B and Department of Clinical Neurosciences and Hotchkiss Brain Institute, University of Calgary, Alberta, Canada E E S
    Stroke 45:1154-6. 2014
    ..We sought to identify baseline determinants of the anatomic pattern of hematoma expansion in patients with intracerebral hemorrhage and spot sign...
  30. doi request reprint Warfarin reversal in anticoagulant-associated intracerebral hemorrhage
    Joshua N Goldstein
    Department of Emergency Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Neurocrit Care 9:277-83. 2008
    ..At our institution, we have focused on improving the rapid and reliable delivery of a combination of intravenous vitamin K and FFP, with continued re-dosing until the desired INR lowering is achieved...
  31. pmc Lymphopenia, Infectious Complications, and Outcome in Spontaneous Intracerebral Hemorrhage
    Andrea Morotti
    Division of Neurocritical Care and Emergency Neurology, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Neurocrit Care . 2016
    ..We investigated whether admission lymphopenia (AL) is associated with increased risk of infectious complications and poor outcome in patients with spontaneous intracerebral hemorrhage (ICH)...
  32. pmc Leukocyte Count and Intracerebral Hemorrhage Expansion
    Andrea Morotti
    From the Neurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy A M, A Pezzini, A Padovani Division of Neurocritical Care and Emergency Neurology, Department of Neurology A M, C L P, C D A, M J J, J N G, J R, Hemorrhagic Stroke Research Center A M, C L P, C D A, M J J, K S, A A, M E G, A V, S M G, J N G, J R, and Department of Emergency Medicine J N G, Massachusetts General Hospital, Boston
    Stroke 47:1473-8. 2016
    ..Leukocytes, because of their interaction with platelets and coagulation factors, may in turn play a role in hemostasis. We investigated whether admission leukocytosis was associated with reduced bleeding after acute ICH...
  33. pmc Genetic variants in CETP increase risk of intracerebral hemorrhage
    Christopher D Anderson
    Center for Human Genetic Research, Massachusetts General Hospital MGH, Boston, MA
    Ann Neurol 80:730-740. 2016
    ..Here, we test the hypothesis that CETP DNA sequence variants associated with higher HDL-C also increase risk for ICH...
  34. doi request reprint Improving door-to-needle times: a single center validation of the target stroke hypothesis
    Ilana M Ruff
    From the Departments of Neurology I R, S A, N R, L S, Radiology W C, M L, and Emergency Medicine J G, J M, Massachusetts General Hospital, Harvard Medical School, Boston, MA
    Stroke 45:504-8. 2014
    ..In 2007, we implemented a new institutional acute stroke care model to include 10 best practices and evaluated the effect of this intervention on improving door-to-computed tomography (CT) and door-to-needle (DTN) times at our hospital...
  35. pmc Ischemic-appearing electrocardiographic changes predict myocardial injury in patients with intracerebral hemorrhage
    Kohei Hasegawa
    Department of Emergency Medicine, Massachusetts General Hospital, Boston, MA 02114, USA
    Am J Emerg Med 30:545-52. 2012
    ..Our objective is to examine whether ischemic-appearing ECG changes predict subsequent myocardial injury in the context of ICH...
  36. doi request reprint Intracranial atherosclerosis and cerebral small vessel disease in intracerebral hemorrhage patients
    Gregoire Boulouis
    Hemorrhagic Stroke Research Program, Department of Neurology, Massachusetts General Hospital Stroke Research Center, Harvard Medical School, Boston, MA, USA
    J Neurol Sci 369:324-9. 2016
    ..We sought to investigate this association in patients with intracerebral hemorrhage (ICH), due to severe cSVD...
  37. pmc Body mass index and etiology of intracerebral hemorrhage
    Alessandro Biffi
    Center for Human Genetic Research, Massachusetts General Hospital, 185 Cambridge Street CPZN 6818, Boston, MA 02114, USA
    Stroke 42:2526-30. 2011
    ..Extremes of body mass index (BMI) are associated with increased incidence of intracerebral hemorrhage (ICH). Because ICH can result from different vessel pathologies, we investigated whether the effect of BMI depends on ICH etiology...
