Robert R Edwards

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. pmc The Role of Psychosocial Processes in the Development and Maintenance of Chronic Pain
    Robert R Edwards
    Department of Anesthesiology, Brigham and Women s Hospital and Harvard University, Boston, Massachusetts Electronic address
    J Pain 17:T70-92. 2016
  2. pmc Changes in Pain Sensitivity and Pain Modulation During Oral Opioid Treatment: The Impact of Negative Affect
    R R Edwards
    Department of Anesthesiology
    Pain Med 17:1882-1891. 2016
  3. pmc Variability in conditioned pain modulation predicts response to NSAID treatment in patients with knee osteoarthritis
    Robert R Edwards
    Department of Anesthesiology, Harvard Medical School, Brigham and Women s Hospital, 850 Boylston St, Suite 302, Chestnut Hill, MA, 02467, USA
    BMC Musculoskelet Disord 17:284. 2016
  4. pmc Alteration in pain modulation in women with persistent pain after lumpectomy: influence of catastrophizing
    Robert R Edwards
    Department of Anesthesiology, Harvard Medical School, Brigham and Women s Hospital, Chestnut Hill, MA 02467, USA
    J Pain Symptom Manage 46:30-42. 2013
  5. pmc Association of catastrophizing with interleukin-6 responses to acute pain
    Robert R Edwards
    Department of Anesthesiology, Perioperative and Pain Medicine, Harvard Medical School, Pain Management Center, Brigham and Women s Hospital, Chestnut Hill, MA 02467, USA
    Pain 140:135-44. 2008
  6. pmc Enhanced reactivity to pain in patients with rheumatoid arthritis
    Robert R Edwards
    Department of Anesthesiology, Harvard Medical School, Brigham and Women s Hospital, Chestnut Hill, MA 02467, USA
    Arthritis Res Ther 11:R61. 2009
  7. pmc Catastrophizing and depressive symptoms as prospective predictors of outcomes following total knee replacement
    Robert R Edwards
    Department of Anesthesiology, Perioperative and Pain Medicine, Harvard Medical School, Brigham and Women s Hospital, Chestnut Hill, Massachusetts 02467, USA
    Pain Res Manag 14:307-11. 2009
  8. pmc Moderators of the negative effects of catastrophizing in arthritis
    Robert R Edwards
    Department of Anesthesiology, Perioperative and Pain Medicine, Harvard Medical School, Brigham and Women s Hospital, Chestnut Hill, MA 02467, USA
    Pain Med 11:591-9. 2010
  9. doi request reprint Pain, catastrophizing, and depression in the rheumatic diseases
    Robert R Edwards
    Department of Anesthesiology, Perioperative and Pain Medicine, Harvard Medical School, Brigham and Women s Hospital, 850 Boylston Street, Suite 302, Chestnut Hill, MA 02467, USA
    Nat Rev Rheumatol 7:216-24. 2011
  10. pmc Alterations in pain responses in treated and untreated patients with restless legs syndrome: associations with sleep disruption
    Robert R Edwards
    Department of Anesthesiology, Perioperative and Pain Medicine, Harvard Medical School, Brigham and Women s Hospital, Chesnut Hill, MA 02467, USA
    Sleep Med 12:603-9. 2011

Detail Information

Publications54

  1. pmc The Role of Psychosocial Processes in the Development and Maintenance of Chronic Pain
    Robert R Edwards
    Department of Anesthesiology, Brigham and Women s Hospital and Harvard University, Boston, Massachusetts Electronic address
    J Pain 17:T70-92. 2016
    ..Collectively, the complexity and profound variability in chronic pain highlights the need to better understand the multidimensional array of interacting forces that determine the trajectory of chronic pain conditions...
  2. pmc Changes in Pain Sensitivity and Pain Modulation During Oral Opioid Treatment: The Impact of Negative Affect
    R R Edwards
    Department of Anesthesiology
    Pain Med 17:1882-1891. 2016
    ..We investigated whether individual differences in psychological characteristics were related to opioid-induced changes in pain perception and pain modulation...
