Clark K Colton

Summary

Affiliation: Massachusetts Institute of Technology
Country: USA

Publications

  1. doi request reprint Oxygen supply to encapsulated therapeutic cells
    Clark K Colton
    Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA Electronic address
    Adv Drug Deliv Rev 67:93-110. 2014
  2. pmc Quantitative analysis of cell composition and purity of human pancreatic islet preparations
    Anna Pisania
    Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA 02139 4307
    Lab Invest 90:1661-75. 2010
  3. pmc Enumeration of islets by nuclei counting and light microscopic analysis
    Anna Pisania
    Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139 4307, USA
    Lab Invest 90:1676-86. 2010
  4. ncbi request reprint Engineering challenges in cell-encapsulation technology
    C K Cotton
    Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge 02139 4307, USA
    Trends Biotechnol 14:158-62. 1996
  5. doi request reprint Accurate control of oxygen level in cells during culture on silicone rubber membranes with application to stem cell differentiation
    Daryl E Powers
    Dept of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Biotechnol Prog 26:805-18. 2010
  6. pmc Quantitative assessment of islets of Langerhans encapsulated in alginate
    Amy S Johnson
    Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139 4307, USA
    Tissue Eng Part C Methods 17:435-49. 2011
  7. pmc Prediction of marginal mass required for successful islet transplantation
    Klearchos K Papas
    Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA
    J Invest Surg 23:28-34. 2010
  8. doi request reprint The effects of low oxygen on self-renewal and differentiation of embryonic stem cells
    Jeffrey R Millman
    Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, 02139, USA
    Curr Opin Organ Transplant 14:694-700. 2009
  9. doi request reprint Engineering microenvironments for embryonic stem cell differentiation to cardiomyocytes
    Renita E Horton
    Harvard University School of Engineering and Applied Sciences, 29 Oxford Street, Pierce Hall Room 317, Cambridge, MA 02138, USA
    Regen Med 4:721-32. 2009
  10. pmc A stirred microchamber for oxygen consumption rate measurements with pancreatic islets
    Klearchos K Papas
    Department of Chemical Engineering, Massachusetts Institute of Technology, 25 Ames St, Cambridge, Massachusetts 02139, USA
    Biotechnol Bioeng 98:1071-82. 2007

Research Grants

  1. Assessment of Islet Quality
    Clark Colton; Fiscal Year: 2005

Collaborators

  • Susan Bonner-Weir
  • Maria Koulmanda
  • Abdulkadir Omer
  • Gordon C Weir
  • Anna Pisania
  • Daryl E Powers
  • Jeffrey R Millman
  • Klearchos K Papas
  • Amy S Johnson
  • Michael J Rappel
  • Renita E Horton
  • Haiyan Wu
  • Robert J Fisher
  • Esther O'Sullivan
  • Laura N D'Aoust
  • Andi Qipo
  • Bernhard J Hering
  • Vaja Tchipashvili
  • Ji Lei
  • Rebecca A Nelson
  • John J O'Neil
  • Debra T Auguste
  • Jit Hin Tan
  • Ryan B Huang
  • C K Cotton

Detail Information

Publications11

  1. doi request reprint Oxygen supply to encapsulated therapeutic cells
    Clark K Colton
    Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA Electronic address
    Adv Drug Deliv Rev 67:93-110. 2014
    ..Recent developments, particularly in this latter area, suggest that the field is ready for clinical trials of encapsulated therapeutic cells to treat diabetes. ..
  2. pmc Quantitative analysis of cell composition and purity of human pancreatic islet preparations
    Anna Pisania
    Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA 02139 4307
    Lab Invest 90:1661-75. 2010
    ..Thus, both EM and LM provide accurate methods to determine the cell composition of human islet preparations and can help us understand many of the discrepancies of islet composition in the literature...
  3. pmc Enumeration of islets by nuclei counting and light microscopic analysis
    Anna Pisania
    Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139 4307, USA
    Lab Invest 90:1676-86. 2010
    ..Nuclei counting combined with islet volume fraction measurements from LM is a novel method for achieving accurate islet enumeration...
  4. ncbi request reprint Engineering challenges in cell-encapsulation technology
    C K Cotton
    Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge 02139 4307, USA
    Trends Biotechnol 14:158-62. 1996
    ....
  5. doi request reprint Accurate control of oxygen level in cells during culture on silicone rubber membranes with application to stem cell differentiation
    Daryl E Powers
    Dept of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Biotechnol Prog 26:805-18. 2010
    ..Silicone rubber membranes have significant advantages over polystyrene in controlling pO(2cell), and these results suggest they are a valuable tool for investigating pO(2) effects in many applications, such as stem cell differentiation...
  6. pmc Quantitative assessment of islets of Langerhans encapsulated in alginate
    Amy S Johnson
    Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139 4307, USA
    Tissue Eng Part C Methods 17:435-49. 2011
    ....
  7. pmc Prediction of marginal mass required for successful islet transplantation
    Klearchos K Papas
    Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA
    J Invest Surg 23:28-34. 2010
    ..Because human clinical islet preparations in a previous study had OCR/DNA...
  8. doi request reprint The effects of low oxygen on self-renewal and differentiation of embryonic stem cells
    Jeffrey R Millman
    Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, 02139, USA
    Curr Opin Organ Transplant 14:694-700. 2009
    ..To summarize recent reports on the effects of low oxygen on the undifferentiated phenotype and differentiation of embryonic stem cells (ESCs)...
  9. doi request reprint Engineering microenvironments for embryonic stem cell differentiation to cardiomyocytes
    Renita E Horton
    Harvard University School of Engineering and Applied Sciences, 29 Oxford Street, Pierce Hall Room 317, Cambridge, MA 02138, USA
    Regen Med 4:721-32. 2009
    ..Successful translation of stem cell research to therapeutic applications will need to address large-scale cardiomyocyte differentiation and purification, assessment of cardiac function and synchronization, and safety concerns...
  10. pmc A stirred microchamber for oxygen consumption rate measurements with pancreatic islets
    Klearchos K Papas
    Department of Chemical Engineering, Massachusetts Institute of Technology, 25 Ames St, Cambridge, Massachusetts 02139, USA
    Biotechnol Bioeng 98:1071-82. 2007
    ....
  11. doi request reprint Effects of oxygen on mouse embryonic stem cell growth, phenotype retention, and cellular energetics
    Daryl E Powers
    Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Ave, Room 66 452, Cambridge, Massachusetts 02139, USA
    Biotechnol Bioeng 101:241-54. 2008
    ..Oxygen has minimal effects on undifferentiated cell growth and phenotype, but may exert more substantial effects under differentiating conditions...

Research Grants1

  1. Assessment of Islet Quality
    Clark Colton; Fiscal Year: 2005
    ..abstract_text> ..