Gregory L Fricchione
Affiliation: Massachusetts General Hospital
- Capacity building in global mental health: professional trainingGregory L Fricchione
Harvard Medical School and Pierce Global Division, Department of Psychiatry, Massachusetts General Hospital, Boston 02114, USA
Harv Rev Psychiatry 20:47-57. 2012..In sum, this article discusses human capacity building in global mental health, provides recommendations for training, and offers examples of recent initiatives...
- Consultation-liaison psychiatry: how far have we come?Sherese Ali
Massachusetts General Hospital, Warren 605, 55 Fruit Street, Boston, MA 02114, USA
Curr Psychiatry Rep 8:215-22. 2006..We also offer a contemporary account of the field and finish with a subjective view of the opportunities and pitfalls faced during the next phase of consultation-liaison psychiatry in the 21st century...
- Identification of endogenous morphine and a mu3-like opiate alkaloid receptor in human brain tissue taken from a patient with intractable complex partial epilepsyGregory Fricchione
Department of Psychiatry, Division of Psychiatry and Medicine, Massachusetts General Hospital, Boston, MA 02114, USA
Med Sci Monit 14:CS45-49. 2008..We set out to detect whether morphine is present in tissue taken from a patient with intractable temporal lobe epilepsy and to characterize the presence and nature of mu opiate receptor subtypes in this tissue...
- Postoperative deliriumGregory L Fricchione
Massachusetts General Hospital, Department of Psychiatry, Warren 615, 55 Fruit St, Boston, MA 02114, USA
Am J Psychiatry 165:803-12. 2008
- Placebo neural systems: nitric oxide, morphine and the dopamine brain reward and motivation circuitriesGregory Fricchione
Department of Psychiatry, Division of Psychiatry and Medicine, Massachusetts General Hospital, Boston, 02114, USA
Med Sci Monit 11:MS54-65. 2005..In addition, mesolimbic/mesocortical control of the stress response systems may provide a way for the placebo response to benefit other medical conditions...
- Clinical practice. Generalized anxiety disorderGregory Fricchione
Division of Psychiatry and Medicine, Massachusetts General Hospital, Boston, MA 02114, USA
N Engl J Med 351:675-82. 2004
- Anxiety, independent of depressive symptoms, is associated with in-hospital cardiac complications after acute myocardial infarctionJeff C Huffman
Department of Psychiatry, Massachusetts General Hospital, Boston, MA 02114, USA
J Psychosom Res 65:557-63. 2008..The aim of this exploratory study was to determine whether post-MI anxiety was associated with in-hospital cardiac complications, independent of depressive symptoms...
- Screening for major depression in post-myocardial infarction patients: operating characteristics of the Beck Depression Inventory-IIJeff C Huffman
Harvard Medical School, Boston, Massachusetts, USA
Int J Psychiatry Med 40:187-97. 2010..To assess the operating characteristics of the Beck-Depression Inventory-II (BDI-II) and the BDI-II cognitive subscale (BDI-II-cog) in screening for major depression (MDD) in post-myocardial infarction (MI) patients...
- Relaxation response induces temporal transcriptome changes in energy metabolism, insulin secretion and inflammatory pathwaysManoj K Bhasin
Benson Henry Institute for Mind Body Medicine at Massachusetts General Hospital, Boston, Massachusetts, United States of America
PLoS ONE 8:e62817. 2013..Mitochondrial resiliency might also be promoted by RR-induced downregulation of NF-κB-associated upstream and downstream targets that mitigates stress...
- Pre-existing major depression predicts in-hospital cardiac complications after acute myocardial infarctionJeff C Huffman
Massachusetts General Hospital, 55 Fruit Street Warren 1220C, Boston, MA 02114, USA
Psychosomatics 49:309-16. 2008..Depression (MDD) and anxiety have been associated with negative long-term outcomes among patients with acute myocardial infarction (MI)...
- Impact of a depression care management program for hospitalized cardiac patientsJeff C Huffman
Harvard Medical School, Boston, MA, USA
Circ Cardiovasc Qual Outcomes 4:198-205. 2011..Collaborative care depression management programs have been used in outpatients to improve depression outcomes, but such a program had never been initiated in the hospital or used for patients with a wide range of cardiac illnesses...