  38. doi request reprint Blood pressure burden and outcome in warfarin-related intracerebral hemorrhage
    Frieder Schlunk
    1 Department of Neurology, Massachusetts General Hospital, Boston, USA
    Int J Stroke 11:898-909. 2016
    ..Conclusion We found no evidence that higher 24 h blood pressure burden is associated with hematoma expansion or mortality in anticoagulant-associated intracerebral hemorrhage...
  39. pmc Association Between Serum Calcium Level and Extent of Bleeding in Patients With Intracerebral Hemorrhage
    Andrea Morotti
    Neurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy2Division of Neurocritical Care and Emergency Neurology, Department of Neurology, Massachusetts General Hospital, Boston3J Philip Kistler Stroke Research Center, Massachusetts General Hospital, Boston
    JAMA Neurol 73:1285-1290. 2016
    ..Calcium is a key cofactor of the coagulation cascade and may play a role in the pathophysiology of intracerebral hemorrhage (ICH)...
  40. pmc APOE genotype and extent of bleeding and outcome in lobar intracerebral haemorrhage: a genetic association study
    Alessandro Biffi
    Hemorrhagic Stroke Research Group, Massachusetts General Hospital, Boston, MA, USA
    Lancet Neurol 10:702-9. 2011
    ..We aimed to assess whether these variants also associate with severity of ICH, in terms of haematoma volume at presentation and subsequent outcome...
  41. pmc Interrelationship of superficial siderosis and microbleeds in cerebral amyloid angiopathy
    Ashkan Shoamanesh
    From the Hemorrhagic Stroke Research Program, Massachusetts General Hospital, Harvard Medical School, Boston, MA
    Neurology 83:1838-43. 2014
    ..We sought to explore the mechanisms leading to cerebral amyloid angiopathy (CAA)-related cortical superficial siderosis (cSS) by examining its neuroimaging and genetic association with cerebral microbleeds (CMBs)...
  42. pmc Therapeutic strategies in acute intracerebral hemorrhage
    H Bart Brouwers
    Division of Neurocritical Care and Emergency Neurology, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Neurotherapeutics 9:87-98. 2012
    ..Finally, preventing recurrence of intracerebral hemorrhage is of pivotal importance, and tight blood pressure management is paramount...
  43. pmc Seizure visits in US emergency departments: epidemiology and potential disparities in care
    Daniel J Pallin
    Department of Emergency Medicine, Brigham and Women s Hospital, Boston, MA, 02115, USA
    Int J Emerg Med 1:97-105. 2008
    ..The aim of this investigation was to characterize ED visits for seizure in a large representative US sample and investigate any potential impact of race or ethnicity on management...
  44. pmc Diagnosis and Management of Acute Intracerebral Hemorrhage
    Andrea Morotti
    J P Kistler Stroke Research Center, Massachusetts General Hospital, Harvard Medical School, 175 Cambridge Street, Suite 300, Boston, MA 02114, USA
    Emerg Med Clin North Am 34:883-899. 2016
    ..Prevention of hematoma expansion and minimally invasive hematoma evacuation are promising therapeutic strategies under investigation. This article provides an updated review on ICH diagnosis and management in the emergency department...
  45. pmc Reducing door-to-puncture times for intra-arterial stroke therapy: a pilot quality improvement project
    Brijesh P Mehta
    Division of Interventional Neuroradiology, Department of Radiology, Massachusetts General Hospital, Boston, MA B P M, T M L M, R V C, D L B, J A H, J D R, A J Y Department of Neurology, Massachusetts General Hospital, Boston, MA B P M, T M L M, N S R, L H S
    J Am Heart Assoc 3:e000963. 2014
    ..Little is known regarding the magnitude of, and reasons for, these delays. In a pilot quality improvement (QI) project, we sought to examine and improve our door-puncture times...
  46. pmc Intracranial hemorrhage
    J Alfredo Caceres
    Department of Neurology, Massachusetts General Hospital, Suite 3B, Zero Emerson Place, Boston, MA 01940, USA
    Emerg Med Clin North Am 30:771-94. 2012
    ..This article focuses on the acute diagnosis and management of primary nontraumatic intracerebral hemorrhage and subarachnoid hemorrhage in the emergency department...
