Wolfram Goessling

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. doi request reprint EnaBILEing Growth in the Fetal Liver
    Wolfram Goessling
    Genetics and Gastroenterology Divisions, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA Gastrointestinal Cancer Center, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA Harvard Stem Cell Institute, Harvard University, Cambridge, MA 02138, USA Electronic address
    Cell Stem Cell 18:427-8. 2016
  2. pmc Repairing quite swimmingly: advances in regenerative medicine using zebrafish
    Wolfram Goessling
    Brigham and Women s Hospital Dana Farber Cancer Institute, Boston, MA 02215, USA Harvard Medical School, Boston, MA 02115, USA Harvard Stem Cell Institute, Cambridge, MA 02138, USA
    Dis Model Mech 7:769-76. 2014
  3. pmc Aminotransferase levels and 20-year risk of metabolic syndrome, diabetes, and cardiovascular disease
    Wolfram Goessling
    Division of Genetics and Gastroenterology, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Gastroenterology 135:1935-44, 1944.e1. 2008
  4. pmc Genetic interaction of PGE2 and Wnt signaling regulates developmental specification of stem cells and regeneration
    Wolfram Goessling
    Harvard Stem Cell Institute, Cambridge, MA 02138, USA
    Cell 136:1136-47. 2009
  5. pmc Prostaglandin E2 regulates liver versus pancreas cell-fate decisions and endodermal outgrowth
    Sahar Nissim
    Gastroenterology Division, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA Genetics Division, Brigham and Women s Hospital, Boston, MA 02115, USA Dana Farber Cancer Institute, Boston, MA 02115, USA
    Dev Cell 28:423-37. 2014
  6. pmc Selenoprotein H is an essential regulator of redox homeostasis that cooperates with p53 in development and tumorigenesis
    Andrew G Cox
    Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115
    Proc Natl Acad Sci U S A 113:E5562-71. 2016
  7. pmc Hematopoietic stem cell development is dependent on blood flow
    Trista E North
    Stem Cell Program and Hematology Oncology, Children s Hospital, Howard Hughes Medical Institute, Harvard Stem Cell Institute, Harvard Medical School, Boston, MA 02115, USA
    Cell 137:736-48. 2009
  8. pmc Iterative use of nuclear receptor Nr5a2 regulates multiple stages of liver and pancreas development
    Sahar Nissim
    Gastroenterology Division, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA Genetics Division, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA Dana Farber Cancer Institute, Boston, MA 02115, USA
    Dev Biol 418:108-23. 2016
  9. pmc Cannabinoid receptor signaling regulates liver development and metabolism
    Leah Y Liu
    Genetics Division, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Development 143:609-22. 2016
  10. doi request reprint APC mutant zebrafish uncover a changing temporal requirement for wnt signaling in liver development
    Wolfram Goessling
    Stem Cell Program and Hematology Oncology, Children s Hospital and Dana Farber Cancer Institute, HHMI, Harvard Medical School, Boston, MA 02115, USA
    Dev Biol 320:161-74. 2008

Detail Information

Publications47

  1. doi request reprint EnaBILEing Growth in the Fetal Liver
    Wolfram Goessling
    Genetics and Gastroenterology Divisions, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA Gastrointestinal Cancer Center, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA Harvard Stem Cell Institute, Harvard University, Cambridge, MA 02138, USA Electronic address
    Cell Stem Cell 18:427-8. 2016
    ..Sigurdsson et al. (2016) provide justification for transient fetal liver residence, where select bile acid composition, derived from mother and embryo, provides a protective environment, enabling rapid stem cell expansion. ..
  2. pmc Repairing quite swimmingly: advances in regenerative medicine using zebrafish
    Wolfram Goessling
    Brigham and Women s Hospital Dana Farber Cancer Institute, Boston, MA 02215, USA Harvard Medical School, Boston, MA 02115, USA Harvard Stem Cell Institute, Cambridge, MA 02138, USA
    Dis Model Mech 7:769-76. 2014
    ..The promising results in multiple organs suggest that further insight into regenerative mechanisms and novel clinically relevant therapeutic approaches will emerge from zebrafish research in the future. ..
  3. pmc Aminotransferase levels and 20-year risk of metabolic syndrome, diabetes, and cardiovascular disease
    Wolfram Goessling
    Division of Genetics and Gastroenterology, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Gastroenterology 135:1935-44, 1944.e1. 2008
    ..We studied the relationship between ALT levels and these disorders in a long-term follow-up study...