- Effectiveness of the relaxation response-based group intervention for treating depressed chinese american immigrants: a pilot studyAlbert Yeung
Benson Henry Institute for Mind Body Medicine, Massachusetts General Hospital, 151 Merrimac St, Boston, MA 02114, USA
Int J Environ Res Public Health 11:9186-201. 2014..This study examined the feasibility, safety and efficacy of an 8-week Relaxation Response (RR)-based group...
- Tai chi treatment for depression in Chinese Americans: a pilot studyAlbert Yeung
Benson Henry Institute, Massachusetts General Hospital, Boston, USA
Am J Phys Med Rehabil 91:863-70. 2012..This study examined the feasibility, safety, and efficacy of using tai chi for treating major depressive disorder...
- Tackling the global mental health challenge: a psychosomatic medicine/consultation-liaison psychiatry perspectiveAmy M Bauer
Department of Psychiatry, Cambridge Health Alliance, 1493 Cambridge St, Cambridge, MA 02139, USA
Psychosomatics 51:185-93. 2010..Consultation-liaison (C-L) psychiatry, informed by principles of psychosomatic medicine, is well-positioned to address the global impact of mental disorders through primary care C-L models...
- Post-MI psychiatric syndromes: six unanswered questionsJeff C Huffman
Harvard Medical School and Department of Psychiatry, Massachusetts General Hospital, Boston, MA 02114, USA
Harv Rev Psychiatry 14:305-18. 2006..To make further progress, large, multicenter trials that use optimized screening tools, obtain data at several time points, consider multiple psychosocial variables, and correct carefully for medical/cardiac severity are required...
- Successful implementation of an alcohol-withdrawal pathway in a general hospitalJennifer Repper-DeLisi
Dept of Nursing, Massachusetts General Hospital, Blake 11, Boston, MA 02114, USA
Psychosomatics 49:292-9. 2008..Although alcohol use and abuse are common among general-hospital inpatients, many patients are inadequately assessed and treated for alcohol withdrawal...
- Recognition and treatment of depression and anxiety in patients with acute myocardial infarctionJeff C Huffman
Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts, USA
Am J Cardiol 98:319-24. 2006..Recognition and treatment of anxiety is substantially better, up to 50% of patients who are found to be anxious by psychiatrists after acute myocardial infarction remain unrecognized...
- The feasibility and impact of delivering a mind-body intervention in a virtual worldDaniel B Hoch
The Benson Henry Institute for Mind Body Medicine, Boston, Massachusetts, United States of America
PLoS ONE 7:e33843. 2012..In this pilot study, we explore the feasibility of translating a face-to-face stress reduction program into an online virtual setting and estimate the effect size of the intervention...
- The treatment of depressed chinese americans using qigong in a health care setting: a pilot studyAlbert Yeung
Benson Henry Institute, Massachusetts General Hospital, Boston, MA 02114, USA Depression Clinical and Research Program, Massachusetts General Hospital, One Bowdoin Square, 6 F, Boston, MA 02114, USA South Cove Community Health Center, Boston, MA 02111, USA
Evid Based Complement Alternat Med 2013:168784. 2013..Conclusions. The Qigong intervention provided at a health care setting for the treatment of primary care patients with MDD is feasible. Further studies with larger sample sizes are warranted...
- The therapeutic use of the relaxation response in stress-related diseasesTobias Esch
The Mind Body Medical Institute, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
Med Sci Monit 9:RA23-34. 2003..Further studies are necessary to elucidate the complex physiology underlying the RR and its impact upon stress-related disease states...
- Detection of depression in cardiac inpatients: feasibility and results of systematic screeningGillian Sowden
Harvard Medical School, Boston, MA, USA
Am Heart J 159:780-7. 2010..Our objective was to assess the feasibility and results of such screening on inpatient cardiac units...
- Relaxation response-based yoga improves functioning in young children with autism: a pilot studyLucy E Rosenblatt
Department of Psychiatry, Saint Francis Hospital and Medical Center, Hartford, CT, USA
J Altern Complement Med 17:1029-35. 2011..The study objectives were to develop and objectively assess the therapeutic effect of a novel movement-based complementary and alternative medicine approach for children with an autism-spectrum disorder (ASD)...