  47. pmc Safety and tolerability of deferoxamine mesylate in patients with acute intracerebral hemorrhage
    Magdy Selim
    Department of Neurology, Stroke Division, Beth Israel Deaconess Medical Center, Stroke Division, 330 Brookline Avenue Palmer 127, Boston, MA 02215, USA
    Stroke 42:3067-74. 2011
    ..We aimed to evaluate the feasibility, safety, and tolerability of varying dose-tiers of DFO in patients with spontaneous ICH, and to determine the maximum tolerated dose to be adopted in future efficacy studies...
  48. doi request reprint A brief educational intervention may increase public acceptance of emergency research without consent
    Joshua N Goldstein
    Department of Emergency Medicine, Brigham and Women s Hospital, Boston, Massachusetts, USA
    J Emerg Med 39:419-35. 2010
    ..We hypothesized that knowing the regulations regarding emergency research without consent would increase public support for this type of research...
  49. doi request reprint Accuracy of CT angiography for the diagnosis of vascular abnormalities causing intraparenchymal hemorrhage in young patients
    Javier M Romero
    Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Emerg Radiol 16:195-201. 2009
    ..MD CTA performed in the Emergency Department provides accurate, rapid and critical presurgical and premedical treatment information in young patients with IPH...
  50. ncbi request reprint New Oral Anticoagulants and Their Reversal Agents
    Andrea Morotti
    J P Kistler Stroke Research Center, Massachusetts General Hospital, Harvard Medical School, 175 Cambridge Street, Suite 300, Boston, MA, 02114, USA
    Curr Treat Options Neurol 18:47. 2016
    ..In this review, we provide a summary of DOAC characteristics and an overview of the different therapeutic options available for DOAC reversal...
  51. doi request reprint Lung-Protective Ventilation With Low Tidal Volumes and the Occurrence of Pulmonary Complications in Patients Without Acute Respiratory Distress Syndrome: A Systematic Review and Individual Patient Data Analysis
    Ary Serpa Neto
    1Department of Intensive Care, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands 2Program of Post Graduation, Research and Innovation, Faculdade de Medicina do ABC FMABC, Santo Andre, Brazil 3Department of Critical Care Medicine, Hospital Israelita Albert Einstein, Sao Paulo, Brazil 4Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, MN 5Department of Emergency Medicine, Massachusetts General Hospital, Boston, MA 6School of Medicine, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil 7Department of Anaesthesia and Intensive Care Medicine, Helsinki University Hospital, Peijas Hospital, Vantaa, Finland 8Medical School, Universidade Federal de Ciências da Saúde de Porto Alegre, Porto Alegre, Brazil 9Department of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 10Department of Anesthesiology and Intensive Care Medicine, University Hospital Carl Gustav Carus, Technische Universitat Dresden, Dresden, Germany 11Department of Surgical Sciences and Integrated Diagnostics, IRCCS San Martino IST, University of Genoa, Genoa, Italy 12Laboratory of Experimental Intensive Care and Anesthesiology, Academic Medical Center, UK
    Crit Care Med 43:2155-63. 2015
    ....
  52. pmc Concurrent acute brain infarcts in patients with monocular visual loss
    Johanna Helenius
    A A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Ann Neurol 72:286-93. 2012
    ..We sought to determine the frequency of acute brain infarcts on diffusion-weighted imaging (DWI) in patients with monocular visual loss of presumed ischemic origin (MVL)...
  53. ncbi request reprint Effects of morphine analgesia on diagnostic accuracy in Emergency Department patients with abdominal pain: a prospective, randomized trial
    Stephen H Thomas
    Division of Emergency Medicine, Department of Emergency Services, Massachusetts General Hospital, Boston, MA 02114 2696, USA
    J Am Coll Surg 196:18-31. 2003
    ..The purpose of this study was to address the effects of analgesia on the physical examination and diagnostic accuracy for patients with abdominal pain...
  54. doi request reprint Comparison of a radial artery compression device with invasive radial artery blood pressure monitoring
    Megan L Fix
    Massachusetts General Hospital, Boston, MA, USA
    Blood Press Monit 13:199-203. 2008
    ....
  55. doi request reprint Emergency department seizure epidemiology
    Jennifer L Martindale
    Department of Emergency Medicine, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
    Emerg Med Clin North Am 29:15-27. 2011
    ..Epilepsy is an uncommon cause of seizures in the ED, accounting for a minority of seizure-related visits. Of ED patients with seizure, about 7% have status epilepticus, which has an age-dependent mortality averaging 22%...