  3. pmc Variability in conditioned pain modulation predicts response to NSAID treatment in patients with knee osteoarthritis
    Robert R Edwards
    Department of Anesthesiology, Harvard Medical School, Brigham and Women s Hospital, 850 Boylston St, Suite 302, Chestnut Hill, MA, 02467, USA
    BMC Musculoskelet Disord 17:284. 2016
    ....
  4. pmc Alteration in pain modulation in women with persistent pain after lumpectomy: influence of catastrophizing
    Robert R Edwards
    Department of Anesthesiology, Harvard Medical School, Brigham and Women s Hospital, Chestnut Hill, MA 02467, USA
    J Pain Symptom Manage 46:30-42. 2013
    ..Persistent pain is common after surgical treatment of breast cancer, but fairly little is known about the changes in sensory processing that accompany such pain syndromes...
  5. pmc Association of catastrophizing with interleukin-6 responses to acute pain
    Robert R Edwards
    Department of Anesthesiology, Perioperative and Pain Medicine, Harvard Medical School, Pain Management Center, Brigham and Women s Hospital, Chestnut Hill, MA 02467, USA
    Pain 140:135-44. 2008
    ..This pathway may represent one important mechanism by which catastrophizing and other psychosocial factors shape the experience of both acute and chronic pain in a variety of settings...
  6. pmc Enhanced reactivity to pain in patients with rheumatoid arthritis
    Robert R Edwards
    Department of Anesthesiology, Harvard Medical School, Brigham and Women s Hospital, Chestnut Hill, MA 02467, USA
    Arthritis Res Ther 11:R61. 2009
    ..In the present study, we compared psychophysical and physiological responses to standardized noxious stimulation in 19 RA patients and 21 healthy controls...
  7. pmc Catastrophizing and depressive symptoms as prospective predictors of outcomes following total knee replacement
    Robert R Edwards
    Department of Anesthesiology, Perioperative and Pain Medicine, Harvard Medical School, Brigham and Women s Hospital, Chestnut Hill, Massachusetts 02467, USA
    Pain Res Manag 14:307-11. 2009
    ....
  8. pmc Moderators of the negative effects of catastrophizing in arthritis
    Robert R Edwards
    Department of Anesthesiology, Perioperative and Pain Medicine, Harvard Medical School, Brigham and Women s Hospital, Chestnut Hill, MA 02467, USA
    Pain Med 11:591-9. 2010
    ..In this study, we investigated a variety of factors that might buffer or magnify catastrophizing's deleterious consequences among patients with RA...
  9. doi request reprint Pain, catastrophizing, and depression in the rheumatic diseases
    Robert R Edwards
    Department of Anesthesiology, Perioperative and Pain Medicine, Harvard Medical School, Brigham and Women s Hospital, 850 Boylston Street, Suite 302, Chestnut Hill, MA 02467, USA
    Nat Rev Rheumatol 7:216-24. 2011
    ..Pain, depression, and catastrophizing might all be uniquely important therapeutic targets in the multimodal management of a range of such conditions...
  10. pmc Alterations in pain responses in treated and untreated patients with restless legs syndrome: associations with sleep disruption
    Robert R Edwards
    Department of Anesthesiology, Perioperative and Pain Medicine, Harvard Medical School, Brigham and Women s Hospital, Chesnut Hill, MA 02467, USA
    Sleep Med 12:603-9. 2011
    ..The aim of this study was to evaluate psychophysical responses to noxious heat and pressure stimuli in both treated and untreated RLS patients, compared to matched controls...
  11. pmc Elevated pain sensitivity in chronic pain patients at risk for opioid misuse
    Robert R Edwards
    Department of Anesthesiology, Harvard Medical School, Brigham and Women s Hospital, Chestnut Hill, Massachusetts 0246, USA
    J Pain 12:953-63. 2011
    ....
  12. doi request reprint The association of perceived discrimination with low back pain
    Robert R Edwards
    Department of Anesthesiology, Perioperative, and Pain Medicine, and Psychiatry, Harvard Medical School, Pain Management Center, Brigham and Women s Hospital, 850 Boylston Street, Suite 302, Chestnut Hill, MA 02467, USA
    J Behav Med 31:379-89. 2008
    ....