- The development of a patient-centered program based on the relaxation response: the Relaxation Response Resiliency Program (3RP)Elyse R Park
Massachusetts General Hospital Benson Henry Institute for Mind Body Medicine, Boston, MA 02114, USA
Psychosomatics 54:165-74. 2013..Dr. Benson highlighted how the mind and body function together in one's experience of the stress response and proposed the existence of the relaxation response (RR)...
- Development of a positive psychology intervention for patients with acute cardiovascular diseaseJeff C Huffman
Harvard Medical School, Boston, MA Department of Psychiatry, Massachusetts General Hospital, Boston, MA
Heart Int 6:e14. 2011..Future studies should further develop this promising intervention and examine its impact on psychological and medical outcomes in this vulnerable population of cardiac patients. ..
- Low degree of formal education and musical experience predict degree of music-induced stress reduction in relatives and friends of patients: a single-center, randomized controlled trialAlexandra C Tilt
Department of Surgery, Massachusetts General Hospital, Boston, MA 021114, USA
Ann Surg 257:834-8. 2013..To determine the factors that may predict music-induced relaxation in friends and family of patients in the emergency department...
- Internationalism and the future of academic psychiatryGary S Belkin
Department of Psychiatry, Bellevue Hospital Center, NY University Medical School of Medicine, USA
Acad Psychiatry 29:240-3. 2005
- The impact of music on hypermetabolism in critical illnessAaron Nelson
Tufts University, School of Medicine, Boston, Massachusetts, USA
Curr Opin Clin Nutr Metab Care 11:790-4. 2008..This review summarizes recent evidence on the effects of music on the hypermetabolic response of critical illness...
- The relaxation response: reducing stress and improving cognition in healthy aging adultsJennifer A Galvin
Mind Body Medical Institute and Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
Complement Ther Clin Pract 12:186-91. 2006..All subjects' salivary cortisol levels were within low-normal range and did not significantly change. Our 5-week program in highly educated, mobile, healthy, aging adults significantly improved performance on a simple attention task...
- Relaxation Response and Resiliency Training and Its Effect on Healthcare Resource UtilizationJames E Stahl
MGH Benson Henry Institute, Massachusetts General Hospital, Boston, Massachusetts, United States of America Dartmouth Hitchcock Medical Center, Section of General Internal Medicine, Lebanon, New Hampshire, United States of America MGH Institute for Technology Assessment, Massachusetts General Hospital, Boston, Massachusetts, United States of America
PLoS ONE 10:e0140212. 2015..Mind-body interventions can reduce stress and build resiliency. The rationale for this study is therefore to estimate the effect of mind-body interventions on healthcare utilization...
- Stress-related diseases -- a potential role for nitric oxideTobias Esch
The Mind Body Medical Institute, CareGroup and Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
Med Sci Monit 8:RA103-18. 2002..A failure to terminate or shift originally protective mechanisms may lead to a vicious cycle of disease-supporting pathophysiological pathways...
- Nest making and oxytocin comparably promote wound healing in isolation reared ratsAntonia Vitalo
Department of Surgery, Massachusetts General Hospital, Boston, Massachusetts, USA
PLoS ONE 4:e5523. 2009....
- Stress in cardiovascular diseasesTobias Esch
The Mind Body Medical Institute, CareGroup and Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA
Med Sci Monit 8:RA93-RA101. 2002..Evidence for a connection between stress and selected cardiovascular diseases is analyzed. Does stress cause or exacerbate cardiovascular diseases?..
- Using the differential from complete blood counts as a biomarker of fatigue in advanced non-small-cell lung cancer: an exploratory analysisJohanna S Paddison
Division of Psychiatry and Medicine, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
Palliat Support Care 7:213-7. 2009..Our exploratory investigation considered whether variations in routinely available hematological parameters relate to the severity of fatigue reports...
- Suicidal behavior-related hospitalizations among pregnant women in the USA, 2006-2012Qiu Yue Zhong
Department of Epidemiology, Harvard T H Chan School of Public Health, Boston, MA, 02115, USA
Arch Womens Ment Health 19:463-72. 2016..Our findings highlight the increasing burden and racial differences in suicidal ideation among US pregnant women. Targeted suicide prevention efforts are needed for high-risk pregnant women including teens, blacks, and low-income women. ..