  4. pmc Genetic interaction of PGE2 and Wnt signaling regulates developmental specification of stem cells and regeneration
    Wolfram Goessling
    Harvard Stem Cell Institute, Cambridge, MA 02138, USA
    Cell 136:1136-47. 2009
    ..Our work provides in vivo evidence that Wnt activation in stem cells requires PGE2, and suggests the PGE2/Wnt interaction is a master regulator of vertebrate regeneration and recovery...
  5. pmc Prostaglandin E2 regulates liver versus pancreas cell-fate decisions and endodermal outgrowth
    Sahar Nissim
    Gastroenterology Division, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA Genetics Division, Brigham and Women s Hospital, Boston, MA 02115, USA Dana Farber Cancer Institute, Boston, MA 02115, USA
    Dev Cell 28:423-37. 2014
    ..PGE2 remains important for adult organ growth, as it modulates liver regeneration. This work provides in vivo evidence that PGE2 may act as a morphogen to regulate cell-fate decisions and outgrowth of the embryonic endodermal anlagen. ..
  6. pmc Selenoprotein H is an essential regulator of redox homeostasis that cooperates with p53 in development and tumorigenesis
    Andrew G Cox
    Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115
    Proc Natl Acad Sci U S A 113:E5562-71. 2016
    ..Overall, our findings establish that seph regulates redox homeostasis and suppresses DNA damage. We hypothesize that SepH deficiency may contribute to the increased cancer risk observed in cohorts with low selenium levels. ..
  7. pmc Hematopoietic stem cell development is dependent on blood flow
    Trista E North
    Stem Cell Program and Hematology Oncology, Children s Hospital, Howard Hughes Medical Institute, Harvard Stem Cell Institute, Harvard Medical School, Boston, MA 02115, USA
    Cell 137:736-48. 2009
    ..This work links blood flow to AGM hematopoiesis and identifies NO as a conserved downstream regulator of HSC development...
  8. pmc Iterative use of nuclear receptor Nr5a2 regulates multiple stages of liver and pancreas development
    Sahar Nissim
    Gastroenterology Division, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA Genetics Division, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA Dana Farber Cancer Institute, Boston, MA 02115, USA
    Dev Biol 418:108-23. 2016
    ..These findings define critical iterative and pleiotropic roles for Nr5a2 at distinct stages of pancreas and liver organogenesis, and provide novel perspectives for interpreting the role of Nr5a2 in disease. ..
  9. pmc Cannabinoid receptor signaling regulates liver development and metabolism
    Leah Y Liu
    Genetics Division, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Development 143:609-22. 2016
    ..Our work describes a novel developmental role for EC signaling, whereby Cnr-mediated regulation of Srebfs and methionine metabolism impacts liver development and function. ..
  10. doi request reprint APC mutant zebrafish uncover a changing temporal requirement for wnt signaling in liver development
    Wolfram Goessling
    Stem Cell Program and Hematology Oncology, Children s Hospital and Dana Farber Cancer Institute, HHMI, Harvard Medical School, Boston, MA 02115, USA
    Dev Biol 320:161-74. 2008
    ..These studies reveal an important and time-dependent role for wnt signaling during liver development and regeneration...
  11. pmc Estrogen defines the dorsal-ventral limit of VEGF regulation to specify the location of the hemogenic endothelial niche
    Kelli J Carroll
    Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA
    Dev Cell 29:437-53. 2014
    ..Together, these data suggest that yolk-derived E2 sets the ventral boundary of hemogenic vascular niche specification by antagonizing the dorsal-ventral regulatory limits of VEGF...
  12. pmc PGE2-regulated wnt signaling and N-acetylcysteine are synergistically hepatoprotective in zebrafish acetaminophen injury
    Trista E North
    Department of Pathology, Beth Israel Deaconess Medical Center, MA 02115, USA
    Proc Natl Acad Sci U S A 107:17315-20. 2010
    ....
  13. pmc Cannabinoid Receptor-2 Regulates Embryonic Hematopoietic Stem Cell Development via Prostaglandin E2 and P-Selectin Activity
    Virginie Esain
    Department of Pathology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
    Stem Cells 33:2596-612. 2015
    ..Together, these data suggest CNR2-signaling optimizes the production, expansion, and migration of embryonic HSCs by modulating multiple downstream signaling pathways...