  13. pmc Disrupted brain circuitry for pain-related reward/punishment in fibromyalgia
    Marco L Loggia
    Massachusetts General Hospital, Brigham and Women s Hospital, and Harvard Medical School, Boston, Massachusetts
    Arthritis Rheumatol 66:203-12. 2014
    ..This study was undertaken to investigate potential dysregulation of the neural circuitry underlying cognitive and hedonic aspects of the subjective experience of pain, such as anticipation of pain and anticipation of pain relief...
  14. pmc Sustained deep-tissue pain alters functional brain connectivity
    Jieun Kim
    MGH MIT HMS Athinoula A Martinos Center for Biomedical Imaging, Charlestown, MA, USA
    Pain 154:1343-51. 2013
    ..Furthermore, increased connectivity between S1/M1 and both sensory and affective processing areas may be an important contribution to interindividual differences in pain sensitivity...
  15. pmc Disentangling linear and nonlinear brain responses to evoked deep tissue pain
    Marco L Loggia
    Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Pain 153:2140-51. 2012
    ..Future studies should apply a similar approach using innocuous stimuli of multiple intensities to evaluate whether the response profiles reported here can also be generalized to nonpainful somatosensory processing...
  16. pmc The role of sleep problems in central pain processing in rheumatoid arthritis
    Yvonne C Lee
    Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Arthritis Rheum 65:59-68. 2013
    ..This study was undertaken to examine the level of CPM, pressure-pain threshold, and pressure-pain tolerance among RA patients compared to healthy controls...
  17. pmc Pain sensitivity and pain reactivity in osteoarthritis
    Yvonne C Lee
    Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Arthritis Care Res (Hoboken) 63:320-7. 2011
    ....
  18. pmc The lateral prefrontal cortex mediates the hyperalgesic effects of negative cognitions in chronic pain patients
    Marco L Loggia
    Massachusetts General Hospital Massachusetts Institute of Technology Harvard Medical School Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital, Harvard Medical School, Chestnut Hill, Massachusetts Electronic address
    J Pain 16:692-9. 2015
    ....
  19. pmc Enhanced cortisol increase upon awakening is associated with greater pain ratings but not salivary cortisol or soluble tumor necrosis factor-α receptor II responses to acute pain
    Burel R Goodin
    University of Florida, Comprehensive Center for Pain Research, Gainesville, FL 32610, USA
    Clin J Pain 28:291-9. 2012
    ..In addition to evoked pain ratings, this study also tested whether CAR was prospectively related with salivary cortisol and soluble tumor necrosis factor-α receptor II responses to acute pain stimulation...
  20. pmc Day-to-day pain symptoms are only weakly associated with opioid craving among patients with chronic pain prescribed opioid therapy
    Marc O Martel
    Department of Anesthesiology, Harvard Medical School, Brigham and Women s Hospital, Boston, MA, USA Electronic address
    Drug Alcohol Depend 162:130-6. 2016
    ..Although research has elucidated some of the factors associated with opioid craving, the contribution of patients' levels of pain to opioid craving remains unclear...
  21. pmc Effect of Milnacipran on Pain in Patients with Rheumatoid Arthritis with Widespread Pain: A Randomized Blinded Crossover Trial
    Yvonne C Lee
    From the Division of Rheumatology, Immunology and Allergy, and Department of Anesthesiology, Brigham and Women s Hospital Division of Rheumatology, Immunology and Allergy, Massachusetts General Hospital, Boston, Massachusetts Department of Anesthesiology, University of Michigan Medical Center, Ann Arbor, Michigan, USA Y C Lee, MD, MMSc, Division of Rheumatology, Department of Medicine, Brigham and Women s Hospital E Massarotti, MD, Division of Rheumatology, Brigham and Women s Hospital R R Edwards, PhD, Pain Management Center, Brigham and Women s Hospital B Lu, MD, DRPH, Division of Rheumatology, Brigham and Women s Hospital C Liu, PhD, Division of Rheumatology, Brigham and Women s Hospital Y Lo, MPH, Division of Rheumatology, Brigham and Women s Hospital A Wohlfahrt, BA, Division of Rheumatology, Brigham and Women s Hospital N D Kim, MD, Division of Rheumatology, Immunology and Allergy, Massachusetts General Hospital D J Clauw, MD, University of Michigan D H Solomon, MD, MPH
    J Rheumatol 43:38-45. 2016
    ..We examined the effect of milnacipran on self-reported pain intensity and experimental pain sensitivity among patients with rheumatoid arthritis (RA) with widespread pain and stable RA disease activity...