- Genomic and clinical effects associated with a relaxation response mind-body intervention in patients with irritable bowel syndrome and inflammatory bowel diseaseBraden Kuo
Gastrointestinal Unit, Massachusetts General Hospital, Boston, Massachusetts, United States of America
PLoS ONE 10:e0123861. 2015..The impact of mind-body interventions (MBIs) on IBS and IBD patients has not previously been examined...
- Trust violated: analgesics for addictsRichard T Penson
Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts 02114 2617, USA
Oncologist 8:199-209. 2003..With open and honest support, the team was able to both care for and empower the patient. Issues of trust, liability, opioid tolerance, and barriers to optimal analgesia for cancer pain are discussed...
- Chronic variable stress activates hematopoietic stem cellsTimo Heidt
1 Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA 2
Nat Med 20:754-8. 2014..When atherosclerosis-prone Apoe(-/-) mice were subjected to chronic stress, accelerated hematopoiesis promoted plaque features associated with vulnerable lesions that cause myocardial infarction and stroke in humans. ..
- Predictors and outcomes of deliriumSarah L Minden
Department of Psychiatry, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
Gen Hosp Psychiatry 27:209-14. 2005..To determine factors associated with the occurrence of delirium among patients undergoing surgical repair of abdominal aortic aneurysm (AAA)...
- Catatonic coma with profound bradycardiaOliver Freudenreich
Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA
Psychosomatics 48:74-8. 2007....
- Catatonia and psychosis in a patient with AIDS: treatment with lorazepam and aripiprazoleJeff C Huffman
J Clin Psychopharmacol 25:508-10. 2005
- Endogenous morphine signaling via nitric oxide regulates the expression of CYP2D6 and COMT: autocrine/paracrine feedback inhibitionKirk J Mantione
Neuroscience Research Institute, State University of New York College at Old Westbury, 11568, USA
Addict Biol 13:118-23. 2008..Taken together, it appears that morphine has the ability to modulate its own synthesis via autocrine and paracrine signaling...
- Encephalitis and catatonia treated with ECTSherese Ali
Department of Neuropsychiatry, Toronto Western Hospital, Toronto, Ontario, Canada
Cogn Behav Neurol 21:46-51. 2008..To describe 2 cases of encephalitis with neuropsychiatric symptoms including catatonia, compounded by neuroleptic use for delirious agitation culminating in malignant catatonia responsive to electroconvulsive therapy (ECT)...
- Potential intervention for depression associated with increased mortality risk in patients after myocardial infarctionGregory L Fricchione
Am J Cardiol 89:112-3. 2002
- Pregnancy and malignant catatoniaMariana Espinola-Nadurille
Neuropsychiatry Unit, National Institute of Neurology and Neurosurgery, Mexico City 14269, Mexico
Gen Hosp Psychiatry 29:69-71. 2007....
- Relaxation: molecular and physiological significanceGeorge B Stefano
Neuroscience Research Institute, State University of New York College at Old Westbury, Old Westbury, NY 11568, USA
Med Sci Monit 12:HY21-31. 2006..We conclude that enough scientific information exists to support these phenotmena as actual physical processes that can be harnessed to provide better patient care...
- Hypercalcemic delirium associated with hyperparathyroidism and a vitamin D analogJeff C Huffman
Gen Hosp Psychiatry 27:374-6. 2005
- The blueprint for stress can be found in invertebratesGeorge B Stefano
Neuroscience Research Institute, State University of New York at Old Westbury, Old Westbury, NY 11568, USA
Neuro Endocrinol Lett 23:85-93. 2002..Thus, it would appear that these responses evolved first in simpler organisms and were then maintained and enhanced during evolution...
- The role of stress in neurodegenerative diseases and mental disordersTobias Esch
The Mind Body Medical Institute, CareGroup and Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston MA 02215, USA
Neuro Endocrinol Lett 23:199-208. 2002..Evidence for a connection between stress and selected neurodegenerative diseases as well as mental disorders is analyzed. Does stress cause or exacerbate related pathophysiological disease processes?..
- Nicotine, alcohol and cocaine coupling to reward processes via endogenous morphine signaling: the dopamine-morphine hypothesisGeorge B Stefano
Neuroscience Research Institute, State University of New York College at Old Westbury, Old Westbury, NY 11568, USA
Med Sci Monit 13:RA91-102. 2007..Additionally, addictive drugs are capable of directly acting on reward pathways, now, in part, via endogenous morphine processes...