Affiliation: Massachusetts General Hospital
- Scara1 deficiency impairs clearance of soluble amyloid-β by mononuclear phagocytes and accelerates Alzheimer's-like disease progressionDan Frenkel
Department of Neurobiology, Sagol School of Neuroscience, George S Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv 699788, Israel
Nat Commun 4:2030. 2013..In contrast, pharmacological upregulation of Scara1 expression on mononuclear phagocytes increases Aβ clearance. This approach is a potential treatment strategy for Alzheimer's disease. ..
- Mechanisms of microglia accumulation in Alzheimer's disease: therapeutic implicationsJoseph El Khoury
Division of Rheumatology, Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
Trends Pharmacol Sci 29:626-32. 2008..Here, we review the role of microglia in AD and the mechanisms of their accumulation and discuss implications for AD therapy...
- Ccr2 deficiency impairs microglial accumulation and accelerates progression of Alzheimer-like diseaseJoseph El Khoury
Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Harvard Medical School, 149 13th Street, Charlestown, Massachusetts 02129, USA
Nat Med 13:432-8. 2007..Thus, Ccr2-dependent microglial accumulation plays a protective role in the early stages of Alzheimer disease by promoting Abeta clearance...
- Linezolid in the treatment of vancomycin-resistant Enterococcus faecium in solid organ transplant recipients: report of a multicenter compassionate-use trialJ El-Khoury
Infectious Disease Division, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
Transpl Infect Dis 5:121-5. 2003..Linezolid appears to be a safe and effective treatment option for VRE, even in the presence of bacteremia, and may lead to decreased mortality in solid organ transplant recipients with VRE infection...
- A CD36-initiated signaling cascade mediates inflammatory effects of beta-amyloidKathryn J Moore
Lipid Metabolism Unit, Massachusetts General Hospital, Harvard Medical School, Boston 02114, USA
J Biol Chem 277:47373-9. 2002....
- CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimerCameron R Stewart
Lipid Metabolism Unit, Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA
Nat Immunol 11:155-61. 2010....
- Cryptococcus neoformans Kin1 protein kinase homologue, identified through a Caenorhabditis elegans screen, promotes virulence in mammalsEleftherios Mylonakis
Division of Infectious Diseases, Massachusetts General Hospital, Boston, MA 02114, USA
Mol Microbiol 54:407-19. 2004..These findings show that the C. neoformans Kin1 kinase homologue is required for full virulence in disparate hosts and that C. elegans can be used as a substitute host to identify novel factors involved in fungal pathogenesis in mammals...
- Evolutionarily conserved recognition and innate immunity to fungal pathogens by the scavenger receptors SCARF1 and CD36Terry K Means
Center for Immunology and Inflammatory Diseases and Division of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA
J Exp Med 206:637-53. 2009..Binding of these pathogens to SCARF1 and CD36 was beta-glucan dependent. Thus, CED-1/SCARF1 and C03F11.3/CD36 are beta-glucan binding receptors and define an evolutionarily conserved pathway for the innate sensing of fungal pathogens...
- Microglial dysfunction and defective beta-amyloid clearance pathways in aging Alzheimer's disease miceSuzanne E Hickman
Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy, and Immunology, and Division of Infectious Diseases, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129
J Neurosci 28:8354-60. 2008..Antiinflammatory therapy for AD should take this dichotomous microglial role into consideration...
- Mechanisms of mononuclear phagocyte recruitment in Alzheimer's diseaseSuzanne E Hickman
Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Charlestown, 02129, USA
CNS Neurol Disord Drug Targets 9:168-73. 2010....
- Chemokines and microglia in Alzheimer's diseaseJoseph El Khoury; Fiscal Year: 2005....