  14. pmc Topoisomerase II alpha is required for embryonic development and liver regeneration in zebrafish
    Michael Dovey
    Children s Hospital and Dana Farber Cancer Institute, Boston, MA, USA
    Mol Cell Biol 29:3746-53. 2009
    ..Regeneration analysis of other adult tissues, including fins, revealed no heterozygous phenotype. Our results confirm a conserved role for TOP2A in vertebrates as well as a dose-sensitive requirement for top2a in adults...
  15. pmc Deficiency of the cytoskeletal protein SPECC1L leads to oblique facial clefting
    Irfan Saadi
    Division of Genetics, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Am J Hum Genet 89:44-55. 2011
    ..Collectively, these data demonstrate that SPECC1L functions in actin-cytoskeleton reorganization and is required for proper facial morphogenesis...
  16. pmc The Wnt/beta-catenin pathway is required for the development of leukemia stem cells in AML
    Yingzi Wang
    Division of Hematology Oncology, Children s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Science 327:1650-3. 2010
    ..beta-catenin is not absolutely required for self-renewal of adult HSCs; thus, targeting the Wnt/beta-catenin pathway may represent a new therapeutic opportunity in AML...
  17. pmc The Central Nervous System Regulates Embryonic HSPC Production via Stress-Responsive Glucocorticoid Receptor Signaling
    Wanda Kwan
    Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA
    Cell Stem Cell 19:370-82. 2016
    ..Our data establish that embryonic HSC production responds to physiologic stress via CNS-derived serotonin synthesis and central feedback regulation to control HSC numbers. ..
  18. pmc Functional validation of GWAS gene candidates for abnormal liver function during zebrafish liver development
    Leah Y Liu
    Genetics Division, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Dis Model Mech 6:1271-8. 2013
    ..Our analysis can be extended to GWAS for additional disease-associated phenotypes. ..
  19. pmc Glucose metabolism impacts the spatiotemporal onset and magnitude of HSC induction in vivo
    James M Harris
    Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA
    Blood 121:2483-93. 2013
    ..We propose that this fundamental metabolic-sensing mechanism enables the embryo to respond to changes in environmental energy input and adjust hematopoietic output to maintain embryonic growth and ensure viability...
  20. pmc Rargb regulates organ laterality in a zebrafish model of right atrial isomerism
    Maija K Garnaas
    Genetics Division, Brigham and Women s Hospital, Harvard Medical School, Brigham and Women s Hospital, Boston, MA, USA
    Dev Biol 372:178-89. 2012
    ..Our findings uncover a novel role for RA in regulating organ laterality and provide an animal model of one form of human heterotaxia...
  21. doi request reprint Developmental Vitamin D Availability Impacts Hematopoietic Stem Cell Production
    Mauricio Cortes
    Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Cell Rep 17:458-468. 2016
    ..Together, these findings highlight the relevance of developmental 1,25(OH)D3 availability for definitive hematopoiesis and suggest potential therapeutic utility in HSPC expansion...
  22. pmc Accumulation of the Vitamin D Precursor Cholecalciferol Antagonizes Hedgehog Signaling to Impair Hemogenic Endothelium Formation
    Mauricio Cortes
    Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA
    Stem Cell Reports 5:471-9. 2015
    ..These findings highlight a direct impact of inefficient vitamin D synthesis on cell fate commitment and maturation in Hh-regulated tissues, which may have implications beyond hemogenic endothelium specification...
  23. doi request reprint Endoderm specification, liver development, and regeneration
    Trista E North
    Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
    Methods Cell Biol 101:205-23. 2011
    ..Liver dysfunction frequently leads to significant morbidity and mortality; however, in most settings of organ injury, the liver exhibits remarkable regenerative capacity...
  24. ncbi request reprint Ultrasound biomicroscopy permits in vivo characterization of zebrafish liver tumors
    Wolfram Goessling
    Stem Cell Program, Hematology Oncology, Children s Hospital and Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nat Methods 4:551-3. 2007
    ..Ultrasound biomicroscopy allows longitudinal studies of tumor development and real-time assessment of therapeutic effects in zebrafish...
  25. pmc Ferritinophagy via NCOA4 is required for erythropoiesis and is regulated by iron dependent HERC2-mediated proteolysis
    Joseph D Mancias
    Department of Cell Biology, Harvard Medical School, Boston, United States
    elife 4:. 2015
    ..This work reveals the molecular nature of the NCOA4-ferritin complex and explains how intracellular iron levels modulate NCOA4-mediated ferritinophagy in cells and in an iron-dependent physiological setting. ..