  22. pmc Quantitative sensory testing and pain-evoked cytokine reactivity: comparison of patients with sickle cell disease to healthy matched controls
    Claudia M Campbell
    aDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA bDivision of Hematology, Johns Hopkins University School of Medicine, Baltimore, MD, USA cHarvard Medical School, Departments of Anesthesiology, Perioperative, Pain Medicine, and Psychiatry, Brigham and Women s Hospital, Pain Management Center, Chestnut Hill, MA, USA dDepartment of Acute and Chronic Care, Johns Hopkins University School of Nursing, Baltimore, MD, USA
    Pain 157:949-56. 2016
    ..Future research is warranted to evaluate the impact of enhanced pain-related cytokine response and whether it is predictive of clinical characteristics and the frequency/severity of pain crises in patients with SCD...
  23. pmc Phenotype matters: the absence of a positive association between cortical thinning and chronic low back pain when controlling for salient clinical variables
    Andrew J Dolman
    Departments of Anesthesiology Psychiatry, Brigham and Women s Hospital Departments of Radiology Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA Departments of Anesthesiology Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA
    Clin J Pain 30:839-45. 2014
    ..But these studies have not controlled for important clinical variables (such as a comorbid affective disorder, pain medication, age, or pain phenotype), which may reduce or eliminate these associations...
  24. pmc Effects of Cognitive-behavioral Therapy (CBT) on Brain Connectivity Supporting Catastrophizing in Fibromyalgia
    Asimina Lazaridou
    Department of Anesthesiology, Harvard Medical School, Brigham and Women s Hospital, 850 Boylston St, Suite 302, Chestnut Hill, MA 02467, USA MGH MIT HMS Athinoula A Martinos Center for Biomedical Imaging, Charlestown, MA Korea Institute of Oriental Medicine, Clinical Research Division, Daejeon, Korea Department of Medicine, Division of Rheumatology, Harvard Medical School, Brigham and Women s Hospital
    Clin J Pain . 2016
    ....
  25. doi request reprint Distraction analgesia in chronic pain patients: the impact of catastrophizing
    Kristin L Schreiber
    From the Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital, Boston, Massachusetts K L S, S G, R N J, R R E Department of Psychiatry and Behavioral Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland C C, A D W Department of Anesthesiology and Psychiatry, University of Pittsburgh Medical Center C C, A D W Department of Psychiatry, Brigham and Women s Hospital M O M, R N J, R R E and Center for Pain and the Brain, P A I N Group, Boston Children s Hospital, Boston, Massachusetts D B
    Anesthesiology 121:1292-301. 2014
    ..Its effects are variable across individuals, however, and the authors hypothesized that chronic pain patients who reported higher levels of pain catastrophizing would derive less pain-reducing benefit from distraction...
  26. pmc Pain modality- and sex-specific effects of COMT genetic functional variants
    Inna Belfer
    Department of Anesthesiology, University of Pittsburgh, Pittsburgh, PA, USA
    Pain 154:1368-76. 2013
    ..These findings reemphasize the fundamental contribution of COMT to pain processes, and provide a fine-grained resolution of this contribution at the genetic level that can be used to guide future studies in the area of pain genetics. ..
  27. doi request reprint Efficacy of the Opioid Compliance Checklist to Monitor Chronic Pain Patients Receiving Opioid Therapy in Primary Care
    Robert N Jamison
    Pain Management Center, Departments of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts Pain Management Center, Department of Psychiatry, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts Electronic address
    J Pain 17:414-23. 2016
    ..The OCC seemed to be a reliable and valid screening tool to help detect current and future aberrant drug-related behavior and nonadherence among chronic pain patients in primary care...
