Affiliation: Massachusetts General Hospital
- Dietary modification and changes in blood pressureP R Conlin
Endocrinology Hypertension Division, Brigham and Women s Hospital, Medical Service, VA Boston Healthcare Syste, Boston, Massachusetts 02115, USA
Curr Opin Nephrol Hypertens 10:359-63. 2001..This reaffirms the role of lifestyle modifications as both preventative and adjunctive means to lower blood pressure...
- Redefining efficacy of antihypertensive therapies beyond blood pressure reduction--the role of angiotensin II antagonistsP R Conlin
Endocrinology, Diabetes and Hypertension Division, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
Int J Clin Pract 59:214-24. 2005..The results of these AIIA outcome trials have impacted on recently issued clinical guidelines for management of hypertension...
- Interactions of high salt intake and the response of the cardiovascular system to aldosteronePaul R Conlin
Division of Endocrinology, Diabetes and Hypertension Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
Cardiol Rev 13:118-24. 2005..Thus, aldosterone blockade with mineralocorticoid receptor antagonists offers target organ protection and may blunt some of the adverse effects of chronic high salt intake...
- The DASH diet enhances the blood pressure response to losartan in hypertensive patientsPaul R Conlin
Division of Endocrinology, Diabetes and Hypertension PRC, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
Am J Hypertens 16:337-42. 2003..We conducted a clinical trial to assess the BP response to the DASH diet with an antihypertensive medication, losartan, in participants with essential hypertension...
- Benefits of angiotensin converting enzyme inhibition and angiotensin II receptor antagonists in hypertensionP R Conlin
Endocrinology Hypertension Division, Brigham and Women s Hospital, Harvard Medical School, 221 Longwood Avenue, Boston, MA 02115, USA
J Med Liban 48:382-6. 2000..The review has illustrated specific clinical conditions where the use of an hypertensive agent that inhibits the renin-angiotensin system may offer added benefit to the patient while producing the needed anti-hypertensive effects...
- Rationale and design of the Optimal Macro-Nutrient Intake Heart Trial to Prevent Heart Disease (OMNI-Heart)Vincent J Carey
Channing Laboratory, Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
Clin Trials 2:529-37. 2005..Whether partial replacement of some carbohydrate (C) with either protein (P) or unsaturated fat (U) can further improve these and other cardiovascular (CVD) risk factors is unknown...
- Changes in aortic stiffness and augmentation index after acute converting enzyme or vasopeptidase inhibitionGary F Mitchell
Cardiovascular Engineering, Inc, Waltham, MA 02453, USA
Hypertension 46:1111-7. 2005..Our findings indicate that AI is a complex surrogate marker that is inversely related to changes in proximal aortic stiffness in systolic hypertension...
- Effects of protein, monounsaturated fat, and carbohydrate intake on blood pressure and serum lipids: results of the OmniHeart randomized trialLawrence J Appel
Welch Center for Prevention, Epidemiology and Clinical Research, Division of General Internal Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205 2223, USA
JAMA 294:2455-64. 2005..Reduced intake of saturated fat is widely recommended for prevention of cardiovascular disease. The type of macronutrient that should replace saturated fat remains uncertain...
- Web-based care management in patients with poorly controlled diabetesGraham T McMahon
Division of Endocrinology, Diabetes and Hypertension, Brigham and Women s Hospital, Boston, MA, USA
Diabetes Care 28:1624-9. 2005..To assess the effects of web-based care management on glucose and blood pressure control over 12 months in patients with poorly controlled diabetes...
- A randomized trial comparing intensive and passive education in patients with diabetes mellitusAnnaswamy Raji
Endocrinology Hypertension Division, Brigham and Women s Hospital, 221 Longwood Ave, Boston, MA 02115, USA
Arch Intern Med 162:1301-4. 2002..Patient education is a cornerstone of treatment in diabetes mellitus, but there is not unanimity of opinion as to how it should be delivered...
- Effect of the dietary approaches to stop hypertension diet and reduced sodium intake on blood pressure controlLaura P Svetkey
Duke Hypertension Center, Duke University Medical Center, Durham, NC 27710, USA
J Clin Hypertens (Greenwich) 6:373-81. 2004..BP became normal or optimal in 71% of persons consuming the control/lower sodium diet and 77% of persons consuming the DASH/lower sodium diet. Both the DASH diet and reduced sodium intake improved BP control...