  26. pmc Yap reprograms glutamine metabolism to increase nucleotide biosynthesis and enable liver growth
    Andrew G Cox
    Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nat Cell Biol 18:886-96. 2016
    ..Together, our findings demonstrate that Yap1 integrates the anabolic demands of tissue growth during development and tumorigenesis by reprogramming nitrogen metabolism to stimulate nucleotide biosynthesis. ..
  27. pmc S-nitrosothiol signaling regulates liver development and improves outcome following toxic liver injury
    Andrew G Cox
    Genetics Division, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Cell Rep 6:56-69. 2014
    ..These studies demonstrate that GSNOR inhibitors will be beneficial therapeutic candidates for treating liver injury. ..
  28. pmc Identification of small molecules for human hepatocyte expansion and iPS differentiation
    Jing Shan
    Harvard Massachusetts Institute of Technology Division of Health Sciences and Technology, MIT, Cambridge, Massachusetts, USA
    Nat Chem Biol 9:514-20. 2013
    ..The identification of these small molecules can help address a major challenge affecting many facets of liver research and may lead to the development of new therapeutics for liver diseases. ..
  29. ncbi request reprint New waves of discovery: modeling cancer in zebrafish
    Wolfram Goessling
    Stem Cell Program and Division of Hematology Oncology, Children s Hospital, and Dana Farber Cancer Institute, Harvard Medical School, Harvard Stem Cell Institute, Howard Hughes Medical Institute, Boston, MA 02115, USA
    J Clin Oncol 25:2473-9. 2007
  30. pmc Prostaglandin E2 regulates vertebrate haematopoietic stem cell homeostasis
    Trista E North
    Stem Cell Program and Division of Hematology Oncology, Children s Hospital, Harvard Stem Cell Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 447:1007-11. 2007
    ..The conserved role for PGE2 in the regulation of vertebrate HSC homeostasis indicates that modulation of the prostaglandin pathway may facilitate expansion of HSC number for therapeutic purposes...
  31. pmc Transparent adult zebrafish as a tool for in vivo transplantation analysis
    Richard Mark White
    Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Cell Stem Cell 2:183-9. 2008
    ..This transparent adult zebrafish serves as the ideal combination of both sensitivity and resolution for in vivo stem cell analyses...
  32. pmc PTGER2 overexpression in colorectal cancer is associated with microsatellite instability, independent of CpG island methylator phenotype
    Yoshifumi Baba
    Department of Medical Oncology, Dana FarberCancer Institute and Harvard Medical School, Boston, Massachusetts, USA
    Cancer Epidemiol Biomarkers Prev 19:822-31. 2010
    ..However, the prognostic significance of PTGER2 expression or its relationship with MSI, CIMP, LINE-1 hypomethylation, or PTGS2 (COX-2) remains uncertain...
  33. pmc Prostaglandin E2 enhances human cord blood stem cell xenotransplants and shows long-term safety in preclinical nonhuman primate transplant models
    Wolfram Goessling
    Genetics and Gastroenterology Divisions, Brigham and Women s Hospital, Gastrointestinal Cancer Center, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Cell Stem Cell 8:445-58. 2011
    ..Together, our analyses indicated that dmPGE2 mediates conserved responses in HSCs from human and nonhuman primates and provided sufficient preclinical information to support proceeding to an FDA-approved phase 1 clinical trial...
  34. doi request reprint Baiting for Cancer: Using the Zebrafish as a Model in Liver and Pancreatic Cancer
    Katie L Hwang
    Harvard Medical School, Medical Scientist Training Program, Boston, MA, USA
    Adv Exp Med Biol 916:391-410. 2016
    ..In this chapter, we review the recent approaches and advances in the field to study both hepatocellular carcinomas and pancreatic cancer. ..
  35. doi request reprint Haematopoietic stem cells show their true colours
    Trista E North
    Beth Israel Deaconess Medical Center, Department of Pathology, Harvard Medical School, Harvard Stem Cell Institute, CLS 536, 3 Blackfan Circle, Boston, Massachusetts 02115, USA
    Nat Cell Biol 19:10-12. 2016
    ....
  36. pmc The lure of zebrafish in liver research: regulation of hepatic growth in development and regeneration
    Andrew G Cox
    Brigham and Women s Hospital, Harvard Medical School, Boston, MA, United States
    Curr Opin Genet Dev 32:153-61. 2015
    ....