  28. pmc The association between negative affect and prescription opioid misuse in patients with chronic pain: the mediating role of opioid craving
    Marc O Martel
    Department of Anesthesiology, Harvard Medical School, Brigham and Women s Hospital, Boston, Massachusetts Electronic address
    J Pain 15:90-100. 2014
    ..The clinical implications of our findings are also discussed...
  29. pmc Self-reports of medication side effects and pain-related activity interference in patients with chronic pain: a longitudinal cohort study
    Marc O Martel
    aDepartment of Anesthesiology, Harvard Medical School, Brigham and Women s Hospital Pain Management Center, Chestnut Hill, MA, USA bDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA cDepartment of Social and Behavioral Sciences, Harvard School of Public Health, Boston, MA, USA dUPMC Pain Medicine, Departments of Anesthesiology and Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA
    Pain 156:1092-100. 2015
    ..The implications of our findings for clinical practice and the management of patients with chronic pain conditions are discussed. ..
  30. pmc Sex differences in the stability of conditioned pain modulation (CPM) among patients with chronic pain
    Marc O Martel
    Department of Anesthesiology, Harvard Medical School, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Pain Med 14:1757-68. 2013
    ..The study also examined the factors that might be responsible for the stability of CPM...
  31. pmc Relationship of negative affect and outcome of an opioid therapy trial among low back pain patients
    Robert N Jamison
    Pain Management Center, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Pain Pract 13:173-81. 2013
    ....
  32. pmc The relationship between disease activity, sleep, psychiatric distress and pain sensitivity in rheumatoid arthritis: a cross-sectional study
    Yvonne C Lee
    Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, 75 Francis Street, PBB B3, Boston, MA 02115, USA
    Arthritis Res Ther 11:R160. 2009
    ..The etiology of RA pain is likely multifactorial, including both inflammatory and non-inflammatory components. In this study, we examine the association between disease activity, sleep, psychiatric distress and pain sensitivity in RA...
  33. pmc Multiple Levels of Suffering: Discrimination in Health-Care Settings is Associated With Enhanced Laboratory Pain Sensitivity in Sickle Cell Disease
    Vani A Mathur
    Johns Hopkins University School of Medicine, Department of Psychiatry and Behavioral Sciences, Baltimore, MD Texas A and M University, Department of Psychology, College Station, TX Johns Hopkins University School of Medicine, Division of Hematology University of Maryland, Baltimore County, Department of Psychology, Baltimore, MD Harvard Medical School, Departments of Anesthesiology, Perioperative, Pain Medicine, and Psychiatry Brigham and Women s Hospital, Pain Management Center, Harvard Medical School, Chestnut Hill, MA
    Clin J Pain 32:1076-1085. 2016
    ..In this particularly relevant context, we examined the relationship between perceived discrimination and both clinical and laboratory pain...
  34. pmc Distress Intolerance and Prescription Opioid Misuse Among Patients With Chronic Pain
    R Kathryn McHugh
    Division of Alcohol and Drug Abuse, McLean Hospital, Belmont, Massachusetts Department of Psychiatry, Harvard Medical School, Boston, Massachusetts Electronic address
    J Pain 17:806-14. 2016
    ..Distress intolerance may be a relevant marker of risk for opioid misuse among those with chronic pain...
  35. pmc The subjective psychoactive effects of oral dronabinol studied in a randomized, controlled crossover clinical trial for pain
    Mohammed A Issa
    Departments of Anesthesiology, Perioperative, and Pain Medicine Psychiatry, Brigham and Women s Hospital Behavioral Psychopharmacology Research Laboratory, McLean Hospital Harvard Medical School, Boston, MA
    Clin J Pain 30:472-8. 2014
    ..We hypothesized that when used for pain, dronabinol has psychoactive effects in a dose-response relationship, whose peak effects are comparable with smoking marijuana...