- Dietary sodium intake modulates myocardial relaxation responsiveness to angiotensin IIJonathan S Williams
Division of Endocrinology, Diabetes and Hypertension, Brigham and Women s Hospital and Harvard Medical School, Boston, Mass 02115, USA
Transl Res 148:49-54. 2006..Ang II may play a role in the interaction between dietary sodium and myocardial relaxation. Future research will investigate whether abnormalities in these mechanisms play a role in disorders of diastolic function...
- Web-based education in systems-based practice: a randomized trialB Price Kerfoot
Urology Section, Veterans Affairs Boston Healthcare System, Harvard Medical School, and Endocrinology, Diabetes, and Hypertension Division, Brigham and Women s Hospital, Boston, Mass 02130, USA
Arch Intern Med 167:361-6. 2007..Medical schools are now adopting similar competency frameworks. We investigated whether a Web-based program could effectively teach and assess elements of systems-based practice...
- Practitioner-level determinants of inappropriate prostate-specific antigen screeningB Price Kerfoot
VA Boston Healthcare System, 150 S Huntington Ave, 151DIA, Jamaica Plain, MA 02130, USA
Arch Intern Med 167:1367-72. 2007..We investigated the practitioner-level determinants of inappropriate PSA screening in 7 Veterans Health Administration (VHA) hospitals...
- Framework for a national teleretinal imaging program to screen for diabetic retinopathy in Veterans Health Administration patientsPaul R Conlin
Endocrinology Section, Department of Veterans Affairs VA Boston Healthcare System, Boston, MA 02130, USA
J Rehabil Res Dev 43:741-8. 2006....
- Eat your fruits and vegetables but hold the saltPaul R Conlin
Circulation 116:1530-1. 2007
- Aortic diameter, wall stiffness, and wave reflection in systolic hypertensionGary F Mitchell
Cardiovascular Engineering Inc, University Office Park, Bldg 2, Suite 100, 51 Sawyer Road, Waltham, MA 02453, USA
Hypertension 51:105-11. 2008..Among individuals with systolic hypertension, increased PP is primarily attributable to increased wall stiffness and reduced aortic diameter rather than premature wave reflection...
- Red blood cell Na+/H+ exchange activity is insulin resistant in hypertensive patientsJose R Romero
Endocrinology Hypertension Division, Brigham and Women s Hospital, Boston, MA 02115, USA
Clin Exp Hypertens 24:277-87. 2002..Hypertensive patients have elevated basal NHE activity but a blunted response to insulin suggesting that RBC may be a model to study insulin resistance in essential hypertensive patients...
- Successfully recruiting a multicultural population: the DASH-Sodium experienceBetty M Kennedy
Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA
Ethn Dis 15:123-9. 2005..Although the most successful method of recruitment was mass mailing brochures, three times as many brochures were distributed to obtain similar success as in the initial DASH trial...
- Effect of dietary sodium intake on blood lipids: results from the DASH-sodium trialDavid W Harsha
Pennington Biomedical Research Center, Baton Rouge, LA, USA
Hypertension 43:393-8. 2004..There were no significant interactions between the effects of sodium and the DASH diet on serum lipids. In conclusion, changes in dietary sodium intake over the range of 50 to 150 mmol/d did not affect blood lipid concentrations...
- Sodium and blood pressure: no data dredging, please!Frank M Sacks
Am J Hypertens 16:614-6. 2003
- Effects of the Dietary Approaches to Stop Hypertension (DASH) diet on the pressure-natriuresis relationshipSachie Akita
Department of Internal Medicine and Pathophysiology, Nagoya City University Graduate School of Medical Sciences, Mizuho cho, Mizuho ku, Nagoya 467 8601, Japan
Hypertension 42:8-13. 2003..5+/-3.4 vs 64.9+/-13.1 [mmol/d]/mm Hg, P=0.0002) without significantly shifting the x-intercept (94.1+/-0.5 vs 93.2+/-0.6 mm Hg, NS) of the relationship. These data suggest a natriuretic action of the DASH diet...
- Genes and environment in blood pressure control--salt intake again shows its importancePaul R Conlin
Am J Clin Nutr 88:255-6. 2008
- Cardiovascular and renal hemodynamics and the DASH dietPaul Conlin; Fiscal Year: 2009..abstract_text> ..