  37. pmc Systematic proteomics of the VCP-UBXD adaptor network identifies a role for UBXN10 in regulating ciliogenesis
    Malavika Raman
    Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, Massachusetts 02115, USA
    Nat Cell Biol 17:1356-69. 2015
    ..This study provides a resource for exploring the landscape of UBXD proteins in biology and identifies an unexpected requirement for VCP-UBXN10 in ciliogenesis. ..
  38. pmc Hypoxia as a therapy for mitochondrial disease
    Isha H Jain
    Department of Molecular Biology and Howard Hughes Medical Institute, Massachusetts General Hospital, Boston, MA, USA Department of Systems Biology, Harvard Medical School, Boston, MA, USA Broad Institute of Harvard and MIT, Cambridge, MA, USA
    Science 352:54-61. 2016
    ..Further preclinical studies are required to assess whether hypoxic exposure can be developed into a safe and effective treatment for human diseases associated with mitochondrial dysfunction. ..
  39. doi request reprint Hematopoietic stem cell development: using the zebrafish to identify the signaling networks and physical forces regulating hematopoiesis
    Wolfram Goessling
    Genetics Division, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Methods Cell Biol 105:117-36. 2011
    ..The zebrafish has proven to be an excellent model for discovering and characterizing the signaling networks and physical forces regulating vertebrate hematopoietic development...
  40. ncbi request reprint Increased liver chemistry in an asymptomatic patient
    Wolfram Goessling
    Harvard Medical School, Boston, Massachusetts Gastrointestinal Unit, Massachusetts General Hospital, Boston, MA, USA
    Clin Gastroenterol Hepatol 3:852-8. 2005
  41. pmc Mutation mapping and identification by whole-genome sequencing
    Ignaty Leshchiner
    Genetics Division, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Genome Res 22:1541-8. 2012
    ..Our novel methodology and online tools will make next-generation sequencing an easily applicable resource for mutation mapping in all model systems...
  42. pmc Effects of RAS on the genesis of embryonal rhabdomyosarcoma
    David M Langenau
    Stem Cell Program and Division of Hematology, Children s Hospital Boston and Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    Genes Dev 21:1382-95. 2007
    ..When coupled with gene expression studies of this cell population, we propose that the zebrafish RMS cancer stem cell shares similar self-renewal programs as those found in activated satellite cells...
  43. pmc Multicenter phase II study of tivozanib (AV-951) and everolimus (RAD001) for patients with refractory, metastatic colorectal cancer
    Brian M Wolpin
    Department of Medical Oncology, Dana Farber Cancer Institute, Boston, Massachusetts, USA
    Oncologist 18:377-8. 2013
    ..We evaluated tolerability and efficacy of tivozanib (an oral VEGF receptor-1, -2, -3 inhibitor) plus everolimus (an oral mammalian target of rapamycin inhibitor)...
  44. pmc β-Catenin-driven cancers require a YAP1 transcriptional complex for survival and tumorigenesis
    Joseph Rosenbluh
    Department of Medical Oncology, Dana Farber Cancer Institute, 450 Brookline Avenue, Boston, MA 02215, USA
    Cell 151:1457-73. 2012
    ..These observations define a β-catenin-YAP1-TBX5 complex essential to the transformation and survival of β-catenin-driven cancers...
  45. pmc SCF(β-TRCP) suppresses angiogenesis and thyroid cancer cell migration by promoting ubiquitination and destruction of VEGF receptor 2
    Shavali Shaik
    Division of Cancer Biology and Angiogenesis, Department of Pathology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA
    J Exp Med 209:1289-307. 2012
    ..These results provide a new biomarker that may aid a rational use of tyrosine kinase inhibitors to treat refractory PTC...
  46. doi request reprint Previews. NOTCHing an arrow at cord blood: translating stem cell knowledge into clinical practice
    Trista E North
    Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA
    Cell Stem Cell 6:186-7. 2010
    ..Umbilical cord transplants have emerged as an important therapeutic option for patients with leukemia and lymphoma. A recent study in Nature Medicine highlights the potential and challenges of translating cell-based therapies to the clinic...
  47. ncbi request reprint Merkel cell carcinoma
    Wolfram Goessling
    Department of Adult Oncology, Dana Farber Cancer Institute, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Clin Oncol 20:588-98. 2002