  36. pmc Integrating pain management in clinical practice
    Robert N Jamison
    Department of Anesthesiology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Clin Psychol Med Settings 19:49-64. 2012
    ..Finally, we offer a future look at the role of integrating pain management in clinical practice in the psychological assessment and treatment for persons with chronic pain...
  37. pmc The use of functional neuroimaging to evaluate psychological and other non-pharmacological treatments for clinical pain
    Karin B Jensen
    Department of Psychiatry, Massachusetts General Hospital MGH Harvard Medical School HMS, Boston, MA, USA
    Neurosci Lett 520:156-64. 2012
    ..Evaluations of treatment-related brain changes (functional and structural) might also allow for sub-grouping of patients and help to develop individualized treatments...
  38. pmc A Pilot Comparison of a Smartphone App with or without 2-Way Messaging Among Chronic Pain Patients: Who Benefits from a Pain App?
    Robert N Jamison
    Pain Management Center, Departments of Anesthesiology, Perioperative and Pain Medicine Psychiatry, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115 USA
    Clin J Pain . 2016
    ..The overall aim of this study was to determine the effect of introducing a smartphone pain app, for both Android and iPhone devices that enables chronic pain patients to assess, monitor, and communicate their status to their providers...
  39. ncbi request reprint Reduced insula habituation associated with amplification of trigeminal brainstem input in migraine
    Jeungchan Lee
    Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Cephalalgia . 2016
    ..Impaired sensory processing in migraine can reflect diminished habituation, increased activation, or even increased gain or amplification of activity from the primary synapse in the brainstem to higher cortical/subcortical brain regions...
  40. pmc Persistent pain in postmastectomy patients: comparison of psychophysical, medical, surgical, and psychosocial characteristics between patients with and without pain
    Kristin L Schreiber
    Department of Anesthesiology, University of Pittsburgh, Pittsburgh, PA, USA
    Pain 154:660-8. 2013
    ..These findings suggest that an individual's psychophysical and psychosocial profile may be more strongly related to PPMP than their surgical treatment...
  41. pmc The association between catastrophizing and craving in patients with chronic pain prescribed opioid therapy: a preliminary analysis
    Marc O Martel
    Department of Anesthesiology, Harvard Medical School, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Pain Med 15:1757-64. 2014
    ..Based on previous research, there is reason to believe that catastrophizing might be associated with heightened opioid craving...
  42. pmc Validation of a brief Opioid Compliance Checklist for patients with chronic pain
    Robert N Jamison
    Pain Management Center, Departments of Anesthesia and Psychiatry, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts Electronic address
    J Pain 15:1092-101. 2014
    ..67). Although further testing is needed, these results suggest that the OCC is an easy-to-use, promising measure in monitoring opioid adherence among persons with chronic pain...
  43. pmc Gender differences in risk factors for aberrant prescription opioid use
    Robert N Jamison
    Pain Management Center, Departments of Anesthesia and Psychiatry, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02467, USA
    J Pain 11:312-20. 2010
    ..These results suggest that risk factors associated with prescription opioid misuse may differ between men and women...
  44. doi request reprint Effects of testosterone replacement on metabolic and inflammatory markers in men with opioid-induced androgen deficiency
    Grace Huang
    The Research Program in Men s Health Aging and Metabolism, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Clin Endocrinol (Oxf) 85:232-8. 2016
    ..The objective of this investigation was to determine the effects of testosterone administration on metabolic and inflammatory markers in adult men with opioid-induced androgen deficiency...
  45. pmc Evoked pain analgesia in chronic pelvic pain patients using respiratory-gated auricular vagal afferent nerve stimulation
    Vitaly Napadow
    Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA, USA
    Pain Med 13:777-89. 2012
    ..The dorsal medullary vagal system operates in tune with respiration, and we propose that supplying vagal afferent stimulation gated to the exhalation phase of respiration can optimize t-VNS...
  46. doi request reprint Patient phenotyping in clinical trials of chronic pain treatments: IMMPACT recommendations
    Robert R Edwards
    aHarvard Medical School, Boston, MA, USA bUniversity of Rochester, Rochester, NY, USA cUniversity of Washington, Seattle, WA, USA dStanford University, Palo Alto, CA, USA eEast Carolina University, Greenville, NC, USA fOslo University Hospital, Oslo, Norway and Karolinska Institute, Stockholm, Sweden gWashington University, St Louis, MO, USA hAalborg University, Aalborg, Denmark iHôpital Ambroise Paré, APHP and INSERM U 987, Boulogne Billancourt, France and University Versailles Saint Quentin, Versailles, France jUniversity of Kiel, Kiel, Germany kMetroHealth Medical Center, Cleveland, OH, USA lDepomed, Newark, CA, USA mLORA Group, LLC, Royal Oak, MD, USA nUniversity of Maryland, Baltimore, MD,
    Pain 157:1851-71. 2016
    ..We provide evidence-based recommendations for core phenotyping domains and recommend measures of each domain. ..
  47. ncbi request reprint Effects of Testosterone Replacement on Pain Catastrophizing and Sleep Quality in Men with Opioid-Induced Androgen Deficiency
    Grace Huang
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, The Research Program on Men s Health, Aging and Metabolism, Boston, Massachusetts
    Pain Med . 2016
    ..The objective of this investigation was to determine the effects of testosterone administration on pain catastrophizing and sleep quality in adult men with opioid-induced androgen deficiency...
  48. doi request reprint Predicting, preventing and managing persistent pain after breast cancer surgery: the importance of psychosocial factors
    Kristin L Schreiber
    Brigham and Women s Hospital, Department of Anesthesiology Perioperative and Pain Medicine, 75 Francis St, Boston, MA 02115, USA
    Pain Manag 4:445-59. 2014
    ....
  49. pmc The catechol-O-methyltransferase (COMT) val158met polymorphism affects brain responses to repeated painful stimuli
    Marco L Loggia
    Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 6:e27764. 2011
    ..These findings may help explain the inconsistencies in reported findings of the impact of COMT in pain regulation...
  50. doi request reprint Pretreatment psychosocial variables as predictors of outcomes following lumbar surgery and spinal cord stimulation: a systematic review and literature synthesis
    James Celestin
    Psychiatry Department, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Pain Med 10:639-53. 2009
    ..However, it remains unclear which, if any, variables are most predictive of pain-related treatment outcomes...
  51. pmc Temporal preference in individuals reporting chronic pain: discounting of delayed pain-related and monetary outcomes
    D Andrew Tompkins
    aDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA bDepartment of Psychology, California State University Chico, Chico, CA, USA cDepartment of Anesthesiology, Perioperative, and Pain Medicine, Harvard Medical School, Brigham and Women s Hospital, Boston, MA, USA
    Pain 157:1724-32. 2016
    ..Measures of DD may have promise in more accurately identifying individuals at highest risk for opioid misuse during chronic opioid therapy. ..
  52. doi request reprint Effects of testosterone replacement in men with opioid-induced androgen deficiency: a randomized controlled trial
    Shehzad Basaria
    aThe Research Program in Men s Health Aging and Metabolism, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA bDepartment of Biostatistics, Boston University School of Public Health, Boston, MA, USA cDepartment of Medicine, Boston University School of Medicine, Boston, MA, USA dDepartment of Anesthesiology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA eDepartments of Anesthesiology and Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Pain 156:280-8. 2015
    ..In conclusion, in men with opioid-induced androgen deficiency, testosterone administration improved pain sensitivity, sexual desire, body composition, and aspects of quality of life. ..
  53. pmc Evidence for brain glial activation in chronic pain patients
    Marco L Loggia
    1 MGH MIT HMS Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA 2 Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02155, USA
    Brain 138:604-15. 2015
    ....
  54. doi request reprint Risk factor assessment for problematic use of opioids for chronic pain
    Robert N Jamison
    Pain Management Center, Department of Anesthesiology, Perioperative, and Pain Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Clin Neuropsychol 27:60-80. 2013
    ..Finally we briefly discuss the effect of opiate analgesics on cognition and review some intervention strategies for chronic pain patients...